GPBAR1

Functionⁱ

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.2 Publications

GO - Molecular functionⁱ

bile acid receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12419312
- 12524422
G-protein coupled bile acid receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 12419312

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface bile acid receptor signaling pathway
Source: UniProtKB
Inferred by curatorⁱ
- 12524422
G-protein coupled receptor signaling pathway Source: Reactome
regulation of bicellular tight junction assembly Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418555 G alpha (s) signalling events

Protein family/group databases

TCDBⁱ

9.A.14.21.1 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipidsⁱ	SLP:000001566

SwissLipidsⁱ

SLP:000001566

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G-protein coupled bile acid receptor 1 Alternative name(s): G-protein coupled receptor GPCR19 Short name: hGPCR19 Membrane-type receptor for bile acids Short name: M-BAR hBG37 Short name: BG37
Gene namesⁱ	Name:GPBAR1 Synonyms:TGR5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179921.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19680 GPBAR1
MIMⁱ	610147 gene
neXtProtⁱ	NX_Q8TDU6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 19	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	20 – 40	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	41 – 50	CytoplasmicSequence analysis	10
Transmembraneⁱ	51 – 71	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	72 – 85	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	86 – 106	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	107 – 125	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	126 – 146	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	147 – 165	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	166 – 186	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	187 – 228	CytoplasmicSequence analysisAdd BLAST	42
Transmembraneⁱ	229 – 249	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	250 – 261	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	262 – 282	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	283 – 330	CytoplasmicSequence analysisAdd BLAST	48

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	151306
Open Targets More...OpenTargetsⁱ	ENSG00000179921
PharmGKBⁱ	PA134903170

Chemistry databases

ChEMBLⁱ	CHEMBL5409
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	37

Polymorphism and mutation databases

BioMutaⁱ	GPBAR1
DMDMⁱ	74762624

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069500	1 – 330	G-protein coupled bile acid receptor 1Add BLAST		330

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	4	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	76	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	85 ↔ 155	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8TDU6
PeptideAtlas More...PeptideAtlasⁱ	Q8TDU6
PRIDEⁱ	Q8TDU6
ProteomicsDBⁱ	74340

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000179921 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_GPBAR1
Genevisibleⁱ	Q8TDU6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA062890

HPAⁱ

HPA062890

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q8TDU6, 8 interactors
STRINGⁱ	9606.ENSP00000428824

Chemistry databases

BindingDBⁱ

Q8TDU6

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TDU6
SMRⁱ	Q8TDU6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IZAJ Eukaryota ENOG411075X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010256
HOGENOMⁱ	HOG000065748
HOVERGENⁱ	HBG081571
InParanoidⁱ	Q8TDU6
KEGG Orthology (KO) More...KOⁱ	K08400
OMAⁱ	DICRLHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MRP
PhylomeDBⁱ	Q8TDU6
TreeFamⁱ	TF333321

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8TDU6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA 
        60         70         80         90        100
GCFFLSLLLA GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL 
       110        120        130        140        150
ANLLLVHGER YMAVLRPLQP PGSIRLALLL TWAGPLLFAS LPALGWNHWT 
       160        170        180        190        200
PGANCSSQAI FPAPYLYLEV YGLLLPAVGA AAFLSVRVLA TAHRQLQDIC 
       210        220        230        240        250
RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY VATLLLSVLA 
       260        270        280        290        300
YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ 
       310        320        330
GLWGRASRDS PGPSIAYHPS SQSSVDLDLN

Length:330

Mass (Da):35,248

Last modified:June 1, 2002 - v1

Checksum:ⁱB3A1AEDADEAFE021

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB086170 mRNA Translation: BAC65343.1 AB089307 mRNA Translation: BAC55235.1 AB083601 Genomic DNA Translation: BAB89314.1 AK122658 mRNA Translation: BAG53647.1 AK122660 mRNA Translation: BAG53648.1 CH471063 Genomic DNA Translation: EAW70598.1 BC033625 mRNA Translation: AAH33625.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46515.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001070659.1, NM_001077191.1 NP_001070662.1, NM_001077194.1 NP_001308879.1, NM_001321950.1 NP_733800.1, NM_170699.2 XP_011509045.1, XM_011510743.1 XP_016858956.1, XM_017003467.1 XP_016858957.1, XM_017003468.1 XP_016858958.1, XM_017003469.1
UniGeneⁱ	Hs.160954

Genome annotation databases

Ensemblⁱ	ENST00000479077; ENSP00000430698; ENSG00000179921 ENST00000519574; ENSP00000430202; ENSG00000179921 ENST00000521462; ENSP00000428824; ENSG00000179921 ENST00000522678; ENSP00000430886; ENSG00000179921
GeneIDⁱ	151306
KEGGⁱ	hsa:151306
UCSC genome browser More...UCSCⁱ	uc010zjw.1 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TDU6	G-protein coupled bile acid receptor 1		MACMU		330	UniRef90_Q8TDU6
Uncharacterized protein		MANLE		330
G protein-coupled bile acid receptor 1		PANTR		330
Uncharacterized protein		MACFA		330
Uncharacterized protein		PANPA		330
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8TDU6	G-protein coupled bile acid receptor 1		BOVIN		329	UniRef50_Q8TDU6
Uncharacterized protein		MANLE		330
G protein-coupled bile acid receptor 1		PANTR		330
G protein-coupled bile acid receptor 1		GORGO		330
Uncharacterized protein		MACFA		330
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB086170 mRNA Translation: BAC65343.1 AB089307 mRNA Translation: BAC55235.1 AB083601 Genomic DNA Translation: BAB89314.1 AK122658 mRNA Translation: BAG53647.1 AK122660 mRNA Translation: BAG53648.1 CH471063 Genomic DNA Translation: EAW70598.1 BC033625 mRNA Translation: AAH33625.1
CCDSⁱ	CCDS46515.1
RefSeqⁱ	NP_001070659.1, NM_001077191.1 NP_001070662.1, NM_001077194.1 NP_001308879.1, NM_001321950.1 NP_733800.1, NM_170699.2 XP_011509045.1, XM_011510743.1 XP_016858956.1, XM_017003467.1 XP_016858957.1, XM_017003468.1 XP_016858958.1, XM_017003469.1
UniGeneⁱ	Hs.160954

3D structure databases

ProteinModelPortalⁱ	Q8TDU6
SMRⁱ	Q8TDU6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8TDU6, 8 interactors
STRINGⁱ	9606.ENSP00000428824

Chemistry databases

BindingDBⁱ	Q8TDU6
ChEMBLⁱ	CHEMBL5409
GuidetoPHARMACOLOGYⁱ	37
SwissLipidsⁱ	SLP:000001566

Protein family/group databases

TCDBⁱ	9.A.14.21.1 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

Polymorphism and mutation databases

BioMutaⁱ	GPBAR1
DMDMⁱ	74762624

Proteomic databases

PaxDbⁱ	Q8TDU6
PeptideAtlasⁱ	Q8TDU6
PRIDEⁱ	Q8TDU6
ProteomicsDBⁱ	74340

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	151306
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000479077; ENSP00000430698; ENSG00000179921 ENST00000519574; ENSP00000430202; ENSG00000179921 ENST00000521462; ENSP00000428824; ENSG00000179921 ENST00000522678; ENSP00000430886; ENSG00000179921
GeneIDⁱ	151306
KEGGⁱ	hsa:151306
UCSCⁱ	uc010zjw.1 human

Organism-specific databases

CTDⁱ	151306
DisGeNETⁱ	151306
EuPathDBⁱ	HostDB:ENSG00000179921.14
GeneCardsⁱ	GPBAR1
HGNCⁱ	HGNC:19680 GPBAR1
HPAⁱ	HPA062890
MIMⁱ	610147 gene
neXtProtⁱ	NX_Q8TDU6
OpenTargetsⁱ	ENSG00000179921
PharmGKBⁱ	PA134903170
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZAJ Eukaryota ENOG411075X LUCA
GeneTreeⁱ	ENSGT00390000010256
HOGENOMⁱ	HOG000065748
HOVERGENⁱ	HBG081571
InParanoidⁱ	Q8TDU6
KOⁱ	K08400
OMAⁱ	DICRLHR
OrthoDBⁱ	EOG091G0MRP
PhylomeDBⁱ	Q8TDU6
TreeFamⁱ	TF333321

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiⁱ	G_protein-coupled_bile_acid_receptor
GenomeRNAiⁱ	151306
Protein Ontology More...PROⁱ	PR:Q8TDU6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179921 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_GPBAR1
Genevisibleⁱ	Q8TDU6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPBAR_HUMAN
Accessionⁱ	Q8TDU6Primary (citable) accession number: Q8TDU6 Secondary accession number(s): B3KV35
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	June 1, 2002
	Last modified:	September 12, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8TDU6 (GPBAR_HUMAN)

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G-protein coupled bile acid receptor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ