UniProtKB - Q8TE58 (ATS15_HUMAN)
Protein
A disintegrin and metalloproteinase with thrombospondin motifs 15
Gene
ADAMTS15
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 174 | Zinc; in inhibited formBy similarity | 1 | |
Metal bindingi | 361 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 362 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 365 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 371 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- extracellular matrix binding Source: Ensembl
- heparin binding Source: Ensembl
- metalloendopeptidase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- extracellular matrix organization Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TE58 |
Reactomei | R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
Protein family/group databases
MEROPSi | M12.025 |
Names & Taxonomyi
Protein namesi | Recommended name: A disintegrin and metalloproteinase with thrombospondin motifs 15 (EC:3.4.24.-)Short name: ADAM-TS 15 Short name: ADAM-TS15 Short name: ADAMTS-15 |
Gene namesi | Name:ADAMTS15 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16305, ADAMTS15 |
MIMi | 607509, gene |
neXtProti | NX_Q8TE58 |
VEuPathDBi | HostDB:ENSG00000166106.3 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: InterPro
- extracellular matrix Source: GO_Central
- extracellular space Source: Ensembl
Other locations
- cell surface Source: Ensembl
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 170689 |
OpenTargetsi | ENSG00000166106 |
PharmGKBi | PA24541 |
Miscellaneous databases
Pharosi | Q8TE58, Tbio |
Genetic variation databases
BioMutai | ADAMTS15 |
DMDMi | 48474504 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
PropeptideiPRO_0000029192 | 18 – 212 | By similarityAdd BLAST | 195 | |
ChainiPRO_0000029193 | 213 – 950 | A disintegrin and metalloproteinase with thrombospondin motifs 15Add BLAST | 738 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 141 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 293 ↔ 345 | By similarity | ||
Disulfide bondi | 322 ↔ 327 | By similarity | ||
Disulfide bondi | 339 ↔ 422 | By similarity | ||
Disulfide bondi | 377 ↔ 406 | By similarity | ||
Disulfide bondi | 448 ↔ 470 | By similarity | ||
Disulfide bondi | 459 ↔ 480 | By similarity | ||
Disulfide bondi | 465 ↔ 499 | By similarity | ||
Disulfide bondi | 493 ↔ 504 | By similarity | ||
Disulfide bondi | 528 ↔ 565 | By similarity | ||
Disulfide bondi | 532 ↔ 570 | By similarity | ||
Disulfide bondi | 543 ↔ 555 | By similarity | ||
Glycosylationi | 591 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 623 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 679 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, ZymogenProteomic databases
jPOSTi | Q8TE58 |
MassIVEi | Q8TE58 |
MaxQBi | Q8TE58 |
PaxDbi | Q8TE58 |
PeptideAtlasi | Q8TE58 |
PRIDEi | Q8TE58 |
ProteomicsDBi | 74400 |
PTM databases
GlyGeni | Q8TE58, 4 sites |
iPTMneti | Q8TE58 |
PhosphoSitePlusi | Q8TE58 |
Expressioni
Tissue specificityi
Expressed in fetal liver and kidney, but not in any of the adult tissues examined.
Gene expression databases
Bgeei | ENSG00000166106, Expressed in metanephros and 157 other tissues |
Genevisiblei | Q8TE58, HS |
Organism-specific databases
HPAi | ENSG00000166106, Tissue enhanced (adipose) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128081, 3 interactors |
STRINGi | 9606.ENSP00000299164 |
Miscellaneous databases
RNActi | Q8TE58, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 218 – 427 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 210 | |
Domaini | 428 – 515 | DisintegrinAdd BLAST | 88 | |
Domaini | 516 – 571 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 839 – 895 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 896 – 949 | TSP type-1 3PROSITE-ProRule annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 701 – 838 | SpacerAdd BLAST | 138 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 172 – 179 | Cysteine switchBy similarity | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 572 – 700 | Cys-richAdd BLAST | 129 |
Domaini
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG3538, Eukaryota |
GeneTreei | ENSGT00940000155801 |
HOGENOMi | CLU_000660_3_0_1 |
InParanoidi | Q8TE58 |
OMAi | DINGRHY |
OrthoDBi | 125522at2759 |
PhylomeDBi | Q8TE58 |
TreeFami | TF331949 |
Family and domain databases
Gene3Di | 2.20.100.10, 3 hits 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR041645, ADAM_CR_2 IPR006586, ADAM_Cys-rich IPR010294, ADAM_spacer1 IPR013273, ADAMTS/ADAMTS-like IPR024079, MetalloPept_cat_dom_sf IPR013277, Pept_M12B_ADAM-TS8 IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF17771, ADAM_CR_2, 1 hit PF05986, ADAM_spacer1, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit PF00090, TSP_1, 1 hit |
PRINTSi | PR01861, ADAMTS8 PR01857, ADAMTSFAMILY |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00209, TSP1, 3 hits |
SUPFAMi | SSF82895, SSF82895, 3 hits |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50092, TSP1, 3 hits PS00142, ZINC_PROTEASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8TE58-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLGILTLA FAGRTAGGSE PEREVVVPIR LDPDINGRRY YWRGPEDSGD
60 70 80 90 100
QGLIFQITAF QEDFYLHLTP DAQFLAPAFS TEHLGVPLQG LTGGSSDLRR
110 120 130 140 150
CFYSGDVNAE PDSFAAVSLC GGLRGAFGYR GAEYVISPLP NASAPAAQRN
160 170 180 190 200
SQGAHLLQRR GVPGGPSGDP TSRCGVASGW NPAILRALDP YKPRRAGFGE
210 220 230 240 250
SRSRRRSGRA KRFVSIPRYV ETLVVADESM VKFHGADLEH YLLTLLATAA
260 270 280 290 300
RLYRHPSILN PINIVVVKVL LLRDRDSGPK VTGNAALTLR NFCAWQKKLN
310 320 330 340 350
KVSDKHPEYW DTAILFTRQD LCGATTCDTL GMADVGTMCD PKRSCSVIED
360 370 380 390 400
DGLPSAFTTA HELGHVFNMP HDNVKVCEEV FGKLRANHMM SPTLIQIDRA
410 420 430 440 450
NPWSACSAAI ITDFLDSGHG DCLLDQPSKP ISLPEDLPGA SYTLSQQCEL
460 470 480 490 500
AFGVGSKPCP YMQYCTKLWC TGKAKGQMVC QTRHFPWADG TSCGEGKLCL
510 520 530 540 550
KGACVERHNL NKHRVDGSWA KWDPYGPCSR TCGGGVQLAR RQCTNPTPAN
560 570 580 590 600
GGKYCEGVRV KYRSCNLEPC PSSASGKSFR EEQCEAFNGY NHSTNRLTLA
610 620 630 640 650
VAWVPKYSGV SPRDKCKLIC RANGTGYFYV LAPKVVDGTL CSPDSTSVCV
660 670 680 690 700
QGKCIKAGCD GNLGSKKRFD KCGVCGGDNK SCKKVTGLFT KPMHGYNFVV
710 720 730 740 750
AIPAGASSID IRQRGYKGLI GDDNYLALKN SQGKYLLNGH FVVSAVERDL
760 770 780 790 800
VVKGSLLRYS GTGTAVESLQ ASRPILEPLT VEVLSVGKMT PPRVRYSFYL
810 820 830 840 850
PKEPREDKSS HPKDPRGPSV LHNSVLSLSN QVEQPDDRPP ARWVAGSWGP
860 870 880 890 900
CSASCGSGLQ KRAVDCRGSA GQRTVPACDA AHRPVETQAC GEPCPTWELS
910 920 930 940 950
AWSPCSKSCG RGFQRRSLKC VGHGGRLLAR DQCNLHRKPQ ELDFCVLRPC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051594 | 623 | N → S. Corresponds to variant dbSNP:rs11222114Ensembl. | 1 | |
Natural variantiVAR_036150 | 770 | Q → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs776537988Ensembl. | 1 | |
Natural variantiVAR_036151 | 878 | C → G in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ315733 mRNA Translation: CAC86014.1 BC109114 mRNA Translation: AAI09115.1 |
CCDSi | CCDS8488.1 |
RefSeqi | NP_620686.1, NM_139055.3 |
Genome annotation databases
Ensembli | ENST00000299164; ENSP00000299164; ENSG00000166106 |
GeneIDi | 170689 |
KEGGi | hsa:170689 |
UCSCi | uc010scd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ315733 mRNA Translation: CAC86014.1 BC109114 mRNA Translation: AAI09115.1 |
CCDSi | CCDS8488.1 |
RefSeqi | NP_620686.1, NM_139055.3 |
3D structure databases
SMRi | Q8TE58 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128081, 3 interactors |
STRINGi | 9606.ENSP00000299164 |
Protein family/group databases
MEROPSi | M12.025 |
PTM databases
GlyGeni | Q8TE58, 4 sites |
iPTMneti | Q8TE58 |
PhosphoSitePlusi | Q8TE58 |
Genetic variation databases
BioMutai | ADAMTS15 |
DMDMi | 48474504 |
Proteomic databases
jPOSTi | Q8TE58 |
MassIVEi | Q8TE58 |
MaxQBi | Q8TE58 |
PaxDbi | Q8TE58 |
PeptideAtlasi | Q8TE58 |
PRIDEi | Q8TE58 |
ProteomicsDBi | 74400 |
Protocols and materials databases
Antibodypediai | 33110, 125 antibodies |
Genome annotation databases
Ensembli | ENST00000299164; ENSP00000299164; ENSG00000166106 |
GeneIDi | 170689 |
KEGGi | hsa:170689 |
UCSCi | uc010scd.3, human |
Organism-specific databases
CTDi | 170689 |
DisGeNETi | 170689 |
GeneCardsi | ADAMTS15 |
HGNCi | HGNC:16305, ADAMTS15 |
HPAi | ENSG00000166106, Tissue enhanced (adipose) |
MIMi | 607509, gene |
neXtProti | NX_Q8TE58 |
OpenTargetsi | ENSG00000166106 |
PharmGKBi | PA24541 |
VEuPathDBi | HostDB:ENSG00000166106.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3538, Eukaryota |
GeneTreei | ENSGT00940000155801 |
HOGENOMi | CLU_000660_3_0_1 |
InParanoidi | Q8TE58 |
OMAi | DINGRHY |
OrthoDBi | 125522at2759 |
PhylomeDBi | Q8TE58 |
TreeFami | TF331949 |
Enzyme and pathway databases
PathwayCommonsi | Q8TE58 |
Reactomei | R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
Miscellaneous databases
BioGRID-ORCSi | 170689, 2 hits in 875 CRISPR screens |
ChiTaRSi | ADAMTS15, human |
GenomeRNAii | 170689 |
Pharosi | Q8TE58, Tbio |
PROi | PR:Q8TE58 |
RNActi | Q8TE58, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166106, Expressed in metanephros and 157 other tissues |
Genevisiblei | Q8TE58, HS |
Family and domain databases
Gene3Di | 2.20.100.10, 3 hits 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR041645, ADAM_CR_2 IPR006586, ADAM_Cys-rich IPR010294, ADAM_spacer1 IPR013273, ADAMTS/ADAMTS-like IPR024079, MetalloPept_cat_dom_sf IPR013277, Pept_M12B_ADAM-TS8 IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF17771, ADAM_CR_2, 1 hit PF05986, ADAM_spacer1, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit PF00090, TSP_1, 1 hit |
PRINTSi | PR01861, ADAMTS8 PR01857, ADAMTSFAMILY |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00209, TSP1, 3 hits |
SUPFAMi | SSF82895, SSF82895, 3 hits |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50092, TSP1, 3 hits PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATS15_HUMAN | |
Accessioni | Q8TE58Primary (citable) accession number: Q8TE58 Secondary accession number(s): Q32MI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot