UniProtKB - Q8TE68 (ES8L1_HUMAN)
Epidermal growth factor receptor kinase substrate 8-like protein 1
EPS8L1
Functioni
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
1 PublicationGO - Molecular functioni
- actin binding Source: UniProtKB
- cadherin binding Source: BHF-UCL
- T cell receptor binding Source: UniProtKB
GO - Biological processi
- positive regulation of ruffle assembly Source: UniProtKB
- regulation of catalytic activity Source: GOC
- regulation of Rho protein signal transduction Source: UniProtKB
- Rho protein signal transduction Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8TE68 |
SignaLinki | Q8TE68 |
Names & Taxonomyi
Protein namesi | Recommended name: Epidermal growth factor receptor kinase substrate 8-like protein 1Short name: EPS8-like protein 1 Alternative name(s): Epidermal growth factor receptor pathway substrate 8-related protein 1 Short name: EPS8-related protein 1 |
Gene namesi | Name:EPS8L1 Synonyms:DRC3, EPS8R1 ORF Names:PP10566 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21295, EPS8L1 |
MIMi | 614987, gene |
neXtProti | NX_Q8TE68 |
VEuPathDBi | HostDB:ENSG00000131037 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
- ruffle membrane Source: UniProtKB
Other locations
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 54869 |
OpenTargetsi | ENSG00000131037 |
PharmGKBi | PA134990326 |
Miscellaneous databases
Pharosi | Q8TE68, Tbio |
Genetic variation databases
BioMutai | EPS8L1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239082 | 1 – 723 | Epidermal growth factor receptor kinase substrate 8-like protein 1Add BLAST | 723 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 182 | PhosphoserineCombined sources | 1 | |
Modified residuei | 187 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8TE68 |
jPOSTi | Q8TE68 |
MassIVEi | Q8TE68 |
MaxQBi | Q8TE68 |
PaxDbi | Q8TE68 |
PeptideAtlasi | Q8TE68 |
PRIDEi | Q8TE68 |
ProteomicsDBi | 74407 [Q8TE68-1] 74408 [Q8TE68-2] 74409 [Q8TE68-3] 74410 [Q8TE68-4] |
PTM databases
iPTMneti | Q8TE68 |
PhosphoSitePlusi | Q8TE68 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000131037, Expressed in lower esophagus mucosa and 191 other tissues |
ExpressionAtlasi | Q8TE68, baseline and differential |
Genevisiblei | Q8TE68, HS |
Organism-specific databases
HPAi | ENSG00000131037, Tissue enhanced (esophagus, skin) |
Interactioni
Subunit structurei
Interacts with ABI1.
Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.
1 PublicationBinary interactionsi
Q8TE68
With | #Exp. | IntAct |
---|---|---|
ADAM19 [Q9H013] | 2 | EBI-7487998,EBI-8567699 |
CD3E [P07766] | 6 | EBI-7487998,EBI-1211297 |
TERF2IP [Q9NYB0] | 2 | EBI-7487998,EBI-750109 |
Isoform 2 [Q8TE68-2]
With | #Exp. | IntAct |
---|---|---|
ABI2 - isoform 2 [Q9NYB9-2] | 3 | EBI-12003490,EBI-11096309 |
CYSRT1 [A8MQ03] | 3 | EBI-12003490,EBI-3867333 |
Isoform 3 [Q8TE68-3]
With | #Exp. | IntAct |
---|---|---|
GRN [P28799] | 3 | EBI-21574901,EBI-747754 |
HTT [P42858] | 3 | EBI-21574901,EBI-466029 |
PEX1 [O43933] | 3 | EBI-21574901,EBI-988601 |
WFS1 [O76024] | 3 | EBI-21574901,EBI-720609 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- cadherin binding Source: BHF-UCL
- T cell receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120218, 53 interactors |
CORUMi | Q8TE68 |
IntActi | Q8TE68, 13 interactors |
MINTi | Q8TE68 |
STRINGi | 9606.ENSP00000201647 |
Miscellaneous databases
RNActi | Q8TE68, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8TE68 |
BMRBi | Q8TE68 |
SMRi | Q8TE68 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TE68 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 478 – 537 | SH3PROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 247 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 442 – 477 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 537 – 589 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 609 – 636 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 689 – 719 | Sequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 182 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 550 – 571 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 572 – 589 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG3557, Eukaryota |
GeneTreei | ENSGT00940000158125 |
HOGENOMi | CLU_014510_0_0_1 |
InParanoidi | Q8TE68 |
OMAi | SEVRRPH |
OrthoDBi | 218804at2759 |
PhylomeDBi | Q8TE68 |
TreeFami | TF313069 |
Family and domain databases
CDDi | cd01210, PTB_EPS8, 1 hit cd11764, SH3_Eps8, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR039801, EPS8-like IPR033928, EPS8_PTB IPR035462, Eps8_SH3 IPR011993, PH-like_dom_sf IPR013625, PTB IPR006020, PTB/PI_dom IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12287, PTHR12287, 1 hit |
Pfami | View protein in Pfam PF08416, PTB, 1 hit PF18016, SAM_3, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSTATGPEAA PKPSAKSIYE QRKRYSTVVM ADVSQYPVNH LVTFCLGEDD
60 70 80 90 100
GVHTVEDASR KLAVMDSQGR VWAQEMLLRV SPDHVTLLDP ASKEELESYP
110 120 130 140 150
LGAIVRCDAV MPPGRSRSLL LLVCQEPERA QPDVHFFQGL RLGAELIRED
160 170 180 190 200
IQGALHNYRS GRGERRAAAL RATQEELQRD RSPAAETPPL QRRPSVRAVI
210 220 230 240 250
STVERGAGRG RPQAKPIPEA EEAQRPEPVG TSSNADSASP DLGPRGPDLA
260 270 280 290 300
VLQAEREVDI LNHVFDDVES FVSRLQKSAE AARVLEHRER GRRSRRRAAG
310 320 330 340 350
EGLLTLRAKP PSEAEYTDVL QKIKYAFSLL ARLRGNIADP SSPELLHFLF
360 370 380 390 400
GPLQMIVNTS GGPEFASSVR RPHLTSDAVA LLRDNVTPRE NELWTSLGDS
410 420 430 440 450
WTRPGLELSP EEGPPYRPEF FSGWEPPVTD PQSRAWEDPV EKQLQHERRR
460 470 480 490 500
RQQSAPQVAV NGHRDLEPES EPQLESETAG KWVLCNYDFQ ARNSSELSVK
510 520 530 540 550
QRDVLEVLDD SRKWWKVRDP AGQEGYVPYN ILTPYPGPRL HHSQSPARSL
560 570 580 590 600
NSTPPPPPAP APAPPPALAR PRWDRPRWDS CDSLNGLDPS EKEKFSQMLI
610 620 630 640 650
VNEELQARLA QGRSGPSRAV PGPRAPEPQL SPGSDASEVR AWLQAKGFSS
660 670 680 690 700
GTVDALGVLT GAQLFSLQKE ELRAVSPEEG ARVYSQVTVQ RSLLEDKEKV
710 720
SELEAVMEKQ KKKVEGEVEM EVI
The sequence of this isoform differs from the canonical sequence as follows:
1-39: MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVN → MGRKAIVLAIANTSLAFPLCQ
451-451: R → RQVTQATQQGRGWEVRGRGRSAWPRLTRLSYFL
509-696: DDSRKWWKVR...VTVQRSLLED → ED
The sequence of this isoform differs from the canonical sequence as follows:
1-177: Missing.
178-187: QRDRSPAAET → MSPLSPGSPL
191-300: QRRPSVRAVI...GRRSRRRAAG → ARADLTAILTGCPPLSACLVLAPRPHRRARLLPS
451-451: R → RQVTQATQQGRGWEVRGRGRSAWPRLTRLSYFL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DKV7 | B4DKV7_HUMAN | Epidermal growth factor receptor ki... | EPS8L1 | 659 | Annotation score: | ||
K7EN83 | K7EN83_HUMAN | EPS8-like 1, isoform CRA_d | EPS8L1 hCG_20264 | 548 | Annotation score: | ||
K7ELW3 | K7ELW3_HUMAN | Epidermal growth factor receptor ki... | EPS8L1 | 409 | Annotation score: | ||
K7EKX9 | K7EKX9_HUMAN | Epidermal growth factor receptor ki... | EPS8L1 | 428 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | M → T in BAC11399 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 555 | P → S in AAL76117 (PubMed:12620401).Curated | 1 | |
Sequence conflicti | 688 | T → I in BAA91041 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 695 | E → G in BAC11399 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060375 | 4 | A → T2 PublicationsCorresponds to variant dbSNP:rs12609976Ensembl. | 1 | |
Natural variantiVAR_060376 | 288 | R → G. Corresponds to variant dbSNP:rs1620074Ensembl. | 1 | |
Natural variantiVAR_056870 | 457 | Q → E2 PublicationsCorresponds to variant dbSNP:rs1628576Ensembl. | 1 | |
Natural variantiVAR_060377 | 669 | K → R3 PublicationsCorresponds to variant dbSNP:rs1054940Ensembl. | 1 | |
Natural variantiVAR_061647 | 703 | L → P. Corresponds to variant dbSNP:rs60073068Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019082 | 1 – 177 | Missing in isoform 4. 1 PublicationAdd BLAST | 177 | |
Alternative sequenceiVSP_019083 | 1 – 127 | Missing in isoform 2. 2 PublicationsAdd BLAST | 127 | |
Alternative sequenceiVSP_019084 | 1 – 39 | MSTAT…QYPVN → MGRKAIVLAIANTSLAFPLC Q in isoform 3. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_019085 | 128 – 143 | ERAQP…GLRLG → MNRTWPRRIWGSSQDE in isoform 2. 2 PublicationsAdd BLAST | 16 | |
Alternative sequenceiVSP_019086 | 178 – 187 | QRDRSPAAET → MSPLSPGSPL in isoform 4. 1 Publication | 10 | |
Alternative sequenceiVSP_019087 | 191 – 300 | QRRPS…RRAAG → ARADLTAILTGCPPLSACLV LAPRPHRRARLLPS in isoform 4. 1 PublicationAdd BLAST | 110 | |
Alternative sequenceiVSP_019088 | 451 | R → RQVTQATQQGRGWEVRGRGR SAWPRLTRLSYFL in isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_019089 | 509 – 696 | DDSRK…SLLED → ED in isoform 3. 1 PublicationAdd BLAST | 188 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF282168 Genomic DNA Translation: AAG03039.1 Sequence problems. AF282167 mRNA Translation: AAG03038.1 Frameshift. AY074928 mRNA Translation: AAL76117.1 AF370395 mRNA Translation: AAQ15231.1 AK000265 mRNA Translation: BAA91041.1 AK075098 mRNA Translation: BAC11399.1 AC005782 Genomic DNA No translation available. AC011476 Genomic DNA No translation available. BC004907 mRNA Translation: AAH04907.2 BC015763 mRNA Translation: AAH15763.1 |
CCDSi | CCDS12914.1 [Q8TE68-1] CCDS12915.1 [Q8TE68-2] |
RefSeqi | NP_060199.3, NM_017729.3 [Q8TE68-2] NP_573441.2, NM_133180.2 [Q8TE68-1] |
Genome annotation databases
Ensembli | ENST00000201647.11; ENSP00000201647.5; ENSG00000131037.15 ENST00000245618.5; ENSP00000245618.4; ENSG00000131037.15 [Q8TE68-2] |
GeneIDi | 54869 |
KEGGi | hsa:54869 |
MANE-Selecti | ENST00000201647.11; ENSP00000201647.5; NM_133180.3; NP_573441.2 |
UCSCi | uc002qis.5, human [Q8TE68-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF282168 Genomic DNA Translation: AAG03039.1 Sequence problems. AF282167 mRNA Translation: AAG03038.1 Frameshift. AY074928 mRNA Translation: AAL76117.1 AF370395 mRNA Translation: AAQ15231.1 AK000265 mRNA Translation: BAA91041.1 AK075098 mRNA Translation: BAC11399.1 AC005782 Genomic DNA No translation available. AC011476 Genomic DNA No translation available. BC004907 mRNA Translation: AAH04907.2 BC015763 mRNA Translation: AAH15763.1 |
CCDSi | CCDS12914.1 [Q8TE68-1] CCDS12915.1 [Q8TE68-2] |
RefSeqi | NP_060199.3, NM_017729.3 [Q8TE68-2] NP_573441.2, NM_133180.2 [Q8TE68-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K2M | NMR | - | A | 481-536 | [»] | |
2ROL | NMR | - | A | 478-537 | [»] | |
AlphaFoldDBi | Q8TE68 | |||||
BMRBi | Q8TE68 | |||||
SMRi | Q8TE68 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120218, 53 interactors |
CORUMi | Q8TE68 |
IntActi | Q8TE68, 13 interactors |
MINTi | Q8TE68 |
STRINGi | 9606.ENSP00000201647 |
PTM databases
iPTMneti | Q8TE68 |
PhosphoSitePlusi | Q8TE68 |
Genetic variation databases
BioMutai | EPS8L1 |
Proteomic databases
EPDi | Q8TE68 |
jPOSTi | Q8TE68 |
MassIVEi | Q8TE68 |
MaxQBi | Q8TE68 |
PaxDbi | Q8TE68 |
PeptideAtlasi | Q8TE68 |
PRIDEi | Q8TE68 |
ProteomicsDBi | 74407 [Q8TE68-1] 74408 [Q8TE68-2] 74409 [Q8TE68-3] 74410 [Q8TE68-4] |
Protocols and materials databases
Antibodypediai | 19481, 159 antibodies from 24 providers |
DNASUi | 54869 |
Genome annotation databases
Ensembli | ENST00000201647.11; ENSP00000201647.5; ENSG00000131037.15 ENST00000245618.5; ENSP00000245618.4; ENSG00000131037.15 [Q8TE68-2] |
GeneIDi | 54869 |
KEGGi | hsa:54869 |
MANE-Selecti | ENST00000201647.11; ENSP00000201647.5; NM_133180.3; NP_573441.2 |
UCSCi | uc002qis.5, human [Q8TE68-1] |
Organism-specific databases
CTDi | 54869 |
DisGeNETi | 54869 |
GeneCardsi | EPS8L1 |
HGNCi | HGNC:21295, EPS8L1 |
HPAi | ENSG00000131037, Tissue enhanced (esophagus, skin) |
MIMi | 614987, gene |
neXtProti | NX_Q8TE68 |
OpenTargetsi | ENSG00000131037 |
PharmGKBi | PA134990326 |
VEuPathDBi | HostDB:ENSG00000131037 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3557, Eukaryota |
GeneTreei | ENSGT00940000158125 |
HOGENOMi | CLU_014510_0_0_1 |
InParanoidi | Q8TE68 |
OMAi | SEVRRPH |
OrthoDBi | 218804at2759 |
PhylomeDBi | Q8TE68 |
TreeFami | TF313069 |
Enzyme and pathway databases
PathwayCommonsi | Q8TE68 |
SignaLinki | Q8TE68 |
Miscellaneous databases
BioGRID-ORCSi | 54869, 19 hits in 1081 CRISPR screens |
ChiTaRSi | EPS8L1, human |
EvolutionaryTracei | Q8TE68 |
GeneWikii | EPS8L1 |
GenomeRNAii | 54869 |
Pharosi | Q8TE68, Tbio |
PROi | PR:Q8TE68 |
RNActi | Q8TE68, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131037, Expressed in lower esophagus mucosa and 191 other tissues |
ExpressionAtlasi | Q8TE68, baseline and differential |
Genevisiblei | Q8TE68, HS |
Family and domain databases
CDDi | cd01210, PTB_EPS8, 1 hit cd11764, SH3_Eps8, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR039801, EPS8-like IPR033928, EPS8_PTB IPR035462, Eps8_SH3 IPR011993, PH-like_dom_sf IPR013625, PTB IPR006020, PTB/PI_dom IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12287, PTHR12287, 1 hit |
Pfami | View protein in Pfam PF08416, PTB, 1 hit PF18016, SAM_3, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ES8L1_HUMAN | |
Accessioni | Q8TE68Primary (citable) accession number: Q8TE68 Secondary accession number(s): Q71RE2 Q9NXH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families