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Entry version 121 (13 Feb 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Probable G-protein coupled receptor 151

Gene

GPR151

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable G-protein coupled receptor 151
Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR151
Synonyms:PGR7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173250.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23624 GPR151

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDV0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 71CytoplasmicSequence analysis9
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 116ExtracellularSequence analysisAdd BLAST24
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 153CytoplasmicSequence analysisAdd BLAST16
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 201ExtracellularSequence analysisAdd BLAST27
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 252CytoplasmicSequence analysisAdd BLAST30
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 286ExtracellularSequence analysisAdd BLAST13
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 419CytoplasmicSequence analysisAdd BLAST112

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
134391

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134975199

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3085617

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPR151

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48428097

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696321 – 419Probable G-protein coupled receptor 151Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi111 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDV0

PeptideAtlas

More...
PeptideAtlasi
Q8TDV0

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDV0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74342

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDV0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDV0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173250 Expressed in 9 organ(s), highest expression level in C1 segment of cervical spinal cord

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8TDV0, 35 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308733

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TDV0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112774

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051787

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDV0

KEGG Orthology (KO)

More...
KOi
K08435

Identification of Orthologs from Complete Genome Data

More...
OMAi
YFWRAYG

Database of Orthologous Groups

More...
OrthoDBi
658542at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDV0

TreeFam database of animal gene trees

More...
TreeFami
TF332591

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TDV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG
60 70 80 90 100
FVGNLCVIGI LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS
110 120 130 140 150
KSVWDLGWFV CKSSDWFIHT CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH
160 170 180 190 200
NYTIWSVLVA IWTVASLLPL PEWFFSTIRH HEGVEMCLVD VPAVAEEFMS
210 220 230 240 250
MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR NQIRSKQVTV
260 270 280 290 300
MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS
310 320 330 340 350
ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV
360 370 380 390 400
PSPESPASIP EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ
410
DNDPIPWEHE DQETGEGVK
Length:419
Mass (Da):46,637
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i769780E6B1FC6140
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05899 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04940440P → L. Corresponds to variant dbSNP:rs17104742Ensembl.1
Natural variantiVAR_049405144A → V. Corresponds to variant dbSNP:rs7713676Ensembl.1
Natural variantiVAR_049406261L → V. Corresponds to variant dbSNP:rs7709485Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY351676 mRNA Translation: AAQ62567.1
AB083592 Genomic DNA Translation: BAB89305.1
AB065674 Genomic DNA Translation: BAC05899.1 Different initiation.
AY255557 mRNA Translation: AAO85069.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34266.1

NCBI Reference Sequences

More...
RefSeqi
NP_919227.2, NM_194251.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.483732

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311104; ENSP00000308733; ENSG00000173250

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
134391

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:134391

UCSC genome browser

More...
UCSCi
uc003lod.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY351676 mRNA Translation: AAQ62567.1
AB083592 Genomic DNA Translation: BAB89305.1
AB065674 Genomic DNA Translation: BAC05899.1 Different initiation.
AY255557 mRNA Translation: AAO85069.1
CCDSiCCDS34266.1
RefSeqiNP_919227.2, NM_194251.2
UniGeneiHs.483732

3D structure databases

ProteinModelPortaliQ8TDV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TDV0, 35 interactors
STRINGi9606.ENSP00000308733

Chemistry databases

ChEMBLiCHEMBL3085617

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ8TDV0
PhosphoSitePlusiQ8TDV0

Polymorphism and mutation databases

BioMutaiGPR151
DMDMi48428097

Proteomic databases

PaxDbiQ8TDV0
PeptideAtlasiQ8TDV0
PRIDEiQ8TDV0
ProteomicsDBi74342

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
134391
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311104; ENSP00000308733; ENSG00000173250
GeneIDi134391
KEGGihsa:134391
UCSCiuc003lod.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
134391
DisGeNETi134391
EuPathDBiHostDB:ENSG00000173250.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GPR151
HGNCiHGNC:23624 GPR151
neXtProtiNX_Q8TDV0
PharmGKBiPA134975199

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000153784
HOGENOMiHOG000112774
HOVERGENiHBG051787
InParanoidiQ8TDV0
KOiK08435
OMAiYFWRAYG
OrthoDBi658542at2759
PhylomeDBiQ8TDV0
TreeFamiTF332591

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GPR151

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
134391

Protein Ontology

More...
PROi
PR:Q8TDV0

Gene expression databases

BgeeiENSG00000173250 Expressed in 9 organ(s), highest expression level in C1 segment of cervical spinal cord

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP151_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDV0
Secondary accession number(s): Q86SN8, Q8NGV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: February 13, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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