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UniProtKB - Q8TE59 (ATS19_HUMAN)

Entry version 161 (02 Dec 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 19

Gene

ADAMTS19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi294Zinc; in inhibited formBy similarity1
Metal bindingi482Zinc; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei483PROSITE-ProRule annotation1
Metal bindingi486Zinc; catalyticBy similarity1
Metal bindingi492Zinc; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TE59

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...MEROPSi		M12.029

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 19 (EC:3.4.24.-)
Short name:
ADAM-TS 19
Short name:
ADAM-TS19
Short name:
ADAMTS-19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAMTS19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000145808.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:17111, ADAMTS19

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607513, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TE59

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		171019

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24545

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TE59, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADAMTS19

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434402

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002920222 – 316By similarityAdd BLAST295
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029203317 – 1207A disintegrin and metalloproteinase with thrombospondin motifs 19Add BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi401 ↔ 466By similarity
Disulfide bondi441 ↔ 448By similarity
Disulfide bondi460 ↔ 540By similarity
Disulfide bondi499 ↔ 524By similarity
Disulfide bondi569 ↔ 593By similarity
Disulfide bondi580 ↔ 601By similarity
Disulfide bondi588 ↔ 620By similarity
Disulfide bondi614 ↔ 625By similarity
Disulfide bondi645 ↔ 680By similarity
Disulfide bondi649 ↔ 685By similarity
Disulfide bondi660 ↔ 670By similarity
Glycosylationi797N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi907N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi949N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi988 ↔ 1031By similarity
Disulfide bondi992 ↔ 1036By similarity
Disulfide bondi1003 ↔ 1020By similarity
Glycosylationi1009N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TE59

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TE59

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TE59

PeptideAtlas

More...PeptideAtlasi		Q8TE59

PRoteomics IDEntifications database

More...PRIDEi		Q8TE59

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74401

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TE59, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TE59

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TE59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000145808, Expressed in colon and 108 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TE59, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000145808, Tissue enhanced (cervix, uterine, endometrium, smooth muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q8TE59, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000274487

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TE59, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini325 – 545Peptidase M12BPROSITE-ProRule annotationAdd BLAST221
Domaini546 – 633DisintegrinAdd BLAST88
Domaini634 – 686TSP type-1 1PROSITE-ProRule annotationAdd BLAST53
Domaini915 – 975TSP type-1 2PROSITE-ProRule annotationAdd BLAST61
Domaini976 – 1037TSP type-1 3PROSITE-ProRule annotationAdd BLAST62
Domaini1039 – 1083TSP type-1 4PROSITE-ProRule annotationAdd BLAST45
Domaini1087 – 1144TSP type-1 5PROSITE-ProRule annotationAdd BLAST58
Domaini1160 – 1199PLACPROSITE-ProRule annotationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni791 – 914SpacerAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi292 – 299Cysteine switchBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi88 – 216Pro-richAdd BLAST129
Compositional biasi687 – 790Cys-richAdd BLAST104

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3538, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000660_8_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TE59

Identification of Orthologs from Complete Genome Data

More...OMAi		GEWSMWS

Database of Orthologous Groups

More...OrthoDBi		125522at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TE59

TreeFam database of animal gene trees

More...TreeFami		TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 5 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041645, ADAM_CR_2
IPR006586, ADAM_Cys-rich
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00608, ACR, 1 hit
SM00209, TSP1, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82895, SSF82895, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits
PS00142, ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8TE59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLTHICCCC LLYQLGFLSN GIVSELQFAP DREEWEVVFP ALWRREPVDP 
        60         70         80         90        100
AGGSGGSADP GWVRGVGGGG SARAQAAGSS REVRSVAPVP LEEPVEGRSE 
       110        120        130        140        150
SRLRPPPPSE GEEDEELESQ ELPRGSSGAA ALSPGAPASW QPPPPPQPPP 
       160        170        180        190        200
SPPPAQHAEP DGDEVLLRIP AFSRDLYLLL RRDGRFLAPR FAVEQRPNPG 
       210        220        230        240        250
PGPTGAASAP QPPAPPDAGC FYTGAVLRHP GSLASFSTCG GGLMGFIQLN 
       260        270        280        290        300
EDFIFIEPLN DTMAITGHPH RVYRQKRSME EKVTEKSALH SHYCGIISDK 
       310        320        330        340        350
GRPRSRKIAE SGRGKRYSYK LPQEYNIETV VVADPAMVSY HGADAARRFI 
       360        370        380        390        400
LTILNMVFNL FQHKSLSVQV NLRVIKLILL HETPPELYIG HHGEKMLESF 
       410        420        430        440        450
CKWQHEEFGK KNDIHLEMST NWGEDMTSVD AAILITRKDF CVHKDEPCDT 
       460        470        480        490        500
VGIAYLSGMC SEKRKCIIAE DNGLNLAFTI AHEMGHNMGI NHDNDHPSCA 
       510        520        530        540        550
DGLHIMSGEW IKGQNLGDVS WSRCSKEDLE RFLRSKASNC LLQTNPQSVN 
       560        570        580        590        600
SVMVPSKLPG MTYTADEQCQ ILFGPLASFC QEMQHVICTG LWCKVEGEKE 
       610        620        630        640        650
CRTKLDPPMD GTDCDLGKWC KAGECTSRTS APEHLAGEWS LWSPCSRTCS 
       660        670        680        690        700
AGISSRERKC PGLDSEARDC NGPRKQYRIC ENPPCPAGLP GFRDWQCQAY 
       710        720        730        740        750
SVRTSSPKHI LQWQAVLDEE KPCALFCSPV GKEQPILLSE KVMDGTSCGY 
       760        770        780        790        800
QGLDICANGR CQKVGCDGLL GSLAREDHCG VCNGNGKSCK IIKGDFNHTR 
       810        820        830        840        850
GAGYVEVLVI PAGARRIKVV EEKPAHSYLA LRDAGKQSIN SDWKIEHSGA 
       860        870        880        890        900
FNLAGTTVHY VRRGLWEKIS AKGPTTAPLH LLVLLFQDQN YGLHYEYTIP 
       910        920        930        940        950
SDPLPENQSS KAPEPLFMWT HTSWEDCDAT CGGGERKTTV SCTKIMSKNI 
       960        970        980        990       1000
SIVDNEKCKY LTKPEPQIRK CNEQPCQTRW MMTEWTPCSR TCGKGMQSRQ 
      1010       1020       1030       1040       1050
VACTQQLSNG TLIRARERDC IGPKPASAQR CEGQDCMTVW EAGVWSECSV 
      1060       1070       1080       1090       1100
KCGKGIRHRT VRCTNPRKKC VLSTRPREAE DCEDYSKCYV WRMGDWSKCS 
      1110       1120       1130       1140       1150
ITCGKGMQSR VIQCMHKITG RHGNECFSSE KPAAYRPCHL QPCNEKINVN 
      1160       1170       1180       1190       1200
TITSPRLAAL TFKCLGDQWP VYCRVIREKN LCQDMRWYQR CCETCRDFYA 

QKLQQKS
Length:1,207
Mass (Da):134,048
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21EFB26660DEB6D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1X7SBR9A0A1X7SBR9_HUMAN
A disintegrin and metalloproteinase...
ADAMTS19
1,213Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8Y0H0Y8Y0_HUMAN
A disintegrin and metalloproteinase...
ADAMTS19
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9M2D6R9M2_HUMAN
A disintegrin and metalloproteinase...
ADAMTS19
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti367S → G in CAC84565 (PubMed:11867212).Curated1
Sequence conflicti1048C → F in CAC84565 (PubMed:11867212).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036154360L → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_057087582E → G. Corresponds to variant dbSNP:rs10062501Ensembl.1
Natural variantiVAR_0245991089Y → F. Corresponds to variant dbSNP:rs11749126Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ311904 mRNA Translation: CAC84565.1
AC008425 Genomic DNA No translation available.
AC008528 Genomic DNA No translation available.
AC008591 Genomic DNA No translation available.
AC106781 Genomic DNA No translation available.
AC129713 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_598377.4, NM_133638.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000638972; ENSP00000491408; ENSG00000145808

Database of genes from NCBI RefSeq genomes

More...GeneIDi		171019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:171019

UCSC genome browser

More...UCSCi		uc003kvb.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311904 mRNA Translation: CAC84565.1
AC008425 Genomic DNA No translation available.
AC008528 Genomic DNA No translation available.
AC008591 Genomic DNA No translation available.
AC106781 Genomic DNA No translation available.
AC129713 Genomic DNA No translation available.
RefSeqiNP_598377.4, NM_133638.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8TE59, 1 interactor
STRINGi9606.ENSP00000274487

Protein family/group databases

MEROPSiM12.029

PTM databases

GlyGeniQ8TE59, 5 sites
iPTMnetiQ8TE59
PhosphoSitePlusiQ8TE59

Polymorphism and mutation databases

BioMutaiADAMTS19
DMDMi296434402

Proteomic databases

EPDiQ8TE59
MassIVEiQ8TE59
PaxDbiQ8TE59
PeptideAtlasiQ8TE59
PRIDEiQ8TE59
ProteomicsDBi74401

Genome annotation databases

EnsembliENST00000638972; ENSP00000491408; ENSG00000145808
GeneIDi171019
KEGGihsa:171019
UCSCiuc003kvb.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		171019
DisGeNETi171019
EuPathDBiHostDB:ENSG00000145808.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADAMTS19
HGNCiHGNC:17111, ADAMTS19
HPAiENSG00000145808, Tissue enhanced (cervix, uterine, endometrium, smooth muscle)
MIMi607513, gene
neXtProtiNX_Q8TE59
PharmGKBiPA24545

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
HOGENOMiCLU_000660_8_1_1
InParanoidiQ8TE59
OMAiGEWSMWS
OrthoDBi125522at2759
PhylomeDBiQ8TE59
TreeFamiTF313537

Enzyme and pathway databases

PathwayCommonsiQ8TE59
ReactomeiR-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		171019, 1 hit in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADAMTS19, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		171019
PharosiQ8TE59, Tbio

Protein Ontology

More...PROi		PR:Q8TE59
RNActiQ8TE59, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000145808, Expressed in colon and 108 other tissues
GenevisibleiQ8TE59, HS

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR006586, ADAM_Cys-rich
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00608, ACR, 1 hit
SM00209, TSP1, 5 hits
SUPFAMiSSF82895, SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits
PS00142, ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TE59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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