UniProtKB - Q8TDZ2 (MICA1_HUMAN)
[F-actin]-monooxygenase MICAL1
MICAL1
Functioni
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822).
In the absence of actin, it also functions as a NADPH oxidase producing H2O2 (PubMed:21864500, PubMed:26845023, PubMed:29343822).
Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity).
May act as Rab effector protein and play a role in vesicle trafficking.
By similarity1 Publication5 PublicationsCaution
Catalytic activityi
- H+ + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP+1 PublicationEC:1.14.13.2251 Publication
- EC:1.6.3.13 Publications
Cofactori
Kineticsi
- KM=4.7 µM for F-actin (at saturating NADPH concentration)1 Publication
- KM=375 µM for NADPH (for the NADPH oxidase reaction)1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 95 | FADBy similarity | 1 | |
Binding sitei | 181 | FAD; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 293 | FADBy similarity | 1 | |
Binding sitei | 393 | FADBy similarity | 1 | |
Metal bindingi | 697 | Zinc 1Combined sources | 1 | |
Metal bindingi | 700 | Zinc 1Combined sources | 1 | |
Metal bindingi | 718 | Zinc 1; via pros nitrogenCombined sources | 1 | |
Metal bindingi | 721 | Zinc 1Combined sources | 1 | |
Metal bindingi | 724 | Zinc 2Combined sources | 1 | |
Metal bindingi | 727 | Zinc 2Combined sources | 1 | |
Metal bindingi | 747 | Zinc 2Combined sources | 1 | |
Metal bindingi | 750 | Zinc 2; via pros nitrogenCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 114 – 116 | FADBy similarity | 3 | |
Nucleotide bindingi | 121 – 123 | FADBy similarity | 3 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- FAD binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- NAD(P)H oxidase H2O2-forming activity Source: UniProtKB
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: UniProtKB
- protein kinase binding Source: Ensembl
- SH3 domain binding Source: UniProtKB
- small GTPase binding Source: Ensembl
GO - Biological processi
- actin filament bundle assembly Source: GO_Central
- actin filament depolymerization Source: UniProtKB
- cytoskeleton organization Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of protein phosphorylation Source: Ensembl
- regulation of regulated secretory pathway Source: Ensembl
- signal transduction Source: UniProtKB
- sulfur oxidation Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Monooxygenase, Oxidoreductase |
Ligand | FAD, Flavoprotein, Metal-binding, NADP, Zinc |
Enzyme and pathway databases
BRENDAi | 1.14.13.225, 2681 |
PathwayCommonsi | Q8TDZ2 |
Reactomei | R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SABIO-RKi | Q8TDZ2 |
SignaLinki | Q8TDZ2 |
Names & Taxonomyi
Protein namesi | Recommended name: [F-actin]-monooxygenase MICAL1Curated (EC:1.14.13.2251 Publication, EC:1.6.3.13 Publications)Alternative name(s): Molecule interacting with CasL protein 1 Short name: MICAL-1 NEDD9-interacting protein with calponin homology and LIM domains |
Gene namesi | Name:MICAL1 Synonyms:MICAL, NICAL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20619, MICAL1 |
MIMi | 607129, gene |
neXtProti | NX_Q8TDZ2 |
VEuPathDBi | HostDB:ENSG00000135596 |
Subcellular locationi
Cytoskeleton
Cytoplasm and Cytosol
Other locations
- Midbody 1 Publication
Note: Accumulates transiently at the abscission site before abscission occurs.1 Publication
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- intermediate filament Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- intercellular bridge Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- hippocampal mossy fiber expansion Source: Ensembl
- midbody Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 64780 |
GeneReviewsi | MICAL1 |
MalaCardsi | MICAL1 |
OpenTargetsi | ENSG00000135596 |
PharmGKBi | PA134900249 |
Miscellaneous databases
Pharosi | Q8TDZ2, Tbio |
Genetic variation databases
BioMutai | MICAL1 |
DMDMi | 45593495 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075842 | 1 – 1067 | [F-actin]-monooxygenase MICAL1Add BLAST | 1067 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 475 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 617 | PhosphoserineCombined sources | 1 | |
Modified residuei | 872 | PhosphoserineCombined sources | 1 | |
Modified residuei | 875 | PhosphoserineCombined sources | 1 | |
Modified residuei | 876 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1057 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8TDZ2 |
jPOSTi | Q8TDZ2 |
MassIVEi | Q8TDZ2 |
MaxQBi | Q8TDZ2 |
PaxDbi | Q8TDZ2 |
PeptideAtlasi | Q8TDZ2 |
PRIDEi | Q8TDZ2 |
ProteomicsDBi | 74376 [Q8TDZ2-1] 74377 [Q8TDZ2-2] 74378 [Q8TDZ2-3] 74379 [Q8TDZ2-4] |
PTM databases
GlyGeni | Q8TDZ2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8TDZ2 |
MetOSitei | Q8TDZ2 |
PhosphoSitePlusi | Q8TDZ2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000135596, Expressed in blood and 203 other tissues |
ExpressionAtlasi | Q8TDZ2, baseline and differential |
Genevisiblei | Q8TDZ2, HS |
Organism-specific databases
HPAi | ENSG00000135596, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with STK38 and STK38L (By similarity).
Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously; ternary complex formation of RAB8A, RAB13 and MICAL1 is possible. Associates with the SH3 domain of NEDD9.
Interacts with VIM and PLXNA3.
Interacts with RAB1B.
By similarity5 PublicationsBinary interactionsi
Q8TDZ2
With | #Exp. | IntAct |
---|---|---|
CASS4 - isoform 2 [Q9NQ75-2] | 2 | EBI-7153876,EBI-12270182 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- protein kinase binding Source: Ensembl
- SH3 domain binding Source: UniProtKB
- small GTPase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 122290, 73 interactors |
CORUMi | Q8TDZ2 |
IntActi | Q8TDZ2, 24 interactors |
MINTi | Q8TDZ2 |
STRINGi | 9606.ENSP00000351664 |
Miscellaneous databases
RNActi | Q8TDZ2, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8TDZ2 |
BMRBi | Q8TDZ2 |
SASBDBi | Q8TDZ2 |
SMRi | Q8TDZ2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TDZ2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 508 – 612 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 695 – 757 | LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 918 – 1067 | bMERBPROSITE-ProRule annotation2 PublicationsAdd BLAST | 150 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 489 | Monooxygenase domainBy similarityAdd BLAST | 489 | |
Regioni | 645 – 688 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 755 – 838 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 867 – 886 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 646 – 666 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 919 – 962 | Sequence analysisAdd BLAST | 44 | |
Coiled coili | 999 – 1027 | Sequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 645 – 665 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 776 – 795 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 802 – 821 | Polar residuesSequence analysisAdd BLAST | 20 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, LIM domainPhylogenomic databases
eggNOGi | KOG1700, Eukaryota |
GeneTreei | ENSGT00940000159117 |
HOGENOMi | CLU_000329_0_0_1 |
InParanoidi | Q8TDZ2 |
OMAi | CKAQSIQ |
OrthoDBi | 430978at2759 |
PhylomeDBi | Q8TDZ2 |
TreeFami | TF324129 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR022735, bMERB_dom IPR001715, CH-domain IPR036872, CH_dom_sf IPR002938, FAD-bd IPR036188, FAD/NAD-bd_sf IPR045268, LIMA-like IPR029937, MICAL1 IPR001781, Znf_LIM |
PANTHERi | PTHR24206, PTHR24206, 1 hit PTHR24206:SF59, PTHR24206:SF59, 1 hit |
Pfami | View protein in Pfam PF00307, CH, 1 hit PF12130, DUF3585, 1 hit PF01494, FAD_binding_3, 1 hit PF00412, LIM, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 1 hit SM00132, LIM, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS51848, BMERB, 1 hit PS50021, CH, 1 hit PS00478, LIM_DOMAIN_1, 1 hit PS50023, LIM_DOMAIN_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASPTSTNPA HAHFESFLQA QLCQDVLSSF QELCGALGLE PGGGLPQYHK
60 70 80 90 100
IKDQLNYWSA KSLWTKLDKR AGQPVYQQGR ACTSTKCLVV GAGPCGLRVA
110 120 130 140 150
VELALLGARV VLVEKRTKFS RHNVLHLWPF TIHDLRALGA KKFYGRFCTG
160 170 180 190 200
TLDHISIRQL QLLLLKVALL LGVEIHWGVT FTGLQPPPRK GSGWRAQLQP
210 220 230 240 250
NPPAQLANYE FDVLISAAGG KFVPEGFKVR EMRGKLAIGI TANFVNGRTV
260 270 280 290 300
EETQVPEISG VARIYNQSFF QSLLKATGID LENIVYYKDD THYFVMTAKK
310 320 330 340 350
QCLLRLGVLR QDWPDTNRLL GSANVVPEAL QRFTRAAADF ATHGKLGKLE
360 370 380 390 400
FAQDAHGQPD VSAFDFTSMM RAESSARVQE KHGARLLLGL VGDCLVEPFW
410 420 430 440 450
PLGTGVARGF LAAFDAAWMV KRWAEGAESL EVLAERESLY QLLSQTSPEN
460 470 480 490 500
MHRNVAQYGL DPATRYPNLN LRAVTPNQVR DLYDVLAKEP VQRNNDKTDT
510 520 530 540 550
GMPATGSAGT QEELLRWCQE QTAGYPGVHV SDLSSSWADG LALCALVYRL
560 570 580 590 600
QPGLLEPSEL QGLGALEATA WALKVAENEL GITPVVSAQA VVAGSDPLGL
610 620 630 640 650
IAYLSHFHSA FKSMAHSPGP VSQASPGTSS AVLFLSKLQR TLQRSRAKEN
660 670 680 690 700
AEDAGGKKLR LEMEAETPST EVPPDPEPGV PLTPPSQHQE AGAGDLCALC
710 720 730 740 750
GEHLYVLERL CVNGHFFHRS CFRCHTCEAT LWPGGYEQHP GDGHFYCLQH
760 770 780 790 800
LPQTDHKAEG SDRGPESPEL PTPSENSMPP GLSTPTASQE GAGPVPDPSQ
810 820 830 840 850
PTRRQIRLSS PERQRLSSLN LTPDPEMEPP PKPPRSCSAL ARHALESSFV
860 870 880 890 900
GWGLPVQSPQ ALVAMEKEEK ESPFSSEEEE EDVPLDSDVE QALQTFAKTS
910 920 930 940 950
GTMNNYPTWR RTLLRRAKEE EMKRFCKAQT IQRRLNEIEA ALRELEAEGV
960 970 980 990 1000
KLELALRRQS SSPEQQKKLW VGQLLQLVDK KNSLVAEEAE LMITVQELNL
1010 1020 1030 1040 1050
EEKQWQLDQE LRGYMNREEN LKTAADRQAE DQVLRKLVDL VNQRDALIRF
1060
QEERRLSELA LGTGAQG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y6Z4 | H0Y6Z4_HUMAN | [F-actin]-monooxygenase MICAL1 | MICAL1 | 252 | Annotation score: | ||
Q5TED7 | Q5TED7_HUMAN | [F-actin]-monooxygenase MICAL1 | MICAL1 | 244 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 767 | S → C in BAB15124 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 816 | L → S in BAH12301 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 877 | E → V in BAH12301 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 887 | S → L in CAB59266 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 981 | K → N in BAB13949 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067063 | 12 | A → S. Corresponds to variant dbSNP:rs4946977Ensembl. | 1 | |
Natural variantiVAR_050153 | 12 | A → T. Corresponds to variant dbSNP:rs4946977Ensembl. | 1 | |
Natural variantiVAR_050154 | 153 | D → A. Corresponds to variant dbSNP:rs34726911Ensembl. | 1 | |
Natural variantiVAR_067064 | 195 | R → H. Corresponds to variant dbSNP:rs34699467EnsemblClinVar. | 1 | |
Natural variantiVAR_036191 | 309 | L → M in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_067065 | 453 | R → C1 PublicationCorresponds to variant dbSNP:rs17854785Ensembl. | 1 | |
Natural variantiVAR_067066 | 624 | A → T1 PublicationCorresponds to variant dbSNP:rs17850590Ensembl. | 1 | |
Natural variantiVAR_017903 | 758 | A → E. Corresponds to variant dbSNP:rs9320288Ensembl. | 1 | |
Natural variantiVAR_067067 | 758 | A → K Requires 2 nucleotide substitutions. 3 PublicationsCorresponds to variant dbSNP:rs35260632Ensembl. | 1 | |
Natural variantiVAR_067068 | 758 | A → S. Corresponds to variant dbSNP:rs59056467Ensembl. | 1 | |
Natural variantiVAR_061355 | 758 | A → T. Corresponds to variant dbSNP:rs59056467Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009637 | 1 – 735 | Missing in isoform 3. 1 PublicationAdd BLAST | 735 | |
Alternative sequenceiVSP_042590 | 1 | M → MSCLSHSSLPSCCPPQEASM in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_009639 | 312 – 397 | Missing in isoform 2. 1 PublicationAdd BLAST | 86 | |
Alternative sequenceiVSP_009638 | 736 – 768 | YEQHP…GPESP → MPRLTFAPKGWPHPPTSLHP GQVTDQTTWWLFQ in isoform 3. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB048948 mRNA Translation: BAB86289.1 AK024500 mRNA Translation: BAB15790.1 AK021999 mRNA Translation: BAB13949.1 AK025392 mRNA Translation: BAB15124.1 AK296284 mRNA Translation: BAH12301.1 AL109947 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48344.1 CH471051 Genomic DNA Translation: EAW48345.1 BC009972 mRNA Translation: AAH09972.2 BC042144 mRNA Translation: AAH42144.1 BC052983 mRNA Translation: AAH52983.1 AL122098 mRNA Translation: CAB59266.1 |
CCDSi | CCDS5076.1 [Q8TDZ2-1] CCDS55047.1 [Q8TDZ2-2] CCDS69170.1 [Q8TDZ2-4] |
PIRi | T34532 |
RefSeqi | NP_001152763.1, NM_001159291.1 [Q8TDZ2-2] NP_001273542.1, NM_001286613.1 [Q8TDZ2-4] NP_073602.3, NM_022765.3 [Q8TDZ2-1] |
Genome annotation databases
Ensembli | ENST00000358577.7; ENSP00000351385.3; ENSG00000135596.18 [Q8TDZ2-2] ENST00000358807.8; ENSP00000351664.3; ENSG00000135596.18 ENST00000630715.2; ENSP00000486901.1; ENSG00000135596.18 [Q8TDZ2-4] |
GeneIDi | 64780 |
KEGGi | hsa:64780 |
MANE-Selecti | ENST00000358807.8; ENSP00000351664.3; NM_022765.4; NP_073602.3 |
UCSCi | uc003ptk.4, human [Q8TDZ2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB048948 mRNA Translation: BAB86289.1 AK024500 mRNA Translation: BAB15790.1 AK021999 mRNA Translation: BAB13949.1 AK025392 mRNA Translation: BAB15124.1 AK296284 mRNA Translation: BAH12301.1 AL109947 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48344.1 CH471051 Genomic DNA Translation: EAW48345.1 BC009972 mRNA Translation: AAH09972.2 BC042144 mRNA Translation: AAH42144.1 BC052983 mRNA Translation: AAH52983.1 AL122098 mRNA Translation: CAB59266.1 |
CCDSi | CCDS5076.1 [Q8TDZ2-1] CCDS55047.1 [Q8TDZ2-2] CCDS69170.1 [Q8TDZ2-4] |
PIRi | T34532 |
RefSeqi | NP_001152763.1, NM_001159291.1 [Q8TDZ2-2] NP_001273542.1, NM_001286613.1 [Q8TDZ2-4] NP_073602.3, NM_022765.3 [Q8TDZ2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WYL | NMR | - | A | 510-612 | [»] | |
2CO8 | NMR | - | A | 687-755 | [»] | |
2DK9 | NMR | - | A | 506-614 | [»] | |
5LE0 | X-ray | 3.30 | B | 918-1067 | [»] | |
5LPN | X-ray | 2.80 | B | 918-1067 | [»] | |
6KU0 | X-ray | 1.60 | B/D | 799-822 | [»] | |
AlphaFoldDBi | Q8TDZ2 | |||||
BMRBi | Q8TDZ2 | |||||
SASBDBi | Q8TDZ2 | |||||
SMRi | Q8TDZ2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122290, 73 interactors |
CORUMi | Q8TDZ2 |
IntActi | Q8TDZ2, 24 interactors |
MINTi | Q8TDZ2 |
STRINGi | 9606.ENSP00000351664 |
PTM databases
GlyGeni | Q8TDZ2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8TDZ2 |
MetOSitei | Q8TDZ2 |
PhosphoSitePlusi | Q8TDZ2 |
Genetic variation databases
BioMutai | MICAL1 |
DMDMi | 45593495 |
Proteomic databases
EPDi | Q8TDZ2 |
jPOSTi | Q8TDZ2 |
MassIVEi | Q8TDZ2 |
MaxQBi | Q8TDZ2 |
PaxDbi | Q8TDZ2 |
PeptideAtlasi | Q8TDZ2 |
PRIDEi | Q8TDZ2 |
ProteomicsDBi | 74376 [Q8TDZ2-1] 74377 [Q8TDZ2-2] 74378 [Q8TDZ2-3] 74379 [Q8TDZ2-4] |
Protocols and materials databases
Antibodypediai | 32258, 265 antibodies from 24 providers |
DNASUi | 64780 |
Genome annotation databases
Ensembli | ENST00000358577.7; ENSP00000351385.3; ENSG00000135596.18 [Q8TDZ2-2] ENST00000358807.8; ENSP00000351664.3; ENSG00000135596.18 ENST00000630715.2; ENSP00000486901.1; ENSG00000135596.18 [Q8TDZ2-4] |
GeneIDi | 64780 |
KEGGi | hsa:64780 |
MANE-Selecti | ENST00000358807.8; ENSP00000351664.3; NM_022765.4; NP_073602.3 |
UCSCi | uc003ptk.4, human [Q8TDZ2-1] |
Organism-specific databases
CTDi | 64780 |
DisGeNETi | 64780 |
GeneCardsi | MICAL1 |
GeneReviewsi | MICAL1 |
HGNCi | HGNC:20619, MICAL1 |
HPAi | ENSG00000135596, Low tissue specificity |
MalaCardsi | MICAL1 |
MIMi | 607129, gene |
neXtProti | NX_Q8TDZ2 |
OpenTargetsi | ENSG00000135596 |
PharmGKBi | PA134900249 |
VEuPathDBi | HostDB:ENSG00000135596 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1700, Eukaryota |
GeneTreei | ENSGT00940000159117 |
HOGENOMi | CLU_000329_0_0_1 |
InParanoidi | Q8TDZ2 |
OMAi | CKAQSIQ |
OrthoDBi | 430978at2759 |
PhylomeDBi | Q8TDZ2 |
TreeFami | TF324129 |
Enzyme and pathway databases
BRENDAi | 1.14.13.225, 2681 |
PathwayCommonsi | Q8TDZ2 |
Reactomei | R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SABIO-RKi | Q8TDZ2 |
SignaLinki | Q8TDZ2 |
Miscellaneous databases
BioGRID-ORCSi | 64780, 10 hits in 1078 CRISPR screens |
ChiTaRSi | MICAL1, human |
EvolutionaryTracei | Q8TDZ2 |
GeneWikii | MICAL1 |
GenomeRNAii | 64780 |
Pharosi | Q8TDZ2, Tbio |
PROi | PR:Q8TDZ2 |
RNActi | Q8TDZ2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135596, Expressed in blood and 203 other tissues |
ExpressionAtlasi | Q8TDZ2, baseline and differential |
Genevisiblei | Q8TDZ2, HS |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR022735, bMERB_dom IPR001715, CH-domain IPR036872, CH_dom_sf IPR002938, FAD-bd IPR036188, FAD/NAD-bd_sf IPR045268, LIMA-like IPR029937, MICAL1 IPR001781, Znf_LIM |
PANTHERi | PTHR24206, PTHR24206, 1 hit PTHR24206:SF59, PTHR24206:SF59, 1 hit |
Pfami | View protein in Pfam PF00307, CH, 1 hit PF12130, DUF3585, 1 hit PF01494, FAD_binding_3, 1 hit PF00412, LIM, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 1 hit SM00132, LIM, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS51848, BMERB, 1 hit PS50021, CH, 1 hit PS00478, LIM_DOMAIN_1, 1 hit PS50023, LIM_DOMAIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MICA1_HUMAN | |
Accessioni | Q8TDZ2Primary (citable) accession number: Q8TDZ2 Secondary accession number(s): B7Z3R5 Q9UFF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | March 15, 2004 | |
Last modified: | May 25, 2022 | |
This is version 189 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families