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Entry version 158 (26 Feb 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Gene

ASAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes cell proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri441 – 464C4-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Development and differentiation-enhancing factor-like 1
Protein up-regulated in liver cancer 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASAP3
Synonyms:DDEFL1, UPLC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14987 ASAP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616594 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDY4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55616

Open Targets

More...
OpenTargetsi
ENSG00000088280

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164716179

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TDY4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASAP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751433

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002328871 – 903Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3Add BLAST903

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TDY4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TDY4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TDY4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDY4

PeptideAtlas

More...
PeptideAtlasi
Q8TDY4

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDY4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74371 [Q8TDY4-1]
74372 [Q8TDY4-2]
74373 [Q8TDY4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDY4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000088280 Expressed in right ovary and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TDY4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDY4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020537
HPA020546

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120756, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TDY4, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338769

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TDY4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1903
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TDY4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TDY4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini302 – 394PHPROSITE-ProRule annotationAdd BLAST93
Domaini426 – 551Arf-GAPPROSITE-ProRule annotationAdd BLAST126
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati585 – 617ANK 1Add BLAST33
Repeati621 – 650ANK 2Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili141 – 172Sequence analysisAdd BLAST32
Coiled coili248 – 275Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi798 – 801Poly-Ser4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri441 – 464C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0521 Eukaryota
COG5347 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161085

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_676064_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDY4

KEGG Orthology (KO)

More...
KOi
K12488

Identification of Orthologs from Complete Genome Data

More...
OMAi
NGYSIHQ

Database of Orthologous Groups

More...
OrthoDBi
751525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDY4

TreeFam database of animal gene trees

More...
TreeFami
TF325156

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13251 PH_ASAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR028775 ASAP3
IPR011993 PH-like_dom_sf
IPR037844 PH_ASAP
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR45854:SF1 PTHR45854:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF00169 PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405 REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEQFSVAEF LAVTAEDLSS PAGAAAFAAK MPRYRGAALA REEILEGDQA
60 70 80 90 100
ILQRIKKAVR AIHSSGLGHV ENEEQYREAV ESLGNSHLSQ NSHELSTGFL
110 120 130 140 150
NLAVFTREVA ALFKNLIQNL NNIVSFPLDS LMKGQLRDGR QDSKKQLEKA
160 170 180 190 200
WKDYEAKMAK LEKERDRARV TGGIPGEVAQ DMQRERRIFQ LHMCEYLLKA
210 220 230 240 250
GESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLFPFI EKLAASVHAL
260 270 280 290 300
HQAQEDELQK LTQLRDSLRG TLQLESREEH LSRKNSGCGY SIHQHQGNKQ
310 320 330 340 350
FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSTIN RPPVKLTLLT
360 370 380 390 400
CQVRPNPEEK KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA
410 420 430 440 450
FLGEPSAGPG SWGSAGHDGE PHDLTKLLIA EVKSRPGNSQ CCDCGAADPT
460 470 480 490 500
WLSTNLGVLT CIQCSGVHRE LGVRFSRMQS LTLDLLGPSE LLLALNMGNT
510 520 530 540 550
SFNEVMEAQL PSHGGPKPSA ESDMGTRRDY IMAKYVEHRF ARRCTPEPQR
560 570 580 590 600
LWTAICNRDL LSVLEAFANG QDFGQPLPGP DAQAPEELVL HLAVKVANQA
610 620 630 640 650
SLPLVDFIIQ NGGHLDAKAA DGNTALHYAA LYNQPDCLKL LLKGRALVGT
660 670 680 690 700
VNEAGETALD IARKKHHKEC EELLEQAQAG TFAFPLHVDY SWVISTEPGS
710 720 730 740 750
DSEEDEEEKR CLLKLPAQAH WASGRLDISN KTYETVASLG AATPQGESED
760 770 780 790 800
CPPPLPVKNS SRTLVQGCAR HASGDRSEVS SLSSEAPETP ESLGSPASSS
810 820 830 840 850
SLMSPLEPGD PSQAPPNSEE GLREPPGTSR PSLTSGTTPS EMYLPVRFSS
860 870 880 890 900
ESTRSYRRGA RSPEDGPSAR QPLPRRNVPV GITEGDGSRT GSLPASSVQL

LQD
Length:903
Mass (Da):99,155
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5E89518AFC86656
GO
Isoform 2 (identifier: Q8TDY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-496: Missing.

Show »
Length:407
Mass (Da):43,695
Checksum:i563CCA514252A27A
GO
Isoform 3 (identifier: Q8TDY4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-158: DSKKQLEKAWKDYEAKM → ASLSLGSR

Show »
Length:894
Mass (Da):97,847
Checksum:i124043E01A5F8C85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEB0H0YEB0_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YER8H0YER8_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE36H0YE36_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0Y5A0A087X0Y5_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY49V9GY49_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS98E9PS98_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti319V → A in AAH60786 (PubMed:15489334).Curated1
Sequence conflicti521E → G in BAA91008 (PubMed:14702039).Curated1
Sequence conflicti596V → D in BAA91008 (PubMed:14702039).Curated1
Sequence conflicti802L → V in BAA91008 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048295377E → A. Corresponds to variant dbSNP:rs16828486Ensembl.1
Natural variantiVAR_035612617A → T in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0180131 – 496Missing in isoform 2. 1 PublicationAdd BLAST496
Alternative sequenceiVSP_039827142 – 158DSKKQ…YEAKM → ASLSLGSR in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB056749 mRNA Translation: BAB85677.1
AK000206 mRNA Translation: BAA91008.1
AK092291 mRNA Translation: BAG52522.1
AK295100 mRNA Translation: BAG58136.1
AL021154 Genomic DNA No translation available.
AL357134 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95050.1
BC052305 mRNA Translation: AAH52305.1
BC060786 mRNA Translation: AAH60786.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS235.1 [Q8TDY4-1]
CCDS44087.1 [Q8TDY4-3]

NCBI Reference Sequences

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RefSeqi
NP_001137250.1, NM_001143778.1 [Q8TDY4-3]
NP_060177.2, NM_017707.3 [Q8TDY4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336689; ENSP00000338769; ENSG00000088280 [Q8TDY4-1]
ENST00000437606; ENSP00000408826; ENSG00000088280 [Q8TDY4-3]
ENST00000495646; ENSP00000436150; ENSG00000088280 [Q8TDY4-2]
ENST00000634513; ENSP00000488934; ENSG00000282854 [Q8TDY4-2]
ENST00000634561; ENSP00000488946; ENSG00000282854 [Q8TDY4-1]
ENST00000635198; ENSP00000488953; ENSG00000282854 [Q8TDY4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55616

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55616

UCSC genome browser

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UCSCi
uc001bgy.1 human [Q8TDY4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056749 mRNA Translation: BAB85677.1
AK000206 mRNA Translation: BAA91008.1
AK092291 mRNA Translation: BAG52522.1
AK295100 mRNA Translation: BAG58136.1
AL021154 Genomic DNA No translation available.
AL357134 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95050.1
BC052305 mRNA Translation: AAH52305.1
BC060786 mRNA Translation: AAH60786.1
CCDSiCCDS235.1 [Q8TDY4-1]
CCDS44087.1 [Q8TDY4-3]
RefSeqiNP_001137250.1, NM_001143778.1 [Q8TDY4-3]
NP_060177.2, NM_017707.3 [Q8TDY4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B0OX-ray2.06E/F/G/H416-697[»]
3LVQX-ray3.38E416-697[»]
3LVRX-ray3.38E416-697[»]
SMRiQ8TDY4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120756, 18 interactors
IntActiQ8TDY4, 16 interactors
STRINGi9606.ENSP00000338769

PTM databases

iPTMnetiQ8TDY4
PhosphoSitePlusiQ8TDY4

Polymorphism and mutation databases

BioMutaiASAP3
DMDMi74751433

Proteomic databases

jPOSTiQ8TDY4
MassIVEiQ8TDY4
MaxQBiQ8TDY4
PaxDbiQ8TDY4
PeptideAtlasiQ8TDY4
PRIDEiQ8TDY4
ProteomicsDBi74371 [Q8TDY4-1]
74372 [Q8TDY4-2]
74373 [Q8TDY4-3]

Genome annotation databases

EnsembliENST00000336689; ENSP00000338769; ENSG00000088280 [Q8TDY4-1]
ENST00000437606; ENSP00000408826; ENSG00000088280 [Q8TDY4-3]
ENST00000495646; ENSP00000436150; ENSG00000088280 [Q8TDY4-2]
ENST00000634513; ENSP00000488934; ENSG00000282854 [Q8TDY4-2]
ENST00000634561; ENSP00000488946; ENSG00000282854 [Q8TDY4-1]
ENST00000635198; ENSP00000488953; ENSG00000282854 [Q8TDY4-3]
GeneIDi55616
KEGGihsa:55616
UCSCiuc001bgy.1 human [Q8TDY4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55616
DisGeNETi55616

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ASAP3
HGNCiHGNC:14987 ASAP3
HPAiHPA020537
HPA020546
MIMi616594 gene
neXtProtiNX_Q8TDY4
OpenTargetsiENSG00000088280
PharmGKBiPA164716179

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0521 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00940000161085
HOGENOMiCLU_676064_0_0_1
InParanoidiQ8TDY4
KOiK12488
OMAiNGYSIHQ
OrthoDBi751525at2759
PhylomeDBiQ8TDY4
TreeFamiTF325156

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ASAP3 human
EvolutionaryTraceiQ8TDY4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55616
PharosiQ8TDY4 Tbio

Protein Ontology

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PROi
PR:Q8TDY4
RNActiQ8TDY4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088280 Expressed in right ovary and 205 other tissues
ExpressionAtlasiQ8TDY4 baseline and differential
GenevisibleiQ8TDY4 HS

Family and domain databases

CDDicd13251 PH_ASAP, 1 hit
Gene3Di1.20.1270.60, 1 hit
2.30.29.30, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR028775 ASAP3
IPR011993 PH-like_dom_sf
IPR037844 PH_ASAP
IPR001849 PH_domain
PANTHERiPTHR45854:SF1 PTHR45854:SF1, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASAP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDY4
Secondary accession number(s): B3KRW0
, B4DHH4, Q6P9F4, Q86UY1, Q9NXK2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2002
Last modified: February 26, 2020
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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