UniProtKB - Q8TDV2 (GP148_HUMAN)
Protein
Probable G-protein coupled receptor 148
Gene
GPR148
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- odorant binding Source: GO_Central
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- detection of chemical stimulus involved in sensory perception of smell Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q8TDV2 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 148Alternative name(s): Brain and testis restricted GPCR G-protein coupled receptor PGR6 |
Gene namesi | Name:GPR148 Synonyms:BTR, PGR6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23623, GPR148 |
neXtProti | NX_Q8TDV2 |
VEuPathDBi | HostDB:ENSG00000173302.5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | ExtracellularSequence analysisAdd BLAST | 51 | |
Transmembranei | 52 – 72 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 85 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 86 – 106 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 130 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 131 – 151 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 152 – 165 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 166 – 186 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 214 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 215 – 235 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 236 – 261 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 262 – 282 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 299 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 300 – 322 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 323 – 347 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000173302 |
PharmGKBi | PA134942667 |
Miscellaneous databases
Pharosi | Q8TDV2, Tdark |
Genetic variation databases
BioMutai | GPR148 |
DMDMi | 311033389 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069625 | 1 – 347 | Probable G-protein coupled receptor 148Add BLAST | 347 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8TDV2 |
PeptideAtlasi | Q8TDV2 |
PRIDEi | Q8TDV2 |
ProteomicsDBi | 74343 |
PTM databases
GlyGeni | Q8TDV2, 1 site |
iPTMneti | Q8TDV2 |
PhosphoSitePlusi | Q8TDV2 |
Expressioni
Tissue specificityi
Expression restricted to nervous system and testis. Is also detected in several tumors types, most notably prostate cancer.1 Publication
Gene expression databases
Bgeei | ENSG00000173302, Expressed in islet of Langerhans and 14 other tissues |
Organism-specific databases
HPAi | ENSG00000173302, Group enriched (brain, pancreas, pituitary gland, stomach) |
Interactioni
Binary interactionsi
Q8TDV2
With | #Exp. | IntAct |
---|---|---|
EXOC3L2 [Q2M3D2] | 3 | EBI-17294222,EBI-14890134 |
Protein-protein interaction databases
BioGRIDi | 131308, 1 interactor |
IntActi | Q8TDV2, 1 interactor |
STRINGi | 9606.ENSP00000308908 |
Miscellaneous databases
RNActi | Q8TDV2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 107 – 110 | Poly-Ser | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230341 |
HOGENOMi | CLU_067256_0_0_1 |
InParanoidi | Q8TDV2 |
OMAi | HIDSGTH |
OrthoDBi | 1419205at2759 |
PhylomeDBi | Q8TDV2 |
TreeFami | TF333617 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8TDV2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDELAPCPV GTTAWPALIQ LISKTPCMPQ AASNTSLGLG DLRVPSSMLY
60 70 80 90 100
WLFLPSSLLA AATLAVSPLL LVTILRNQRL RQEPHYLLPA NILLSDLAYI
110 120 130 140 150
LLHMLISSSS LGGWELGRMA CGILTDAVFA ACTSTILSFT AIVLHTYLAV
160 170 180 190 200
IHPLRYLSFM SHGAAWKAVA LIWLVACCFP TFLIWLSKWQ DAQLEEQGAS
210 220 230 240 250
YILPPSMGTQ PGCGLLVIVT YTSILCVLFL CTALIANCFW RIYAEAKTSG
260 270 280 290 300
IWGQGYSRAR GTLLIHSVLI TLYVSTGVVF SLDMVLTRYH HIDSGTHTWL
310 320 330 340
LAANSEVLMM LPRAMLTYLY LLRYRQLLGM VRGHLPSRRH QAIFTIS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 – 62 | CMPQA…LLAAA → SS in AAP34196 (PubMed:15688318).CuratedAdd BLAST | 36 | |
Sequence conflicti | 130 | A → D in AAP34196 (PubMed:15688318).Curated | 1 | |
Sequence conflicti | 138 | S → F in AAP34196 (PubMed:15688318).Curated | 1 | |
Sequence conflicti | 141 | A → G in AAP34196 (PubMed:15688318).Curated | 1 | |
Sequence conflicti | 155 | R → G in AAP34196 (PubMed:15688318).Curated | 1 | |
Sequence conflicti | 168 | A → P in AAP34196 (PubMed:15688318).Curated | 1 | |
Sequence conflicti | 171 | L → F in AAP34196 (PubMed:15688318).Curated | 1 | |
Sequence conflicti | 199 | A → V in AAP34196 (PubMed:15688318).Curated | 1 | |
Sequence conflicti | 215 | L → F in AAP34196 (PubMed:15688318).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049403 | 317 | T → P4 PublicationsCorresponds to variant dbSNP:rs272128Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083589 Genomic DNA Translation: BAB89302.1 AY280965 mRNA Translation: AAP34196.1 AY569570 mRNA Translation: AAS76892.1 AC140481 Genomic DNA No translation available. BC105013 mRNA Translation: AAI05014.1 BC105041 mRNA Translation: AAI05042.1 AY255532 mRNA Translation: AAO85044.1 |
CCDSi | CCDS2163.1 |
RefSeqi | NP_997247.2, NM_207364.2 |
Genome annotation databases
Ensembli | ENST00000309926; ENSP00000308908; ENSG00000173302 |
GeneIDi | 344561 |
KEGGi | hsa:344561 |
UCSCi | uc002trv.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083589 Genomic DNA Translation: BAB89302.1 AY280965 mRNA Translation: AAP34196.1 AY569570 mRNA Translation: AAS76892.1 AC140481 Genomic DNA No translation available. BC105013 mRNA Translation: AAI05014.1 BC105041 mRNA Translation: AAI05042.1 AY255532 mRNA Translation: AAO85044.1 |
CCDSi | CCDS2163.1 |
RefSeqi | NP_997247.2, NM_207364.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 131308, 1 interactor |
IntActi | Q8TDV2, 1 interactor |
STRINGi | 9606.ENSP00000308908 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8TDV2, 1 site |
iPTMneti | Q8TDV2 |
PhosphoSitePlusi | Q8TDV2 |
Genetic variation databases
BioMutai | GPR148 |
DMDMi | 311033389 |
Proteomic databases
PaxDbi | Q8TDV2 |
PeptideAtlasi | Q8TDV2 |
PRIDEi | Q8TDV2 |
ProteomicsDBi | 74343 |
Protocols and materials databases
Antibodypediai | 18608, 56 antibodies |
DNASUi | 344561 |
Genome annotation databases
Ensembli | ENST00000309926; ENSP00000308908; ENSG00000173302 |
GeneIDi | 344561 |
KEGGi | hsa:344561 |
UCSCi | uc002trv.2, human |
Organism-specific databases
CTDi | 344561 |
GeneCardsi | GPR148 |
HGNCi | HGNC:23623, GPR148 |
HPAi | ENSG00000173302, Group enriched (brain, pancreas, pituitary gland, stomach) |
neXtProti | NX_Q8TDV2 |
OpenTargetsi | ENSG00000173302 |
PharmGKBi | PA134942667 |
VEuPathDBi | HostDB:ENSG00000173302.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230341 |
HOGENOMi | CLU_067256_0_0_1 |
InParanoidi | Q8TDV2 |
OMAi | HIDSGTH |
OrthoDBi | 1419205at2759 |
PhylomeDBi | Q8TDV2 |
TreeFami | TF333617 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDV2 |
Miscellaneous databases
BioGRID-ORCSi | 344561, 2 hits in 976 CRISPR screens |
GeneWikii | GPR148 |
GenomeRNAii | 344561 |
Pharosi | Q8TDV2, Tdark |
PROi | PR:Q8TDV2 |
RNActi | Q8TDV2, protein |
Gene expression databases
Bgeei | ENSG00000173302, Expressed in islet of Langerhans and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP148_HUMAN | |
Accessioni | Q8TDV2Primary (citable) accession number: Q8TDV2 Secondary accession number(s): Q2M369, Q86SP7, Q86U87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | November 2, 2010 | |
Last modified: | April 7, 2021 | |
This is version 123 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families