NEK7

Functionⁱ

Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.3 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺

Activity regulationⁱ

Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	63	ATP	1
Siteⁱ	97	Autoinhibitory	1
Active siteⁱ	161	Proton acceptorPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	40 – 48	ATP		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of telomerase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
positive regulation of telomere capping
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
positive regulation of telomere maintenance via telomerase
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 12840024
regulation of mitotic cell cycle
Source: UniProtKB
Traceable author statementⁱ
- 17727698
spindle assembly
Source: UniProtKB
Traceable author statementⁱ
- 17727698

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
SignaLinkⁱ	Q8TDX7
SIGNORⁱ	Q8TDX7

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase Nek7 (EC:2.7.11.1) Alternative name(s): Never in mitosis A-related kinase 7 Short name: NimA-related protein kinase 7
Gene namesⁱ	Name:NEK7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151414.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13386 NEK7
MIMⁱ	606848 gene
neXtProtⁱ	NX_Q8TDX7

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	28	Y → A: Significant decrease in catalytic activity; when associated with A-31. 1 Publication	1
Mutagenesisⁱ	31	L → A: Significant decrease in catalytic activity; when associated with A-28. 1 Publication	1
Mutagenesisⁱ	33	N → D: Significant decrease in catalytic activity. 1 Publication	1
Mutagenesisⁱ	97	Y → A: 5-fold increase in catalytic activity. 1 Publication	1
Mutagenesisⁱ	97	Y → F or L: Moderate increase in catalytic activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	140609
Open Targets More...OpenTargetsⁱ	ENSG00000151414
PharmGKBⁱ	PA31551

Chemistry databases

ChEMBLⁱ	CHEMBL4849

ChEMBLⁱ

CHEMBL4849

Polymorphism and mutation databases

BioMutaⁱ	NEK7
DMDMⁱ	37537965

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086430	1 – 302	Serine/threonine-protein kinase Nek7Add BLAST		302

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	195	Phosphoserine; by NEK91 Publication	1

Post-translational modificationⁱ

Phosphorylation at Ser-195 required for its activation.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8TDX7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TDX7
PaxDbⁱ	Q8TDX7
PeptideAtlas More...PeptideAtlasⁱ	Q8TDX7
PRIDEⁱ	Q8TDX7
ProteomicsDBⁱ	74364 74365 [Q8TDX7-2]

PTM databases

iPTMnetⁱ	Q8TDX7
PhosphoSitePlusⁱ	Q8TDX7

Expressionⁱ

Tissue specificityⁱ

Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000151414 Expressed in 241 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_NEK7
ExpressionAtlasⁱ	Q8TDX7 baseline and differential
Genevisibleⁱ	Q8TDX7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015520 HPA018193

HPAⁱ

HPA015520
HPA018193

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with NEK9.2 Publications

Protein-protein interaction databases

BioGridⁱ	126636, 37 interactors
Database of interacting proteins More...DIPⁱ	DIP-50780N
IntActⁱ	Q8TDX7, 13 interactors
STRINGⁱ	9606.ENSP00000356355

Chemistry databases

BindingDBⁱ

Q8TDX7

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	24 – 26	Combined sources	3
Helixⁱ	31 – 33	Combined sources	3
Beta strandⁱ	34 – 41	Combined sources	8
Beta strandⁱ	47 – 53	Combined sources	7
Turnⁱ	54 – 56	Combined sources	3
Beta strandⁱ	59 – 65	Combined sources	7
Turnⁱ	67 – 70	Combined sources	4
Helixⁱ	73 – 87	Combined sources	15
Beta strandⁱ	97 – 103	Combined sources	7
Beta strandⁱ	106 – 112	Combined sources	7
Helixⁱ	119 – 128	Combined sources	10
Helixⁱ	135 – 154	Combined sources	20
Helixⁱ	164 – 166	Combined sources	3
Beta strandⁱ	167 – 169	Combined sources	3
Beta strandⁱ	175 – 177	Combined sources	3
Helixⁱ	205 – 208	Combined sources	4
Helixⁱ	215 – 231	Combined sources	17
Helixⁱ	243 – 251	Combined sources	9
Turnⁱ	260 – 262	Combined sources	3
Helixⁱ	265 – 274	Combined sources	10
Helixⁱ	279 – 281	Combined sources	3
Helixⁱ	285 – 299	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8TDX7
SMRⁱ	Q8TDX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8TDX7

EvolutionaryTraceⁱ

Q8TDX7

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	34 – 299	Protein kinasePROSITE-ProRule annotationAdd BLAST		266

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	20 – 33	NTE motifAdd BLAST		14

Domainⁱ

Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9.1 Publication

The NTE (N-terminal extension) motif is a structural component of the catalytic domain and thus contributes to activity.1 Publication

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0591 Eukaryota ENOG410XNQP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118997
HOGENOMⁱ	HOG000233029
HOVERGENⁱ	HBG105886
InParanoidⁱ	Q8TDX7
KEGG Orthology (KO) More...KOⁱ	K20876
OMAⁱ	QLVNICI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AER
PhylomeDBⁱ	Q8TDX7
TreeFamⁱ	TF105135

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TDX7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEQSQGMQG PPVPQFQPQK ALRPDMGYNT LANFRIEKKI GRGQFSEVYR 
        60         70         80         90        100
AACLLDGVPV ALKKVQIFDL MDAKARADCI KEIDLLKQLN HPNVIKYYAS 
       110        120        130        140        150
FIEDNELNIV LELADAGDLS RMIKHFKKQK RLIPERTVWK YFVQLCSALE 
       160        170        180        190        200
HMHSRRVMHR DIKPANVFIT ATGVVKLGDL GLGRFFSSKT TAAHSLVGTP 
       210        220        230        240        250
YYMSPERIHE NGYNFKSDIW SLGCLLYEMA ALQSPFYGDK MNLYSLCKKI 
       260        270        280        290        300
EQCDYPPLPS DHYSEELRQL VNMCINPDPE KRPDVTYVYD VAKRMHACTA 

SS

Length:302

Mass (Da):34,551

Last modified:June 1, 2002 - v1

Checksum:ⁱC1FC990B34D94D4C

GO

Isoform 2 (identifier: Q8TDX7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
67-119: IFDLMDAKAR...VLELADAGDL → VCLLPVWERR...VSHHGSFAKK
120-302: Missing.

« Hide

        10         20         30         40         50
MDEQSQGMQG PPVPQFQPQK ALRPDMGYNT LANFRIEKKI GRGQFSEVYR 
        60         70         80         90        100
AACLLDGVPV ALKKVQVCLL PVWERRVCAL NACYFLEIIK GSESLQYMAT 
       110 
LTNLFENLPV SHHGSFAKK

Note: No experimental confirmation available.

Show »

Length:119

Mass (Da):13,402

Checksum:ⁱC5CF3EAC5976AE9F

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WAG2	F8WAG2_HUMAN	Serine/threonine-protein kinase Nek... Serine/threonine-protein kinase Nek7	NEK7	82	Annotation score:
F5H3U7	F5H3U7_HUMAN	Serine/threonine-protein kinase Nek... Serine/threonine-protein kinase Nek7	NEK7	62	Annotation score:
C9J1H8	C9J1H8_HUMAN	Serine/threonine-protein kinase Nek... Serine/threonine-protein kinase Nek7	NEK7	32	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_040924	35	R → G1 PublicationCorresponds to variant dbSNP:rs55833332Ensembl.		1
Natural variantⁱVAR_040925	275	I → M in an ovarian serous carcinoma sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041243	67 – 119	IFDLM…DAGDL → VCLLPVWERRVCALNACYFL EIIKGSESLQYMATLTNLFE NLPVSHHGSFAKK in isoform 2. 1 PublicationAdd BLAST		53
Alternative sequenceⁱVSP_041244	120 – 302	Missing in isoform 2. 1 PublicationAdd BLAST		183

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB062450 mRNA Translation: BAB85632.1 CK819069 mRNA No translation available. AC093419 Genomic DNA No translation available. AC093561 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91294.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1394.1 [Q8TDX7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_598001.1, NM_133494.2 [Q8TDX7-1]
UniGeneⁱ	Hs.24119 Hs.745083

Genome annotation databases

Ensemblⁱ	ENST00000367383; ENSP00000356353; ENSG00000151414 [Q8TDX7-2] ENST00000367385; ENSP00000356355; ENSG00000151414 [Q8TDX7-1] ENST00000538004; ENSP00000444621; ENSG00000151414 [Q8TDX7-1]
GeneIDⁱ	140609
KEGGⁱ	hsa:140609
UCSC genome browser More...UCSCⁱ	uc001gun.5 human [Q8TDX7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TDX7	Uncharacterized protein		CALJA		334	UniRef100_Q8TDX7
NIMA (Never in mitosis gene a)-related kinase 7, isoform CRA_a		HUMAN		302
NEK7 isoform 1		PANTR		302
NEK7 isoform 1		PONAB		302
NIMA related kinase 7		SAIBB		302
+6
Q8TDX7-2	NEK7 isoform 6		PANTR		119	UniRef100_A0A2I3RIA1
NEK7 isoform 5		PONAB		119

Protein	Similar proteins		Species	Score	Length	Source
Q8TDX7	Uncharacterized protein		CALJA		334	UniRef90_Q8TDX7
NIMA (Never in mitosis gene a)-related kinase 7, isoform CRA_a		HUMAN		302
NEK7 isoform 1		PANTR		302
NEK7 isoform 1		PONAB		302
NIMA related kinase 7		SAIBB		302
+46
Q8TDX7-2	NEK7 isoform 6		PANTR		119	UniRef90_A0A2I3RIA1
NEK7 isoform 5		PONAB		119
Uncharacterized protein		MACMU		128
Uncharacterized protein		MACFA		128
Uncharacterized protein		CERAT		128
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8TDX7	Isoform 2 of Serine/threonine-protein kinase Nek6		HUMAN		347	UniRef50_Q9HC98-2
Serine/threonine-protein kinase Nek6		PIG		313
Serine/threonine-protein kinase Nek6		RAT		313
Uncharacterized protein		FELCA		383
Uncharacterized protein		CALJA		351
+349
Q8TDX7-2	NEK7 isoform 6		PANTR		119	UniRef50_A0A2I3RIA1
NEK7 isoform 5		PONAB		119
Uncharacterized protein		CERAT		128
Uncharacterized protein		MANLE		128
Uncharacterized protein		MACMU		128
+12

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB062450 mRNA Translation: BAB85632.1 CK819069 mRNA No translation available. AC093419 Genomic DNA No translation available. AC093561 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91294.1
CCDSⁱ	CCDS1394.1 [Q8TDX7-1]
RefSeqⁱ	NP_598001.1, NM_133494.2 [Q8TDX7-1]
UniGeneⁱ	Hs.24119 Hs.745083

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2WQM	X-ray	2.10	A	1-302	[»]
	2WQN	X-ray	2.30	A	1-302	[»]
	5DE2	X-ray	2.78	A/B	1-302	[»]
	6GT1	X-ray	3.50	A/B/C/D	1-302	[»]
ProteinModelPortalⁱ	Q8TDX7
SMRⁱ	Q8TDX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126636, 37 interactors
DIPⁱ	DIP-50780N
IntActⁱ	Q8TDX7, 13 interactors
STRINGⁱ	9606.ENSP00000356355

Chemistry databases

BindingDBⁱ	Q8TDX7
ChEMBLⁱ	CHEMBL4849

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	Q8TDX7
PhosphoSitePlusⁱ	Q8TDX7

Polymorphism and mutation databases

BioMutaⁱ	NEK7
DMDMⁱ	37537965

Proteomic databases

EPDⁱ	Q8TDX7
MaxQBⁱ	Q8TDX7
PaxDbⁱ	Q8TDX7
PeptideAtlasⁱ	Q8TDX7
PRIDEⁱ	Q8TDX7
ProteomicsDBⁱ	74364 74365 [Q8TDX7-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	140609
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367383; ENSP00000356353; ENSG00000151414 [Q8TDX7-2] ENST00000367385; ENSP00000356355; ENSG00000151414 [Q8TDX7-1] ENST00000538004; ENSP00000444621; ENSG00000151414 [Q8TDX7-1]
GeneIDⁱ	140609
KEGGⁱ	hsa:140609
UCSCⁱ	uc001gun.5 human [Q8TDX7-1]

Organism-specific databases

CTDⁱ	140609
DisGeNETⁱ	140609
EuPathDBⁱ	HostDB:ENSG00000151414.14
GeneCardsⁱ	NEK7
HGNCⁱ	HGNC:13386 NEK7
HPAⁱ	HPA015520 HPA018193
MIMⁱ	606848 gene
neXtProtⁱ	NX_Q8TDX7
OpenTargetsⁱ	ENSG00000151414
PharmGKBⁱ	PA31551
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0591 Eukaryota ENOG410XNQP LUCA
GeneTreeⁱ	ENSGT00760000118997
HOGENOMⁱ	HOG000233029
HOVERGENⁱ	HBG105886
InParanoidⁱ	Q8TDX7
KOⁱ	K20876
OMAⁱ	QLVNICI
OrthoDBⁱ	EOG091G0AER
PhylomeDBⁱ	Q8TDX7
TreeFamⁱ	TF105135

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
SignaLinkⁱ	Q8TDX7
SIGNORⁱ	Q8TDX7

Miscellaneous databases

ChiTaRSⁱ	NEK7 human
EvolutionaryTraceⁱ	Q8TDX7
GenomeRNAiⁱ	140609
Protein Ontology More...PROⁱ	PR:Q8TDX7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151414 Expressed in 241 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_NEK7
ExpressionAtlasⁱ	Q8TDX7 baseline and differential
Genevisibleⁱ	Q8TDX7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEK7_HUMAN
Accessionⁱ	Q8TDX7Primary (citable) accession number: Q8TDX7 Secondary accession number(s): A6NGT8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
	Last sequence update:	June 1, 2002
	Last modified:	October 10, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q8TDX7 (NEK7_HUMAN)

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Serine/threonine-protein kinase Nek7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ