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Entry version 143 (11 Dec 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Immunoglobulin superfamily DCC subclass member 4

Gene

IGDCC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin superfamily DCC subclass member 4
Alternative name(s):
Neighbor of punc e11
Protein DDM36
Short name:
hDDM36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGDCC4
Synonyms:DDM36, KIAA1628, NOPE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103742.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13770 IGDCC4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDY8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 957ExtracellularSequence analysisAdd BLAST933
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei958 – 978HelicalSequence analysisAdd BLAST21
Topological domaini979 – 1250CytoplasmicSequence analysisAdd BLAST272

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57722

Open Targets

More...
OpenTargetsi
ENSG00000103742

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720914

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TDY8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGDCC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74760490

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030462225 – 1250Immunoglobulin superfamily DCC subclass member 4Add BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 121PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 212PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 312PROSITE-ProRule annotation
Disulfide bondi356 ↔ 405PROSITE-ProRule annotation
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei995PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TDY8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TDY8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDY8

PeptideAtlas

More...
PeptideAtlasi
Q8TDY8

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDY8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74374 [Q8TDY8-1]
74375 [Q8TDY8-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1944

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103742 Expressed in 175 organ(s), highest expression level in female gonad

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDY8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008510
HPA008576

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121745, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TDY8, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319623

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TDY8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 137Ig-like C2-type 1Add BLAST109
Domaini143 – 229Ig-like C2-type 2Add BLAST87
Domaini242 – 330Ig-like C2-type 3Add BLAST89
Domaini335 – 421Ig-like C2-type 4Add BLAST87
Domaini431 – 525Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini527 – 623Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini632 – 741Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST110
Domaini752 – 845Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini850 – 945Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi61 – 64Poly-Ala4
Compositional biasi385 – 388Poly-Gly4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4221 Eukaryota
ENOG410Z913 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113009

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDY8

KEGG Orthology (KO)

More...
KOi
K22657

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDRDNQT

Database of Orthologous Groups

More...
OrthoDBi
1010015at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDY8

TreeFam database of animal gene trees

More...
TreeFami
TF321506

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TDY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARGDAGRGR GLLALTFCLL AARGELLLPQ ETTVELSCGV GPLQVILGPE
60 70 80 90 100
QAAVLNCSLG AAAAGPPTRV TWSKDGDTLL EHDHLHLLPN GSLWLSQPLA
110 120 130 140 150
PNGSDESVPE AVGVIEGNYS CLAHGPLGVL ASQTAVVKLA TLADFSLHPE
160 170 180 190 200
SQTVEENGTA RFECHIEGLP APIITWEKDQ VTLPEEPRLI VLPNGVLQIL
210 220 230 240 250
DVQESDAGPY RCVATNSARQ HFSQEALLSV AHRGSLASTR GQDVVIVAAP
260 270 280 290 300
ENTTVVSGQS VVMECVASAD PTPFVSWVRQ DGKPISTDVI VLGRTNLLIA
310 320 330 340 350
NAQPWHSGVY VCRANKPRTR DFATAAAELR VLAAPAITQA PEALSRTRAS
360 370 380 390 400
TARFVCRASG EPRPALRWLH NGAPLRPNGR VKVQGGGGSL VITQIGLQDA
410 420 430 440 450
GYYQCVAENS AGMACAAASL AVVVREGLPS APTRVTATPL SSSAVLVAWE
460 470 480 490 500
RPEMHSEQII GFSLHYQKAR GMDNVEYQFA VNNDTTELQV RDLEPNTDYE
510 520 530 540 550
FYVVAYSQLG ASRTSTPALV HTLDDVPSAA PQLSLSSPNP SDIRVAWLPL
560 570 580 590 600
PPSLSNGQVV KYKIEYGLGK EDQIFSTEVR GNETQLMLNS LQPNKVYRVR
610 620 630 640 650
ISAGTAAGFG APSQWMHHRT PSMHNQSHVP FAPAELKVQA KMESLVVSWQ
660 670 680 690 700
PPPHPTQISG YKLYWREVGA EEEANGDRLP GGRGDQAWDV GPVRLKKKVK
710 720 730 740 750
QYELTQLVPG RLYEVKLVAF NKHEDGYAAV WKGKTEKAPA PDMPIQRGPP
760 770 780 790 800
LPPAHVHAES NSSTSIWLRW KKPDFTTVKI VNYTVRFSPW GLRNASLVTY
810 820 830 840 850
YTSSGEDILI GGLKPFTKYE FAVQSHGVDM DGPFGSVVER STLPDRPSTP
860 870 880 890 900
PSDLRLSPLT PSTVRLHWCP PTEPNGEIVE YLILYSSNHT QPEHQWTLLT
910 920 930 940 950
TQGNIFSAEV HGLESDTRYF FKMGARTEVG PGPFSRLQDV ITLQEKLSDS
960 970 980 990 1000
LDMHSVTGII VGVCLGLLCL LACMCAGLRR SPHRESLPGL SSTATPGNPA
1010 1020 1030 1040 1050
LYSRARLGPP SPPAAHELES LVHPHPQDWS PPPSDVEDRA EVHSLMGGGV
1060 1070 1080 1090 1100
SEGRSHSKRK ISWAQPSGLS WAGSWAGCEL PQAGPRPALT RALLPPAGTG
1110 1120 1130 1140 1150
QTLLLQALVY DAIKGNGRKK SPPACRNQVE AEVIVHSDFS ASNGNPDLHL
1160 1170 1180 1190 1200
QDLEPEDPLP PEAPDLISGV GDPGQGAAWL DRELGGCELA APGPDRLTCL
1210 1220 1230 1240 1250
PEAASASCSY PDLQPGEVLE ETPGDSCQLK SPCPLGASPG LPRSPVSSSA
Length:1,250
Mass (Da):134,210
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i181CA412E935F977
GO
Isoform 2 (identifier: Q8TDY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: MARGDAGRGR...FATAAAELRV → MGRRKGRSAL...IPRSASPLAP

Show »
Length:980
Mass (Da):105,361
Checksum:iA0636C95D4EE951E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04996652A → P. Corresponds to variant dbSNP:rs34355056Ensembl.1
Natural variantiVAR_049967301N → S. Corresponds to variant dbSNP:rs12442757Ensembl.1
Natural variantiVAR_059391803S → C. Corresponds to variant dbSNP:rs1469778Ensembl.1
Natural variantiVAR_0499681102T → A. Corresponds to variant dbSNP:rs33918653Ensembl.1
Natural variantiVAR_0499691125C → Y. Corresponds to variant dbSNP:rs33918653Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0280461 – 331MARGD…AELRV → MGRRKGRSALSRSSLERVNQ GEVKVIGRGAREGGGGQAWG TGGGGRDLSCGIPRSASPLA P in isoform 2. 1 PublicationAdd BLAST331

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB052622 mRNA Translation: BAB86306.1
AB046848 mRNA Translation: BAB13454.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10206.1 [Q8TDY8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_066013.1, NM_020962.2 [Q8TDY8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000352385; ENSP00000319623; ENSG00000103742 [Q8TDY8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57722

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57722

UCSC genome browser

More...
UCSCi
uc002aou.2 human [Q8TDY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052622 mRNA Translation: BAB86306.1
AB046848 mRNA Translation: BAB13454.1
CCDSiCCDS10206.1 [Q8TDY8-1]
RefSeqiNP_066013.1, NM_020962.2 [Q8TDY8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121745, 4 interactors
IntActiQ8TDY8, 3 interactors
STRINGi9606.ENSP00000319623

PTM databases

GlyConnecti1944
iPTMnetiQ8TDY8
PhosphoSitePlusiQ8TDY8

Polymorphism and mutation databases

BioMutaiIGDCC4
DMDMi74760490

Proteomic databases

jPOSTiQ8TDY8
MassIVEiQ8TDY8
PaxDbiQ8TDY8
PeptideAtlasiQ8TDY8
PRIDEiQ8TDY8
ProteomicsDBi74374 [Q8TDY8-1]
74375 [Q8TDY8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57722

Genome annotation databases

EnsembliENST00000352385; ENSP00000319623; ENSG00000103742 [Q8TDY8-1]
GeneIDi57722
KEGGihsa:57722
UCSCiuc002aou.2 human [Q8TDY8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57722
DisGeNETi57722
EuPathDBiHostDB:ENSG00000103742.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IGDCC4
HGNCiHGNC:13770 IGDCC4
HPAiHPA008510
HPA008576
neXtProtiNX_Q8TDY8
OpenTargetsiENSG00000103742
PharmGKBiPA164720914

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4221 Eukaryota
ENOG410Z913 LUCA
GeneTreeiENSGT00940000159637
HOGENOMiHOG000113009
InParanoidiQ8TDY8
KOiK22657
OMAiPDRDNQT
OrthoDBi1010015at2759
PhylomeDBiQ8TDY8
TreeFamiTF321506

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IGDCC4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57722
PharosiQ8TDY8 Tdark

Protein Ontology

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PROi
PR:Q8TDY8
RNActiQ8TDY8 protein

Gene expression databases

BgeeiENSG00000103742 Expressed in 175 organ(s), highest expression level in female gonad
GenevisibleiQ8TDY8 HS

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGDC4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDY8
Secondary accession number(s): Q9HCE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2002
Last modified: December 11, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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