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Protein

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Gene

ASAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri441 – 464C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell migration Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • regulation of stress fiber assembly Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Development and differentiation-enhancing factor-like 1
Protein up-regulated in liver cancer 1
Gene namesi
Name:ASAP3
Synonyms:DDEFL1, UPLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000088280.18
HGNCiHGNC:14987 ASAP3
MIMi616594 gene
neXtProtiNX_Q8TDY4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55616
OpenTargetsiENSG00000088280
PharmGKBiPA164716179

Polymorphism and mutation databases

BioMutaiASAP3
DMDMi74751433

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328871 – 903Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3Add BLAST903

Proteomic databases

EPDiQ8TDY4
MaxQBiQ8TDY4
PaxDbiQ8TDY4
PeptideAtlasiQ8TDY4
PRIDEiQ8TDY4
ProteomicsDBi74371
74372 [Q8TDY4-2]
74373 [Q8TDY4-3]

PTM databases

iPTMnetiQ8TDY4
PhosphoSitePlusiQ8TDY4

Expressioni

Tissue specificityi

Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000088280 Expressed in 206 organ(s), highest expression level in right ovary
CleanExiHS_ASAP3
ExpressionAtlasiQ8TDY4 baseline and differential
GenevisibleiQ8TDY4 HS

Organism-specific databases

HPAiHPA020537
HPA020546

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120756, 16 interactors
IntActiQ8TDY4, 8 interactors
STRINGi9606.ENSP00000338769

Structurei

Secondary structure

1903
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TDY4
SMRiQ8TDY4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TDY4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 394PHPROSITE-ProRule annotationAdd BLAST93
Domaini426 – 551Arf-GAPPROSITE-ProRule annotationAdd BLAST126
Repeati585 – 617ANK 1Add BLAST33
Repeati621 – 650ANK 2Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili141 – 172Sequence analysisAdd BLAST32
Coiled coili248 – 275Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi798 – 801Poly-Ser4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri441 – 464C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0521 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
HOGENOMiHOG000230570
HOVERGENiHBG051327
InParanoidiQ8TDY4
KOiK12488
OMAiIIQNGGH
OrthoDBiEOG091G022H
PhylomeDBiQ8TDY4
TreeFamiTF325156

Family and domain databases

CDDicd00204 ANK, 1 hit
cd13251 PH_ASAP, 1 hit
Gene3Di1.20.1270.60, 1 hit
2.30.29.30, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR028775 ASAP3
IPR011993 PH-like_dom_sf
IPR037844 PH_ASAP
IPR001849 PH_domain
PANTHERiPTHR23180:SF271 PTHR23180:SF271, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF103657 SSF103657, 2 hits
SSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8TDY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEQFSVAEF LAVTAEDLSS PAGAAAFAAK MPRYRGAALA REEILEGDQA
60 70 80 90 100
ILQRIKKAVR AIHSSGLGHV ENEEQYREAV ESLGNSHLSQ NSHELSTGFL
110 120 130 140 150
NLAVFTREVA ALFKNLIQNL NNIVSFPLDS LMKGQLRDGR QDSKKQLEKA
160 170 180 190 200
WKDYEAKMAK LEKERDRARV TGGIPGEVAQ DMQRERRIFQ LHMCEYLLKA
210 220 230 240 250
GESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLFPFI EKLAASVHAL
260 270 280 290 300
HQAQEDELQK LTQLRDSLRG TLQLESREEH LSRKNSGCGY SIHQHQGNKQ
310 320 330 340 350
FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSTIN RPPVKLTLLT
360 370 380 390 400
CQVRPNPEEK KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA
410 420 430 440 450
FLGEPSAGPG SWGSAGHDGE PHDLTKLLIA EVKSRPGNSQ CCDCGAADPT
460 470 480 490 500
WLSTNLGVLT CIQCSGVHRE LGVRFSRMQS LTLDLLGPSE LLLALNMGNT
510 520 530 540 550
SFNEVMEAQL PSHGGPKPSA ESDMGTRRDY IMAKYVEHRF ARRCTPEPQR
560 570 580 590 600
LWTAICNRDL LSVLEAFANG QDFGQPLPGP DAQAPEELVL HLAVKVANQA
610 620 630 640 650
SLPLVDFIIQ NGGHLDAKAA DGNTALHYAA LYNQPDCLKL LLKGRALVGT
660 670 680 690 700
VNEAGETALD IARKKHHKEC EELLEQAQAG TFAFPLHVDY SWVISTEPGS
710 720 730 740 750
DSEEDEEEKR CLLKLPAQAH WASGRLDISN KTYETVASLG AATPQGESED
760 770 780 790 800
CPPPLPVKNS SRTLVQGCAR HASGDRSEVS SLSSEAPETP ESLGSPASSS
810 820 830 840 850
SLMSPLEPGD PSQAPPNSEE GLREPPGTSR PSLTSGTTPS EMYLPVRFSS
860 870 880 890 900
ESTRSYRRGA RSPEDGPSAR QPLPRRNVPV GITEGDGSRT GSLPASSVQL

LQD
Length:903
Mass (Da):99,155
Last modified:June 1, 2002 - v1
Checksum:iD5E89518AFC86656
GO
Isoform 2 (identifier: Q8TDY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-496: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):43,695
Checksum:i563CCA514252A27A
GO
Isoform 3 (identifier: Q8TDY4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-158: DSKKQLEKAWKDYEAKM → ASLSLGSR

Note: No experimental confirmation available.
Show »
Length:894
Mass (Da):97,847
Checksum:i124043E01A5F8C85
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YER8H0YER8_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
120Annotation score:
A0A087X0Y5A0A087X0Y5_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
202Annotation score:
H0YE36H0YE36_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
124Annotation score:
V9GY49V9GY49_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
157Annotation score:
H0YEB0H0YEB0_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
203Annotation score:
E9PS98E9PS98_HUMAN
Arf-GAP with SH3 domain, ANK repeat...
ASAP3
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319V → A in AAH60786 (PubMed:15489334).Curated1
Sequence conflicti521E → G in BAA91008 (PubMed:14702039).Curated1
Sequence conflicti596V → D in BAA91008 (PubMed:14702039).Curated1
Sequence conflicti802L → V in BAA91008 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048295377E → A. Corresponds to variant dbSNP:rs16828486Ensembl.1
Natural variantiVAR_035612617A → T in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0180131 – 496Missing in isoform 2. 1 PublicationAdd BLAST496
Alternative sequenceiVSP_039827142 – 158DSKKQ…YEAKM → ASLSLGSR in isoform 3. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056749 mRNA Translation: BAB85677.1
AK000206 mRNA Translation: BAA91008.1
AK092291 mRNA Translation: BAG52522.1
AK295100 mRNA Translation: BAG58136.1
AL021154 Genomic DNA No translation available.
AL357134 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95050.1
BC052305 mRNA Translation: AAH52305.1
BC060786 mRNA Translation: AAH60786.1
CCDSiCCDS235.1 [Q8TDY4-1]
CCDS44087.1 [Q8TDY4-3]
RefSeqiNP_001137250.1, NM_001143778.1 [Q8TDY4-3]
NP_060177.2, NM_017707.3 [Q8TDY4-1]
UniGeneiHs.437379

Genome annotation databases

EnsembliENST00000336689; ENSP00000338769; ENSG00000088280 [Q8TDY4-1]
ENST00000437606; ENSP00000408826; ENSG00000088280 [Q8TDY4-3]
ENST00000495646; ENSP00000436150; ENSG00000088280 [Q8TDY4-2]
ENST00000634513; ENSP00000488934; ENSG00000282854 [Q8TDY4-2]
ENST00000634561; ENSP00000488946; ENSG00000282854 [Q8TDY4-1]
ENST00000635198; ENSP00000488953; ENSG00000282854 [Q8TDY4-3]
GeneIDi55616
KEGGihsa:55616
UCSCiuc001bgy.1 human [Q8TDY4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056749 mRNA Translation: BAB85677.1
AK000206 mRNA Translation: BAA91008.1
AK092291 mRNA Translation: BAG52522.1
AK295100 mRNA Translation: BAG58136.1
AL021154 Genomic DNA No translation available.
AL357134 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95050.1
BC052305 mRNA Translation: AAH52305.1
BC060786 mRNA Translation: AAH60786.1
CCDSiCCDS235.1 [Q8TDY4-1]
CCDS44087.1 [Q8TDY4-3]
RefSeqiNP_001137250.1, NM_001143778.1 [Q8TDY4-3]
NP_060177.2, NM_017707.3 [Q8TDY4-1]
UniGeneiHs.437379

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B0OX-ray2.06E/F/G/H416-697[»]
3LVQX-ray3.38E416-697[»]
3LVRX-ray3.38E416-697[»]
ProteinModelPortaliQ8TDY4
SMRiQ8TDY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120756, 16 interactors
IntActiQ8TDY4, 8 interactors
STRINGi9606.ENSP00000338769

PTM databases

iPTMnetiQ8TDY4
PhosphoSitePlusiQ8TDY4

Polymorphism and mutation databases

BioMutaiASAP3
DMDMi74751433

Proteomic databases

EPDiQ8TDY4
MaxQBiQ8TDY4
PaxDbiQ8TDY4
PeptideAtlasiQ8TDY4
PRIDEiQ8TDY4
ProteomicsDBi74371
74372 [Q8TDY4-2]
74373 [Q8TDY4-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336689; ENSP00000338769; ENSG00000088280 [Q8TDY4-1]
ENST00000437606; ENSP00000408826; ENSG00000088280 [Q8TDY4-3]
ENST00000495646; ENSP00000436150; ENSG00000088280 [Q8TDY4-2]
ENST00000634513; ENSP00000488934; ENSG00000282854 [Q8TDY4-2]
ENST00000634561; ENSP00000488946; ENSG00000282854 [Q8TDY4-1]
ENST00000635198; ENSP00000488953; ENSG00000282854 [Q8TDY4-3]
GeneIDi55616
KEGGihsa:55616
UCSCiuc001bgy.1 human [Q8TDY4-1]

Organism-specific databases

CTDi55616
DisGeNETi55616
EuPathDBiHostDB:ENSG00000088280.18
GeneCardsiASAP3
H-InvDBiHIX0000247
HGNCiHGNC:14987 ASAP3
HPAiHPA020537
HPA020546
MIMi616594 gene
neXtProtiNX_Q8TDY4
OpenTargetsiENSG00000088280
PharmGKBiPA164716179
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0521 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
HOGENOMiHOG000230570
HOVERGENiHBG051327
InParanoidiQ8TDY4
KOiK12488
OMAiIIQNGGH
OrthoDBiEOG091G022H
PhylomeDBiQ8TDY4
TreeFamiTF325156

Miscellaneous databases

ChiTaRSiASAP3 human
EvolutionaryTraceiQ8TDY4
GenomeRNAii55616
PROiPR:Q8TDY4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088280 Expressed in 206 organ(s), highest expression level in right ovary
CleanExiHS_ASAP3
ExpressionAtlasiQ8TDY4 baseline and differential
GenevisibleiQ8TDY4 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
cd13251 PH_ASAP, 1 hit
Gene3Di1.20.1270.60, 1 hit
2.30.29.30, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR028775 ASAP3
IPR011993 PH-like_dom_sf
IPR037844 PH_ASAP
IPR001849 PH_domain
PANTHERiPTHR23180:SF271 PTHR23180:SF271, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF103657 SSF103657, 2 hits
SSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASAP3_HUMAN
AccessioniPrimary (citable) accession number: Q8TDY4
Secondary accession number(s): B3KRW0
, B4DHH4, Q6P9F4, Q86UY1, Q9NXK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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