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UniProtKB - Q8TDZ2 (MICA1_HUMAN)

Protein

[F-actin]-monooxygenase MICAL1

Gene

MICAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H2O2 (PubMed:21864500, PubMed:26845023). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking.By similarityCurated4 Publications

Caution

The reaction mechanism is subject to discussion. Some work suggest MICAL enzymes directly oxidize actin methionine residues to produce methionine-(R)-S-oxide. Other publications suggest that the enzyme functions as a NADPH oxidase producing H2O2 (EC 1.6.3.1) and that it is the produced H2O2 that is responsible for the methionine-(R)-S-oxide production.By similarity2 Publications

Catalytic activityi

[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O.By similarity

Cofactori

FAD1 Publication

Kineticsi

kcat is 0.28 sec(-1) for NADPH for the NADPH oxidase reaction.1 Publication
  1. KM=4.7 µM for F-actin (at saturing NADPH concentration)1 Publication
  2. KM=375 µM for NADPH (for the NADPH oxidase reaction)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei95FADBy similarity1
    Binding sitei181FAD; via amide nitrogen and carbonyl oxygenBy similarity1
    Binding sitei293FADBy similarity1
    Binding sitei393FADBy similarity1
    Metal bindingi697Zinc 1Combined sources1
    Metal bindingi700Zinc 1Combined sources1
    Metal bindingi718Zinc 1; via pros nitrogenCombined sources1
    Metal bindingi721Zinc 1Combined sources1
    Metal bindingi724Zinc 2Combined sources1
    Metal bindingi727Zinc 2Combined sources1
    Metal bindingi747Zinc 2Combined sources1
    Metal bindingi750Zinc 2; via pros nitrogenCombined sources1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi114 – 116FADBy similarity3
    Nucleotide bindingi121 – 123FADBy similarity3

    GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    View the complete GO annotation on QuickGO ...

    Keywordsi

    Molecular functionActin-binding, Monooxygenase, Oxidoreductase
    LigandFAD, Flavoprotein, Metal-binding, NADP, Zinc

    Enzyme and pathway databases

    ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
    SignaLinkiQ8TDZ2

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    [F-actin]-monooxygenase MICAL1Curated (EC:1.14.13.225By similarity)
    Alternative name(s):
    Molecule interacting with CasL protein 1
    Short name:
    MICAL-1
    NEDD9-interacting protein with calponin homology and LIM domains
    Gene namesi
    Name:MICAL1
    Synonyms:MICAL, NICAL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000135596.17
    HGNCiHGNC:20619 MICAL1
    MIMi607129 gene
    neXtProtiNX_Q8TDZ2

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi64780
    OpenTargetsiENSG00000135596
    PharmGKBiPA134900249

    Polymorphism and mutation databases

    BioMutaiMICAL1
    DMDMi45593495

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000758421 – 1067[F-actin]-monooxygenase MICAL1Add BLAST1067

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei475PhosphothreonineBy similarity1
    Modified residuei617PhosphoserineCombined sources1
    Modified residuei872PhosphoserineCombined sources1
    Modified residuei875PhosphoserineCombined sources1
    Modified residuei876PhosphoserineCombined sources1
    Modified residuei1057PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    EPDiQ8TDZ2
    MaxQBiQ8TDZ2
    PaxDbiQ8TDZ2
    PeptideAtlasiQ8TDZ2
    PRIDEiQ8TDZ2
    ProteomicsDBi74376
    74377 [Q8TDZ2-2]
    74378 [Q8TDZ2-3]
    74379 [Q8TDZ2-4]

    PTM databases

    iPTMnetiQ8TDZ2
    PhosphoSitePlusiQ8TDZ2

    Expressioni

    Tissue specificityi

    Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.1 Publication

    Gene expression databases

    BgeeiENSG00000135596 Expressed in 188 organ(s), highest expression level in blood
    CleanExiHS_MICAL1
    ExpressionAtlasiQ8TDZ2 baseline and differential
    GenevisibleiQ8TDZ2 HS

    Organism-specific databases

    HPAiHPA030175
    HPA030176
    HPA030178

    Interactioni

    Subunit structurei

    Interacts with STK38 and STK38L (By similarity). Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously; ternary complex formation of RAB8A, RAB13 and MICAL1 is possible. Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.By similarity5 Publications

    GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    BioGridi122290, 25 interactors
    CORUMiQ8TDZ2
    IntActiQ8TDZ2, 8 interactors
    MINTiQ8TDZ2
    STRINGi9606.ENSP00000351664

    Structurei

    Secondary structure

    11067
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliQ8TDZ2
    SMRiQ8TDZ2
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TDZ2

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini508 – 612Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST105
    Domaini695 – 757LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63
    Domaini918 – 1067bMERBPROSITE-ProRule annotation2 PublicationsAdd BLAST150

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni1 – 489Monooxygenase domainBy similarityAdd BLAST489

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Coiled coili646 – 666Sequence analysisAdd BLAST21
    Coiled coili919 – 962Sequence analysisAdd BLAST44
    Coiled coili999 – 1027Sequence analysisAdd BLAST29

    Domaini

    The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).1 Publication
    The C-terminal coiled coil part contains the plexin-interacting region.

    Sequence similaritiesi

    Belongs to the Mical family.Curated

    Keywords - Domaini

    Coiled coil, LIM domain

    Phylogenomic databases

    eggNOGiKOG1700 Eukaryota
    COG5069 LUCA
    GeneTreeiENSGT00760000118856
    HOGENOMiHOG000047263
    HOVERGENiHBG052474
    InParanoidiQ8TDZ2
    KOiK19947
    OMAiWALKMAE
    OrthoDBiEOG091G009H
    PhylomeDBiQ8TDZ2
    TreeFamiTF324129

    Family and domain databases

    CDDicd00014 CH, 1 hit
    Gene3Di1.10.418.10, 1 hit
    InterProiView protein in InterPro
    IPR022735 bMERB_dom
    IPR001715 CH-domain
    IPR036872 CH_dom_sf
    IPR002938 FAD-bd
    IPR036188 FAD/NAD-bd_sf
    IPR029937 MICAL1
    IPR001781 Znf_LIM
    PANTHERiPTHR44265:SF2 PTHR44265:SF2, 1 hit
    PfamiView protein in Pfam
    PF00307 CH, 1 hit
    PF12130 DUF3585, 1 hit
    PF01494 FAD_binding_3, 1 hit
    PF00412 LIM, 1 hit
    SMARTiView protein in SMART
    SM00033 CH, 1 hit
    SM00132 LIM, 1 hit
    SUPFAMiSSF47576 SSF47576, 1 hit
    SSF51905 SSF51905, 1 hit
    PROSITEiView protein in PROSITE
    PS51848 BMERB, 1 hit
    PS50021 CH, 1 hit
    PS00478 LIM_DOMAIN_1, 1 hit
    PS50023 LIM_DOMAIN_2, 1 hit

    Sequences (4+)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8TDZ2-1) [UniParc]FASTAAdd to basket
    Also known as: MICAL-1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MASPTSTNPA HAHFESFLQA QLCQDVLSSF QELCGALGLE PGGGLPQYHK 
            60         70         80         90        100
    IKDQLNYWSA KSLWTKLDKR AGQPVYQQGR ACTSTKCLVV GAGPCGLRVA 
           110        120        130        140        150
    VELALLGARV VLVEKRTKFS RHNVLHLWPF TIHDLRALGA KKFYGRFCTG 
           160        170        180        190        200
    TLDHISIRQL QLLLLKVALL LGVEIHWGVT FTGLQPPPRK GSGWRAQLQP 
           210        220        230        240        250
    NPPAQLANYE FDVLISAAGG KFVPEGFKVR EMRGKLAIGI TANFVNGRTV 
           260        270        280        290        300
    EETQVPEISG VARIYNQSFF QSLLKATGID LENIVYYKDD THYFVMTAKK 
           310        320        330        340        350
    QCLLRLGVLR QDWPDTNRLL GSANVVPEAL QRFTRAAADF ATHGKLGKLE 
           360        370        380        390        400
    FAQDAHGQPD VSAFDFTSMM RAESSARVQE KHGARLLLGL VGDCLVEPFW 
           410        420        430        440        450
    PLGTGVARGF LAAFDAAWMV KRWAEGAESL EVLAERESLY QLLSQTSPEN 
           460        470        480        490        500
    MHRNVAQYGL DPATRYPNLN LRAVTPNQVR DLYDVLAKEP VQRNNDKTDT 
           510        520        530        540        550
    GMPATGSAGT QEELLRWCQE QTAGYPGVHV SDLSSSWADG LALCALVYRL 
           560        570        580        590        600
    QPGLLEPSEL QGLGALEATA WALKVAENEL GITPVVSAQA VVAGSDPLGL 
           610        620        630        640        650
    IAYLSHFHSA FKSMAHSPGP VSQASPGTSS AVLFLSKLQR TLQRSRAKEN 
           660        670        680        690        700
    AEDAGGKKLR LEMEAETPST EVPPDPEPGV PLTPPSQHQE AGAGDLCALC 
           710        720        730        740        750
    GEHLYVLERL CVNGHFFHRS CFRCHTCEAT LWPGGYEQHP GDGHFYCLQH 
           760        770        780        790        800
    LPQTDHKAEG SDRGPESPEL PTPSENSMPP GLSTPTASQE GAGPVPDPSQ 
           810        820        830        840        850
    PTRRQIRLSS PERQRLSSLN LTPDPEMEPP PKPPRSCSAL ARHALESSFV 
           860        870        880        890        900
    GWGLPVQSPQ ALVAMEKEEK ESPFSSEEEE EDVPLDSDVE QALQTFAKTS 
           910        920        930        940        950
    GTMNNYPTWR RTLLRRAKEE EMKRFCKAQT IQRRLNEIEA ALRELEAEGV 
           960        970        980        990       1000
    KLELALRRQS SSPEQQKKLW VGQLLQLVDK KNSLVAEEAE LMITVQELNL 
          1010       1020       1030       1040       1050
    EEKQWQLDQE LRGYMNREEN LKTAADRQAE DQVLRKLVDL VNQRDALIRF 
          1060 
    QEERRLSELA LGTGAQG
    Length:1,067
    Mass (Da):117,875
    Last modified:March 15, 2004 - v2
    Checksum:i78C1BBF3E3CCD56B
    GO
    Isoform 2 (identifier: Q8TDZ2-2) [UniParc]FASTAAdd to basket
    Also known as: MICAL-1b

    The sequence of this isoform differs from the canonical sequence as follows:
         312-397: Missing.

    Show »
    Length:981
    Mass (Da):108,552
    Checksum:i8EC7E9C12989C1E9
    GO
    Isoform 3 (identifier: Q8TDZ2-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-735: Missing.
         736-768: YEQHPGDGHFYCLQHLPQTDHKAEGSDRGPESP → MPRLTFAPKGWPHPPTSLHPGQVTDQTTWWLFQ

    Note: No experimental confirmation available.
    Show »
    Length:332
    Mass (Da):37,715
    Checksum:i7FF1E955AE2204DB
    GO
    Isoform 4 (identifier: Q8TDZ2-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSCLSHSSLPSCCPPQEASM

    Note: No experimental confirmation available.
    Show »
    Length:1,086
    Mass (Da):119,821
    Checksum:i947094500071E091
    GO

    Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    Q5TED7Q5TED7_HUMAN
    [F-actin]-monooxygenase MICAL1
    MICAL1
    		244Annotation score:
    H0Y6Z4H0Y6Z4_HUMAN
    [F-actin]-monooxygenase MICAL1
    MICAL1
    		252Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti767S → C in BAB15124 (PubMed:14702039).Curated1
    Sequence conflicti816L → S in BAH12301 (PubMed:14702039).Curated1
    Sequence conflicti877E → V in BAH12301 (PubMed:14702039).Curated1
    Sequence conflicti887S → L in CAB59266 (PubMed:17974005).Curated1
    Sequence conflicti981K → N in BAB13949 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06706312A → S. Corresponds to variant dbSNP:rs4946977Ensembl.1
    Natural variantiVAR_05015312A → T. Corresponds to variant dbSNP:rs4946977Ensembl.1
    Natural variantiVAR_050154153D → A. Corresponds to variant dbSNP:rs34726911Ensembl.1
    Natural variantiVAR_067064195R → H. Corresponds to variant dbSNP:rs34699467Ensembl.1
    Natural variantiVAR_036191309L → M in a breast cancer sample; somatic mutation. 1 Publication1
    Natural variantiVAR_067065453R → C1 PublicationCorresponds to variant dbSNP:rs17854785Ensembl.1
    Natural variantiVAR_067066624A → T1 PublicationCorresponds to variant dbSNP:rs17850590Ensembl.1
    Natural variantiVAR_017903758A → E. Corresponds to variant dbSNP:rs9320288Ensembl.1
    Natural variantiVAR_067067758A → K Requires 2 nucleotide substitutions. 3 PublicationsCorresponds to variant dbSNP:rs35260632Ensembl.1
    Natural variantiVAR_067068758A → S. Corresponds to variant dbSNP:rs59056467Ensembl.1
    Natural variantiVAR_061355758A → T. Corresponds to variant dbSNP:rs59056467Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0096371 – 735Missing in isoform 3. 1 PublicationAdd BLAST735
    Alternative sequenceiVSP_0425901M → MSCLSHSSLPSCCPPQEASM in isoform 4. 1 Publication1
    Alternative sequenceiVSP_009639312 – 397Missing in isoform 2. 1 PublicationAdd BLAST86
    Alternative sequenceiVSP_009638736 – 768YEQHP…GPESP → MPRLTFAPKGWPHPPTSLHP GQVTDQTTWWLFQ in isoform 3. 1 PublicationAdd BLAST33

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AB048948 mRNA Translation: BAB86289.1
    AK024500 mRNA Translation: BAB15790.1
    AK021999 mRNA Translation: BAB13949.1
    AK025392 mRNA Translation: BAB15124.1
    AK296284 mRNA Translation: BAH12301.1
    AL109947 Genomic DNA No translation available.
    CH471051 Genomic DNA Translation: EAW48344.1
    CH471051 Genomic DNA Translation: EAW48345.1
    BC009972 mRNA Translation: AAH09972.2
    BC042144 mRNA Translation: AAH42144.1
    BC052983 mRNA Translation: AAH52983.1
    AL122098 mRNA Translation: CAB59266.1
    CCDSiCCDS5076.1 [Q8TDZ2-1]
    CCDS55047.1 [Q8TDZ2-2]
    CCDS69170.1 [Q8TDZ2-4]
    PIRiT34532
    RefSeqiNP_001152763.1, NM_001159291.1 [Q8TDZ2-2]
    NP_001273542.1, NM_001286613.1 [Q8TDZ2-4]
    NP_073602.3, NM_022765.3 [Q8TDZ2-1]
    UniGeneiHs.33476

    Genome annotation databases

    EnsembliENST00000358577; ENSP00000351385; ENSG00000135596 [Q8TDZ2-2]
    ENST00000358807; ENSP00000351664; ENSG00000135596 [Q8TDZ2-1]
    ENST00000630715; ENSP00000486901; ENSG00000135596 [Q8TDZ2-4]
    GeneIDi64780
    KEGGihsa:64780
    UCSCiuc003ptk.4 human [Q8TDZ2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AB048948 mRNA Translation: BAB86289.1
    AK024500 mRNA Translation: BAB15790.1
    AK021999 mRNA Translation: BAB13949.1
    AK025392 mRNA Translation: BAB15124.1
    AK296284 mRNA Translation: BAH12301.1
    AL109947 Genomic DNA No translation available.
    CH471051 Genomic DNA Translation: EAW48344.1
    CH471051 Genomic DNA Translation: EAW48345.1
    BC009972 mRNA Translation: AAH09972.2
    BC042144 mRNA Translation: AAH42144.1
    BC052983 mRNA Translation: AAH52983.1
    AL122098 mRNA Translation: CAB59266.1
    CCDSiCCDS5076.1 [Q8TDZ2-1]
    CCDS55047.1 [Q8TDZ2-2]
    CCDS69170.1 [Q8TDZ2-4]
    PIRiT34532
    RefSeqiNP_001152763.1, NM_001159291.1 [Q8TDZ2-2]
    NP_001273542.1, NM_001286613.1 [Q8TDZ2-4]
    NP_073602.3, NM_022765.3 [Q8TDZ2-1]
    UniGeneiHs.33476

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1WYLNMR-A510-612[»]
    2CO8NMR-A687-755[»]
    2DK9NMR-A506-614[»]
    5LE0X-ray3.30B918-1067[»]
    5LPNX-ray2.80B918-1067[»]
    ProteinModelPortaliQ8TDZ2
    SMRiQ8TDZ2
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi122290, 25 interactors
    CORUMiQ8TDZ2
    IntActiQ8TDZ2, 8 interactors
    MINTiQ8TDZ2
    STRINGi9606.ENSP00000351664

    PTM databases

    iPTMnetiQ8TDZ2
    PhosphoSitePlusiQ8TDZ2

    Polymorphism and mutation databases

    BioMutaiMICAL1
    DMDMi45593495

    Proteomic databases

    EPDiQ8TDZ2
    MaxQBiQ8TDZ2
    PaxDbiQ8TDZ2
    PeptideAtlasiQ8TDZ2
    PRIDEiQ8TDZ2
    ProteomicsDBi74376
    74377 [Q8TDZ2-2]
    74378 [Q8TDZ2-3]
    74379 [Q8TDZ2-4]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000358577; ENSP00000351385; ENSG00000135596 [Q8TDZ2-2]
    ENST00000358807; ENSP00000351664; ENSG00000135596 [Q8TDZ2-1]
    ENST00000630715; ENSP00000486901; ENSG00000135596 [Q8TDZ2-4]
    GeneIDi64780
    KEGGihsa:64780
    UCSCiuc003ptk.4 human [Q8TDZ2-1]

    Organism-specific databases

    CTDi64780
    DisGeNETi64780
    EuPathDBiHostDB:ENSG00000135596.17
    GeneCardsiMICAL1
    HGNCiHGNC:20619 MICAL1
    HPAiHPA030175
    HPA030176
    HPA030178
    MIMi607129 gene
    neXtProtiNX_Q8TDZ2
    OpenTargetsiENSG00000135596
    PharmGKBiPA134900249
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1700 Eukaryota
    COG5069 LUCA
    GeneTreeiENSGT00760000118856
    HOGENOMiHOG000047263
    HOVERGENiHBG052474
    InParanoidiQ8TDZ2
    KOiK19947
    OMAiWALKMAE
    OrthoDBiEOG091G009H
    PhylomeDBiQ8TDZ2
    TreeFamiTF324129

    Enzyme and pathway databases

    ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production
    SignaLinkiQ8TDZ2

    Miscellaneous databases

    ChiTaRSiMICAL1 human
    EvolutionaryTraceiQ8TDZ2
    GeneWikiiMICAL1
    GenomeRNAii64780
    PROiPR:Q8TDZ2
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000135596 Expressed in 188 organ(s), highest expression level in blood
    CleanExiHS_MICAL1
    ExpressionAtlasiQ8TDZ2 baseline and differential
    GenevisibleiQ8TDZ2 HS

    Family and domain databases

    CDDicd00014 CH, 1 hit
    Gene3Di1.10.418.10, 1 hit
    InterProiView protein in InterPro
    IPR022735 bMERB_dom
    IPR001715 CH-domain
    IPR036872 CH_dom_sf
    IPR002938 FAD-bd
    IPR036188 FAD/NAD-bd_sf
    IPR029937 MICAL1
    IPR001781 Znf_LIM
    PANTHERiPTHR44265:SF2 PTHR44265:SF2, 1 hit
    PfamiView protein in Pfam
    PF00307 CH, 1 hit
    PF12130 DUF3585, 1 hit
    PF01494 FAD_binding_3, 1 hit
    PF00412 LIM, 1 hit
    SMARTiView protein in SMART
    SM00033 CH, 1 hit
    SM00132 LIM, 1 hit
    SUPFAMiSSF47576 SSF47576, 1 hit
    SSF51905 SSF51905, 1 hit
    PROSITEiView protein in PROSITE
    PS51848 BMERB, 1 hit
    PS50021 CH, 1 hit
    PS00478 LIM_DOMAIN_1, 1 hit
    PS50023 LIM_DOMAIN_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiMICA1_HUMAN
    AccessioniPrimary (citable) accession number: Q8TDZ2
    Secondary accession number(s): B7Z3R5
    , E1P5F0, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: March 15, 2004
    Last modified: November 7, 2018
    This is version 167 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
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