UniProtKB - Q8TDW4 (ST7L_HUMAN)
Protein
Suppressor of tumorigenicity 7 protein-like
Gene
ST7L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- negative regulation of cell growth Source: BHF-UCL
Enzyme and pathway databases
PathwayCommonsi | Q8TDW4 |
Names & Taxonomyi
Protein namesi | Recommended name: Suppressor of tumorigenicity 7 protein-likeAlternative name(s): ST7-related protein |
Gene namesi | Name:ST7L Synonyms:ST7R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18441, ST7L |
MIMi | 617640, gene |
neXtProti | NX_Q8TDW4 |
VEuPathDBi | HostDB:ENSG00000007341.18 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 36 – 56 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 80 – 100 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54879 |
OpenTargetsi | ENSG00000007341 |
PharmGKBi | PA38331 |
Miscellaneous databases
Pharosi | Q8TDW4, Tdark |
Genetic variation databases
BioMutai | ST7L |
DMDMi | 74751431 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000339227 | 1 – 575 | Suppressor of tumorigenicity 7 protein-likeAdd BLAST | 575 |
Proteomic databases
jPOSTi | Q8TDW4 |
MassIVEi | Q8TDW4 |
MaxQBi | Q8TDW4 |
PaxDbi | Q8TDW4 |
PeptideAtlasi | Q8TDW4 |
PRIDEi | Q8TDW4 |
ProteomicsDBi | 74346 [Q8TDW4-1] 74347 [Q8TDW4-2] 74348 [Q8TDW4-3] 74349 [Q8TDW4-4] 74350 [Q8TDW4-5] 74351 [Q8TDW4-6] 74352 [Q8TDW4-7] 74353 [Q8TDW4-8] |
PTM databases
iPTMneti | Q8TDW4 |
PhosphoSitePlusi | Q8TDW4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000007341, Expressed in testis and 176 other tissues |
ExpressionAtlasi | Q8TDW4, baseline and differential |
Genevisiblei | Q8TDW4, HS |
Organism-specific databases
HPAi | ENSG00000007341, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120227, 26 interactors |
IntActi | Q8TDW4, 19 interactors |
STRINGi | 9606.ENSP00000350734 |
Miscellaneous databases
RNActi | Q8TDW4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ST7 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3807, Eukaryota |
GeneTreei | ENSGT00390000000873 |
HOGENOMi | CLU_035578_2_0_1 |
InParanoidi | Q8TDW4 |
OMAi | FAMVLTM |
OrthoDBi | 540550at2759 |
PhylomeDBi | Q8TDW4 |
TreeFami | TF314162 |
Family and domain databases
CDDi | cd11557, ST7, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR007311, ST7 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR12745, PTHR12745, 1 hit |
Pfami | View protein in Pfam PF04184, ST7, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TDW4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADRGGVGEA AAVGASPASV PGLNPTLGWR ERLRAGLAGT GASLWFVAGL
60 70 80 90 100
GLLYALRIPL RLCENLAAVT VFLNSLTPKF YVALTGTSSL ISGLIFIFEW
110 120 130 140 150
WYFHKHGTSF IEQVSVSHLQ PLMGGTESSI SEPGSPSRNR ENETSRQNLS
160 170 180 190 200
ECKVWRNPLN LFRGAEYRRY TWVTGKEPLT YYDMNLSAQD HQTFFTCDTD
210 220 230 240 250
FLRPSDTVMQ KAWRERNPPA RIKAAYQALE LNNDCATAYV LLAEEEATTI
260 270 280 290 300
VDAERLFKQA LKAGETIYRQ SQQCQHQSPQ HEAQLRRDTN VLVYIKRRLA
310 320 330 340 350
MCARKLGRIR EAVKIMRDLM KEFPPLTMLN IHENLLESLL ELQAYPDVQA
360 370 380 390 400
VLAKYDDISL PKSAAICYTA ALLKTRTVSE KFSPETASRR GLSTAEINAV
410 420 430 440 450
EAIHRAVEFN PHVPKYLLEM KSLILPPEHI LKRGDSEAIA YAFFHLQHWK
460 470 480 490 500
RIEGALNLLQ CTWEGTFRMI PYPLEKGHLF YPYPSCTETA DRELLPTFHH
510 520 530 540 550
VSVYPKKELP LFIHFTAGFC SSTAMIAILT HQFPEIMGIF AKAVLGLWCP
560 570
QPWASSGFEE NTQDLKSEDL GLSSG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5TEH7 | Q5TEH7_HUMAN | Suppressor of tumorigenicity 7 prot... | ST7L | 229 | Annotation score: | ||
H0Y7M0 | H0Y7M0_HUMAN | Suppressor of tumorigenicity 7 prot... | ST7L | 287 | Annotation score: |
Sequence cautioni
The sequence BAA91060 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAE45803 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | P → H in AAH37830 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 236 | A → T in CAD98103 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 274 | C → Y in CAD97948 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 282 | E → V in CAD98103 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 287 | R → I in CAD97948 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043934 | 451 | R → Q1 PublicationCorresponds to variant dbSNP:rs6658555Ensembl. | 1 | |
Natural variantiVAR_043935 | 455 | A → T. Corresponds to variant dbSNP:rs3736764Ensembl. | 1 | |
Natural variantiVAR_043936 | 571 | G → D. Corresponds to variant dbSNP:rs12069022EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034127 | 1 – 183 | Missing in isoform 4. 1 PublicationAdd BLAST | 183 | |
Alternative sequenceiVSP_034128 | 1 – 122 | Missing in isoform 8. 1 PublicationAdd BLAST | 122 | |
Alternative sequenceiVSP_034129 | 69 – 85 | Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_034130 | 416 – 503 | YLLEM…HHVSV → VEIYPFSPQLNIKAVDNSAI SKYPANIY in isoform 8. 1 PublicationAdd BLAST | 88 | |
Alternative sequenceiVSP_034131 | 466 – 496 | Missing in isoform 2. 2 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_034132 | 504 – 575 | Missing in isoform 8. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_034133 | 545 – 568 | LGLWC…DLKSE → VGVKTQKENAD in isoform 7. 2 PublicationsAdd BLAST | 24 | |
Alternative sequenceiVSP_034134 | 545 – 566 | LGLWC…TQDLK → SMISRTCVDYL in isoform 5 and isoform 6. 2 PublicationsAdd BLAST | 22 | |
Alternative sequenceiVSP_034135 | 567 – 575 | Missing in isoform 5 and isoform 6. 2 Publications | 9 | |
Alternative sequenceiVSP_034136 | 569 – 575 | Missing in isoform 7. 2 Publications | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB081317 mRNA Translation: BAB88871.1 AB081318 mRNA Translation: BAB88872.1 AB081319 mRNA Translation: BAB88873.1 AB081320 mRNA Translation: BAB88874.1 AK000291 mRNA Translation: BAA91060.1 Different initiation. AK097837 mRNA Translation: BAC05180.1 AK291042 mRNA Translation: BAF83731.1 BX537988 mRNA Translation: CAD97948.1 BX538338 mRNA Translation: CAD98103.1 BX640667 mRNA Translation: CAE45803.1 Different initiation. AL109932 Genomic DNA No translation available. AL929470 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56520.1 CH471122 Genomic DNA Translation: EAW56522.1 CH471122 Genomic DNA Translation: EAW56523.1 CH471122 Genomic DNA Translation: EAW56524.1 BC037830 mRNA Translation: AAH37830.1 BC047392 mRNA Translation: AAH47392.1 BC065501 mRNA Translation: AAH65501.1 |
CCDSi | CCDS76189.1 [Q8TDW4-4] CCDS848.1 [Q8TDW4-1] CCDS849.1 [Q8TDW4-3] CCDS850.1 [Q8TDW4-2] CCDS852.1 [Q8TDW4-5] |
RefSeqi | NP_001295193.1, NM_001308264.1 [Q8TDW4-4] NP_060214.2, NM_017744.4 [Q8TDW4-1] NP_620055.1, NM_138727.3 [Q8TDW4-3] NP_620056.1, NM_138728.2 [Q8TDW4-2] NP_620057.1, NM_138729.3 [Q8TDW4-5] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB081317 mRNA Translation: BAB88871.1 AB081318 mRNA Translation: BAB88872.1 AB081319 mRNA Translation: BAB88873.1 AB081320 mRNA Translation: BAB88874.1 AK000291 mRNA Translation: BAA91060.1 Different initiation. AK097837 mRNA Translation: BAC05180.1 AK291042 mRNA Translation: BAF83731.1 BX537988 mRNA Translation: CAD97948.1 BX538338 mRNA Translation: CAD98103.1 BX640667 mRNA Translation: CAE45803.1 Different initiation. AL109932 Genomic DNA No translation available. AL929470 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56520.1 CH471122 Genomic DNA Translation: EAW56522.1 CH471122 Genomic DNA Translation: EAW56523.1 CH471122 Genomic DNA Translation: EAW56524.1 BC037830 mRNA Translation: AAH37830.1 BC047392 mRNA Translation: AAH47392.1 BC065501 mRNA Translation: AAH65501.1 |
CCDSi | CCDS76189.1 [Q8TDW4-4] CCDS848.1 [Q8TDW4-1] CCDS849.1 [Q8TDW4-3] CCDS850.1 [Q8TDW4-2] CCDS852.1 [Q8TDW4-5] |
RefSeqi | NP_001295193.1, NM_001308264.1 [Q8TDW4-4] NP_060214.2, NM_017744.4 [Q8TDW4-1] NP_620055.1, NM_138727.3 [Q8TDW4-3] NP_620056.1, NM_138728.2 [Q8TDW4-2] NP_620057.1, NM_138729.3 [Q8TDW4-5] |
3D structure databases
SMRi | Q8TDW4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120227, 26 interactors |
IntActi | Q8TDW4, 19 interactors |
STRINGi | 9606.ENSP00000350734 |
PTM databases
iPTMneti | Q8TDW4 |
PhosphoSitePlusi | Q8TDW4 |
Genetic variation databases
BioMutai | ST7L |
DMDMi | 74751431 |
Proteomic databases
jPOSTi | Q8TDW4 |
MassIVEi | Q8TDW4 |
MaxQBi | Q8TDW4 |
PaxDbi | Q8TDW4 |
PeptideAtlasi | Q8TDW4 |
PRIDEi | Q8TDW4 |
ProteomicsDBi | 74346 [Q8TDW4-1] 74347 [Q8TDW4-2] 74348 [Q8TDW4-3] 74349 [Q8TDW4-4] 74350 [Q8TDW4-5] 74351 [Q8TDW4-6] 74352 [Q8TDW4-7] 74353 [Q8TDW4-8] |
Protocols and materials databases
Antibodypediai | 46941, 34 antibodies |
DNASUi | 54879 |
Genome annotation databases
Organism-specific databases
CTDi | 54879 |
DisGeNETi | 54879 |
GeneCardsi | ST7L |
HGNCi | HGNC:18441, ST7L |
HPAi | ENSG00000007341, Tissue enhanced (testis) |
MIMi | 617640, gene |
neXtProti | NX_Q8TDW4 |
OpenTargetsi | ENSG00000007341 |
PharmGKBi | PA38331 |
VEuPathDBi | HostDB:ENSG00000007341.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3807, Eukaryota |
GeneTreei | ENSGT00390000000873 |
HOGENOMi | CLU_035578_2_0_1 |
InParanoidi | Q8TDW4 |
OMAi | FAMVLTM |
OrthoDBi | 540550at2759 |
PhylomeDBi | Q8TDW4 |
TreeFami | TF314162 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDW4 |
Miscellaneous databases
BioGRID-ORCSi | 54879, 4 hits in 873 CRISPR screens |
ChiTaRSi | ST7L, human |
GenomeRNAii | 54879 |
Pharosi | Q8TDW4, Tdark |
PROi | PR:Q8TDW4 |
RNActi | Q8TDW4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000007341, Expressed in testis and 176 other tissues |
ExpressionAtlasi | Q8TDW4, baseline and differential |
Genevisiblei | Q8TDW4, HS |
Family and domain databases
CDDi | cd11557, ST7, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR007311, ST7 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR12745, PTHR12745, 1 hit |
Pfami | View protein in Pfam PF04184, ST7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ST7L_HUMAN | |
Accessioni | Q8TDW4Primary (citable) accession number: Q8TDW4 Secondary accession number(s): A8K4S7 Q9NXF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants