UniProtKB - Q8TE68 (ES8L1_HUMAN)

BLAST

>sp|Q8TE68|ES8L1_HUMAN Epidermal growth factor receptor kinase substrate 8-like protein 1 OS=Homo sapiens OX=9606 GN=EPS8L1 PE=1 SV=3
MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASR
KLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLL
LLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRD
RSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASP
DLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAG
EGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTS
GGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEF
FSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAG
KWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRL
HHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLI
VNEELQARLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLT
GAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEM
EVI

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History
Entry version 134 (07 Nov 2018)
Sequence version 3 (18 May 2010)
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Protein

Epidermal growth factor receptor kinase substrate 8-like protein 1

Gene

EPS8L1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.1 Publication

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 14565974
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
T cell receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17617578

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of ruffle assembly
Source: UniProtKB
Inferred from genetic interactionⁱ
- 14565974
regulation of Rho protein signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 14565974
Rho protein signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 14565974

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Epidermal growth factor receptor kinase substrate 8-like protein 1 Short name: EPS8-like protein 1 Alternative name(s): Epidermal growth factor receptor pathway substrate 8-related protein 1 Short name: EPS8-related protein 1
Gene namesⁱ	Name:EPS8L1 Synonyms:DRC3, EPS8R1 ORF Names:PP10566
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131037.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21295 EPS8L1
MIMⁱ	614987 gene
neXtProtⁱ	NX_Q8TE68

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000131037
PharmGKBⁱ	PA134990326

Polymorphism and mutation databases

BioMutaⁱ	EPS8L1

BioMutaⁱ

EPS8L1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000239082	1 – 723	Epidermal growth factor receptor kinase substrate 8-like protein 1Add BLAST		723

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	182	PhosphoserineCombined sources		1
Modified residueⁱ	187	PhosphothreonineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8TE68
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TE68
PaxDbⁱ	Q8TE68
PeptideAtlas More...PeptideAtlasⁱ	Q8TE68
PRIDEⁱ	Q8TE68
ProteomicsDBⁱ	74407 74408 [Q8TE68-2] 74409 [Q8TE68-3] 74410 [Q8TE68-4]

PTM databases

iPTMnetⁱ	Q8TE68
PhosphoSitePlusⁱ	Q8TE68

Expressionⁱ

Tissue specificityⁱ

Detected in placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000131037 Expressed in 172 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_EPS8L1
ExpressionAtlasⁱ	Q8TE68 baseline and differential
Genevisibleⁱ	Q8TE68 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041851 HPA043545

HPAⁱ

HPA041851
HPA043545

Interactionⁱ

Subunit structureⁱ

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CD3E	P07766	6	EBI-7487998,EBI-1211297
TERF2IP	Q9NYB0	2	EBI-7487998,EBI-750109

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 14565974
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
T cell receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17617578

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120218, 10 interactors
CORUMⁱ	Q8TE68
IntActⁱ	Q8TE68, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q8TE68

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	482 – 487	Combined sources	6
Beta strandⁱ	493 – 496	Combined sources	4
Beta strandⁱ	504 – 509	Combined sources	6
Beta strandⁱ	511 – 518	Combined sources	8
Beta strandⁱ	525 – 528	Combined sources	4
Helixⁱ	529 – 531	Combined sources	3
Beta strandⁱ	532 – 534	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8TE68
SMRⁱ	Q8TE68
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8TE68

EvolutionaryTraceⁱ

Q8TE68

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	478 – 537	SH3PROSITE-ProRule annotationAdd BLAST		60

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	689 – 719	Sequence analysisAdd BLAST		31

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	119 – 122	Poly-Leu	4
Compositional biasⁱ	448 – 451	Poly-Arg	4
Compositional biasⁱ	534 – 576	Pro-richAdd BLAST	43

Sequence similaritiesⁱ

Belongs to the EPS8 family.Curated

Keywords - Domainⁱ

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGⁱ	ENOG410IP0J Eukaryota ENOG4111F7Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003646
HOVERGENⁱ	HBG003090
InParanoidⁱ	Q8TE68
KEGG Orthology (KO) More...KOⁱ	K17277
OMAⁱ	SQYPVNH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G023T
PhylomeDBⁱ	Q8TE68
TreeFamⁱ	TF313069

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01210 PTB_EPS8, 1 hit cd11764 SH3_Eps8, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR039801 EPS8-like IPR033928 EPS8_PTB IPR035462 Eps8_SH3 IPR011993 PH-like_dom_sf IPR013625 PTB IPR006020 PTB/PI_dom IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR12287 PTHR12287, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08416 PTB, 1 hit PF00018 SH3_1, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002 SH3, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TE68-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSTATGPEAA PKPSAKSIYE QRKRYSTVVM ADVSQYPVNH LVTFCLGEDD 
        60         70         80         90        100
GVHTVEDASR KLAVMDSQGR VWAQEMLLRV SPDHVTLLDP ASKEELESYP 
       110        120        130        140        150
LGAIVRCDAV MPPGRSRSLL LLVCQEPERA QPDVHFFQGL RLGAELIRED 
       160        170        180        190        200
IQGALHNYRS GRGERRAAAL RATQEELQRD RSPAAETPPL QRRPSVRAVI 
       210        220        230        240        250
STVERGAGRG RPQAKPIPEA EEAQRPEPVG TSSNADSASP DLGPRGPDLA 
       260        270        280        290        300
VLQAEREVDI LNHVFDDVES FVSRLQKSAE AARVLEHRER GRRSRRRAAG 
       310        320        330        340        350
EGLLTLRAKP PSEAEYTDVL QKIKYAFSLL ARLRGNIADP SSPELLHFLF 
       360        370        380        390        400
GPLQMIVNTS GGPEFASSVR RPHLTSDAVA LLRDNVTPRE NELWTSLGDS 
       410        420        430        440        450
WTRPGLELSP EEGPPYRPEF FSGWEPPVTD PQSRAWEDPV EKQLQHERRR 
       460        470        480        490        500
RQQSAPQVAV NGHRDLEPES EPQLESETAG KWVLCNYDFQ ARNSSELSVK 
       510        520        530        540        550
QRDVLEVLDD SRKWWKVRDP AGQEGYVPYN ILTPYPGPRL HHSQSPARSL 
       560        570        580        590        600
NSTPPPPPAP APAPPPALAR PRWDRPRWDS CDSLNGLDPS EKEKFSQMLI 
       610        620        630        640        650
VNEELQARLA QGRSGPSRAV PGPRAPEPQL SPGSDASEVR AWLQAKGFSS 
       660        670        680        690        700
GTVDALGVLT GAQLFSLQKE ELRAVSPEEG ARVYSQVTVQ RSLLEDKEKV 
       710        720 
SELEAVMEKQ KKKVEGEVEM EVI

Length:723

Mass (Da):80,251

Last modified:May 18, 2010 - v3

Checksum:ⁱE55F71B6E128151E

Isoform 2 (identifier: Q8TE68-2) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
1-127: Missing.
128-143: ERAQPDVHFFQGLRLG → MNRTWPRRIWGSSQDE

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        10         20         30         40         50
MNRTWPRRIW GSSQDEAELI REDIQGALHN YRSGRGERRA AALRATQEEL 
        60         70         80         90        100
QRDRSPAAET PPLQRRPSVR AVISTVERGA GRGRPQAKPI PEAEEAQRPE 
       110        120        130        140        150
PVGTSSNADS ASPDLGPRGP DLAVLQAERE VDILNHVFDD VESFVSRLQK 
       160        170        180        190        200
SAEAARVLEH RERGRRSRRR AAGEGLLTLR AKPPSEAEYT DVLQKIKYAF 
       210        220        230        240        250
SLLARLRGNI ADPSSPELLH FLFGPLQMIV NTSGGPEFAS SVRRPHLTSD 
       260        270        280        290        300
AVALLRDNVT PRENELWTSL GDSWTRPGLE LSPEEGPPYR PEFFSGWEPP 
       310        320        330        340        350
VTDPQSRAWE DPVEKQLQHE RRRRQQSAPQ VAVNGHRDLE PESEPQLESE 
       360        370        380        390        400
TAGKWVLCNY DFQARNSSEL SVKQRDVLEV LDDSRKWWKV RDPAGQEGYV 
       410        420        430        440        450
PYNILTPYPG PRLHHSQSPA RSLNSTPPPP PAPAPAPPPA LARPRWDRPR 
       460        470        480        490        500
WDSCDSLNGL DPSEKEKFSQ MLIVNEELQA RLAQGRSGPS RAVPGPRAPE 
       510        520        530        540        550
PQLSPGSDAS EVRAWLQAKG FSSGTVDALG VLTGAQLFSL QKEELRAVSP 
       560        570        580        590 
EEGARVYSQV TVQRSLLEDK EKVSELEAVM EKQKKKVEGE VEMEVI

Show »

Length:596

Mass (Da):66,477

Checksum:ⁱCA417997A8419B8F

Isoform 3 (identifier: Q8TE68-3) [UniParc]FASTA Add to basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVN → MGRKAIVLAIANTSLAFPLCQ
     451-451: R → RQVTQATQQGRGWEVRGRGRSAWPRLTRLSYFL
     509-696: DDSRKWWKVR...VTVQRSLLED → ED

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        10         20         30         40         50
MGRKAIVLAI ANTSLAFPLC QHLVTFCLGE DDGVHTVEDA SRKLAVMDSQ 
        60         70         80         90        100
GRVWAQEMLL RVSPDHVTLL DPASKEELES YPLGAIVRCD AVMPPGRSRS 
       110        120        130        140        150
LLLLVCQEPE RAQPDVHFFQ GLRLGAELIR EDIQGALHNY RSGRGERRAA 
       160        170        180        190        200
ALRATQEELQ RDRSPAAETP PLQRRPSVRA VISTVERGAG RGRPQAKPIP 
       210        220        230        240        250
EAEEAQRPEP VGTSSNADSA SPDLGPRGPD LAVLQAEREV DILNHVFDDV 
       260        270        280        290        300
ESFVSRLQKS AEAARVLEHR ERGRRSRRRA AGEGLLTLRA KPPSEAEYTD 
       310        320        330        340        350
VLQKIKYAFS LLARLRGNIA DPSSPELLHF LFGPLQMIVN TSGGPEFASS 
       360        370        380        390        400
VRRPHLTSDA VALLRDNVTP RENELWTSLG DSWTRPGLEL SPEEGPPYRP 
       410        420        430        440        450
EFFSGWEPPV TDPQSRAWED PVEKQLQHER RRRQVTQATQ QGRGWEVRGR 
       460        470        480        490        500
GRSAWPRLTR LSYFLQQSAP QVAVNGHRDL EPESEPQLES ETAGKWVLCN 
       510        520        530        540        550
YDFQARNSSE LSVKQRDVLE VLEDKEKVSE LEAVMEKQKK KVEGEVEMEV 

I

Show »

Length:551

Mass (Da):61,682

Checksum:ⁱ39325B1AB8281946

Isoform 4 (identifier: Q8TE68-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     178-187: QRDRSPAAET → MSPLSPGSPL
     191-300: QRRPSVRAVI...GRRSRRRAAG → ARADLTAILTGCPPLSACLVLAPRPHRRARLLPS
     451-451: R → RQVTQATQQGRGWEVRGRGRSAWPRLTRLSYFL

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        10         20         30         40         50
MSPLSPGSPL PPLARADLTA ILTGCPPLSA CLVLAPRPHR RARLLPSEGL 
        60         70         80         90        100
LTLRAKPPSE AEYTDVLQKI KYAFSLLARL RGNIADPSSP ELLHFLFGPL 
       110        120        130        140        150
QMIVNTSGGP EFASSVRRPH LTSDAVALLR DNVTPRENEL WTSLGDSWTR 
       160        170        180        190        200
PGLELSPEEG PPYRPEFFSG WEPPVTDPQS RAWEDPVEKQ LQHERRRRQV 
       210        220        230        240        250
TQATQQGRGW EVRGRGRSAW PRLTRLSYFL QQSAPQVAVN GHRDLEPESE 
       260        270        280        290        300
PQLESETAGK WVLCNYDFQA RNSSELSVKQ RDVLEVLDDS RKWWKVRDPA 
       310        320        330        340        350
GQEGYVPYNI LTPYPGPRLH HSQSPARSLN STPPPPPAPA PAPPPALARP 
       360        370        380        390        400
RWDRPRWDSC DSLNGLDPSE KEKFSQMLIV NEELQARLAQ GRSGPSRAVP 
       410        420        430        440        450
GPRAPEPQLS PGSDASEVRA WLQAKGFSSG TVDALGVLTG AQLFSLQKEE 
       460        470        480        490        500
LRAVSPEEGA RVYSQVTVQR SLLEDKEKVS ELEAVMEKQK KKVEGEVEME 

VI

Show »

Length:502

Mass (Da):55,807

Checksum:ⁱ03BA1843CECD229A

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EN83	K7EN83_HUMAN	EPS8-like 1, isoform CRA_d EPS8-like 1, isoform CRA_d (Epidermal growth factor receptor kinase substrate 8-like protein 1)	EPS8L1 hCG_20264	548	Annotation score:
B4DKV7	B4DKV7_HUMAN	cDNA FLJ60287, highly similar to Ep... cDNA FLJ60287, highly similar to Epidermal growth factor receptor kinase substrate 8-like protein 1	EPS8L1	659	Annotation score:
K7ELW3	K7ELW3_HUMAN	Epidermal growth factor receptor ki... Epidermal growth factor receptor kinase substrate 8-like protein 1	EPS8L1	409	Annotation score:
K7EKX9	K7EKX9_HUMAN	Epidermal growth factor receptor ki... Epidermal growth factor receptor kinase substrate 8-like protein 1	EPS8L1	428	Annotation score:

Sequence cautionⁱ

The sequence AAG03038 differs from that shown. Reason: Frameshift at position 596.Curated

The sequence AAG03039 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30	M → T in BAC11399 (PubMed:14702039).Curated	1
Sequence conflictⁱ	555	P → S in AAL76117 (PubMed:12620401).Curated	1
Sequence conflictⁱ	688	T → I in BAA91041 (PubMed:14702039).Curated	1
Sequence conflictⁱ	695	E → G in BAC11399 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_060375	4	A → T2 PublicationsCorresponds to variant dbSNP:rs12609976Ensembl.	1
Natural variantⁱVAR_060376	288	R → G. Corresponds to variant dbSNP:rs1620074Ensembl.	1
Natural variantⁱVAR_056870	457	Q → E2 PublicationsCorresponds to variant dbSNP:rs1628576Ensembl.	1
Natural variantⁱVAR_060377	669	K → R3 PublicationsCorresponds to variant dbSNP:rs1054940Ensembl.	1
Natural variantⁱVAR_061647	703	L → P. Corresponds to variant dbSNP:rs60073068Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_019082	1 – 177	Missing in isoform 4. 1 PublicationAdd BLAST	177
Alternative sequenceⁱVSP_019083	1 – 127	Missing in isoform 2. 2 PublicationsAdd BLAST	127
Alternative sequenceⁱVSP_019084	1 – 39	MSTAT…QYPVN → MGRKAIVLAIANTSLAFPLC Q in isoform 3. 1 PublicationAdd BLAST	39
Alternative sequenceⁱVSP_019085	128 – 143	ERAQP…GLRLG → MNRTWPRRIWGSSQDE in isoform 2. 2 PublicationsAdd BLAST	16
Alternative sequenceⁱVSP_019086	178 – 187	QRDRSPAAET → MSPLSPGSPL in isoform 4. 1 Publication	10
Alternative sequenceⁱVSP_019087	191 – 300	QRRPS…RRAAG → ARADLTAILTGCPPLSACLV LAPRPHRRARLLPS in isoform 4. 1 PublicationAdd BLAST	110
Alternative sequenceⁱVSP_019088	451	R → RQVTQATQQGRGWEVRGRGR SAWPRLTRLSYFL in isoform 3 and isoform 4. 2 Publications	1
Alternative sequenceⁱVSP_019089	509 – 696	DDSRK…SLLED → ED in isoform 3. 1 PublicationAdd BLAST	188

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF282168 Genomic DNA Translation: AAG03039.1 Sequence problems. AF282167 mRNA Translation: AAG03038.1 Frameshift. AY074928 mRNA Translation: AAL76117.1 AF370395 mRNA Translation: AAQ15231.1 AK000265 mRNA Translation: BAA91041.1 AK075098 mRNA Translation: BAC11399.1 AC005782 Genomic DNA No translation available. AC011476 Genomic DNA No translation available. BC004907 mRNA Translation: AAH04907.2 BC015763 mRNA Translation: AAH15763.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12914.1 [Q8TE68-1] CCDS12915.1 [Q8TE68-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_060199.3, NM_017729.3 [Q8TE68-2] NP_573441.2, NM_133180.2 [Q8TE68-1]
UniGeneⁱ	Hs.438862

Genome annotation databases

Ensemblⁱ	ENST00000201647; ENSP00000201647; ENSG00000131037 [Q8TE68-1] ENST00000245618; ENSP00000245618; ENSG00000131037 [Q8TE68-2]
GeneIDⁱ	54869
KEGGⁱ	hsa:54869
UCSC genome browser More...UCSCⁱ	uc002qis.5 human [Q8TE68-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TE68	cDNA FLJ60287, highly similar to Epidermal growth factor receptor kinase substrate 8-like protein 1		HUMAN		659	UniRef100_Q8TE68

Protein	Similar proteins		Species	Score	Length	Source
Q8TE68	cDNA FLJ60287, highly similar to Epidermal growth factor receptor kinase substrate 8-like protein 1		HUMAN		659	UniRef90_Q8TE68
EPS8 like 1		SAIBB		772
EPS8 like 1		GORGO		723
Uncharacterized protein		Cebus capucinus imitator		720
Uncharacterized protein		RHIRO		718
+34
Q8TE68-2	EPS8 like 1		CALJA		597	UniRef90_Q8TE68-2
Uncharacterized protein		PANPA		596
Uncharacterized protein		PAPAN		591
EPS8L1 isoform 8		PONAB		591
EPS8L1 isoform 5		PANTR		591
+9
Q8TE68-3	EPS8-like 1, isoform CRA_d		HUMAN		548	UniRef90_Q8TE68-3
EPS8L1 isoform 1		PONAB		548
EPS8 like 1		PANTR		548
Uncharacterized protein		PANPA		548
EPS8 like 1		GORGO		548
+14
Q8TE68-4	Epidermal growth factor receptor kinase substrate 8-like protein 1		HUMAN		409	UniRef90_Q8TE68-4
Uncharacterized protein		PANPA		409
EPS8 like 1		GORGO		409
EPS8L1 isoform 9		PONAB		404
EPS8 like 1		PANTR		404
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	)	MOUSE		716	UniRef50_Q8TE68
cDNA FLJ60287, highly similar to Epidermal growth factor receptor kinase substrate 8-like protein 1		HUMAN		659
EPS8 like 1		SAIBB		772
EPS8 like 1		GORGO		723
Uncharacterized protein		Cebus capucinus imitator		720
+176
Q8TE68-2	EPS8 like 1		CALJA		597	UniRef50_Q8TE68-2
Uncharacterized protein		PANPA		596
EPS8L1 isoform 5		PANTR		591
EPS8L1 isoform 8		PONAB		591
Uncharacterized protein		PAPAN		591
+57
Q8TE68-3	Isoform 2 of Epidermal growth factor receptor kinase substrate 8-like protein 1		HUMAN		596	UniRef50_Q8TE68-2
EPS8 like 1		CALJA		597
Uncharacterized protein		PANPA		596
EPS8L1 isoform 5		PANTR		591
EPS8L1 isoform 8		PONAB		591
+57
Q8TE68-4	EPS8 like 1		GORGO		409	UniRef50_Q8TE68-4
Uncharacterized protein		PANPA		409
cDNA FLJ60362, highly similar to Epidermal growth factor receptor kinase substrate 8-like protein 1		HUMAN		409
EPS8L1 isoform 9		PONAB		404
EPS8 like 1		PANTR		404
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF282168 Genomic DNA Translation: AAG03039.1 Sequence problems. AF282167 mRNA Translation: AAG03038.1 Frameshift. AY074928 mRNA Translation: AAL76117.1 AF370395 mRNA Translation: AAQ15231.1 AK000265 mRNA Translation: BAA91041.1 AK075098 mRNA Translation: BAC11399.1 AC005782 Genomic DNA No translation available. AC011476 Genomic DNA No translation available. BC004907 mRNA Translation: AAH04907.2 BC015763 mRNA Translation: AAH15763.1
CCDSⁱ	CCDS12914.1 [Q8TE68-1] CCDS12915.1 [Q8TE68-2]
RefSeqⁱ	NP_060199.3, NM_017729.3 [Q8TE68-2] NP_573441.2, NM_133180.2 [Q8TE68-1]
UniGeneⁱ	Hs.438862

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2K2M	NMR	-	A	481-536	[»]
	2ROL	NMR	-	A	478-537	[»]
ProteinModelPortalⁱ	Q8TE68
SMRⁱ	Q8TE68
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120218, 10 interactors
CORUMⁱ	Q8TE68
IntActⁱ	Q8TE68, 4 interactors
MINTⁱ	Q8TE68

PTM databases

iPTMnetⁱ	Q8TE68
PhosphoSitePlusⁱ	Q8TE68

Polymorphism and mutation databases

BioMutaⁱ	EPS8L1

BioMutaⁱ

EPS8L1

Proteomic databases

EPDⁱ	Q8TE68
MaxQBⁱ	Q8TE68
PaxDbⁱ	Q8TE68
PeptideAtlasⁱ	Q8TE68
PRIDEⁱ	Q8TE68
ProteomicsDBⁱ	74407 74408 [Q8TE68-2] 74409 [Q8TE68-3] 74410 [Q8TE68-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000201647; ENSP00000201647; ENSG00000131037 [Q8TE68-1] ENST00000245618; ENSP00000245618; ENSG00000131037 [Q8TE68-2]
GeneIDⁱ	54869
KEGGⁱ	hsa:54869
UCSCⁱ	uc002qis.5 human [Q8TE68-1]

Organism-specific databases

CTDⁱ	54869
EuPathDBⁱ	HostDB:ENSG00000131037.14
GeneCardsⁱ	EPS8L1
HGNCⁱ	HGNC:21295 EPS8L1
HPAⁱ	HPA041851 HPA043545
MIMⁱ	614987 gene
neXtProtⁱ	NX_Q8TE68
OpenTargetsⁱ	ENSG00000131037
PharmGKBⁱ	PA134990326
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IP0J Eukaryota ENOG4111F7Z LUCA
GeneTreeⁱ	ENSGT00390000003646
HOVERGENⁱ	HBG003090
InParanoidⁱ	Q8TE68
KOⁱ	K17277
OMAⁱ	SQYPVNH
OrthoDBⁱ	EOG091G023T
PhylomeDBⁱ	Q8TE68
TreeFamⁱ	TF313069

Miscellaneous databases

ChiTaRSⁱ	EPS8L1 human
EvolutionaryTraceⁱ	Q8TE68
GeneWikiⁱ	EPS8L1
GenomeRNAiⁱ	54869
Protein Ontology More...PROⁱ	PR:Q8TE68
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131037 Expressed in 172 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_EPS8L1
ExpressionAtlasⁱ	Q8TE68 baseline and differential
Genevisibleⁱ	Q8TE68 HS

Family and domain databases

CDDⁱ	cd01210 PTB_EPS8, 1 hit cd11764 SH3_Eps8, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR039801 EPS8-like IPR033928 EPS8_PTB IPR035462 Eps8_SH3 IPR011993 PH-like_dom_sf IPR013625 PTB IPR006020 PTB/PI_dom IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR12287 PTHR12287, 1 hit
Pfamⁱ	View protein in Pfam PF08416 PTB, 1 hit PF00018 SH3_1, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ES8L1_HUMAN
Accessionⁱ	Q8TE68Primary (citable) accession number: Q8TE68 Secondary accession number(s): Q71RE2 , Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8TE68 (ES8L1_HUMAN)

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Epidermal growth factor receptor kinase substrate 8-like protein 1

EPS8L1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

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Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Proteomic databases

Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ