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Protein

Glucose-dependent insulinotropic receptor

Gene

GPR119

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
SIGNORiQ8TDV5

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-dependent insulinotropic receptor
Alternative name(s):
G-protein coupled receptor 119
Gene namesi
Name:GPR119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147262.3
HGNCiHGNC:19060 GPR119
MIMi300513 gene
neXtProtiNX_Q8TDV5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12ExtracellularSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini34 – 37CytoplasmicSequence analysis4
Transmembranei38 – 58Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini59 – 81ExtracellularSequence analysisAdd BLAST23
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 125CytoplasmicSequence analysisAdd BLAST23
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 164ExtracellularSequence analysisAdd BLAST18
Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini186 – 226CytoplasmicSequence analysisAdd BLAST41
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 262ExtracellularSequence analysisAdd BLAST15
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 335CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi139760
OpenTargetsiENSG00000147262
PharmGKBiPA134928131

Chemistry databases

ChEMBLiCHEMBL5652
DrugBankiDB05166 APD668
GuidetoPHARMACOLOGYi126

Polymorphism and mutation databases

BioMutaiGPR119
DMDMi62510696

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696071 – 335Glucose-dependent insulinotropic receptorAdd BLAST335

Proteomic databases

PaxDbiQ8TDV5
PRIDEiQ8TDV5
ProteomicsDBi74344

PTM databases

iPTMnetiQ8TDV5
PhosphoSitePlusiQ8TDV5

Expressioni

Tissue specificityi

Predominantly expressed in the pancreas, especially in the islets.1 Publication

Gene expression databases

BgeeiENSG00000147262 Expressed in 2 organ(s), highest expression level in body of pancreas
CleanExiHS_GPR119

Interactioni

Protein-protein interaction databases

BioGridi126586, 1 interactor
IntActiQ8TDV5, 1 interactor
STRINGi9606.ENSP00000276218

Chemistry databases

BindingDBiQ8TDV5

Structurei

3D structure databases

ProteinModelPortaliQ8TDV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000112765
HOVERGENiHBG051773
InParanoidiQ8TDV5
KOiK08424
OMAiSFFAVFH
OrthoDBiEOG091G0I71
PhylomeDBiQ8TDV5
TreeFamiTF325411

Family and domain databases

CDDicd15104 7tmA_GPR119_R_insulinotropic_r, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028336 GPR119
PANTHERiPTHR22750:SF7 PTHR22750:SF7, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TDV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESSFSFGVI LAVLASLIIA TNTLVAVAVL LLIHKNDGVS LCFTLNLAVA
60 70 80 90 100
DTLIGVAISG LLTDQLSSPS RPTQKTLCSL RMAFVTSSAA ASVLTVMLIT
110 120 130 140 150
FDRYLAIKQP FRYLKIMSGF VAGACIAGLW LVSYLIGFLP LGIPMFQQTA
160 170 180 190 200
YKGQCSFFAV FHPHFVLTLS CVGFFPAMLL FVFFYCDMLK IASMHSQQIR
210 220 230 240 250
KMEHAGAMAG GYRSPRTPSD FKALRTVSVL IGSFALSWTP FLITGIVQVA
260 270 280 290 300
CQECHLYLVL ERYLWLLGVG NSLLNPLIYA YWQKEVRLQL YHMALGVKKV
310 320 330
LTSFLLFLSA RNCGPERPRE SSCHIVTISS SEFDG
Length:335
Mass (Da):36,889
Last modified:June 1, 2002 - v1
Checksum:i16BAF93AEA145FB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325I → T in AAI01167 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037221309S → L. Corresponds to variant dbSNP:rs5975187Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083584 Genomic DNA Translation: BAB89297.1
AB065936 Genomic DNA Translation: BAC06151.1
AY288416 mRNA Translation: AAP72125.1
AL035423 Genomic DNA No translation available.
BC095502 mRNA Translation: AAH95502.1
BC101166 mRNA Translation: AAI01167.1
BC101167 mRNA Translation: AAI01168.1
BC101168 mRNA Translation: AAI01169.1
BC126179 mRNA Translation: AAI26180.1
BC126181 mRNA Translation: AAI26182.1
CCDSiCCDS14625.1
RefSeqiNP_848566.1, NM_178471.2
UniGeneiHs.496762

Genome annotation databases

EnsembliENST00000276218; ENSP00000276218; ENSG00000147262
GeneIDi139760
KEGGihsa:139760
UCSCiuc011muv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083584 Genomic DNA Translation: BAB89297.1
AB065936 Genomic DNA Translation: BAC06151.1
AY288416 mRNA Translation: AAP72125.1
AL035423 Genomic DNA No translation available.
BC095502 mRNA Translation: AAH95502.1
BC101166 mRNA Translation: AAI01167.1
BC101167 mRNA Translation: AAI01168.1
BC101168 mRNA Translation: AAI01169.1
BC126179 mRNA Translation: AAI26180.1
BC126181 mRNA Translation: AAI26182.1
CCDSiCCDS14625.1
RefSeqiNP_848566.1, NM_178471.2
UniGeneiHs.496762

3D structure databases

ProteinModelPortaliQ8TDV5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126586, 1 interactor
IntActiQ8TDV5, 1 interactor
STRINGi9606.ENSP00000276218

Chemistry databases

BindingDBiQ8TDV5
ChEMBLiCHEMBL5652
DrugBankiDB05166 APD668
GuidetoPHARMACOLOGYi126

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8TDV5
PhosphoSitePlusiQ8TDV5

Polymorphism and mutation databases

BioMutaiGPR119
DMDMi62510696

Proteomic databases

PaxDbiQ8TDV5
PRIDEiQ8TDV5
ProteomicsDBi74344

Protocols and materials databases

DNASUi139760
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276218; ENSP00000276218; ENSG00000147262
GeneIDi139760
KEGGihsa:139760
UCSCiuc011muv.3 human

Organism-specific databases

CTDi139760
DisGeNETi139760
EuPathDBiHostDB:ENSG00000147262.3
GeneCardsiGPR119
HGNCiHGNC:19060 GPR119
MIMi300513 gene
neXtProtiNX_Q8TDV5
OpenTargetsiENSG00000147262
PharmGKBiPA134928131
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000112765
HOVERGENiHBG051773
InParanoidiQ8TDV5
KOiK08424
OMAiSFFAVFH
OrthoDBiEOG091G0I71
PhylomeDBiQ8TDV5
TreeFamiTF325411

Enzyme and pathway databases

ReactomeiR-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
SIGNORiQ8TDV5

Miscellaneous databases

GeneWikiiGPR119
GenomeRNAii139760
PROiPR:Q8TDV5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147262 Expressed in 2 organ(s), highest expression level in body of pancreas
CleanExiHS_GPR119

Family and domain databases

CDDicd15104 7tmA_GPR119_R_insulinotropic_r, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028336 GPR119
PANTHERiPTHR22750:SF7 PTHR22750:SF7, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP119_HUMAN
AccessioniPrimary (citable) accession number: Q8TDV5
Secondary accession number(s): Q495H7, Q4VBN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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