UniProtKB - Q8TE59 (ATS19_HUMAN)
Protein
A disintegrin and metalloproteinase with thrombospondin motifs 19
Gene
ADAMTS19
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 294 | Zinc; in inhibited formBy similarity | 1 | |
Metal bindingi | 482 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 483 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 486 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 492 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: GO_Central
GO - Biological processi
- extracellular matrix organization Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TE59 |
Reactomei | R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
Protein family/group databases
MEROPSi | M12.029 |
Names & Taxonomyi
Protein namesi | Recommended name: A disintegrin and metalloproteinase with thrombospondin motifs 19 (EC:3.4.24.-)Short name: ADAM-TS 19 Short name: ADAM-TS19 Short name: ADAMTS-19 |
Gene namesi | Name:ADAMTS19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000145808.8 |
HGNCi | HGNC:17111, ADAMTS19 |
MIMi | 607513, gene |
neXtProti | NX_Q8TE59 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 171019 |
PharmGKBi | PA24545 |
Miscellaneous databases
Pharosi | Q8TE59, Tbio |
Polymorphism and mutation databases
BioMutai | ADAMTS19 |
DMDMi | 296434402 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000029202 | 22 – 316 | By similarityAdd BLAST | 295 | |
ChainiPRO_0000029203 | 317 – 1207 | A disintegrin and metalloproteinase with thrombospondin motifs 19Add BLAST | 891 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 260 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 401 ↔ 466 | By similarity | ||
Disulfide bondi | 441 ↔ 448 | By similarity | ||
Disulfide bondi | 460 ↔ 540 | By similarity | ||
Disulfide bondi | 499 ↔ 524 | By similarity | ||
Disulfide bondi | 569 ↔ 593 | By similarity | ||
Disulfide bondi | 580 ↔ 601 | By similarity | ||
Disulfide bondi | 588 ↔ 620 | By similarity | ||
Disulfide bondi | 614 ↔ 625 | By similarity | ||
Disulfide bondi | 645 ↔ 680 | By similarity | ||
Disulfide bondi | 649 ↔ 685 | By similarity | ||
Disulfide bondi | 660 ↔ 670 | By similarity | ||
Glycosylationi | 797 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 907 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 949 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 988 ↔ 1031 | By similarity | ||
Disulfide bondi | 992 ↔ 1036 | By similarity | ||
Disulfide bondi | 1003 ↔ 1020 | By similarity | ||
Glycosylationi | 1009 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, ZymogenProteomic databases
EPDi | Q8TE59 |
MassIVEi | Q8TE59 |
PaxDbi | Q8TE59 |
PeptideAtlasi | Q8TE59 |
PRIDEi | Q8TE59 |
ProteomicsDBi | 74401 |
PTM databases
GlyGeni | Q8TE59, 5 sites |
iPTMneti | Q8TE59 |
PhosphoSitePlusi | Q8TE59 |
Expressioni
Tissue specificityi
Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.
Gene expression databases
Bgeei | ENSG00000145808, Expressed in colon and 108 other tissues |
Genevisiblei | Q8TE59, HS |
Organism-specific databases
HPAi | ENSG00000145808, Tissue enhanced (cervix, uterine, endometrium, smooth muscle) |
Interactioni
Protein-protein interaction databases
IntActi | Q8TE59, 1 interactor |
STRINGi | 9606.ENSP00000274487 |
Miscellaneous databases
RNActi | Q8TE59, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 325 – 545 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 221 | |
Domaini | 546 – 633 | DisintegrinAdd BLAST | 88 | |
Domaini | 634 – 686 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 915 – 975 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 976 – 1037 | TSP type-1 3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 1039 – 1083 | TSP type-1 4PROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 1087 – 1144 | TSP type-1 5PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 1160 – 1199 | PLACPROSITE-ProRule annotationAdd BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 791 – 914 | SpacerAdd BLAST | 124 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 292 – 299 | Cysteine switchBy similarity | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 88 – 216 | Pro-richAdd BLAST | 129 | |
Compositional biasi | 687 – 790 | Cys-richAdd BLAST | 104 |
Domaini
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG3538, Eukaryota |
HOGENOMi | CLU_000660_8_1_1 |
InParanoidi | Q8TE59 |
OMAi | GEWSMWS |
OrthoDBi | 125522at2759 |
PhylomeDBi | Q8TE59 |
TreeFami | TF313537 |
Family and domain databases
Gene3Di | 2.20.100.10, 5 hits 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR041645, ADAM_CR_2 IPR006586, ADAM_Cys-rich IPR010294, ADAM_spacer1 IPR013273, ADAMTS/ADAMTS-like IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR010909, PLAC IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF17771, ADAM_CR_2, 1 hit PF05986, ADAM_spacer1, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit PF00090, TSP_1, 1 hit |
PRINTSi | PR01857, ADAMTSFAMILY |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00209, TSP1, 5 hits |
SUPFAMi | SSF82895, SSF82895, 5 hits |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50900, PLAC, 1 hit PS50092, TSP1, 5 hits PS00142, ZINC_PROTEASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8TE59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLTHICCCC LLYQLGFLSN GIVSELQFAP DREEWEVVFP ALWRREPVDP
60 70 80 90 100
AGGSGGSADP GWVRGVGGGG SARAQAAGSS REVRSVAPVP LEEPVEGRSE
110 120 130 140 150
SRLRPPPPSE GEEDEELESQ ELPRGSSGAA ALSPGAPASW QPPPPPQPPP
160 170 180 190 200
SPPPAQHAEP DGDEVLLRIP AFSRDLYLLL RRDGRFLAPR FAVEQRPNPG
210 220 230 240 250
PGPTGAASAP QPPAPPDAGC FYTGAVLRHP GSLASFSTCG GGLMGFIQLN
260 270 280 290 300
EDFIFIEPLN DTMAITGHPH RVYRQKRSME EKVTEKSALH SHYCGIISDK
310 320 330 340 350
GRPRSRKIAE SGRGKRYSYK LPQEYNIETV VVADPAMVSY HGADAARRFI
360 370 380 390 400
LTILNMVFNL FQHKSLSVQV NLRVIKLILL HETPPELYIG HHGEKMLESF
410 420 430 440 450
CKWQHEEFGK KNDIHLEMST NWGEDMTSVD AAILITRKDF CVHKDEPCDT
460 470 480 490 500
VGIAYLSGMC SEKRKCIIAE DNGLNLAFTI AHEMGHNMGI NHDNDHPSCA
510 520 530 540 550
DGLHIMSGEW IKGQNLGDVS WSRCSKEDLE RFLRSKASNC LLQTNPQSVN
560 570 580 590 600
SVMVPSKLPG MTYTADEQCQ ILFGPLASFC QEMQHVICTG LWCKVEGEKE
610 620 630 640 650
CRTKLDPPMD GTDCDLGKWC KAGECTSRTS APEHLAGEWS LWSPCSRTCS
660 670 680 690 700
AGISSRERKC PGLDSEARDC NGPRKQYRIC ENPPCPAGLP GFRDWQCQAY
710 720 730 740 750
SVRTSSPKHI LQWQAVLDEE KPCALFCSPV GKEQPILLSE KVMDGTSCGY
760 770 780 790 800
QGLDICANGR CQKVGCDGLL GSLAREDHCG VCNGNGKSCK IIKGDFNHTR
810 820 830 840 850
GAGYVEVLVI PAGARRIKVV EEKPAHSYLA LRDAGKQSIN SDWKIEHSGA
860 870 880 890 900
FNLAGTTVHY VRRGLWEKIS AKGPTTAPLH LLVLLFQDQN YGLHYEYTIP
910 920 930 940 950
SDPLPENQSS KAPEPLFMWT HTSWEDCDAT CGGGERKTTV SCTKIMSKNI
960 970 980 990 1000
SIVDNEKCKY LTKPEPQIRK CNEQPCQTRW MMTEWTPCSR TCGKGMQSRQ
1010 1020 1030 1040 1050
VACTQQLSNG TLIRARERDC IGPKPASAQR CEGQDCMTVW EAGVWSECSV
1060 1070 1080 1090 1100
KCGKGIRHRT VRCTNPRKKC VLSTRPREAE DCEDYSKCYV WRMGDWSKCS
1110 1120 1130 1140 1150
ITCGKGMQSR VIQCMHKITG RHGNECFSSE KPAAYRPCHL QPCNEKINVN
1160 1170 1180 1190 1200
TITSPRLAAL TFKCLGDQWP VYCRVIREKN LCQDMRWYQR CCETCRDFYA
QKLQQKS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1X7SBR9 | A0A1X7SBR9_HUMAN | A disintegrin and metalloproteinase... | ADAMTS19 | 1,213 | Annotation score: | ||
H0Y8Y0 | H0Y8Y0_HUMAN | A disintegrin and metalloproteinase... | ADAMTS19 | 145 | Annotation score: | ||
D6R9M2 | D6R9M2_HUMAN | A disintegrin and metalloproteinase... | ADAMTS19 | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 367 | S → G in CAC84565 (PubMed:11867212).Curated | 1 | |
Sequence conflicti | 1048 | C → F in CAC84565 (PubMed:11867212).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036154 | 360 | L → I in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_057087 | 582 | E → G. Corresponds to variant dbSNP:rs10062501Ensembl. | 1 | |
Natural variantiVAR_024599 | 1089 | Y → F. Corresponds to variant dbSNP:rs11749126Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ311904 mRNA Translation: CAC84565.1 AC008425 Genomic DNA No translation available. AC008528 Genomic DNA No translation available. AC008591 Genomic DNA No translation available. AC106781 Genomic DNA No translation available. AC129713 Genomic DNA No translation available. |
RefSeqi | NP_598377.4, NM_133638.4 |
Genome annotation databases
Ensembli | ENST00000638972; ENSP00000491408; ENSG00000145808 |
GeneIDi | 171019 |
KEGGi | hsa:171019 |
UCSCi | uc003kvb.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ311904 mRNA Translation: CAC84565.1 AC008425 Genomic DNA No translation available. AC008528 Genomic DNA No translation available. AC008591 Genomic DNA No translation available. AC106781 Genomic DNA No translation available. AC129713 Genomic DNA No translation available. |
RefSeqi | NP_598377.4, NM_133638.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8TE59, 1 interactor |
STRINGi | 9606.ENSP00000274487 |
Protein family/group databases
MEROPSi | M12.029 |
PTM databases
GlyGeni | Q8TE59, 5 sites |
iPTMneti | Q8TE59 |
PhosphoSitePlusi | Q8TE59 |
Polymorphism and mutation databases
BioMutai | ADAMTS19 |
DMDMi | 296434402 |
Proteomic databases
EPDi | Q8TE59 |
MassIVEi | Q8TE59 |
PaxDbi | Q8TE59 |
PeptideAtlasi | Q8TE59 |
PRIDEi | Q8TE59 |
ProteomicsDBi | 74401 |
Genome annotation databases
Ensembli | ENST00000638972; ENSP00000491408; ENSG00000145808 |
GeneIDi | 171019 |
KEGGi | hsa:171019 |
UCSCi | uc003kvb.2, human |
Organism-specific databases
CTDi | 171019 |
DisGeNETi | 171019 |
EuPathDBi | HostDB:ENSG00000145808.8 |
GeneCardsi | ADAMTS19 |
HGNCi | HGNC:17111, ADAMTS19 |
HPAi | ENSG00000145808, Tissue enhanced (cervix, uterine, endometrium, smooth muscle) |
MIMi | 607513, gene |
neXtProti | NX_Q8TE59 |
PharmGKBi | PA24545 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3538, Eukaryota |
HOGENOMi | CLU_000660_8_1_1 |
InParanoidi | Q8TE59 |
OMAi | GEWSMWS |
OrthoDBi | 125522at2759 |
PhylomeDBi | Q8TE59 |
TreeFami | TF313537 |
Enzyme and pathway databases
PathwayCommonsi | Q8TE59 |
Reactomei | R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
Miscellaneous databases
BioGRID-ORCSi | 171019, 1 hit in 843 CRISPR screens |
ChiTaRSi | ADAMTS19, human |
GenomeRNAii | 171019 |
Pharosi | Q8TE59, Tbio |
PROi | PR:Q8TE59 |
RNActi | Q8TE59, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145808, Expressed in colon and 108 other tissues |
Genevisiblei | Q8TE59, HS |
Family and domain databases
Gene3Di | 2.20.100.10, 5 hits 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR041645, ADAM_CR_2 IPR006586, ADAM_Cys-rich IPR010294, ADAM_spacer1 IPR013273, ADAMTS/ADAMTS-like IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR010909, PLAC IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF17771, ADAM_CR_2, 1 hit PF05986, ADAM_spacer1, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit PF00090, TSP_1, 1 hit |
PRINTSi | PR01857, ADAMTSFAMILY |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00209, TSP1, 5 hits |
SUPFAMi | SSF82895, SSF82895, 5 hits |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50900, PLAC, 1 hit PS50092, TSP1, 5 hits PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATS19_HUMAN | |
Accessioni | Q8TE59Primary (citable) accession number: Q8TE59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 25, 2003 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations