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UniProtKB - Q8TDW5 (SYTL5_HUMAN)

Entry version 163 (25 May 2022)
Sequence version 1 (01 Jun 2002)
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Protein

Synaptotagmin-like protein 5

Gene

SYTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri64 – 106FYVE-typeAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TDW5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8TDW5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-like protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYTL5
Synonyms:SLP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15589, SYTL5

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDW5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000147041

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		94122

Open Targets

More...OpenTargetsi		ENSG00000147041

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37988

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TDW5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYTL5

Domain mapping of disease mutations (DMDM)

More...DMDMi		33301662

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902191 – 730Synaptotagmin-like protein 5Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei147PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TDW5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TDW5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TDW5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TDW5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDW5

PeptideAtlas

More...PeptideAtlasi		Q8TDW5

PRoteomics IDEntifications database

More...PRIDEi		Q8TDW5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74354 [Q8TDW5-1]
74355 [Q8TDW5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDW5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147041, Expressed in palpebral conjunctiva and 145 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDW5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147041, Tissue enhanced (brain, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125121, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q8TDW5, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000395220

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TDW5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8TDW5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDW5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 123RabBDPROSITE-ProRule annotationAdd BLAST117
Domaini406 – 527C2 1PROSITE-ProRule annotationAdd BLAST122
Domaini563 – 694C2 2PROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni147 – 188DisorderedSequence analysisAdd BLAST42
Regioni217 – 271DisorderedSequence analysisAdd BLAST55
Regioni294 – 355DisorderedSequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 186Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi226 – 271Polar residuesSequence analysisAdd BLAST46
Compositional biasi294 – 327Polar residuesSequence analysisAdd BLAST34

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 106FYVE-typeAdd BLAST43

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1028, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158618

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002711_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDW5

Identification of Orthologs from Complete Genome Data

More...OMAi		GHWKCSV

Database of Orthologous Groups

More...OrthoDBi		916843at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDW5

TreeFam database of animal gene trees

More...TreeFami		TF341184

Family and domain databases

Conserved Domains Database

More...CDDi		cd04029, C2A_SLP-4_5, 1 hit
cd04020, C2B_SLP_1-2-3-4, 1 hit
cd15766, FYVE_Slp5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR010911, Rab_BD
IPR037303, SLP-4/5_C2A
IPR028702, Slp5
IPR043567, SYTL1-5_C2B
IPR042783, SYTL5_FYVE
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR45716:SF6, PTHR45716:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 2 hits
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TDW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK 
        60         70         80         90        100
RRSGKTQQEA SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS 
       110        120        130        140        150
WKCTVCDKIA QLRIITGEWF FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA 
       160        170        180        190        200
EEVQSQEQTR QDAEKSDTSP VAGKKASHDG PKRKGFLLSK FRSATRGEII 
       210        220        230        240        250
TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND QEPGPRTPKS 
       260        270        280        290        300
SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS 
       310        320        330        340        350
HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG 
       360        370        380        390        400
ALDKDSLEET EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD 
       410        420        430        440        450
YGNVKVSGEI LLHISYCYKT GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY 
       460        470        480        490        500
LLPDKSRNNK RKTKIRTGTN PEFNETLKYT ISHTQLETRT LQLSVWHYDR 
       510        520        530        540        550
FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG LQYKGELTVV 
       560        570        580        590        600
LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT 
       610        620        630        640        650
AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP 
       660        670        680        690        700
QDIKNVCLEL TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE 
       710        720        730
QRLWQKMANN PGTPFEGVLM LRSSMGKCRL
Length:730
Mass (Da):81,523
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9E0DA98880A95ED
GO
Isoform 2 (identifier: Q8TDW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     384-384: S → STSSQAGSDRKWTYLNVPDADSD

Show »
Length:752
Mass (Da):83,918
Checksum:iBDCE53EAABC65723
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024601275I → V. Corresponds to variant dbSNP:rs4827331Ensembl.1
Natural variantiVAR_061753302R → C. Corresponds to variant dbSNP:rs57226394Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042659384S → STSSQAGSDRKWTYLNVPDA DSD in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB080222 mRNA Translation: BAB88906.1
AL121578 Genomic DNA No translation available.
BC131585 mRNA Translation: AAI31586.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14244.1 [Q8TDW5-1]
CCDS55399.1 [Q8TDW5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001156806.1, NM_001163334.1 [Q8TDW5-2]
NP_001156807.1, NM_001163335.1 [Q8TDW5-1]
NP_620135.1, NM_138780.2 [Q8TDW5-1]
XP_011542303.1, XM_011544001.2 [Q8TDW5-2]
XP_011542304.1, XM_011544002.2 [Q8TDW5-2]
XP_016885461.1, XM_017029972.1 [Q8TDW5-2]
XP_016885462.1, XM_017029973.1 [Q8TDW5-2]
XP_016885463.1, XM_017029974.1 [Q8TDW5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297875.7; ENSP00000297875.2; ENSG00000147041.12
ENST00000456733.2; ENSP00000395220.2; ENSG00000147041.12 [Q8TDW5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		94122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:94122

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000297875.7; ENSP00000297875.2; NM_138780.3; NP_620135.1

UCSC genome browser

More...UCSCi		uc004ddv.4, human [Q8TDW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080222 mRNA Translation: BAB88906.1
AL121578 Genomic DNA No translation available.
BC131585 mRNA Translation: AAI31586.1
CCDSiCCDS14244.1 [Q8TDW5-1]
CCDS55399.1 [Q8TDW5-2]
RefSeqiNP_001156806.1, NM_001163334.1 [Q8TDW5-2]
NP_001156807.1, NM_001163335.1 [Q8TDW5-1]
NP_620135.1, NM_138780.2 [Q8TDW5-1]
XP_011542303.1, XM_011544001.2 [Q8TDW5-2]
XP_011542304.1, XM_011544002.2 [Q8TDW5-2]
XP_016885461.1, XM_017029972.1 [Q8TDW5-2]
XP_016885462.1, XM_017029973.1 [Q8TDW5-2]
XP_016885463.1, XM_017029974.1 [Q8TDW5-2]

3D structure databases

AlphaFoldDBiQ8TDW5
SMRiQ8TDW5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125121, 16 interactors
IntActiQ8TDW5, 12 interactors
STRINGi9606.ENSP00000395220

PTM databases

iPTMnetiQ8TDW5
PhosphoSitePlusiQ8TDW5

Genetic variation databases

BioMutaiSYTL5
DMDMi33301662

Proteomic databases

EPDiQ8TDW5
jPOSTiQ8TDW5
MassIVEiQ8TDW5
MaxQBiQ8TDW5
PaxDbiQ8TDW5
PeptideAtlasiQ8TDW5
PRIDEiQ8TDW5
ProteomicsDBi74354 [Q8TDW5-1]
74355 [Q8TDW5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10579, 97 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		94122

Genome annotation databases

EnsembliENST00000297875.7; ENSP00000297875.2; ENSG00000147041.12
ENST00000456733.2; ENSP00000395220.2; ENSG00000147041.12 [Q8TDW5-2]
GeneIDi94122
KEGGihsa:94122
MANE-SelectiENST00000297875.7; ENSP00000297875.2; NM_138780.3; NP_620135.1
UCSCiuc004ddv.4, human [Q8TDW5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		94122
DisGeNETi94122

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYTL5
HGNCiHGNC:15589, SYTL5
HPAiENSG00000147041, Tissue enhanced (brain, stomach)
neXtProtiNX_Q8TDW5
OpenTargetsiENSG00000147041
PharmGKBiPA37988
VEuPathDBiHostDB:ENSG00000147041

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000158618
HOGENOMiCLU_002711_5_0_1
InParanoidiQ8TDW5
OMAiGHWKCSV
OrthoDBi916843at2759
PhylomeDBiQ8TDW5
TreeFamiTF341184

Enzyme and pathway databases

PathwayCommonsiQ8TDW5
SignaLinkiQ8TDW5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		94122, 8 hits in 694 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYTL5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		94122
PharosiQ8TDW5, Tbio

Protein Ontology

More...PROi		PR:Q8TDW5
RNActiQ8TDW5, protein

Gene expression databases

BgeeiENSG00000147041, Expressed in palpebral conjunctiva and 145 other tissues
GenevisibleiQ8TDW5, HS

Family and domain databases

CDDicd04029, C2A_SLP-4_5, 1 hit
cd04020, C2B_SLP_1-2-3-4, 1 hit
cd15766, FYVE_Slp5, 1 hit
Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR010911, Rab_BD
IPR037303, SLP-4/5_C2A
IPR028702, Slp5
IPR043567, SYTL1-5_C2B
IPR042783, SYTL5_FYVE
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45716:SF6, PTHR45716:SF6, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
SMARTiView protein in SMART
SM00239, C2, 2 hits
SUPFAMiSSF49562, SSF49562, 2 hits
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYTL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDW5
Secondary accession number(s): A2RRF2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: May 25, 2022
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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