Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 144 (02 Jun 2021)
Sequence version 2 (30 May 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Epidermal growth factor receptor kinase substrate 8-like protein 3

Gene

EPS8L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TE67

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 3
Short name:
EPS8-like protein 3
Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 3
Short name:
EPS8-related protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPS8L3
Synonyms:EPS8R3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21297, EPS8L3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614989, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TE67

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000198758.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypotrichosis 5 (HYPT5)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionA form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT5 is an autosomal dominant form characterized by little or no scalp hair at birth, wiry and irregular scalp hair in childhood, and sparse or no forehead and parietal hair at puberty. Eyebrows and eyelashes are thin, and pubic and axillary hair fails to develop. Scarring alopecia is modest, and vertex hair is normal.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0838298A → T in HYPT5; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease variant, Hypotrichosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
79574

MalaCards human disease database

More...
MalaCardsi
EPS8L3
MIMi612841, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198758

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
444, Marie Unna hereditary hypotrichosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134940846

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TE67, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EPS8L3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108864727

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002390871 – 593Epidermal growth factor receptor kinase substrate 8-like protein 3Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TE67

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TE67

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TE67

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TE67

PeptideAtlas

More...
PeptideAtlasi
Q8TE67

PRoteomics IDEntifications database

More...
PRIDEi
Q8TE67

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74404 [Q8TE67-1]
74405 [Q8TE67-2]
74406 [Q8TE67-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TE67

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TE67

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198758, Expressed in small intestine and 129 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TE67, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TE67, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198758, Group enriched (gallbladder, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ABI1.

Part of a complex that contains SOS1, ABI1 and EPS8L2.

Interacts with FASLG.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122721, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8TE67

Protein interaction database and analysis system

More...
IntActi
Q8TE67, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8TE67

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358820

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TE67, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TE67

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TE67

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini450 – 509SH3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 171DisorderedSequence analysisAdd BLAST23
Regioni184 – 239DisorderedSequence analysisAdd BLAST56
Regioni374 – 451DisorderedSequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi391 – 405Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EPS8 family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3557, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014510_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TE67

Identification of Orthologs from Complete Genome Data

More...
OMAi
NFILARC

Database of Orthologous Groups

More...
OrthoDBi
1324479at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TE67

TreeFam database of animal gene trees

More...
TreeFami
TF313069

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01210, PTB_EPS8, 1 hit
cd11764, SH3_Eps8, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039801, EPS8-like
IPR033928, EPS8_PTB
IPR035462, Eps8_SH3
IPR011993, PH-like_dom_sf
IPR013625, PTB
IPR013761, SAM/pointed_sf
IPR041418, SAM_3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR12287, PTHR12287, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08416, PTB, 1 hit
PF18016, SAM_3, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TE67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRPSSRAIY LHRKEYSQNL TSEPTLLQHR VEHLMTCKQG SQRVQGPEDA
60 70 80 90 100
LQKLFEMDAQ GRVWSQDLIL QVRDGWLQLL DIETKEELDS YRLDSIQAMN
110 120 130 140 150
VALNTCSYNS ILSITVQEPG LPGTSTLLFQ CQEVGAERLK TSLQKALEEE
160 170 180 190 200
LEQRPRLGGL QPGQDRWRGP AMERPLPMEQ ARYLEPGIPP EQPHQRTLEH
210 220 230 240 250
SLPPSPRPLP RHTSAREPSA FTLPPPRRSS SPEDPERDEE VLNHVLRDIE
260 270 280 290 300
LFMGKLEKAQ AKTSRKKKFG KKNKDQGGLT QAQYIDCFQK IKHSFNLLGR
310 320 330 340 350
LATWLKETSA PELVHILFKS LNFILARCPE AGLAAQVISP LLTPKAINLL
360 370 380 390 400
QSCLSPPESN LWMGLGPAWT TSRADWTGDE PLPYQPTFSD DWQLPEPSSQ
410 420 430 440 450
APLGYQDPVS LRRGSHRLGS TSHFPQEKTH NHDPQPGDPN SRPSSPKPAQ
460 470 480 490 500
PALKMQVLYE FEARNPRELT VVQGEKLEVL DHSKRWWLVK NEAGRSGYIP
510 520 530 540 550
SNILEPLQPG TPGTQGQSPS RVPMLRLSSR PEEVTDWLQA ENFSTATVRT
560 570 580 590
LGSLTGSQLL RIRPGELQML CPQEAPRILS RLEAVRRMLG ISP
Length:593
Mass (Da):66,861
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BB9B52ADD338F88
GO
Isoform 2 (identifier: Q8TE67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-441: Missing.

Show »
Length:563
Mass (Da):63,502
Checksum:iA3D9199068057B9F
GO
Isoform 3 (identifier: Q8TE67-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: Q → QS

Show »
Length:594
Mass (Da):66,948
Checksum:iE114E2211130CAAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X104A0A087X104_HUMAN
Epidermal growth factor receptor ki...
EPS8L3
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0838298A → T in HYPT5; unknown pathological significance. 1 Publication1
Natural variantiVAR_05097635M → I. Corresponds to variant dbSNP:rs17598321Ensembl.1
Natural variantiVAR_026580163G → S1 PublicationCorresponds to variant dbSNP:rs6693815Ensembl.1
Natural variantiVAR_026581293H → Y2 PublicationsCorresponds to variant dbSNP:rs3818562Ensembl.1
Natural variantiVAR_026582356P → S. Corresponds to variant dbSNP:rs11102001Ensembl.1
Natural variantiVAR_050977581R → Q. Corresponds to variant dbSNP:rs35072794Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019095153Q → QS in isoform 3. 1 Publication1
Alternative sequenceiVSP_019096412 – 441Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY074930 mRNA Translation: AAL76119.1
AK025175 mRNA Translation: BAB15081.1
AK292198 mRNA Translation: BAF84887.1
AL158847 Genomic DNA No translation available.
BC012926 mRNA Translation: AAH12926.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS813.1 [Q8TE67-2]
CCDS814.1 [Q8TE67-1]
CCDS815.1 [Q8TE67-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001306881.1, NM_001319952.1
NP_078802.2, NM_024526.3 [Q8TE67-2]
NP_573444.2, NM_133181.3 [Q8TE67-1]
NP_620641.1, NM_139053.2 [Q8TE67-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361852; ENSP00000354551; ENSG00000198758 [Q8TE67-2]
ENST00000361965; ENSP00000355255; ENSG00000198758 [Q8TE67-1]
ENST00000369805; ENSP00000358820; ENSG00000198758 [Q8TE67-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79574

UCSC genome browser

More...
UCSCi
uc001dyq.3, human [Q8TE67-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074930 mRNA Translation: AAL76119.1
AK025175 mRNA Translation: BAB15081.1
AK292198 mRNA Translation: BAF84887.1
AL158847 Genomic DNA No translation available.
BC012926 mRNA Translation: AAH12926.1
CCDSiCCDS813.1 [Q8TE67-2]
CCDS814.1 [Q8TE67-1]
CCDS815.1 [Q8TE67-3]
RefSeqiNP_001306881.1, NM_001319952.1
NP_078802.2, NM_024526.3 [Q8TE67-2]
NP_573444.2, NM_133181.3 [Q8TE67-1]
NP_620641.1, NM_139053.2 [Q8TE67-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WXTNMR-A453-507[»]
SMRiQ8TE67
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122721, 4 interactors
CORUMiQ8TE67
IntActiQ8TE67, 4 interactors
MINTiQ8TE67
STRINGi9606.ENSP00000358820

PTM databases

iPTMnetiQ8TE67
PhosphoSitePlusiQ8TE67

Genetic variation databases

BioMutaiEPS8L3
DMDMi108864727

Proteomic databases

jPOSTiQ8TE67
MassIVEiQ8TE67
MaxQBiQ8TE67
PaxDbiQ8TE67
PeptideAtlasiQ8TE67
PRIDEiQ8TE67
ProteomicsDBi74404 [Q8TE67-1]
74405 [Q8TE67-2]
74406 [Q8TE67-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q8TE67, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53746, 169 antibodies

The DNASU plasmid repository

More...
DNASUi
79574

Genome annotation databases

EnsembliENST00000361852; ENSP00000354551; ENSG00000198758 [Q8TE67-2]
ENST00000361965; ENSP00000355255; ENSG00000198758 [Q8TE67-1]
ENST00000369805; ENSP00000358820; ENSG00000198758 [Q8TE67-3]
GeneIDi79574
KEGGihsa:79574
UCSCiuc001dyq.3, human [Q8TE67-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79574
DisGeNETi79574

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EPS8L3
HGNCiHGNC:21297, EPS8L3
HPAiENSG00000198758, Group enriched (gallbladder, intestine)
MalaCardsiEPS8L3
MIMi612841, phenotype
614989, gene
neXtProtiNX_Q8TE67
OpenTargetsiENSG00000198758
Orphaneti444, Marie Unna hereditary hypotrichosis
PharmGKBiPA134940846
VEuPathDBiHostDB:ENSG00000198758.10

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3557, Eukaryota
GeneTreeiENSGT00940000158169
HOGENOMiCLU_014510_0_1_1
InParanoidiQ8TE67
OMAiNFILARC
OrthoDBi1324479at2759
PhylomeDBiQ8TE67
TreeFamiTF313069

Enzyme and pathway databases

PathwayCommonsiQ8TE67

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79574, 38 hits in 980 CRISPR screens
EvolutionaryTraceiQ8TE67

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EPS8L3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79574
PharosiQ8TE67, Tdark

Protein Ontology

More...
PROi
PR:Q8TE67
RNActiQ8TE67, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198758, Expressed in small intestine and 129 other tissues
ExpressionAtlasiQ8TE67, baseline and differential
GenevisibleiQ8TE67, HS

Family and domain databases

CDDicd01210, PTB_EPS8, 1 hit
cd11764, SH3_Eps8, 1 hit
Gene3Di1.10.150.50, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039801, EPS8-like
IPR033928, EPS8_PTB
IPR035462, Eps8_SH3
IPR011993, PH-like_dom_sf
IPR013625, PTB
IPR013761, SAM/pointed_sf
IPR041418, SAM_3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR12287, PTHR12287, 1 hit
PfamiView protein in Pfam
PF08416, PTB, 1 hit
PF18016, SAM_3, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiES8L3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TE67
Secondary accession number(s): A8K833
, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: June 2, 2021
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again