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Protein

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Gene

ACMSD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.1 Publication

Catalytic activityi

2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.1 Publication

Pathwayi: quinolate metabolism

This protein is involved in the pathway quinolate metabolism, which is part of Secondary metabolite metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway quinolate metabolism and in Secondary metabolite metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Zinc1 Publication1
Metal bindingi8Zinc1 Publication1
Binding sitei47Substrate1 Publication1
Metal bindingi174Zinc1 Publication1
Metal bindingi291Zinc1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS14455-MONOMER
BRENDAi4.1.1.45 2681
ReactomeiR-HSA-71240 Tryptophan catabolism
UniPathwayi
UPA00270

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase1 Publication (EC:4.1.1.451 Publication)
Alternative name(s):
Picolinate carboxylase1 Publication
Gene namesi
Name:ACMSD
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000153086.13
HGNCiHGNC:19288 ACMSD
MIMi608889 gene
neXtProtiNX_Q8TDX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi130013
OpenTargetsiENSG00000153086
PharmGKBiPA134973312

Polymorphism and mutation databases

BioMutaiACMSD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001909791 – 3362-amino-3-carboxymuconate-6-semialdehyde decarboxylaseAdd BLAST336

Proteomic databases

PaxDbiQ8TDX5
PeptideAtlasiQ8TDX5
PRIDEiQ8TDX5
ProteomicsDBi74359
74360 [Q8TDX5-2]

PTM databases

iPTMnetiQ8TDX5
PhosphoSitePlusiQ8TDX5

Expressioni

Gene expression databases

BgeeiENSG00000153086 Expressed in 81 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_ACMSD
ExpressionAtlasiQ8TDX5 baseline and differential
GenevisibleiQ8TDX5 HS

Organism-specific databases

HPAiHPA010533
HPA011179

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA11P43364-23EBI-749859,EBI-10178634

Protein-protein interaction databases

BioGridi126217, 2 interactors
IntActiQ8TDX5, 4 interactors
STRINGi9606.ENSP00000348459

Structurei

Secondary structure

1336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TDX5
SMRiQ8TDX5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TDX5

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4245 Eukaryota
COG2159 LUCA
GeneTreeiENSGT00490000043417
HOGENOMiHOG000254105
HOVERGENiHBG050450
InParanoidiQ8TDX5
KOiK03392
OMAiNEWDLNA
OrthoDBiEOG091G0BZB
PhylomeDBiQ8TDX5
TreeFamiTF313232

Family and domain databases

InterProiView protein in InterPro
IPR032465 ACMSD
IPR006680 Amidohydro-rel
IPR032466 Metal_Hydrolase
PANTHERiPTHR21240 PTHR21240, 1 hit
PfamiView protein in Pfam
PF04909 Amidohydro_2, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q8TDX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKIDIHSHIL PKEWPDLKKR FGYGGWVQLQ HHSKGEAKLL KDGKVFRVVR
60 70 80 90 100
ENCWDPEVRI REMDQKGVTV QALSTVPVMF SYWAKPEDTL NLCQLLNNDL
110 120 130 140 150
ASTVVSYPRR FVGLGTLPMQ APELAVKEME RCVKELGFPG VQIGTHVNEW
160 170 180 190 200
DLNAQELFPV YAAAERLKCS LFVHPWDMQM DGRMAKYWLP WLVGMPAETT
210 220 230 240 250
IAICSMIMGG VFEKFPKLKV CFAHGGGAFP FTVGRISHGF SMRPDLCAQD
260 270 280 290 300
NPMNPKKYLG SFYTDALVHD PLSLKLLTDV IGKDKVILGT DYPFPLGELE
310 320 330
PGKLIESMEE FDEETKNKLK AGNALAFLGL ERKQFE
Length:336
Mass (Da):38,035
Last modified:June 1, 2002 - v1
Checksum:i892B01D2A77C35A5
GO
Isoform 2Curated (identifier: Q8TDX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     59-83: RIREMDQKGVTVQALSTVPVMFSYW → MGKSSEWCERIAGIQKFVLEKWTKK

Note: No experimental confirmation available.Curated
Show »
Length:278
Mass (Da):31,213
Checksum:i4F7B961D6B0C9185
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0506221 – 58Missing in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_05062359 – 83RIREM…MFSYW → MGKSSEWCERIAGIQKFVLE KWTKK in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071418 mRNA Translation: BAB86938.1
AC016725 Genomic DNA Translation: AAY14997.1
CH471058 Genomic DNA Translation: EAX11650.1
CH471058 Genomic DNA Translation: EAX11651.1
CH471058 Genomic DNA Translation: EAX11652.1
BC016018 mRNA Translation: AAH16018.1
BC107420 mRNA Translation: AAI07421.1
CCDSiCCDS2173.2 [Q8TDX5-1]
CCDS77464.1 [Q8TDX5-2]
RefSeqiNP_001294912.1, NM_001307983.1 [Q8TDX5-2]
NP_612199.2, NM_138326.2 [Q8TDX5-1]
XP_005263645.1, XM_005263588.4 [Q8TDX5-2]
XP_011508894.1, XM_011510592.2 [Q8TDX5-2]
XP_016858814.1, XM_017003325.1 [Q8TDX5-2]
XP_016858815.1, XM_017003326.1 [Q8TDX5-2]
UniGeneiHs.655728

Genome annotation databases

EnsembliENST00000356140; ENSP00000348459; ENSG00000153086 [Q8TDX5-1]
ENST00000392928; ENSP00000376659; ENSG00000153086 [Q8TDX5-2]
GeneIDi130013
KEGGihsa:130013
UCSCiuc002ttz.4 human [Q8TDX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071418 mRNA Translation: BAB86938.1
AC016725 Genomic DNA Translation: AAY14997.1
CH471058 Genomic DNA Translation: EAX11650.1
CH471058 Genomic DNA Translation: EAX11651.1
CH471058 Genomic DNA Translation: EAX11652.1
BC016018 mRNA Translation: AAH16018.1
BC107420 mRNA Translation: AAI07421.1
CCDSiCCDS2173.2 [Q8TDX5-1]
CCDS77464.1 [Q8TDX5-2]
RefSeqiNP_001294912.1, NM_001307983.1 [Q8TDX5-2]
NP_612199.2, NM_138326.2 [Q8TDX5-1]
XP_005263645.1, XM_005263588.4 [Q8TDX5-2]
XP_011508894.1, XM_011510592.2 [Q8TDX5-2]
XP_016858814.1, XM_017003325.1 [Q8TDX5-2]
XP_016858815.1, XM_017003326.1 [Q8TDX5-2]
UniGeneiHs.655728

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WM1X-ray2.01A1-336[»]
4IGMX-ray2.39A/B/C/D/E/F1-332[»]
4IGNX-ray2.33A/B/C/D/E/F1-332[»]
4IH3X-ray2.49A/B/C/D/E/F1-332[»]
4OFCX-ray1.99A/B/C/D/E/F1-335[»]
ProteinModelPortaliQ8TDX5
SMRiQ8TDX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126217, 2 interactors
IntActiQ8TDX5, 4 interactors
STRINGi9606.ENSP00000348459

PTM databases

iPTMnetiQ8TDX5
PhosphoSitePlusiQ8TDX5

Polymorphism and mutation databases

BioMutaiACMSD

Proteomic databases

PaxDbiQ8TDX5
PeptideAtlasiQ8TDX5
PRIDEiQ8TDX5
ProteomicsDBi74359
74360 [Q8TDX5-2]

Protocols and materials databases

DNASUi130013
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356140; ENSP00000348459; ENSG00000153086 [Q8TDX5-1]
ENST00000392928; ENSP00000376659; ENSG00000153086 [Q8TDX5-2]
GeneIDi130013
KEGGihsa:130013
UCSCiuc002ttz.4 human [Q8TDX5-1]

Organism-specific databases

CTDi130013
DisGeNETi130013
EuPathDBiHostDB:ENSG00000153086.13
GeneCardsiACMSD
H-InvDBiHIX0019780
HGNCiHGNC:19288 ACMSD
HPAiHPA010533
HPA011179
MIMi608889 gene
neXtProtiNX_Q8TDX5
OpenTargetsiENSG00000153086
PharmGKBiPA134973312
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4245 Eukaryota
COG2159 LUCA
GeneTreeiENSGT00490000043417
HOGENOMiHOG000254105
HOVERGENiHBG050450
InParanoidiQ8TDX5
KOiK03392
OMAiNEWDLNA
OrthoDBiEOG091G0BZB
PhylomeDBiQ8TDX5
TreeFamiTF313232

Enzyme and pathway databases

UniPathwayi
UPA00270

BioCyciMetaCyc:HS14455-MONOMER
BRENDAi4.1.1.45 2681
ReactomeiR-HSA-71240 Tryptophan catabolism

Miscellaneous databases

ChiTaRSiACMSD human
EvolutionaryTraceiQ8TDX5
GenomeRNAii130013
PROiPR:Q8TDX5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153086 Expressed in 81 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_ACMSD
ExpressionAtlasiQ8TDX5 baseline and differential
GenevisibleiQ8TDX5 HS

Family and domain databases

InterProiView protein in InterPro
IPR032465 ACMSD
IPR006680 Amidohydro-rel
IPR032466 Metal_Hydrolase
PANTHERiPTHR21240 PTHR21240, 1 hit
PfamiView protein in Pfam
PF04909 Amidohydro_2, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACMSD_HUMAN
AccessioniPrimary (citable) accession number: Q8TDX5
Secondary accession number(s): Q3B7X3, Q53SR5, Q96KY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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