UniProtKB - Q8TDU6 (GPBAR_HUMAN)
Protein
G-protein coupled bile acid receptor 1
Gene
GPBAR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.2 Publications
GO - Molecular functioni
- bile acid receptor activity Source: UniProtKB
- G protein-coupled bile acid receptor activity Source: UniProtKB
GO - Biological processi
- cell surface bile acid receptor signaling pathway Source: UniProtKB
- cellular response to bile acid Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- positive regulation of cholangiocyte proliferation Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- regulation of bicellular tight junction assembly Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q8TDU6 |
Reactomei | R-HSA-373076, Class A/1 (Rhodopsin-like receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Protein family/group databases
TCDBi | 9.A.14.21.1, the g-protein-coupled receptor (gpcr) family |
Chemistry databases
SwissLipidsi | SLP:000001566 |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled bile acid receptor 1Alternative name(s): G-protein coupled receptor GPCR19 Short name: hGPCR19 Membrane-type receptor for bile acids Short name: M-BAR hBG37 Short name: BG37 |
Gene namesi | Name:GPBAR1 Synonyms:TGR5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19680, GPBAR1 |
MIMi | 610147, gene |
neXtProti | NX_Q8TDU6 |
VEuPathDBi | HostDB:ENSG00000179921.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 40 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 41 – 50 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 51 – 71 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 72 – 85 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 86 – 106 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 125 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 126 – 146 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 147 – 165 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 166 – 186 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 228 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 229 – 249 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 250 – 261 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 262 – 282 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 283 – 330 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 151306 |
OpenTargetsi | ENSG00000179921 |
PharmGKBi | PA134903170 |
Miscellaneous databases
Pharosi | Q8TDU6, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5409 |
DrugBanki | DB06777, Chenodeoxycholic acid DB02659, Cholic Acid DB03619, Deoxycholic acid |
DrugCentrali | Q8TDU6 |
GuidetoPHARMACOLOGYi | 37 |
Genetic variation databases
BioMutai | GPBAR1 |
DMDMi | 74762624 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069500 | 1 – 330 | G-protein coupled bile acid receptor 1Add BLAST | 330 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 76 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 85 ↔ 155 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8TDU6 |
PeptideAtlasi | Q8TDU6 |
PRIDEi | Q8TDU6 |
ProteomicsDBi | 74340 |
PTM databases
GlyGeni | Q8TDU6, 2 sites |
Expressioni
Tissue specificityi
Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.3 Publications
Gene expression databases
Bgeei | ENSG00000179921, Expressed in monocyte and 102 other tissues |
Genevisiblei | Q8TDU6, HS |
Organism-specific databases
HPAi | ENSG00000179921, Group enriched (blood, gallbladder) |
Interactioni
Protein-protein interaction databases
IntActi | Q8TDU6, 8 interactors |
STRINGi | 9606.ENSP00000430886 |
Chemistry databases
BindingDBi | Q8TDU6 |
Miscellaneous databases
RNActi | Q8TDU6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SQ0C, Eukaryota |
GeneTreei | ENSGT00390000010256 |
HOGENOMi | CLU_895831_0_0_1 |
InParanoidi | Q8TDU6 |
OMAi | DICRLHR |
OrthoDBi | 1173007at2759 |
PhylomeDBi | Q8TDU6 |
TreeFami | TF333321 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8TDU6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA
60 70 80 90 100
GCFFLSLLLA GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL
110 120 130 140 150
ANLLLVHGER YMAVLRPLQP PGSIRLALLL TWAGPLLFAS LPALGWNHWT
160 170 180 190 200
PGANCSSQAI FPAPYLYLEV YGLLLPAVGA AAFLSVRVLA TAHRQLQDIC
210 220 230 240 250
RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY VATLLLSVLA
260 270 280 290 300
YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ
310 320 330
GLWGRASRDS PGPSIAYHPS SQSSVDLDLN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB086170 mRNA Translation: BAC65343.1 AB089307 mRNA Translation: BAC55235.1 AB083601 Genomic DNA Translation: BAB89314.1 AK122658 mRNA Translation: BAG53647.1 AK122660 mRNA Translation: BAG53648.1 CH471063 Genomic DNA Translation: EAW70598.1 BC033625 mRNA Translation: AAH33625.1 |
CCDSi | CCDS46515.1 |
RefSeqi | NP_001070659.1, NM_001077191.1 NP_001070662.1, NM_001077194.1 NP_001308879.1, NM_001321950.1 NP_733800.1, NM_170699.2 XP_011509045.1, XM_011510743.1 XP_016858956.1, XM_017003467.1 XP_016858957.1, XM_017003468.1 XP_016858958.1, XM_017003469.1 |
Genome annotation databases
Ensembli | ENST00000479077; ENSP00000430698; ENSG00000179921 ENST00000519574; ENSP00000430202; ENSG00000179921 ENST00000521462; ENSP00000428824; ENSG00000179921 ENST00000522678; ENSP00000430886; ENSG00000179921 |
GeneIDi | 151306 |
KEGGi | hsa:151306 |
UCSCi | uc010zjw.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB086170 mRNA Translation: BAC65343.1 AB089307 mRNA Translation: BAC55235.1 AB083601 Genomic DNA Translation: BAB89314.1 AK122658 mRNA Translation: BAG53647.1 AK122660 mRNA Translation: BAG53648.1 CH471063 Genomic DNA Translation: EAW70598.1 BC033625 mRNA Translation: AAH33625.1 |
CCDSi | CCDS46515.1 |
RefSeqi | NP_001070659.1, NM_001077191.1 NP_001070662.1, NM_001077194.1 NP_001308879.1, NM_001321950.1 NP_733800.1, NM_170699.2 XP_011509045.1, XM_011510743.1 XP_016858956.1, XM_017003467.1 XP_016858957.1, XM_017003468.1 XP_016858958.1, XM_017003469.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7BW0 | electron microscopy | 3.90 | R | 6-307 | [»] | |
7CFM | electron microscopy | 3.00 | R | 1-330 | [»] | |
7CFN | electron microscopy | 3.00 | R | 1-330 | [»] | |
SMRi | Q8TDU6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q8TDU6, 8 interactors |
STRINGi | 9606.ENSP00000430886 |
Chemistry databases
BindingDBi | Q8TDU6 |
ChEMBLi | CHEMBL5409 |
DrugBanki | DB06777, Chenodeoxycholic acid DB02659, Cholic Acid DB03619, Deoxycholic acid |
DrugCentrali | Q8TDU6 |
GuidetoPHARMACOLOGYi | 37 |
SwissLipidsi | SLP:000001566 |
Protein family/group databases
TCDBi | 9.A.14.21.1, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8TDU6, 2 sites |
Genetic variation databases
BioMutai | GPBAR1 |
DMDMi | 74762624 |
Proteomic databases
PaxDbi | Q8TDU6 |
PeptideAtlasi | Q8TDU6 |
PRIDEi | Q8TDU6 |
ProteomicsDBi | 74340 |
Protocols and materials databases
Antibodypediai | 34258, 299 antibodies |
DNASUi | 151306 |
Genome annotation databases
Ensembli | ENST00000479077; ENSP00000430698; ENSG00000179921 ENST00000519574; ENSP00000430202; ENSG00000179921 ENST00000521462; ENSP00000428824; ENSG00000179921 ENST00000522678; ENSP00000430886; ENSG00000179921 |
GeneIDi | 151306 |
KEGGi | hsa:151306 |
UCSCi | uc010zjw.1, human |
Organism-specific databases
CTDi | 151306 |
DisGeNETi | 151306 |
GeneCardsi | GPBAR1 |
HGNCi | HGNC:19680, GPBAR1 |
HPAi | ENSG00000179921, Group enriched (blood, gallbladder) |
MIMi | 610147, gene |
neXtProti | NX_Q8TDU6 |
OpenTargetsi | ENSG00000179921 |
PharmGKBi | PA134903170 |
VEuPathDBi | HostDB:ENSG00000179921.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SQ0C, Eukaryota |
GeneTreei | ENSGT00390000010256 |
HOGENOMi | CLU_895831_0_0_1 |
InParanoidi | Q8TDU6 |
OMAi | DICRLHR |
OrthoDBi | 1173007at2759 |
PhylomeDBi | Q8TDU6 |
TreeFami | TF333321 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDU6 |
Reactomei | R-HSA-373076, Class A/1 (Rhodopsin-like receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 151306, 5 hits in 871 CRISPR screens |
GeneWikii | G_protein-coupled_bile_acid_receptor |
GenomeRNAii | 151306 |
Pharosi | Q8TDU6, Tchem |
PROi | PR:Q8TDU6 |
RNActi | Q8TDU6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179921, Expressed in monocyte and 102 other tissues |
Genevisiblei | Q8TDU6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPBAR_HUMAN | |
Accessioni | Q8TDU6Primary (citable) accession number: Q8TDU6 Secondary accession number(s): B3KV35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families