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UniProtKB - Q8TDW4 (ST7L_HUMAN)

Entry version 156 (07 Apr 2021)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
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Protein

Suppressor of tumorigenicity 7 protein-like

Gene

ST7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TDW4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppressor of tumorigenicity 7 protein-like
Alternative name(s):
ST7-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ST7L
Synonyms:ST7R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18441, ST7L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617640, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDW4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000007341.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54879

Open Targets

More...OpenTargetsi		ENSG00000007341

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TDW4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ST7L

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751431

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003392271 – 575Suppressor of tumorigenicity 7 protein-likeAdd BLAST575

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TDW4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TDW4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TDW4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDW4

PeptideAtlas

More...PeptideAtlasi		Q8TDW4

PRoteomics IDEntifications database

More...PRIDEi		Q8TDW4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74346 [Q8TDW4-1]
74347 [Q8TDW4-2]
74348 [Q8TDW4-3]
74349 [Q8TDW4-4]
74350 [Q8TDW4-5]
74351 [Q8TDW4-6]
74352 [Q8TDW4-7]
74353 [Q8TDW4-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000007341, Expressed in testis and 176 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TDW4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDW4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000007341, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120227, 26 interactors

Protein interaction database and analysis system

More...IntActi		Q8TDW4, 19 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000350734

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TDW4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDW4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ST7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3807, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000873

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035578_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDW4

Identification of Orthologs from Complete Genome Data

More...OMAi		FAMVLTM

Database of Orthologous Groups

More...OrthoDBi		540550at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDW4

TreeFam database of animal gene trees

More...TreeFami		TF314162

Family and domain databases

Conserved Domains Database

More...CDDi		cd11557, ST7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007311, ST7
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR12745, PTHR12745, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04184, ST7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADRGGVGEA AAVGASPASV PGLNPTLGWR ERLRAGLAGT GASLWFVAGL 
        60         70         80         90        100
GLLYALRIPL RLCENLAAVT VFLNSLTPKF YVALTGTSSL ISGLIFIFEW 
       110        120        130        140        150
WYFHKHGTSF IEQVSVSHLQ PLMGGTESSI SEPGSPSRNR ENETSRQNLS 
       160        170        180        190        200
ECKVWRNPLN LFRGAEYRRY TWVTGKEPLT YYDMNLSAQD HQTFFTCDTD 
       210        220        230        240        250
FLRPSDTVMQ KAWRERNPPA RIKAAYQALE LNNDCATAYV LLAEEEATTI 
       260        270        280        290        300
VDAERLFKQA LKAGETIYRQ SQQCQHQSPQ HEAQLRRDTN VLVYIKRRLA 
       310        320        330        340        350
MCARKLGRIR EAVKIMRDLM KEFPPLTMLN IHENLLESLL ELQAYPDVQA 
       360        370        380        390        400
VLAKYDDISL PKSAAICYTA ALLKTRTVSE KFSPETASRR GLSTAEINAV 
       410        420        430        440        450
EAIHRAVEFN PHVPKYLLEM KSLILPPEHI LKRGDSEAIA YAFFHLQHWK 
       460        470        480        490        500
RIEGALNLLQ CTWEGTFRMI PYPLEKGHLF YPYPSCTETA DRELLPTFHH 
       510        520        530        540        550
VSVYPKKELP LFIHFTAGFC SSTAMIAILT HQFPEIMGIF AKAVLGLWCP 
       560        570 
QPWASSGFEE NTQDLKSEDL GLSSG
Length:575
Mass (Da):64,779
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26F30D175DD6E8A0
GO
Isoform 2 (identifier: Q8TDW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-496: Missing.

Show »
Length:544
Mass (Da):61,111
Checksum:i88CDD2D91F8046A5
GO
Isoform 3 (identifier: Q8TDW4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-85: Missing.

Show »
Length:558
Mass (Da):62,884
Checksum:iE191DC80594FF5A7
GO
Isoform 4 (identifier: Q8TDW4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Show »
Length:392
Mass (Da):44,655
Checksum:i6784552BCBC7B263
GO
Isoform 5 (identifier: Q8TDW4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     545-566: LGLWCPQPWASSGFEENTQDLK → SMISRTCVDYL
     567-575: Missing.

Show »
Length:555
Mass (Da):62,714
Checksum:i5182E3020871ECD5
GO
Isoform 6 (identifier: Q8TDW4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-85: Missing.
     545-566: LGLWCPQPWASSGFEENTQDLK → SMISRTCVDYL
     567-575: Missing.

Show »
Length:538
Mass (Da):60,819
Checksum:i31C82C38F028CD73
GO
Isoform 7 (identifier: Q8TDW4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     545-568: LGLWCPQPWASSGFEENTQDLKSE → VGVKTQKENAD
     569-575: Missing.

Show »
Length:555
Mass (Da):62,615
Checksum:i9CBFCBAAD5F69963
GO
Isoform 8 (identifier: Q8TDW4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     416-503: YLLEMKSLIL...LLPTFHHVSV → VEIYPFSPQLNIKAVDNSAISKYPANIY
     504-575: Missing.

Show »
Length:321
Mass (Da):36,665
Checksum:i9BF14DF740862D0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TEH7Q5TEH7_HUMAN
Suppressor of tumorigenicity 7 prot...
ST7L
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7M0H0Y7M0_HUMAN
Suppressor of tumorigenicity 7 prot...
ST7L
287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91060 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAE45803 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti204P → H in AAH37830 (PubMed:15489334).Curated1
Sequence conflicti236A → T in CAD98103 (PubMed:17974005).Curated1
Sequence conflicti274C → Y in CAD97948 (PubMed:17974005).Curated1
Sequence conflicti282E → V in CAD98103 (PubMed:17974005).Curated1
Sequence conflicti287R → I in CAD97948 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043934451R → Q1 PublicationCorresponds to variant dbSNP:rs6658555Ensembl.1
Natural variantiVAR_043935455A → T. Corresponds to variant dbSNP:rs3736764Ensembl.1
Natural variantiVAR_043936571G → D. Corresponds to variant dbSNP:rs12069022EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0341271 – 183Missing in isoform 4. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_0341281 – 122Missing in isoform 8. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_03412969 – 85Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_034130416 – 503YLLEM…HHVSV → VEIYPFSPQLNIKAVDNSAI SKYPANIY in isoform 8. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_034131466 – 496Missing in isoform 2. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_034132504 – 575Missing in isoform 8. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_034133545 – 568LGLWC…DLKSE → VGVKTQKENAD in isoform 7. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_034134545 – 566LGLWC…TQDLK → SMISRTCVDYL in isoform 5 and isoform 6. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_034135567 – 575Missing in isoform 5 and isoform 6. 2 Publications9
Alternative sequenceiVSP_034136569 – 575Missing in isoform 7. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB081317 mRNA Translation: BAB88871.1
AB081318 mRNA Translation: BAB88872.1
AB081319 mRNA Translation: BAB88873.1
AB081320 mRNA Translation: BAB88874.1
AK000291 mRNA Translation: BAA91060.1 Different initiation.
AK097837 mRNA Translation: BAC05180.1
AK291042 mRNA Translation: BAF83731.1
BX537988 mRNA Translation: CAD97948.1
BX538338 mRNA Translation: CAD98103.1
BX640667 mRNA Translation: CAE45803.1 Different initiation.
AL109932 Genomic DNA No translation available.
AL929470 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56520.1
CH471122 Genomic DNA Translation: EAW56522.1
CH471122 Genomic DNA Translation: EAW56523.1
CH471122 Genomic DNA Translation: EAW56524.1
BC037830 mRNA Translation: AAH37830.1
BC047392 mRNA Translation: AAH47392.1
BC065501 mRNA Translation: AAH65501.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS76189.1 [Q8TDW4-4]
CCDS848.1 [Q8TDW4-1]
CCDS849.1 [Q8TDW4-3]
CCDS850.1 [Q8TDW4-2]
CCDS852.1 [Q8TDW4-5]

NCBI Reference Sequences

More...RefSeqi		NP_001295193.1, NM_001308264.1 [Q8TDW4-4]
NP_060214.2, NM_017744.4 [Q8TDW4-1]
NP_620055.1, NM_138727.3 [Q8TDW4-3]
NP_620056.1, NM_138728.2 [Q8TDW4-2]
NP_620057.1, NM_138729.3 [Q8TDW4-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343210; ENSP00000345312; ENSG00000007341 [Q8TDW4-5]
ENST00000358039; ENSP00000350734; ENSG00000007341 [Q8TDW4-1]
ENST00000360743; ENSP00000353972; ENSG00000007341 [Q8TDW4-2]
ENST00000361846; ENSP00000436499; ENSG00000007341 [Q8TDW4-7]
ENST00000369666; ENSP00000358680; ENSG00000007341 [Q8TDW4-6]
ENST00000369669; ENSP00000358683; ENSG00000007341 [Q8TDW4-4]
ENST00000490067; ENSP00000417140; ENSG00000007341 [Q8TDW4-3]
ENST00000490715; ENSP00000436544; ENSG00000007341 [Q8TDW4-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54879

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54879

UCSC genome browser

More...UCSCi		uc001ecc.4, human [Q8TDW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081317 mRNA Translation: BAB88871.1
AB081318 mRNA Translation: BAB88872.1
AB081319 mRNA Translation: BAB88873.1
AB081320 mRNA Translation: BAB88874.1
AK000291 mRNA Translation: BAA91060.1 Different initiation.
AK097837 mRNA Translation: BAC05180.1
AK291042 mRNA Translation: BAF83731.1
BX537988 mRNA Translation: CAD97948.1
BX538338 mRNA Translation: CAD98103.1
BX640667 mRNA Translation: CAE45803.1 Different initiation.
AL109932 Genomic DNA No translation available.
AL929470 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56520.1
CH471122 Genomic DNA Translation: EAW56522.1
CH471122 Genomic DNA Translation: EAW56523.1
CH471122 Genomic DNA Translation: EAW56524.1
BC037830 mRNA Translation: AAH37830.1
BC047392 mRNA Translation: AAH47392.1
BC065501 mRNA Translation: AAH65501.1
CCDSiCCDS76189.1 [Q8TDW4-4]
CCDS848.1 [Q8TDW4-1]
CCDS849.1 [Q8TDW4-3]
CCDS850.1 [Q8TDW4-2]
CCDS852.1 [Q8TDW4-5]
RefSeqiNP_001295193.1, NM_001308264.1 [Q8TDW4-4]
NP_060214.2, NM_017744.4 [Q8TDW4-1]
NP_620055.1, NM_138727.3 [Q8TDW4-3]
NP_620056.1, NM_138728.2 [Q8TDW4-2]
NP_620057.1, NM_138729.3 [Q8TDW4-5]

3D structure databases

SMRiQ8TDW4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120227, 26 interactors
IntActiQ8TDW4, 19 interactors
STRINGi9606.ENSP00000350734

PTM databases

iPTMnetiQ8TDW4
PhosphoSitePlusiQ8TDW4

Genetic variation databases

BioMutaiST7L
DMDMi74751431

Proteomic databases

jPOSTiQ8TDW4
MassIVEiQ8TDW4
MaxQBiQ8TDW4
PaxDbiQ8TDW4
PeptideAtlasiQ8TDW4
PRIDEiQ8TDW4
ProteomicsDBi74346 [Q8TDW4-1]
74347 [Q8TDW4-2]
74348 [Q8TDW4-3]
74349 [Q8TDW4-4]
74350 [Q8TDW4-5]
74351 [Q8TDW4-6]
74352 [Q8TDW4-7]
74353 [Q8TDW4-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46941, 36 antibodies

The DNASU plasmid repository

More...DNASUi		54879

Genome annotation databases

EnsembliENST00000343210; ENSP00000345312; ENSG00000007341 [Q8TDW4-5]
ENST00000358039; ENSP00000350734; ENSG00000007341 [Q8TDW4-1]
ENST00000360743; ENSP00000353972; ENSG00000007341 [Q8TDW4-2]
ENST00000361846; ENSP00000436499; ENSG00000007341 [Q8TDW4-7]
ENST00000369666; ENSP00000358680; ENSG00000007341 [Q8TDW4-6]
ENST00000369669; ENSP00000358683; ENSG00000007341 [Q8TDW4-4]
ENST00000490067; ENSP00000417140; ENSG00000007341 [Q8TDW4-3]
ENST00000490715; ENSP00000436544; ENSG00000007341 [Q8TDW4-7]
GeneIDi54879
KEGGihsa:54879
UCSCiuc001ecc.4, human [Q8TDW4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54879
DisGeNETi54879

GeneCards: human genes, protein and diseases

More...GeneCardsi		ST7L
HGNCiHGNC:18441, ST7L
HPAiENSG00000007341, Tissue enhanced (testis)
MIMi617640, gene
neXtProtiNX_Q8TDW4
OpenTargetsiENSG00000007341
PharmGKBiPA38331
VEuPathDBiHostDB:ENSG00000007341.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3807, Eukaryota
GeneTreeiENSGT00390000000873
HOGENOMiCLU_035578_2_0_1
InParanoidiQ8TDW4
OMAiFAMVLTM
OrthoDBi540550at2759
PhylomeDBiQ8TDW4
TreeFamiTF314162

Enzyme and pathway databases

PathwayCommonsiQ8TDW4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54879, 5 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ST7L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54879
PharosiQ8TDW4, Tdark

Protein Ontology

More...PROi		PR:Q8TDW4
RNActiQ8TDW4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000007341, Expressed in testis and 176 other tissues
ExpressionAtlasiQ8TDW4, baseline and differential
GenevisibleiQ8TDW4, HS

Family and domain databases

CDDicd11557, ST7, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR007311, ST7
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR12745, PTHR12745, 1 hit
PfamiView protein in Pfam
PF04184, ST7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiST7L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDW4
Secondary accession number(s): A8K4S7
, Q49AH6, Q5TEI4, Q5U5K6, Q6N067, Q7Z2Z0, Q7Z3C2, Q8N7P8, Q8TDW1, Q8TDW2, Q8TDW3, Q9NXF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2002
Last modified: April 7, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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