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Protein

Synaptotagmin-like protein 5

Gene

SYTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 106FYVE-typeAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 5
Gene namesi
Name:SYTL5
Synonyms:SLP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147041.11
HGNCiHGNC:15589 SYTL5
neXtProtiNX_Q8TDW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi94122
OpenTargetsiENSG00000147041
PharmGKBiPA37988

Polymorphism and mutation databases

BioMutaiSYTL5
DMDMi33301662

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902191 – 730Synaptotagmin-like protein 5Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TDW5
PaxDbiQ8TDW5
PeptideAtlasiQ8TDW5
PRIDEiQ8TDW5
ProteomicsDBi74354
74355 [Q8TDW5-2]

PTM databases

iPTMnetiQ8TDW5
PhosphoSitePlusiQ8TDW5

Expressioni

Tissue specificityi

Highly expressed in placenta and liver.

Gene expression databases

BgeeiENSG00000147041
CleanExiHS_SYTL5
GenevisibleiQ8TDW5 HS

Organism-specific databases

HPAiHPA026074

Interactioni

Subunit structurei

Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125121, 7 interactors
IntActiQ8TDW5, 9 interactors
STRINGi9606.ENSP00000395220

Structurei

3D structure databases

ProteinModelPortaliQ8TDW5
SMRiQ8TDW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 123RabBDPROSITE-ProRule annotationAdd BLAST117
Domaini408 – 511C2 1PROSITE-ProRule annotationAdd BLAST104
Domaini574 – 678C2 2PROSITE-ProRule annotationAdd BLAST105

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 106FYVE-typeAdd BLAST43

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IT3S Eukaryota
ENOG410Y1U8 LUCA
GeneTreeiENSGT00810000125376
HOGENOMiHOG000231332
HOVERGENiHBG054255
InParanoidiQ8TDW5
KOiK17598
OMAiETGDYGN
OrthoDBiEOG091G07OO
PhylomeDBiQ8TDW5
TreeFamiTF341184

Family and domain databases

CDDicd04029 C2A_SLP-4_5, 1 hit
Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010911 Rab_BD
IPR037303 SLP-4/5_C2A
IPR028702 Slp5
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF13 PTHR10024:SF13, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50916 RABBD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TDW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK
60 70 80 90 100
RRSGKTQQEA SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS
110 120 130 140 150
WKCTVCDKIA QLRIITGEWF FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA
160 170 180 190 200
EEVQSQEQTR QDAEKSDTSP VAGKKASHDG PKRKGFLLSK FRSATRGEII
210 220 230 240 250
TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND QEPGPRTPKS
260 270 280 290 300
SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS
310 320 330 340 350
HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG
360 370 380 390 400
ALDKDSLEET EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD
410 420 430 440 450
YGNVKVSGEI LLHISYCYKT GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY
460 470 480 490 500
LLPDKSRNNK RKTKIRTGTN PEFNETLKYT ISHTQLETRT LQLSVWHYDR
510 520 530 540 550
FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG LQYKGELTVV
560 570 580 590 600
LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT
610 620 630 640 650
AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP
660 670 680 690 700
QDIKNVCLEL TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE
710 720 730
QRLWQKMANN PGTPFEGVLM LRSSMGKCRL
Length:730
Mass (Da):81,523
Last modified:June 1, 2002 - v1
Checksum:iD9E0DA98880A95ED
GO
Isoform 2 (identifier: Q8TDW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     384-384: S → STSSQAGSDRKWTYLNVPDADSD

Note: No experimental confirmation available.
Show »
Length:752
Mass (Da):83,918
Checksum:iBDCE53EAABC65723
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024601275I → V. Corresponds to variant dbSNP:rs4827331Ensembl.1
Natural variantiVAR_061753302R → C. Corresponds to variant dbSNP:rs57226394Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042659384S → STSSQAGSDRKWTYLNVPDA DSD in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080222 mRNA Translation: BAB88906.1
AL121578 Genomic DNA No translation available.
BC131585 mRNA Translation: AAI31586.1
CCDSiCCDS14244.1 [Q8TDW5-1]
CCDS55399.1 [Q8TDW5-2]
RefSeqiNP_001156806.1, NM_001163334.1 [Q8TDW5-2]
NP_001156807.1, NM_001163335.1 [Q8TDW5-1]
NP_620135.1, NM_138780.2 [Q8TDW5-1]
XP_011542303.1, XM_011544001.2 [Q8TDW5-2]
XP_011542304.1, XM_011544002.2 [Q8TDW5-2]
XP_016885461.1, XM_017029972.1 [Q8TDW5-2]
XP_016885462.1, XM_017029973.1 [Q8TDW5-2]
XP_016885463.1, XM_017029974.1 [Q8TDW5-2]
UniGeneiHs.662334

Genome annotation databases

EnsembliENST00000297875; ENSP00000297875; ENSG00000147041 [Q8TDW5-1]
ENST00000456733; ENSP00000395220; ENSG00000147041 [Q8TDW5-2]
GeneIDi94122
KEGGihsa:94122
UCSCiuc004ddv.4 human [Q8TDW5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYTL5_HUMAN
AccessioniPrimary (citable) accession number: Q8TDW5
Secondary accession number(s): A2RRF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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