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UniProtKB - Q8TDU6 (GPBAR_HUMAN)

Entry version 134 (08 May 2019)
Sequence version 1 (01 Jun 2002)
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Protein

G-protein coupled bile acid receptor 1

Gene

GPBAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418555 G alpha (s) signalling events

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.21.1 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001566

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled bile acid receptor 1
Alternative name(s):
G-protein coupled receptor GPCR19
Short name:
hGPCR19
Membrane-type receptor for bile acids
Short name:
M-BAR
hBG37
Short name:
BG37
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPBAR1
Synonyms:TGR5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19680 GPBAR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610147 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDU6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 50CytoplasmicSequence analysis10
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 85ExtracellularSequence analysisAdd BLAST14
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 125CytoplasmicSequence analysisAdd BLAST19
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 165ExtracellularSequence analysisAdd BLAST19
Transmembranei166 – 186Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini187 – 228CytoplasmicSequence analysisAdd BLAST42
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 261ExtracellularSequence analysisAdd BLAST12
Transmembranei262 – 282Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini283 – 330CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		151306

Open Targets

More...OpenTargetsi		ENSG00000179921

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134903170

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5409

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		37

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPBAR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762624

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000695001 – 330G-protein coupled bile acid receptor 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi85 ↔ 155PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TDU6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDU6

PeptideAtlas

More...PeptideAtlasi		Q8TDU6

PRoteomics IDEntifications database

More...PRIDEi		Q8TDU6

ProteomicsDB human proteome resource

More...ProteomicsDBi		74340

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000179921 Expressed in 82 organ(s), highest expression level in leukocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDU6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA062890

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q8TDU6, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000430886

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8TDU6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDU6

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IZAJ Eukaryota
ENOG411075X LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010256

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000065748

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDU6

KEGG Orthology (KO)

More...KOi		K08400

Identification of Orthologs from Complete Genome Data

More...OMAi		DICRLHR

Database of Orthologous Groups

More...OrthoDBi		819314at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDU6

TreeFam database of animal gene trees

More...TreeFami		TF333321

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TDU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA 
        60         70         80         90        100
GCFFLSLLLA GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL 
       110        120        130        140        150
ANLLLVHGER YMAVLRPLQP PGSIRLALLL TWAGPLLFAS LPALGWNHWT 
       160        170        180        190        200
PGANCSSQAI FPAPYLYLEV YGLLLPAVGA AAFLSVRVLA TAHRQLQDIC 
       210        220        230        240        250
RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY VATLLLSVLA 
       260        270        280        290        300
YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ 
       310        320        330
GLWGRASRDS PGPSIAYHPS SQSSVDLDLN
Length:330
Mass (Da):35,248
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3A1AEDADEAFE021
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB086170 mRNA Translation: BAC65343.1
AB089307 mRNA Translation: BAC55235.1
AB083601 Genomic DNA Translation: BAB89314.1
AK122658 mRNA Translation: BAG53647.1
AK122660 mRNA Translation: BAG53648.1
CH471063 Genomic DNA Translation: EAW70598.1
BC033625 mRNA Translation: AAH33625.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46515.1

NCBI Reference Sequences

More...RefSeqi		NP_001070659.1, NM_001077191.1
NP_001070662.1, NM_001077194.1
NP_001308879.1, NM_001321950.1
NP_733800.1, NM_170699.2
XP_011509045.1, XM_011510743.1
XP_016858956.1, XM_017003467.1
XP_016858957.1, XM_017003468.1
XP_016858958.1, XM_017003469.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000479077; ENSP00000430698; ENSG00000179921
ENST00000519574; ENSP00000430202; ENSG00000179921
ENST00000521462; ENSP00000428824; ENSG00000179921
ENST00000522678; ENSP00000430886; ENSG00000179921

Database of genes from NCBI RefSeq genomes

More...GeneIDi		151306

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:151306

UCSC genome browser

More...UCSCi		uc010zjw.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086170 mRNA Translation: BAC65343.1
AB089307 mRNA Translation: BAC55235.1
AB083601 Genomic DNA Translation: BAB89314.1
AK122658 mRNA Translation: BAG53647.1
AK122660 mRNA Translation: BAG53648.1
CH471063 Genomic DNA Translation: EAW70598.1
BC033625 mRNA Translation: AAH33625.1
CCDSiCCDS46515.1
RefSeqiNP_001070659.1, NM_001077191.1
NP_001070662.1, NM_001077194.1
NP_001308879.1, NM_001321950.1
NP_733800.1, NM_170699.2
XP_011509045.1, XM_011510743.1
XP_016858956.1, XM_017003467.1
XP_016858957.1, XM_017003468.1
XP_016858958.1, XM_017003469.1

3D structure databases

SMRiQ8TDU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TDU6, 8 interactors
STRINGi9606.ENSP00000430886

Chemistry databases

BindingDBiQ8TDU6
ChEMBLiCHEMBL5409
GuidetoPHARMACOLOGYi37
SwissLipidsiSLP:000001566

Protein family/group databases

TCDBi9.A.14.21.1 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

Polymorphism and mutation databases

BioMutaiGPBAR1
DMDMi74762624

Proteomic databases

jPOSTiQ8TDU6
PaxDbiQ8TDU6
PeptideAtlasiQ8TDU6
PRIDEiQ8TDU6
ProteomicsDBi74340

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		151306
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000479077; ENSP00000430698; ENSG00000179921
ENST00000519574; ENSP00000430202; ENSG00000179921
ENST00000521462; ENSP00000428824; ENSG00000179921
ENST00000522678; ENSP00000430886; ENSG00000179921
GeneIDi151306
KEGGihsa:151306
UCSCiuc010zjw.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		151306
DisGeNETi151306

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPBAR1
HGNCiHGNC:19680 GPBAR1
HPAiHPA062890
MIMi610147 gene
neXtProtiNX_Q8TDU6
OpenTargetsiENSG00000179921
PharmGKBiPA134903170

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IZAJ Eukaryota
ENOG411075X LUCA
GeneTreeiENSGT00390000010256
HOGENOMiHOG000065748
InParanoidiQ8TDU6
KOiK08400
OMAiDICRLHR
OrthoDBi819314at2759
PhylomeDBiQ8TDU6
TreeFamiTF333321

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		G_protein-coupled_bile_acid_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		151306

Protein Ontology

More...PROi		PR:Q8TDU6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000179921 Expressed in 82 organ(s), highest expression level in leukocyte
GenevisibleiQ8TDU6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPBAR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDU6
Secondary accession number(s): B3KV35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: May 8, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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