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Entry version 151 (07 Apr 2021)
Sequence version 2 (11 Jan 2011)
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Protein

Volume-regulated anion channel subunit LRRC8C

Gene

LRRC8C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TDW0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5223345, Miscellaneous transport and binding events

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.25.3.1, the gap junction-forming innexin (innexin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Volume-regulated anion channel subunit LRRC8CCurated
Alternative name(s):
Factor for adipocyte differentiation 1581 Publication
Leucine-rich repeat-containing protein 8C1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC8C1 PublicationImported
Synonyms:AD1581 Publication, FAD1581 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25075, LRRC8C

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612889, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDW0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000171488.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 125ExtracellularSequence analysisAdd BLAST82
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 266CytoplasmicSequence analysisAdd BLAST120
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 320ExtracellularSequence analysisAdd BLAST33
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 803CytoplasmicSequence analysisAdd BLAST462

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi6E → C: Decreased amplitudes of swelling-activated current. 1 Publication1
Mutagenesisi44T → C: Alters channel anion selectivity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84230

Open Targets

More...
OpenTargetsi
ENSG00000171488

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671536

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TDW0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC8C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373383

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762471 – 803Volume-regulated anion channel subunit LRRC8CAdd BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 308By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi115 ↔ 293By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei212PhosphoserineCombined sources1
Modified residuei215PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TDW0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TDW0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TDW0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TDW0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDW0

PeptideAtlas

More...
PeptideAtlasi
Q8TDW0

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDW0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74345

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8TDW0, 4 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDW0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDW0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171488, Expressed in blood and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TDW0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDW0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171488, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterohexamer (By similarity). Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8D and/or LRRC8E) to form a heterohexamer (Probable). Detected in a channel complex that contains LRRC8A, LRRC8C and LRRC8E (PubMed:28193731). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable).

By similarity3 Publications1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123963, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8TDW0

Database of interacting proteins

More...
DIPi
DIP-61362N

Protein interaction database and analysis system

More...
IntActi
Q8TDW0, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359483

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TDW0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati397 – 420LRR 1Sequence analysisAdd BLAST24
Repeati421 – 443LRR 2Sequence analysisAdd BLAST23
Repeati446 – 466LRR 3Sequence analysisAdd BLAST21
Repeati467 – 488LRR 4Sequence analysisAdd BLAST22
Repeati490 – 513LRR 5Sequence analysisAdd BLAST24
Repeati515 – 537LRR 6Sequence analysisAdd BLAST23
Repeati541 – 563LRR 7Sequence analysisAdd BLAST23
Repeati565 – 587LRR 8Sequence analysisAdd BLAST23
Repeati588 – 611LRR 9Sequence analysisAdd BLAST24
Repeati613 – 635LRR 10Sequence analysisAdd BLAST23
Repeati636 – 659LRR 11Sequence analysisAdd BLAST24
Repeati660 – 682LRR 12Sequence analysisAdd BLAST23
Repeati684 – 705LRR 13Sequence analysisAdd BLAST22
Repeati706 – 728LRR 14Sequence analysisAdd BLAST23
Repeati730 – 751LRR 15Sequence analysisAdd BLAST22
Repeati753 – 774LRR 16Sequence analysisAdd BLAST22
Repeati776 – 799LRR 17Sequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.By similarity
The cytoplasmic N-terminus preceding the first transmembrane (residues 1-22) regulates volume-regulated anion channel (VRAC) conductance, ion permeability and inactivation gating.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRC8 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159250

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019019_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDW0

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEWTADK

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TDW0

TreeFam database of animal gene trees

More...
TreeFami
TF331443

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR026906, LRR_5
IPR032675, LRR_dom_sf
IPR021040, LRRC8_Pannexin-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13306, LRR_5, 1 hit
PF13855, LRR_8, 1 hit
PF12534, Pannexin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8TDW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPVTEFRQF SEQQPAFRVL KPWWDVFTDY LSVAMLMIGV FGCTLQVMQD
60 70 80 90 100
KIICLPKRVQ PAQNHSSLSN VSQAVASTTP LPPPKPSPAN PITVEMKGLK
110 120 130 140 150
TDLDLQQYSF INQMCYERAL HWYAKYFPYL VLIHTLVFML CSNFWFKFPG
160 170 180 190 200
SSSKIEHFIS ILGKCFDSPW TTRALSEVSG EDSEEKDNRK NNMNRSNTIQ
210 220 230 240 250
SGPEDSLVNS QSLKSIPEKF VVDKSTAGAL DKKEGEQAKA LFEKVKKFRL
260 270 280 290 300
HVEEGDILYA MYVRQTVLKV IKFLIIIAYN SALVSKVQFT VDCNVDIQDM
310 320 330 340 350
TGYKNFSCNH TMAHLFSKLS FCYLCFVSIY GLTCLYTLYW LFYRSLREYS
360 370 380 390 400
FEYVRQETGI DDIPDVKNDF AFMLHMIDQY DPLYSKRFAV FLSEVSENKL
410 420 430 440 450
KQLNLNNEWT PDKLRQKLQT NAHNRLELPL IMLSGLPDTV FEITELQSLK
460 470 480 490 500
LEIIKNVMIP ATIAQLDNLQ ELSLHQCSVK IHSAALSFLK ENLKVLSVKF
510 520 530 540 550
DDMRELPPWM YGLRNLEELY LVGSLSHDIS RNVTLESLRD LKSLKILSIK
560 570 580 590 600
SNVSKIPQAV VDVSSHLQKM CIHNDGTKLV MLNNLKKMTN LTELELVHCD
610 620 630 640 650
LERIPHAVFS LLSLQELDLK ENNLKSIEEI VSFQHLRKLT VLKLWHNSIT
660 670 680 690 700
YIPEHIKKLT SLERLSFSHN KIEVLPSHLF LCNKIRYLDL SYNDIRFIPP
710 720 730 740 750
EIGVLQSLQY FSITCNKVES LPDELYFCKK LKTLKIGKNS LSVLSPKIGN
760 770 780 790 800
LLFLSYLDVK GNHFEILPPE LGDCRALKRA GLVVEDALFE TLPSDVREQM

KTE
Length:803
Mass (Da):92,450
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95D179F028BF3F50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHY6E9PHY6_HUMAN
Volume-regulated anion channel subu...
LRRC8C
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti570M → T in BAG54591 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051129205D → GCombined sources4 PublicationsCorresponds to variant dbSNP:rs474536Ensembl.1
Natural variantiVAR_051130468N → S. Corresponds to variant dbSNP:rs12032393Ensembl.1
Natural variantiVAR_051131800M → I. Corresponds to variant dbSNP:rs12036569Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB081509 mRNA Translation: BAB86303.1
AK127881 mRNA Translation: BAG54591.1
AC093423 Genomic DNA No translation available.
BC113973 mRNA Translation: AAI13974.1
AL136919 mRNA Translation: CAB66853.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS725.1

NCBI Reference Sequences

More...
RefSeqi
NP_115646.2, NM_032270.4
XP_011540584.1, XM_011542282.2
XP_016857992.1, XM_017002503.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370454; ENSP00000359483; ENSG00000171488

Database of genes from NCBI RefSeq genomes

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GeneIDi
84230

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84230

UCSC genome browser

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UCSCi
uc001dnl.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081509 mRNA Translation: BAB86303.1
AK127881 mRNA Translation: BAG54591.1
AC093423 Genomic DNA No translation available.
BC113973 mRNA Translation: AAI13974.1
AL136919 mRNA Translation: CAB66853.2
CCDSiCCDS725.1
RefSeqiNP_115646.2, NM_032270.4
XP_011540584.1, XM_011542282.2
XP_016857992.1, XM_017002503.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123963, 19 interactors
CORUMiQ8TDW0
DIPiDIP-61362N
IntActiQ8TDW0, 7 interactors
STRINGi9606.ENSP00000359483

Protein family/group databases

TCDBi1.A.25.3.1, the gap junction-forming innexin (innexin) family

PTM databases

GlyGeniQ8TDW0, 4 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ8TDW0
PhosphoSitePlusiQ8TDW0

Genetic variation databases

BioMutaiLRRC8C
DMDMi317373383

Proteomic databases

EPDiQ8TDW0
jPOSTiQ8TDW0
MassIVEiQ8TDW0
MaxQBiQ8TDW0
PaxDbiQ8TDW0
PeptideAtlasiQ8TDW0
PRIDEiQ8TDW0
ProteomicsDBi74345

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33620, 21 antibodies

Genome annotation databases

EnsembliENST00000370454; ENSP00000359483; ENSG00000171488
GeneIDi84230
KEGGihsa:84230
UCSCiuc001dnl.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84230
DisGeNETi84230

GeneCards: human genes, protein and diseases

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GeneCardsi
LRRC8C
HGNCiHGNC:25075, LRRC8C
HPAiENSG00000171488, Low tissue specificity
MIMi612889, gene
neXtProtiNX_Q8TDW0
OpenTargetsiENSG00000171488
PharmGKBiPA142671536
VEuPathDBiHostDB:ENSG00000171488.14

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000159250
HOGENOMiCLU_019019_0_0_1
InParanoidiQ8TDW0
OMAiNEWTADK
PhylomeDBiQ8TDW0
TreeFamiTF331443

Enzyme and pathway databases

PathwayCommonsiQ8TDW0
ReactomeiR-HSA-5223345, Miscellaneous transport and binding events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84230, 6 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LRRC8C, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84230
PharosiQ8TDW0, Tdark

Protein Ontology

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PROi
PR:Q8TDW0
RNActiQ8TDW0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000171488, Expressed in blood and 218 other tissues
ExpressionAtlasiQ8TDW0, baseline and differential
GenevisibleiQ8TDW0, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR026906, LRR_5
IPR032675, LRR_dom_sf
IPR021040, LRRC8_Pannexin-like
PfamiView protein in Pfam
PF13306, LRR_5, 1 hit
PF13855, LRR_8, 1 hit
PF12534, Pannexin_like, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 7 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC8C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDW0
Secondary accession number(s): B3KXS9, Q29RV6, Q9H075
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: January 11, 2011
Last modified: April 7, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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