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Protein

Probable G-protein coupled receptor 151

Gene

GPR151

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 151
Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037
Gene namesi
Name:GPR151
Synonyms:PGR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000173250.2
HGNCiHGNC:23624 GPR151
neXtProtiNX_Q8TDV0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 71CytoplasmicSequence analysis9
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 116ExtracellularSequence analysisAdd BLAST24
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 153CytoplasmicSequence analysisAdd BLAST16
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 201ExtracellularSequence analysisAdd BLAST27
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 252CytoplasmicSequence analysisAdd BLAST30
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 286ExtracellularSequence analysisAdd BLAST13
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 419CytoplasmicSequence analysisAdd BLAST112

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi134391
PharmGKBiPA134975199

Chemistry databases

ChEMBLiCHEMBL3085617

Polymorphism and mutation databases

BioMutaiGPR151
DMDMi48428097

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696321 – 419Probable G-protein coupled receptor 151Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TDV0
PeptideAtlasiQ8TDV0
PRIDEiQ8TDV0
ProteomicsDBi74342

PTM databases

iPTMnetiQ8TDV0
PhosphoSitePlusiQ8TDV0

Expressioni

Gene expression databases

BgeeiENSG00000173250 Expressed in 9 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_GPR151

Interactioni

Protein-protein interaction databases

IntActiQ8TDV0, 35 interactors
STRINGi9606.ENSP00000308733

Structurei

3D structure databases

ProteinModelPortaliQ8TDV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00640000091572
HOGENOMiHOG000112774
HOVERGENiHBG051787
InParanoidiQ8TDV0
KOiK08435
OMAiFYFWRAY
OrthoDBiEOG091G09J0
PhylomeDBiQ8TDV0
TreeFamiTF332591

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TDV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG
60 70 80 90 100
FVGNLCVIGI LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS
110 120 130 140 150
KSVWDLGWFV CKSSDWFIHT CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH
160 170 180 190 200
NYTIWSVLVA IWTVASLLPL PEWFFSTIRH HEGVEMCLVD VPAVAEEFMS
210 220 230 240 250
MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR NQIRSKQVTV
260 270 280 290 300
MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS
310 320 330 340 350
ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV
360 370 380 390 400
PSPESPASIP EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ
410
DNDPIPWEHE DQETGEGVK
Length:419
Mass (Da):46,637
Last modified:June 1, 2002 - v1
Checksum:i769780E6B1FC6140
GO

Sequence cautioni

The sequence BAC05899 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04940440P → L. Corresponds to variant dbSNP:rs17104742Ensembl.1
Natural variantiVAR_049405144A → V. Corresponds to variant dbSNP:rs7713676Ensembl.1
Natural variantiVAR_049406261L → V. Corresponds to variant dbSNP:rs7709485Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY351676 mRNA Translation: AAQ62567.1
AB083592 Genomic DNA Translation: BAB89305.1
AB065674 Genomic DNA Translation: BAC05899.1 Different initiation.
AY255557 mRNA Translation: AAO85069.1
CCDSiCCDS34266.1
RefSeqiNP_919227.2, NM_194251.2
UniGeneiHs.483732

Genome annotation databases

EnsembliENST00000311104; ENSP00000308733; ENSG00000173250
GeneIDi134391
KEGGihsa:134391
UCSCiuc003lod.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGP151_HUMAN
AccessioniPrimary (citable) accession number: Q8TDV0
Secondary accession number(s): Q86SN8, Q8NGV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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