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Entry version 125 (12 Aug 2020)
Sequence version 2 (26 Feb 2008)
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Protein

Anion exchange transporter

Gene

SLC26A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.By similarity2 Publications

Miscellaneous

Is active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Ion transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TE54

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427601, Multifunctional anion exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.2.6, the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange transporter
Alternative name(s):
Solute carrier family 26 member 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC26A7Imported
Synonyms:SUT2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147606.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14467, SLC26A7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608479, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TE54

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 144ExtracellularSequence analysisAdd BLAST48
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166CytoplasmicSequence analysis1
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 202ExtracellularSequence analysisAdd BLAST15
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 227CytoplasmicSequence analysis4
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 254ExtracellularSequence analysis6
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 306CytoplasmicSequence analysisAdd BLAST31
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 343ExtracellularSequence analysisAdd BLAST16
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 383CytoplasmicSequence analysisAdd BLAST19
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 448ExtracellularSequence analysisAdd BLAST23
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 656CytoplasmicSequence analysisAdd BLAST187

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
115111

Open Targets

More...
OpenTargetsi
ENSG00000147606

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37884

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TE54, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC26A7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172045817

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206811 – 656Anion exchange transporterAdd BLAST656

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TE54

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TE54

PeptideAtlas

More...
PeptideAtlasi
Q8TE54

PRoteomics IDEntifications database

More...
PRIDEi
Q8TE54

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74394 [Q8TE54-1]
74395 [Q8TE54-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2019, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8TE54, 1 site, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TE54

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TE54

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147606, Expressed in thyroid gland and 138 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TE54, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TE54, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147606, Tissue enriched (thyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125414, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309504

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TE54, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TE54

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini492 – 641STASPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni641 – 656Membrane targeting1 PublicationAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0236, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183057

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003182_9_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TE54

KEGG Orthology (KO)

More...
KOi
K13962

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMDCKNR

Database of Orthologous Groups

More...
OrthoDBi
690428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TE54

TreeFam database of animal gene trees

More...
TreeFami
TF313784

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.750.24, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR030329, SLC26A7
IPR002645, STAS_dom
IPR036513, STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814, PTHR11814, 1 hit
PTHR11814:SF75, PTHR11814:SF75, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52091, SSF52091, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50801, STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8TE54-1) [UniParc]FASTAAdd to basket
Also known as: 1A1 Publication, 1B1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD
60 70 80 90 100
TVSGIMLAVQ QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA
110 120 130 140 150
TGTFALTSLI SANAVERIVP QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA
160 170 180 190 200
VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS AMTTGAATHV VTSQVKYLLG
210 220 230 240 250
MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV LVLVKELNEQ
260 270 280 290 300
FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP
310 320 330 340 350
PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS
360 370 380 390 400
NIVSSFFFCI PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL
410 420 430 440 450
LYWLPMCVLA SIIVVGLKGM LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC
460 470 480 490 500
FAANVGLLFG VVCTIAIVIG RFPRAMTVSI KNMKEMEFKV KTEMDSETLQ
510 520 530 540 550
QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI SKCEQNTLLN
560 570 580 590 600
SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR
610 620 630 640 650
SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL

SDHSEV
Length:656
Mass (Da):72,213
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F8D2E140E5C00CB
GO
Isoform 22 Publications (identifier: Q8TE54-2) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     646-656: NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL

Show »
Length:663
Mass (Da):73,033
Checksum:i1F8967404F54DC9F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZI7A0A087WZI7_HUMAN
Anion exchange transporter
SLC26A7
355Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFH2E5RFH2_HUMAN
Anion exchange transporter
SLC26A7
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB61H0YB61_HUMAN
Anion exchange transporter
SLC26A7
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGL8E5RGL8_HUMAN
Anion exchange transporter
SLC26A7
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132T → A in CAC88371 (PubMed:11829495).Curated1
Sequence conflicti521T → A in AAI14475 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053666215I → V. Corresponds to variant dbSNP:rs16912250Ensembl.1
Natural variantiVAR_053667381V → G. Corresponds to variant dbSNP:rs34921316Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052689646 – 656NLSKLSDHSEV → ASYKLLFDNLDLPTMPPL in isoform 2. 3 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ413228 mRNA Translation: CAC88370.1
AJ413229 mRNA Translation: CAC88371.1
AJ413230 mRNA Translation: CAC88372.1
AF331521 mRNA Translation: AAK95665.1
CH471060 Genomic DNA Translation: EAW91680.1
CH471060 Genomic DNA Translation: EAW91679.1
BC094730 mRNA Translation: AAH94730.1
BC113866 mRNA Translation: AAI13867.1
BC114474 mRNA Translation: AAI14475.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6254.1 [Q8TE54-1]
CCDS6255.1 [Q8TE54-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001269285.1, NM_001282356.1 [Q8TE54-1]
NP_001269286.1, NM_001282357.1
NP_439897.1, NM_052832.3 [Q8TE54-1]
NP_599028.1, NM_134266.1 [Q8TE54-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276609; ENSP00000276609; ENSG00000147606 [Q8TE54-1]
ENST00000309536; ENSP00000309504; ENSG00000147606 [Q8TE54-2]
ENST00000523719; ENSP00000428849; ENSG00000147606 [Q8TE54-1]
ENST00000617233; ENSP00000482549; ENSG00000147606 [Q8TE54-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
115111

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:115111

UCSC genome browser

More...
UCSCi
uc003yex.5, human [Q8TE54-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ413228 mRNA Translation: CAC88370.1
AJ413229 mRNA Translation: CAC88371.1
AJ413230 mRNA Translation: CAC88372.1
AF331521 mRNA Translation: AAK95665.1
CH471060 Genomic DNA Translation: EAW91680.1
CH471060 Genomic DNA Translation: EAW91679.1
BC094730 mRNA Translation: AAH94730.1
BC113866 mRNA Translation: AAI13867.1
BC114474 mRNA Translation: AAI14475.1
CCDSiCCDS6254.1 [Q8TE54-1]
CCDS6255.1 [Q8TE54-2]
RefSeqiNP_001269285.1, NM_001282356.1 [Q8TE54-1]
NP_001269286.1, NM_001282357.1
NP_439897.1, NM_052832.3 [Q8TE54-1]
NP_599028.1, NM_134266.1 [Q8TE54-2]

3D structure databases

SMRiQ8TE54
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125414, 1 interactor
STRINGi9606.ENSP00000309504

Protein family/group databases

TCDBi2.A.53.2.6, the sulfate permease (sulp) family

PTM databases

GlyConnecti2019, 1 N-Linked glycan (1 site)
GlyGeniQ8TE54, 1 site, 1 N-linked glycan (1 site)
iPTMnetiQ8TE54
PhosphoSitePlusiQ8TE54

Polymorphism and mutation databases

BioMutaiSLC26A7
DMDMi172045817

Proteomic databases

MassIVEiQ8TE54
PaxDbiQ8TE54
PeptideAtlasiQ8TE54
PRIDEiQ8TE54
ProteomicsDBi74394 [Q8TE54-1]
74395 [Q8TE54-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25657, 67 antibodies

Genome annotation databases

EnsembliENST00000276609; ENSP00000276609; ENSG00000147606 [Q8TE54-1]
ENST00000309536; ENSP00000309504; ENSG00000147606 [Q8TE54-2]
ENST00000523719; ENSP00000428849; ENSG00000147606 [Q8TE54-1]
ENST00000617233; ENSP00000482549; ENSG00000147606 [Q8TE54-1]
GeneIDi115111
KEGGihsa:115111
UCSCiuc003yex.5, human [Q8TE54-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
115111
DisGeNETi115111
EuPathDBiHostDB:ENSG00000147606.8

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC26A7
HGNCiHGNC:14467, SLC26A7
HPAiENSG00000147606, Tissue enriched (thyroid)
MIMi608479, gene
neXtProtiNX_Q8TE54
OpenTargetsiENSG00000147606
PharmGKBiPA37884

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0236, Eukaryota
GeneTreeiENSGT00950000183057
HOGENOMiCLU_003182_9_5_1
InParanoidiQ8TE54
KOiK13962
OMAiYMDCKNR
OrthoDBi690428at2759
PhylomeDBiQ8TE54
TreeFamiTF313784

Enzyme and pathway databases

PathwayCommonsiQ8TE54
ReactomeiR-HSA-427601, Multifunctional anion exchangers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
115111, 4 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC26A7, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC26A7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
115111
PharosiQ8TE54, Tbio

Protein Ontology

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PROi
PR:Q8TE54
RNActiQ8TE54, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147606, Expressed in thyroid gland and 138 other tissues
ExpressionAtlasiQ8TE54, baseline and differential
GenevisibleiQ8TE54, HS

Family and domain databases

Gene3Di3.30.750.24, 1 hit
InterProiView protein in InterPro
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR030329, SLC26A7
IPR002645, STAS_dom
IPR036513, STAS_dom_sf
PANTHERiPTHR11814, PTHR11814, 1 hit
PTHR11814:SF75, PTHR11814:SF75, 1 hit
PfamiView protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit
SUPFAMiSSF52091, SSF52091, 1 hit
PROSITEiView protein in PROSITE
PS50801, STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS26A7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TE54
Secondary accession number(s): Q24JS8, Q8TE53, Q96RN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: August 12, 2020
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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