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UniProtKB - Q8TE57 (ATS16_HUMAN)

Entry version 168 (23 Feb 2022)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 16

Gene

ADAMTS16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi249Zinc; in inhibited formBy similarity1
Metal bindingi433Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei434PROSITE-ProRule annotation1
Metal bindingi437Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi443Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TE57

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-5083635, Defective B3GALTL causes PpS
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8TE57

Protein family/group databases

MEROPS protease database

More...MEROPSi		M12.026

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 16 (EC:3.4.24.-)
Short name:
ADAM-TS 16
Short name:
ADAM-TS16
Short name:
ADAMTS-16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAMTS16
Synonyms:KIAA2029
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17108, ADAMTS16

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607510, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TE57

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000145536

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		170690

Open Targets

More...OpenTargetsi		ENSG00000145536

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24542

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TE57, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADAMTS16

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439429

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002919425 – 279By similarityAdd BLAST255
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029195280 – 1224A disintegrin and metalloproteinase with thrombospondin motifs 16Add BLAST945

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi366 ↔ 417By similarity
Disulfide bondi392 ↔ 399By similarity
Disulfide bondi411 ↔ 490By similarity
Disulfide bondi450 ↔ 474By similarity
Disulfide bondi518 ↔ 543By similarity
Disulfide bondi529 ↔ 550By similarity
Disulfide bondi538 ↔ 569By similarity
Disulfide bondi563 ↔ 574By similarity
Disulfide bondi598 ↔ 635By similarity
Disulfide bondi602 ↔ 640By similarity
Disulfide bondi613 ↔ 625By similarity
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi835N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi905N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi935N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi939 ↔ 981By similarity
Disulfide bondi943 ↔ 986By similarity
Disulfide bondi954 ↔ 970By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TE57

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TE57

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TE57

PeptideAtlas

More...PeptideAtlasi		Q8TE57

PRoteomics IDEntifications database

More...PRIDEi		Q8TE57

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74398 [Q8TE57-1]
74399 [Q8TE57-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TE57, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TE57

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TE57

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal lung and kidney and in adult prostate and ovary.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000145536, Expressed in tendon and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TE57, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TE57, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000145536, Tissue enhanced (brain, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128082, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q8TE57, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000274181

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TE57, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TE57

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini290 – 495Peptidase M12BPROSITE-ProRule annotationAdd BLAST206
Domaini496 – 585DisintegrinAdd BLAST90
Domaini586 – 641TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini874 – 922TSP type-1 2PROSITE-ProRule annotationAdd BLAST49
Domaini927 – 987TSP type-1 3PROSITE-ProRule annotationAdd BLAST61
Domaini988 – 1048TSP type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini1051 – 1115TSP type-1 5PROSITE-ProRule annotationAdd BLAST65
Domaini1127 – 1181TSP type-1 6PROSITE-ProRule annotationAdd BLAST55
Domaini1186 – 1223PLACPROSITE-ProRule annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 53DisorderedSequence analysisAdd BLAST23
Regioni747 – 873SpacerAdd BLAST127

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi247 – 254Cysteine switchBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 52Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3538, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000660_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TE57

Identification of Orthologs from Complete Genome Data

More...OMAi		DFHMDLK

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TE57

TreeFam database of animal gene trees

More...TreeFami		TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 5 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013273, ADAMTS/ADAMTS-like
IPR041645, ADAMTS_CR_2
IPR045371, ADAMTS_CR_3
IPR010294, ADAMTS_spacer1
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF19236, ADAM_CR_3, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF08686, PLAC, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00209, TSP1, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82895, SSF82895, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TE57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPRARGWRG LAALWMLLAQ VAEQAPACAM GPAAAAPGSP SVPRPPPPAE 
        60         70         80         90        100
RPGWMEKGEY DLVSAYEVDH RGDYVSHEIM HHQRRRRAVP VSEVESLHLR 
       110        120        130        140        150
LKGSRHDFHM DLRTSSSLVA PGFIVQTLGK TGTKSVQTLP PEDFCFYQGS 
       160        170        180        190        200
LRSHRNSSVA LSTCQGLSGM IRTEEADYFL RPLPSHLSWK LGRAAQGSSP 
       210        220        230        240        250
SHVLYKRSTE PHAPGASEVL VTSRTWELAH QPLHSSDLRL GLPQKQHFCG 
       260        270        280        290        300
RRKKYMPQPP KEDLFILPDE YKSCLRHKRS LLRSHRNEEL NVETLVVVDK 
       310        320        330        340        350
KMMQNHGHEN ITTYVLTILN MVSALFKDGT IGGNINIAIV GLILLEDEQP 
       360        370        380        390        400
GLVISHHADH TLSSFCQWQS GLMGKDGTRH DHAILLTGLD ICSWKNEPCD 
       410        420        430        440        450
TLGFAPISGM CSKYRSCTIN EDTGLGLAFT IAHESGHNFG MIHDGEGNMC 
       460        470        480        490        500
KKSEGNIMSP TLAGRNGVFS WSPCSRQYLH KFLSTAQAIC LADQPKPVKE 
       510        520        530        540        550
YKYPEKLPGE LYDANTQCKW QFGEKAKLCM LDFKKDICKA LWCHRIGRKC 
       560        570        580        590        600
ETKFMPAAEG TICGHDMWCR GGQCVKYGDE GPKPTHGHWS DWSSWSPCSR 
       610        620        630        640        650
TCGGGVSHRS RLCTNPKPSH GGKFCEGSTR TLKLCNSQKC PRDSVDFRAA 
       660        670        680        690        700
QCAEHNSRRF RGRHYKWKPY TQVEDQDLCK LYCIAEGFDF FFSLSNKVKD 
       710        720        730        740        750
GTPCSEDSRN VCIDGICERV GCDNVLGSDA VEDVCGVCNG NNSACTIHRG 
       760        770        780        790        800
LYTKHHHTNQ YYHMVTIPSG ARSIRIYEMN VSTSYISVRN ALRRYYLNGH 
       810        820        830        840        850
WTVDWPGRYK FSGTTFDYRR SYNEPENLIA TGPTNETLIV ELLFQGRNPG 
       860        870        880        890        900
VAWEYSMPRL GTEKQPPAQP SYTWAIVRSE CSVSCGGGQM TVREGCYRDL 
       910        920        930        940        950
KFQVNMSFCN PKTRPVTGLV PCKVSACPPS WSVGNWSACS RTCGGGAQSR 
       960        970        980        990       1000
PVQCTRRVHY DSEPVPASLC PQPAPSSRQA CNSQSCPPAW SAGPWAECSH 
      1010       1020       1030       1040       1050
TCGKGWRKRA VACKSTNPSA RAQLLPDAVC TSEPKPRMHE ACLLQRCHKP 
      1060       1070       1080       1090       1100
KKLQWLVSAW SQCSVTCERG TQKRFLKCAE KYVSGKYREL ASKKCSHLPK 
      1110       1120       1130       1140       1150
PSLELERACA PLPCPRHPPF AAAGPSRGSW FASPWSQCTA SCGGGVQTRS 
      1160       1170       1180       1190       1200
VQCLAGGRPA SGCLLHQKPS ASLACNTHFC PIAEKKDAFC KDYFHWCYLV 
      1210       1220 
PQHGMCSHKF YGKQCCKTCS KSNL
Length:1,224
Mass (Da):136,203
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB6115E6C97A9683
GO
Isoform 2 (identifier: Q8TE57-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1063-1072: CSVTCERGTQ → VGALVSRERG
     1073-1224: Missing.

Show »
Length:1,072
Mass (Da):119,507
Checksum:i3E2C0FF34194E631
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q2XQZ0Q2XQZ0_HUMAN
A disintegrin and metalloproteinase...
ADAMTS16
570Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90P → A in CAC86015 (PubMed:11867212).Curated1
Sequence conflicti104S → P in CAC86015 (PubMed:11867212).Curated1
Sequence conflicti284S → Y in BAC23125 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057076110M → V. Corresponds to variant dbSNP:rs1863968Ensembl.1
Natural variantiVAR_057077486A → T. Corresponds to variant dbSNP:rs16875054Ensembl.1
Natural variantiVAR_057078789R → C. Corresponds to variant dbSNP:rs9313105Ensembl.1
Natural variantiVAR_057079859R → L. Corresponds to variant dbSNP:rs16875122Ensembl.1
Natural variantiVAR_057080863E → K. Corresponds to variant dbSNP:rs35394775Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0076641063 – 1072CSVTCERGTQ → VGALVSRERG in isoform 2. 1 Publication10
Alternative sequenceiVSP_0076651073 – 1224Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ315734 mRNA Translation: CAC86015.1
FJ515844 Genomic DNA Translation: ACS13738.1
AC010269 Genomic DNA No translation available.
AC022424 Genomic DNA No translation available.
AC091978 Genomic DNA No translation available.
AB095949 mRNA Translation: BAC23125.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43299.1 [Q8TE57-1]

NCBI Reference Sequences

More...RefSeqi		NP_620687.2, NM_139056.3 [Q8TE57-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000274181; ENSP00000274181; ENSG00000145536

Database of genes from NCBI RefSeq genomes

More...GeneIDi		170690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:170690

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000274181.7; ENSP00000274181.7; NM_139056.4; NP_620687.2

UCSC genome browser

More...UCSCi		uc003jdl.4, human [Q8TE57-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315734 mRNA Translation: CAC86015.1
FJ515844 Genomic DNA Translation: ACS13738.1
AC010269 Genomic DNA No translation available.
AC022424 Genomic DNA No translation available.
AC091978 Genomic DNA No translation available.
AB095949 mRNA Translation: BAC23125.1
CCDSiCCDS43299.1 [Q8TE57-1]
RefSeqiNP_620687.2, NM_139056.3 [Q8TE57-1]

3D structure databases

SMRiQ8TE57
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128082, 2 interactors
IntActiQ8TE57, 2 interactors
STRINGi9606.ENSP00000274181

Protein family/group databases

MEROPSiM12.026

PTM databases

GlyGeniQ8TE57, 7 sites
iPTMnetiQ8TE57
PhosphoSitePlusiQ8TE57

Genetic variation databases

BioMutaiADAMTS16
DMDMi296439429

Proteomic databases

jPOSTiQ8TE57
MassIVEiQ8TE57
PaxDbiQ8TE57
PeptideAtlasiQ8TE57
PRIDEiQ8TE57
ProteomicsDBi74398 [Q8TE57-1]
74399 [Q8TE57-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		59056, 46 antibodies from 14 providers

The DNASU plasmid repository

More...DNASUi		170690

Genome annotation databases

EnsembliENST00000274181; ENSP00000274181; ENSG00000145536
GeneIDi170690
KEGGihsa:170690
MANE-SelectiENST00000274181.7; ENSP00000274181.7; NM_139056.4; NP_620687.2
UCSCiuc003jdl.4, human [Q8TE57-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		170690
DisGeNETi170690

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADAMTS16
HGNCiHGNC:17108, ADAMTS16
HPAiENSG00000145536, Tissue enhanced (brain, ovary)
MIMi607510, gene
neXtProtiNX_Q8TE57
OpenTargetsiENSG00000145536
PharmGKBiPA24542
VEuPathDBiHostDB:ENSG00000145536

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000159433
HOGENOMiCLU_000660_1_0_1
InParanoidiQ8TE57
OMAiDFHMDLK
PhylomeDBiQ8TE57
TreeFamiTF313537

Enzyme and pathway databases

PathwayCommonsiQ8TE57
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-5083635, Defective B3GALTL causes PpS
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins
SignaLinkiQ8TE57

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		170690, 2 hits in 1036 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		170690
PharosiQ8TE57, Tbio

Protein Ontology

More...PROi		PR:Q8TE57
RNActiQ8TE57, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000145536, Expressed in tendon and 113 other tissues
ExpressionAtlasiQ8TE57, baseline and differential
GenevisibleiQ8TE57, HS

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR013273, ADAMTS/ADAMTS-like
IPR041645, ADAMTS_CR_2
IPR045371, ADAMTS_CR_3
IPR010294, ADAMTS_spacer1
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF19236, ADAM_CR_3, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF08686, PLAC, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00209, TSP1, 6 hits
SUPFAMiSSF82895, SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TE57
Secondary accession number(s): C6G490, Q8IVE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: May 18, 2010
Last modified: February 23, 2022
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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