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Protein

G-protein coupled bile acid receptor 1

Gene

GPBAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.2 Publications

GO - Molecular functioni

  • bile acid receptor activity Source: UniProtKB
  • G-protein coupled bile acid receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418555 G alpha (s) signalling events

Protein family/group databases

TCDBi9.A.14.21.1 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipidsiSLP:000001566

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled bile acid receptor 1
Alternative name(s):
G-protein coupled receptor GPCR19
Short name:
hGPCR19
Membrane-type receptor for bile acids
Short name:
M-BAR
hBG37
Short name:
BG37
Gene namesi
Name:GPBAR1
Synonyms:TGR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000179921.14
HGNCiHGNC:19680 GPBAR1
MIMi610147 gene
neXtProtiNX_Q8TDU6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 50CytoplasmicSequence analysis10
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 85ExtracellularSequence analysisAdd BLAST14
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 125CytoplasmicSequence analysisAdd BLAST19
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 165ExtracellularSequence analysisAdd BLAST19
Transmembranei166 – 186Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini187 – 228CytoplasmicSequence analysisAdd BLAST42
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 261ExtracellularSequence analysisAdd BLAST12
Transmembranei262 – 282Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini283 – 330CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi151306
OpenTargetsiENSG00000179921
PharmGKBiPA134903170

Chemistry databases

ChEMBLiCHEMBL5409
GuidetoPHARMACOLOGYi37

Polymorphism and mutation databases

BioMutaiGPBAR1
DMDMi74762624

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695001 – 330G-protein coupled bile acid receptor 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 155PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8TDU6
PeptideAtlasiQ8TDU6
PRIDEiQ8TDU6
ProteomicsDBi74340

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.3 Publications

Gene expression databases

BgeeiENSG00000179921 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExiHS_GPBAR1
GenevisibleiQ8TDU6 HS

Organism-specific databases

HPAiHPA062890

Interactioni

Protein-protein interaction databases

IntActiQ8TDU6, 8 interactors
STRINGi9606.ENSP00000428824

Chemistry databases

BindingDBiQ8TDU6

Structurei

3D structure databases

ProteinModelPortaliQ8TDU6
SMRiQ8TDU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZAJ Eukaryota
ENOG411075X LUCA
GeneTreeiENSGT00390000010256
HOGENOMiHOG000065748
HOVERGENiHBG081571
InParanoidiQ8TDU6
KOiK08400
OMAiDICRLHR
OrthoDBiEOG091G0MRP
PhylomeDBiQ8TDU6
TreeFamiTF333321

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TDU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA
60 70 80 90 100
GCFFLSLLLA GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL
110 120 130 140 150
ANLLLVHGER YMAVLRPLQP PGSIRLALLL TWAGPLLFAS LPALGWNHWT
160 170 180 190 200
PGANCSSQAI FPAPYLYLEV YGLLLPAVGA AAFLSVRVLA TAHRQLQDIC
210 220 230 240 250
RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY VATLLLSVLA
260 270 280 290 300
YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ
310 320 330
GLWGRASRDS PGPSIAYHPS SQSSVDLDLN
Length:330
Mass (Da):35,248
Last modified:June 1, 2002 - v1
Checksum:iB3A1AEDADEAFE021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086170 mRNA Translation: BAC65343.1
AB089307 mRNA Translation: BAC55235.1
AB083601 Genomic DNA Translation: BAB89314.1
AK122658 mRNA Translation: BAG53647.1
AK122660 mRNA Translation: BAG53648.1
CH471063 Genomic DNA Translation: EAW70598.1
BC033625 mRNA Translation: AAH33625.1
CCDSiCCDS46515.1
RefSeqiNP_001070659.1, NM_001077191.1
NP_001070662.1, NM_001077194.1
NP_001308879.1, NM_001321950.1
NP_733800.1, NM_170699.2
XP_011509045.1, XM_011510743.1
XP_016858956.1, XM_017003467.1
XP_016858957.1, XM_017003468.1
XP_016858958.1, XM_017003469.1
UniGeneiHs.160954

Genome annotation databases

EnsembliENST00000479077; ENSP00000430698; ENSG00000179921
ENST00000519574; ENSP00000430202; ENSG00000179921
ENST00000521462; ENSP00000428824; ENSG00000179921
ENST00000522678; ENSP00000430886; ENSG00000179921
GeneIDi151306
KEGGihsa:151306
UCSCiuc010zjw.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086170 mRNA Translation: BAC65343.1
AB089307 mRNA Translation: BAC55235.1
AB083601 Genomic DNA Translation: BAB89314.1
AK122658 mRNA Translation: BAG53647.1
AK122660 mRNA Translation: BAG53648.1
CH471063 Genomic DNA Translation: EAW70598.1
BC033625 mRNA Translation: AAH33625.1
CCDSiCCDS46515.1
RefSeqiNP_001070659.1, NM_001077191.1
NP_001070662.1, NM_001077194.1
NP_001308879.1, NM_001321950.1
NP_733800.1, NM_170699.2
XP_011509045.1, XM_011510743.1
XP_016858956.1, XM_017003467.1
XP_016858957.1, XM_017003468.1
XP_016858958.1, XM_017003469.1
UniGeneiHs.160954

3D structure databases

ProteinModelPortaliQ8TDU6
SMRiQ8TDU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TDU6, 8 interactors
STRINGi9606.ENSP00000428824

Chemistry databases

BindingDBiQ8TDU6
ChEMBLiCHEMBL5409
GuidetoPHARMACOLOGYi37
SwissLipidsiSLP:000001566

Protein family/group databases

TCDBi9.A.14.21.1 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPBAR1
DMDMi74762624

Proteomic databases

PaxDbiQ8TDU6
PeptideAtlasiQ8TDU6
PRIDEiQ8TDU6
ProteomicsDBi74340

Protocols and materials databases

DNASUi151306
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000479077; ENSP00000430698; ENSG00000179921
ENST00000519574; ENSP00000430202; ENSG00000179921
ENST00000521462; ENSP00000428824; ENSG00000179921
ENST00000522678; ENSP00000430886; ENSG00000179921
GeneIDi151306
KEGGihsa:151306
UCSCiuc010zjw.1 human

Organism-specific databases

CTDi151306
DisGeNETi151306
EuPathDBiHostDB:ENSG00000179921.14
GeneCardsiGPBAR1
HGNCiHGNC:19680 GPBAR1
HPAiHPA062890
MIMi610147 gene
neXtProtiNX_Q8TDU6
OpenTargetsiENSG00000179921
PharmGKBiPA134903170
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZAJ Eukaryota
ENOG411075X LUCA
GeneTreeiENSGT00390000010256
HOGENOMiHOG000065748
HOVERGENiHBG081571
InParanoidiQ8TDU6
KOiK08400
OMAiDICRLHR
OrthoDBiEOG091G0MRP
PhylomeDBiQ8TDU6
TreeFamiTF333321

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiiG_protein-coupled_bile_acid_receptor
GenomeRNAii151306
PROiPR:Q8TDU6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179921 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExiHS_GPBAR1
GenevisibleiQ8TDU6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPBAR_HUMAN
AccessioniPrimary (citable) accession number: Q8TDU6
Secondary accession number(s): B3KV35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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