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UniProtKB - Q8TDX7 (NEK7_HUMAN)

Entry version 171 (23 Feb 2022)
Sequence version 1 (01 Jun 2002)
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Protein

Serine/threonine-protein kinase Nek7

Gene

NEK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132).

Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596).

Phosphorylates RPS6KB1 (By similarity).

Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757).

Essential protein for NLRP3 inflammasome assembly and activation that acts downstream stimuli such as K+ efflux. Dispensable for the induction of core inflammasome components, but necessary for subsequent formation of the NLRP3:PYCARD complex, and activation of CASP1. Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division. Exerts its effects on the NLRP3 inflammasome independently of its kinase activity (PubMed:26642356).

By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63ATP1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei97Autoinhibitory1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei161Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi40 – 48ATP9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TDX7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8TDX7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8TDX7

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek7 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 7
Short name:
NimA-related protein kinase 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEK7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13386, NEK7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606848, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDX7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28Y → A: Significant decrease in catalytic activity; when associated with A-31. 1 Publication1
Mutagenesisi31L → A: Significant decrease in catalytic activity; when associated with A-28. 1 Publication1
Mutagenesisi33N → D: Significant decrease in catalytic activity. 1 Publication1
Mutagenesisi97Y → A: 5-fold increase in catalytic activity. 1 Publication1
Mutagenesisi97Y → F or L: Moderate increase in catalytic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		140609

Open Targets

More...OpenTargetsi		ENSG00000151414

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31551

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TDX7, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4849

DrugCentral

More...DrugCentrali		Q8TDX7

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NEK7

Domain mapping of disease mutations (DMDM)

More...DMDMi		37537965

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000864301 – 302Serine/threonine-protein kinase Nek7Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei195Phosphoserine; by NEK91 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-195 required for its activation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1621

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TDX7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TDX7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TDX7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TDX7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDX7

PeptideAtlas

More...PeptideAtlasi		Q8TDX7

PRoteomics IDEntifications database

More...PRIDEi		Q8TDX7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74364 [Q8TDX7-1]
74365 [Q8TDX7-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TDX7, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDX7

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q8TDX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151414, Expressed in heart left ventricle and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TDX7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDX7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151414, Tissue enhanced (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:21320329).

Interacts with NEK9 (PubMed:19414596).

Interacts with ANKS3; this interaction alters the subcellular distribution of NEK7 by preventing its nuclear translocation (PubMed:26188091).

Interacts (via N-terminus) with NLRP3 (via LRR repeat domain); the interaction is required for the formation of the complex NLRP3:PYCARD, oligomerization of PYCARD and activation of CASP1 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TDX7
With#Exp.IntAct
ARHGEF28 - isoform 4 [Q8N1W1-4]3EBI-1055945,EBI-13062134
C1orf216 [Q8TAB5]3EBI-1055945,EBI-747505
CAMTA2 - isoform 5 [O94983-5]3EBI-1055945,EBI-10176008
CNOT3 [O75175]3EBI-1055945,EBI-743073
CRELD2 - isoform 2 [Q6UXH1-2]3EBI-1055945,EBI-21670927
DDIT4L [Q96D03]3EBI-1055945,EBI-742054
DNASE1L1 [P49184]3EBI-1055945,EBI-20894690
DRC7 [Q8IY82]3EBI-1055945,EBI-10262896
EGFL8 [Q99944]3EBI-1055945,EBI-3924130
EPCAM [P16422]3EBI-1055945,EBI-1171184
EVA1B [Q9NVM1]3EBI-1055945,EBI-10314666
FAHD2A [Q96GK7]3EBI-1055945,EBI-21647872
FUT2 [Q10981]3EBI-1055945,EBI-9090702
GJA5 [P36382]3EBI-1055945,EBI-750433
GNAO1 [P09471]3EBI-1055945,EBI-715087
HLA-DRB3 [P79483]3EBI-1055945,EBI-3910269
HSD3B1 [P14060]3EBI-1055945,EBI-17426018
HUWE1 - isoform 2 [Q7Z6Z7-2]3EBI-1055945,EBI-10975491
IDH1 [O75874]3EBI-1055945,EBI-715695
ISY1 [Q9ULR0]3EBI-1055945,EBI-2557660
KIAA1683 [A0JP07]3EBI-1055945,EBI-10171456
KLRC1 [P26715]3EBI-1055945,EBI-9018187
LEG1 [Q6P5S2]3EBI-1055945,EBI-11750531
LGALS1 [P09382]3EBI-1055945,EBI-1048875
LGALS8 - isoform 2 [O00214-2]3EBI-1055945,EBI-12069522
MAGEA2B [P43356]3EBI-1055945,EBI-5650739
MAVS [Q7Z434]3EBI-1055945,EBI-995373
MFI [Q8NCR3]3EBI-1055945,EBI-744790
MGC39372 [Q8TB02]3EBI-1055945,EBI-25834188
MMAB [Q96EY8]3EBI-1055945,EBI-7825413
MYBPHL [A2RUH7]3EBI-1055945,EBI-9088235
MYNN [Q9NPC7]3EBI-1055945,EBI-3446748
NEK6 - isoform 4 [Q9HC98-4]3EBI-1055945,EBI-11750983
NFATC2IP - isoform 2 [Q8NCF5-2]3EBI-1055945,EBI-12305293
NLRP3 [Q96P20]4EBI-1055945,EBI-6253230
NXPE1 [Q8N323]3EBI-1055945,EBI-25834085
PABIR3 - isoform 2 [Q6P4D5-2]3EBI-1055945,EBI-9091052
PIAS4 [Q8N2W9]3EBI-1055945,EBI-473160
POC1A [Q8NBT0]3EBI-1055945,EBI-2557132
PPEF1 [O14829]3EBI-1055945,EBI-2931238
PRAM1 [Q96QH2]3EBI-1055945,EBI-2860740
PSAT1 [Q9Y617]3EBI-1055945,EBI-709652
PSMC4 [P43686]3EBI-1055945,EBI-743997
PSMD2 [Q13200]3EBI-1055945,EBI-357648
PYGO1 [Q9Y3Y4]3EBI-1055945,EBI-3397474
RAB31 [Q13636]3EBI-1055945,EBI-725987
RAB3C [Q96E17]3EBI-1055945,EBI-4287022
RAP1B [P61224]3EBI-1055945,EBI-358143
RASSF2 [P50749]3EBI-1055945,EBI-960081
RBM17 [Q96I25]3EBI-1055945,EBI-740272
RBM5 [P52756]3EBI-1055945,EBI-714003
SLC25A11 [Q02978]3EBI-1055945,EBI-359174
SP6 [Q3SY56]3EBI-1055945,EBI-11175533
SPATA17 [Q96L03]3EBI-1055945,EBI-13322423
SPRED2 [Q7Z698]3EBI-1055945,EBI-7082156
TAZ [F6Y2X3]3EBI-1055945,EBI-25833693
TCOF1 - isoform 5 [Q13428-5]3EBI-1055945,EBI-25832010
TDO2 [P48775]3EBI-1055945,EBI-743494
THAP4 [Q9BQ29]3EBI-1055945,EBI-22013570
THAP7 [Q9BT49]3EBI-1055945,EBI-741350
THBS3 [P49746]3EBI-1055945,EBI-2530931
TMX3 - isoform 2 [Q96JJ7-2]3EBI-1055945,EBI-25833898
TNMD - isoform 2 [Q9H2S6-2]3EBI-1055945,EBI-12003398
TPGS2 - isoform 3 [Q68CL5-3]3EBI-1055945,EBI-9091010
TPX2 [Q9ULW0]3EBI-1055945,EBI-1037322
TRNAU1AP [Q9NX07]3EBI-1055945,EBI-12581310
TUBB [P07437]3EBI-1055945,EBI-350864
U2AF1 [Q7Z780]3EBI-1055945,EBI-25833730
USP12 [O75317]3EBI-1055945,EBI-2511507
ZHX1-C8orf76 [Q96EF9]3EBI-1055945,EBI-25830993
Isoform 1 [Q8TDX7-1]
With#Exp.IntAct
NLRP3 - isoform 2 [Q96P20-1]6EBI-16193799,EBI-14029575

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126636, 58 interactors

Database of interacting proteins

More...DIPi		DIP-50780N

Protein interaction database and analysis system

More...IntActi		Q8TDX7, 96 interactors

Molecular INTeraction database

More...MINTi		Q8TDX7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356355

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8TDX7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TDX7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDX7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8TDX7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 299Protein kinasePROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni20 – 33NTE motifAdd BLAST14

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9.1 Publication
The NTE (N-terminal extension) motif is a structural component of the catalytic domain and thus contributes to activity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0591, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156725

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_63_23_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDX7

Identification of Orthologs from Complete Genome Data

More...OMAi		MSRMIKH

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDX7

TreeFam database of animal gene trees

More...TreeFami		TF105135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEQSQGMQG PPVPQFQPQK ALRPDMGYNT LANFRIEKKI GRGQFSEVYR 
        60         70         80         90        100
AACLLDGVPV ALKKVQIFDL MDAKARADCI KEIDLLKQLN HPNVIKYYAS 
       110        120        130        140        150
FIEDNELNIV LELADAGDLS RMIKHFKKQK RLIPERTVWK YFVQLCSALE 
       160        170        180        190        200
HMHSRRVMHR DIKPANVFIT ATGVVKLGDL GLGRFFSSKT TAAHSLVGTP 
       210        220        230        240        250
YYMSPERIHE NGYNFKSDIW SLGCLLYEMA ALQSPFYGDK MNLYSLCKKI 
       260        270        280        290        300
EQCDYPPLPS DHYSEELRQL VNMCINPDPE KRPDVTYVYD VAKRMHACTA 

SS
Length:302
Mass (Da):34,551
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1FC990B34D94D4C
GO
Isoform 2 (identifier: Q8TDX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-119: IFDLMDAKAR...VLELADAGDL → VCLLPVWERR...VSHHGSFAKK
     120-302: Missing.

Show »
Length:119
Mass (Da):13,402
Checksum:iC5CF3EAC5976AE9F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WAG2F8WAG2_HUMAN
Serine/threonine-protein kinase Nek...
NEK7
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3U7F5H3U7_HUMAN
Serine/threonine-protein kinase Nek...
NEK7
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1H8C9J1H8_HUMAN
Serine/threonine-protein kinase Nek...
NEK7
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04092435R → G1 PublicationCorresponds to variant dbSNP:rs55833332Ensembl.1
Natural variantiVAR_040925275I → M in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04124367 – 119IFDLM…DAGDL → VCLLPVWERRVCALNACYFL EIIKGSESLQYMATLTNLFE NLPVSHHGSFAKK in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_041244120 – 302Missing in isoform 2. 1 PublicationAdd BLAST183

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB062450 mRNA Translation: BAB85632.1
CK819069 mRNA No translation available.
AC093419 Genomic DNA No translation available.
AC093561 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91294.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1394.1 [Q8TDX7-1]

NCBI Reference Sequences

More...RefSeqi		NP_598001.1, NM_133494.2 [Q8TDX7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367383; ENSP00000356353; ENSG00000151414 [Q8TDX7-2]
ENST00000367385; ENSP00000356355; ENSG00000151414
ENST00000538004; ENSP00000444621; ENSG00000151414

Database of genes from NCBI RefSeq genomes

More...GeneIDi		140609

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:140609

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000367385.9; ENSP00000356355.4; NM_133494.3; NP_598001.1

UCSC genome browser

More...UCSCi		uc001gun.5, human [Q8TDX7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062450 mRNA Translation: BAB85632.1
CK819069 mRNA No translation available.
AC093419 Genomic DNA No translation available.
AC093561 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91294.1
CCDSiCCDS1394.1 [Q8TDX7-1]
RefSeqiNP_598001.1, NM_133494.2 [Q8TDX7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WQMX-ray2.10A1-302[»]
2WQNX-ray2.30A1-302[»]
5DE2X-ray2.78A/B1-302[»]
6NPYelectron microscopy3.80B1-302[»]
6S73X-ray3.50A/B/C/D1-302[»]
6S75X-ray3.30A/B/C/D1-302[»]
6S76X-ray3.38A/B/C/D1-302[»]
SMRiQ8TDX7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi126636, 58 interactors
DIPiDIP-50780N
IntActiQ8TDX7, 96 interactors
MINTiQ8TDX7
STRINGi9606.ENSP00000356355

Chemistry databases

BindingDBiQ8TDX7
ChEMBLiCHEMBL4849
DrugCentraliQ8TDX7

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

GlyGeniQ8TDX7, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ8TDX7
MetOSiteiQ8TDX7
PhosphoSitePlusiQ8TDX7

Genetic variation databases

BioMutaiNEK7
DMDMi37537965

Proteomic databases

CPTACiCPTAC-1621
EPDiQ8TDX7
jPOSTiQ8TDX7
MassIVEiQ8TDX7
MaxQBiQ8TDX7
PaxDbiQ8TDX7
PeptideAtlasiQ8TDX7
PRIDEiQ8TDX7
ProteomicsDBi74364 [Q8TDX7-1]
74365 [Q8TDX7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20630, 365 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		140609

Genome annotation databases

EnsembliENST00000367383; ENSP00000356353; ENSG00000151414 [Q8TDX7-2]
ENST00000367385; ENSP00000356355; ENSG00000151414
ENST00000538004; ENSP00000444621; ENSG00000151414
GeneIDi140609
KEGGihsa:140609
MANE-SelectiENST00000367385.9; ENSP00000356355.4; NM_133494.3; NP_598001.1
UCSCiuc001gun.5, human [Q8TDX7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		140609
DisGeNETi140609

GeneCards: human genes, protein and diseases

More...GeneCardsi		NEK7
HGNCiHGNC:13386, NEK7
HPAiENSG00000151414, Tissue enhanced (heart)
MIMi606848, gene
neXtProtiNX_Q8TDX7
OpenTargetsiENSG00000151414
PharmGKBiPA31551
VEuPathDBiHostDB:ENSG00000151414

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0591, Eukaryota
GeneTreeiENSGT00940000156725
HOGENOMiCLU_000288_63_23_1
InParanoidiQ8TDX7
OMAiMSRMIKH
OrthoDBi1318335at2759
PhylomeDBiQ8TDX7
TreeFamiTF105135

Enzyme and pathway databases

PathwayCommonsiQ8TDX7
ReactomeiR-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SignaLinkiQ8TDX7
SIGNORiQ8TDX7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		140609, 10 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NEK7, human
EvolutionaryTraceiQ8TDX7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		140609
PharosiQ8TDX7, Tchem

Protein Ontology

More...PROi		PR:Q8TDX7
RNActiQ8TDX7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151414, Expressed in heart left ventricle and 251 other tissues
ExpressionAtlasiQ8TDX7, baseline and differential
GenevisibleiQ8TDX7, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEK7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDX7
Secondary accession number(s): A6NGT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: February 23, 2022
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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