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Protein

Actin-related protein T2

Gene

ACTRT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8TDY3

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein T2
Short name:
ARP-T2
Alternative name(s):
Actin-related protein M2
Gene namesi
Name:ACTRT2
Synonyms:ARPM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169717.6
HGNCiHGNC:24026 ACTRT2
MIMi608535 gene
neXtProtiNX_Q8TDY3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi140625
OpenTargetsiENSG00000169717
PharmGKBiPA142672647

Polymorphism and mutation databases

BioMutaiACTRT2
DMDMi47115879

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000891441 – 377Actin-related protein T2Add BLAST377

Proteomic databases

PaxDbiQ8TDY3
PeptideAtlasiQ8TDY3
PRIDEiQ8TDY3
ProteomicsDBi74370

PTM databases

iPTMnetiQ8TDY3
PhosphoSitePlusiQ8TDY3

Expressioni

Gene expression databases

BgeeiENSG00000169717 Expressed in 27 organ(s), highest expression level in right testis
CleanExiHS_ACTRT2
GenevisibleiQ8TDY3 HS

Organism-specific databases

HPAiHPA006480
HPA025079

Interactioni

Protein-protein interaction databases

BioGridi126639, 1 interactor
STRINGi9606.ENSP00000367658

Structurei

3D structure databases

ProteinModelPortaliQ8TDY3
SMRiQ8TDY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiQ8TDY3
OMAiFYLSDQA
OrthoDBiEOG091G0AB0
PhylomeDBiQ8TDY3
TreeFamiTF354237

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR027666 ACTRT2
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF38 PTHR11937:SF38, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TDY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNPHALDSP AVIFDNGSGF CKAGLSGEFG PRHMVSSIVG HLKFQAPSAE
60 70 80 90 100
ANQKKYFVGE EALYKQEALQ LHSPFERGLI TGWDDVERLW KHLFEWELGV
110 120 130 140 150
KPSDQPLLAT EPSLNPRENR EKMAEVMFEN FGVPAFYLSD QAVLALYASA
160 170 180 190 200
CVTGLVVDSG DAVTCTVPIF EGYSLPHAVT KLHVAGRDIT ELLMQLLLAS
210 220 230 240 250
GHTFPCQLDK GLVDDIKKKL CYVALEPEKE LSRRPEEVLR EYKLPDGNII
260 270 280 290 300
SLGDPLHQAP EALFVPQQLG SQSPGLSNMV SSSITKCDTD IQKILFGEIV
310 320 330 340 350
LSGGTTLFHG LDDRLLKELE QLASKDTPIK ITAPPDRWFS TWIGASIVTS
360 370
LSSFKQMWVT AADFKEFGTS VVQRRCF
Length:377
Mass (Da):41,702
Last modified:May 10, 2004 - v2
Checksum:i73272DE854B48FEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55Missing in AAH29499 (PubMed:15489334).Curated1
Sequence conflicti224A → P in BAB85862 (PubMed:11750065).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020416247G → R. Corresponds to variant dbSNP:rs3795263Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057364 mRNA Translation: BAB85862.1
AF440740 mRNA Translation: AAM00433.1
AL356984 Genomic DNA No translation available.
CH471248 Genomic DNA Translation: EAW61142.1
BC029499 mRNA Translation: AAH29499.1
CCDSiCCDS45.1
RefSeqiNP_536356.3, NM_080431.4
UniGeneiHs.236635

Genome annotation databases

EnsembliENST00000378404; ENSP00000367658; ENSG00000169717
GeneIDi140625
KEGGihsa:140625
UCSCiuc001ajz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057364 mRNA Translation: BAB85862.1
AF440740 mRNA Translation: AAM00433.1
AL356984 Genomic DNA No translation available.
CH471248 Genomic DNA Translation: EAW61142.1
BC029499 mRNA Translation: AAH29499.1
CCDSiCCDS45.1
RefSeqiNP_536356.3, NM_080431.4
UniGeneiHs.236635

3D structure databases

ProteinModelPortaliQ8TDY3
SMRiQ8TDY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126639, 1 interactor
STRINGi9606.ENSP00000367658

PTM databases

iPTMnetiQ8TDY3
PhosphoSitePlusiQ8TDY3

Polymorphism and mutation databases

BioMutaiACTRT2
DMDMi47115879

Proteomic databases

PaxDbiQ8TDY3
PeptideAtlasiQ8TDY3
PRIDEiQ8TDY3
ProteomicsDBi74370

Protocols and materials databases

DNASUi140625
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378404; ENSP00000367658; ENSG00000169717
GeneIDi140625
KEGGihsa:140625
UCSCiuc001ajz.4 human

Organism-specific databases

CTDi140625
DisGeNETi140625
EuPathDBiHostDB:ENSG00000169717.6
GeneCardsiACTRT2
HGNCiHGNC:24026 ACTRT2
HPAiHPA006480
HPA025079
MIMi608535 gene
neXtProtiNX_Q8TDY3
OpenTargetsiENSG00000169717
PharmGKBiPA142672647
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiQ8TDY3
OMAiFYLSDQA
OrthoDBiEOG091G0AB0
PhylomeDBiQ8TDY3
TreeFamiTF354237

Enzyme and pathway databases

SignaLinkiQ8TDY3

Miscellaneous databases

GenomeRNAii140625
PROiPR:Q8TDY3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169717 Expressed in 27 organ(s), highest expression level in right testis
CleanExiHS_ACTRT2
GenevisibleiQ8TDY3 HS

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR027666 ACTRT2
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF38 PTHR11937:SF38, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACTT2_HUMAN
AccessioniPrimary (citable) accession number: Q8TDY3
Secondary accession number(s): B1AN52, Q8NHS6, Q8TDG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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