UniProtKB - Q8TDW5 (SYTL5_HUMAN)
Protein
Synaptotagmin-like protein 5
Gene
SYTL5
Organism
Homo sapiens (Human)
Status
Functioni
May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 64 – 106 | FYVE-typeAdd BLAST | 43 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- phospholipid binding Source: InterPro
- Rab GTPase binding Source: InterPro
GO - Biological processi
- exocytosis Source: Ensembl
- intracellular protein transport Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-like protein 5 |
Gene namesi | Name:SYTL5 Synonyms:SLP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15589 SYTL5 |
neXtProti | NX_Q8TDW5 |
Subcellular locationi
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Other locations
- exocytic vesicle Source: GO_Central
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 94122 |
OpenTargetsi | ENSG00000147041 |
PharmGKBi | PA37988 |
Miscellaneous databases
Pharosi | Q8TDW5 |
Polymorphism and mutation databases
BioMutai | SYTL5 |
DMDMi | 33301662 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190219 | 1 – 730 | Synaptotagmin-like protein 5Add BLAST | 730 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 147 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8TDW5 |
MassIVEi | Q8TDW5 |
MaxQBi | Q8TDW5 |
PaxDbi | Q8TDW5 |
PeptideAtlasi | Q8TDW5 |
PRIDEi | Q8TDW5 |
ProteomicsDBi | 74354 [Q8TDW5-1] 74355 [Q8TDW5-2] |
PTM databases
iPTMneti | Q8TDW5 |
PhosphoSitePlusi | Q8TDW5 |
Expressioni
Tissue specificityi
Highly expressed in placenta and liver.
Gene expression databases
Bgeei | ENSG00000147041 Expressed in 132 organ(s), highest expression level in palpebral conjunctiva |
Genevisiblei | Q8TDW5 HS |
Organism-specific databases
HPAi | HPA026074 |
Interactioni
Subunit structurei
Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A.
Binary interactionsi
GO - Molecular functioni
- Rab GTPase binding Source: InterPro
Protein-protein interaction databases
BioGridi | 125121, 7 interactors |
IntActi | Q8TDW5, 10 interactors |
STRINGi | 9606.ENSP00000395220 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 123 | RabBDPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 408 – 511 | C2 1PROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 574 – 678 | C2 2PROSITE-ProRule annotationAdd BLAST | 105 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 64 – 106 | FYVE-typeAdd BLAST | 43 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG410IT3S Eukaryota ENOG410Y1U8 LUCA |
GeneTreei | ENSGT00940000158618 |
HOGENOMi | HOG000231332 |
InParanoidi | Q8TDW5 |
KOi | K17598 |
OMAi | SSMRKCN |
OrthoDBi | 916843at2759 |
PhylomeDBi | Q8TDW5 |
TreeFami | TF341184 |
Family and domain databases
CDDi | cd04029 C2A_SLP-4_5, 1 hit cd15766 FYVE_Slp5, 1 hit |
Gene3Di | 2.60.40.150, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR041282 FYVE_2 IPR010911 Rab_BD IPR037303 SLP-4/5_C2A IPR028702 Slp5 IPR042783 SYTL5_FYVE IPR011011 Znf_FYVE_PHD IPR013083 Znf_RING/FYVE/PHD |
PANTHERi | PTHR45716:SF6 PTHR45716:SF6, 1 hit |
Pfami | View protein in Pfam PF00168 C2, 2 hits PF02318 FYVE_2, 1 hit |
SMARTi | View protein in SMART SM00239 C2, 2 hits |
SUPFAMi | SSF57903 SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50004 C2, 2 hits PS50916 RABBD, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8TDW5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK
60 70 80 90 100
RRSGKTQQEA SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS
110 120 130 140 150
WKCTVCDKIA QLRIITGEWF FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA
160 170 180 190 200
EEVQSQEQTR QDAEKSDTSP VAGKKASHDG PKRKGFLLSK FRSATRGEII
210 220 230 240 250
TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND QEPGPRTPKS
260 270 280 290 300
SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS
310 320 330 340 350
HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG
360 370 380 390 400
ALDKDSLEET EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD
410 420 430 440 450
YGNVKVSGEI LLHISYCYKT GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY
460 470 480 490 500
LLPDKSRNNK RKTKIRTGTN PEFNETLKYT ISHTQLETRT LQLSVWHYDR
510 520 530 540 550
FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG LQYKGELTVV
560 570 580 590 600
LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT
610 620 630 640 650
AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP
660 670 680 690 700
QDIKNVCLEL TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE
710 720 730
QRLWQKMANN PGTPFEGVLM LRSSMGKCRL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024601 | 275 | I → V. Corresponds to variant dbSNP:rs4827331Ensembl. | 1 | |
Natural variantiVAR_061753 | 302 | R → C. Corresponds to variant dbSNP:rs57226394Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042659 | 384 | S → STSSQAGSDRKWTYLNVPDA DSD in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB080222 mRNA Translation: BAB88906.1 AL121578 Genomic DNA No translation available. BC131585 mRNA Translation: AAI31586.1 |
CCDSi | CCDS14244.1 [Q8TDW5-1] CCDS55399.1 [Q8TDW5-2] |
RefSeqi | NP_001156806.1, NM_001163334.1 [Q8TDW5-2] NP_001156807.1, NM_001163335.1 [Q8TDW5-1] NP_620135.1, NM_138780.2 [Q8TDW5-1] XP_011542303.1, XM_011544001.2 [Q8TDW5-2] XP_011542304.1, XM_011544002.2 [Q8TDW5-2] XP_016885461.1, XM_017029972.1 [Q8TDW5-2] XP_016885462.1, XM_017029973.1 [Q8TDW5-2] XP_016885463.1, XM_017029974.1 [Q8TDW5-2] |
Genome annotation databases
Ensembli | ENST00000297875; ENSP00000297875; ENSG00000147041 [Q8TDW5-1] ENST00000456733; ENSP00000395220; ENSG00000147041 [Q8TDW5-2] |
GeneIDi | 94122 |
KEGGi | hsa:94122 |
UCSCi | uc004ddv.4 human [Q8TDW5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB080222 mRNA Translation: BAB88906.1 AL121578 Genomic DNA No translation available. BC131585 mRNA Translation: AAI31586.1 |
CCDSi | CCDS14244.1 [Q8TDW5-1] CCDS55399.1 [Q8TDW5-2] |
RefSeqi | NP_001156806.1, NM_001163334.1 [Q8TDW5-2] NP_001156807.1, NM_001163335.1 [Q8TDW5-1] NP_620135.1, NM_138780.2 [Q8TDW5-1] XP_011542303.1, XM_011544001.2 [Q8TDW5-2] XP_011542304.1, XM_011544002.2 [Q8TDW5-2] XP_016885461.1, XM_017029972.1 [Q8TDW5-2] XP_016885462.1, XM_017029973.1 [Q8TDW5-2] XP_016885463.1, XM_017029974.1 [Q8TDW5-2] |
3D structure databases
SMRi | Q8TDW5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 125121, 7 interactors |
IntActi | Q8TDW5, 10 interactors |
STRINGi | 9606.ENSP00000395220 |
PTM databases
iPTMneti | Q8TDW5 |
PhosphoSitePlusi | Q8TDW5 |
Polymorphism and mutation databases
BioMutai | SYTL5 |
DMDMi | 33301662 |
Proteomic databases
jPOSTi | Q8TDW5 |
MassIVEi | Q8TDW5 |
MaxQBi | Q8TDW5 |
PaxDbi | Q8TDW5 |
PeptideAtlasi | Q8TDW5 |
PRIDEi | Q8TDW5 |
ProteomicsDBi | 74354 [Q8TDW5-1] 74355 [Q8TDW5-2] |
Genome annotation databases
Ensembli | ENST00000297875; ENSP00000297875; ENSG00000147041 [Q8TDW5-1] ENST00000456733; ENSP00000395220; ENSG00000147041 [Q8TDW5-2] |
GeneIDi | 94122 |
KEGGi | hsa:94122 |
UCSCi | uc004ddv.4 human [Q8TDW5-1] |
Organism-specific databases
CTDi | 94122 |
DisGeNETi | 94122 |
GeneCardsi | SYTL5 |
HGNCi | HGNC:15589 SYTL5 |
HPAi | HPA026074 |
neXtProti | NX_Q8TDW5 |
OpenTargetsi | ENSG00000147041 |
PharmGKBi | PA37988 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IT3S Eukaryota ENOG410Y1U8 LUCA |
GeneTreei | ENSGT00940000158618 |
HOGENOMi | HOG000231332 |
InParanoidi | Q8TDW5 |
KOi | K17598 |
OMAi | SSMRKCN |
OrthoDBi | 916843at2759 |
PhylomeDBi | Q8TDW5 |
TreeFami | TF341184 |
Miscellaneous databases
ChiTaRSi | SYTL5 human |
GenomeRNAii | 94122 |
Pharosi | Q8TDW5 |
PROi | PR:Q8TDW5 |
Gene expression databases
Bgeei | ENSG00000147041 Expressed in 132 organ(s), highest expression level in palpebral conjunctiva |
Genevisiblei | Q8TDW5 HS |
Family and domain databases
CDDi | cd04029 C2A_SLP-4_5, 1 hit cd15766 FYVE_Slp5, 1 hit |
Gene3Di | 2.60.40.150, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR041282 FYVE_2 IPR010911 Rab_BD IPR037303 SLP-4/5_C2A IPR028702 Slp5 IPR042783 SYTL5_FYVE IPR011011 Znf_FYVE_PHD IPR013083 Znf_RING/FYVE/PHD |
PANTHERi | PTHR45716:SF6 PTHR45716:SF6, 1 hit |
Pfami | View protein in Pfam PF00168 C2, 2 hits PF02318 FYVE_2, 1 hit |
SMARTi | View protein in SMART SM00239 C2, 2 hits |
SUPFAMi | SSF57903 SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50004 C2, 2 hits PS50916 RABBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYTL5_HUMAN | |
Accessioni | Q8TDW5Primary (citable) accession number: Q8TDW5 Secondary accession number(s): A2RRF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | November 13, 2019 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations