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Entry version 128 (17 Jun 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Probable G-protein coupled receptor 152

Gene

GPR152

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable G-protein coupled receptor 152
Alternative name(s):
G-protein coupled receptor PGR5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR152
Synonyms:PGR5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175514.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23622 GPR152

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 65CytoplasmicSequence analysisAdd BLAST11
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 105ExtracellularSequence analysisAdd BLAST19
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 148CytoplasmicSequence analysisAdd BLAST22
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 194ExtracellularSequence analysisAdd BLAST25
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 257CytoplasmicSequence analysisAdd BLAST42
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 281ExtracellularSequence analysis3
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 470CytoplasmicSequence analysisAdd BLAST168

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
390212

Open Targets

More...
OpenTargetsi
ENSG00000175514

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134897297

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TDT2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPR152

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48428096

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696351 – 470Probable G-protein coupled receptor 152Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDT2

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDT2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74338

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175514 Expressed in adrenal gland and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TDT2 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000175514 Tissue enhanced (intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TDT2
With#Exp.IntAct
ABCG4 [Q9H172]3EBI-13345167,EBI-8584118
ABHD16A [O95870]3EBI-13345167,EBI-348517
ACSF2 [Q96CM8]3EBI-13345167,EBI-2876502
ADIPOQ [Q15848]3EBI-13345167,EBI-10827839
AGTRAP - isoform 2 [Q6RW13-2]3EBI-13345167,EBI-11522760
AIG1 - isoform 2 [Q9NVV5-2]3EBI-13345167,EBI-11957045
ANKRD46 - isoform 2 [Q86W74-2]3EBI-13345167,EBI-12109402
APOL3 - isoform 2 [O95236-2]3EBI-13345167,EBI-11976321
AQP10 [Q96PS8]3EBI-13345167,EBI-12820279
AQP3 [Q92482]3EBI-13345167,EBI-2808854
AQP6 [Q13520]3EBI-13345167,EBI-13059134
ARL6IP1 [Q15041]3EBI-13345167,EBI-714543
ARV1 [Q9H2C2]3EBI-13345167,EBI-11724186
ATP6V0C [P27449]3EBI-13345167,EBI-721179
B3GNT7 [Q8NFL0]3EBI-13345167,EBI-17211590
BDNF - isoform 2 [P23560-2]3EBI-13345167,EBI-12275524
BET1 [O15155]3EBI-13345167,EBI-749204
BMP10 [O95393]3EBI-13345167,EBI-3922513
BNIP2 [Q12982]3EBI-13345167,EBI-752094
BNIP3 [Q12983]3EBI-13345167,EBI-749464
C1QL4 [Q86Z23]3EBI-13345167,EBI-12062109
C8A [P07357]3EBI-13345167,EBI-9021639
CCDC167 [Q9P0B6]3EBI-13345167,EBI-9083477
CCL4 [P13236]3EBI-13345167,EBI-2873970
CCL4L2 [Q8NHW4]3EBI-13345167,EBI-10271156
CD53 [P19397]3EBI-13345167,EBI-6657396
CD72 [P21854]3EBI-13345167,EBI-307924
CD81 [P60033]3EBI-13345167,EBI-712921
CDIPT [O14735]3EBI-13345167,EBI-358858
CDS2 [O95674]3EBI-13345167,EBI-3913685
CGRRF1 [Q99675]3EBI-13345167,EBI-2130213
CLDND2 [Q8NHS1]3EBI-13345167,EBI-11959453
CLEC17A [Q6ZS10]3EBI-13345167,EBI-11977093
CLEC1A [Q8NC01]3EBI-13345167,EBI-11996768
CLN5 [A0A024R644]3EBI-13345167,EBI-12838990
CNIH1 [O95406]3EBI-13345167,EBI-12172273
COL8A2 [Q4VAQ0]3EBI-13345167,EBI-10241815
COMT [P21964]3EBI-13345167,EBI-372265
CRISP3 - isoform 2 [P54108-2]3EBI-13345167,EBI-18210151
CSGALNACT2 [Q8N6G5]3EBI-13345167,EBI-10267100
CTXN3 [Q4LDR2]3EBI-13345167,EBI-12019274
CYB561 [P49447]3EBI-13345167,EBI-8646596
CYB561A3 [Q8NBI2]3EBI-13345167,EBI-10269179
CYB5B [O43169]3EBI-13345167,EBI-1058710
CYB5R3 [P00387]3EBI-13345167,EBI-1046040
CYBC1 [Q9BQA9]3EBI-13345167,EBI-2680384
DEFB108B [Q8NET1]3EBI-13345167,EBI-13346443
DGAT2L6 [Q6ZPD8]3EBI-13345167,EBI-12831978
EBP [Q15125]3EBI-13345167,EBI-3915253
EDDM3B [P56851]3EBI-13345167,EBI-10215665
EFNA5 [P52803]3EBI-13345167,EBI-1753674
EMD [P50402]3EBI-13345167,EBI-489887
ERG28 [Q9UKR5]3EBI-13345167,EBI-711490
FA2H [Q7L5A8]3EBI-13345167,EBI-11337888
FAM20B [O75063]3EBI-13345167,EBI-11090967
FAXDC2 [Q96IV6]3EBI-13345167,EBI-12142299
FDFT1 [P37268]3EBI-13345167,EBI-714550
FUNDC2 [Q9BWH2]3EBI-13345167,EBI-714482
FXYD3 - isoform 3 [Q14802-3]3EBI-13345167,EBI-12175685
GAST [P01350]3EBI-13345167,EBI-3436637
GJB2 [P29033]3EBI-13345167,EBI-3905204
GOLT1A [Q6ZVE7]3EBI-13345167,EBI-17231387
GOLT1B [Q9Y3E0]3EBI-13345167,EBI-4402607
GOSR2 [O14653]3EBI-13345167,EBI-4401517
GPR151 [Q8TDV0]3EBI-13345167,EBI-11955647
itself3EBI-13345167,EBI-13345167
GPR37L1 [O60883]3EBI-13345167,EBI-2927498
HHATL [Q9HCP6]3EBI-13345167,EBI-5916693
HMOX1 [P09601]3EBI-13345167,EBI-2806151
HMOX2 [P30519]3EBI-13345167,EBI-712096
IFNA8 [P32881]3EBI-13345167,EBI-18211524
IGF2 - isoform 3 [P01344-3]3EBI-13345167,EBI-13334485
IGFBP5 [P24593]3EBI-13345167,EBI-720480
IL1RL1 - isoform B [Q01638-2]3EBI-13345167,EBI-12838366
INSIG2 [Q9Y5U4]3EBI-13345167,EBI-8503746
JAGN1 [Q8N5M9]3EBI-13345167,EBI-10266796
KCNA1 [Q09470]3EBI-13345167,EBI-8286599
KCNN4 [O15554]3EBI-13345167,EBI-2924473
LAMB1 [P07942]3EBI-13345167,EBI-949174
LAT - isoform 2 [O43561-2]3EBI-13345167,EBI-8070286
LEPROTL1 [O95214]3EBI-13345167,EBI-750776
LHFPL2 [Q6ZUX7]3EBI-13345167,EBI-17566767
LHFPL5 [Q8TAF8]3EBI-13345167,EBI-2820517
LTC4S [Q16873]3EBI-13345167,EBI-12241118
MAL [P21145]3EBI-13345167,EBI-3932027
MAL2 [Q969L2]3EBI-13345167,EBI-944295
MFF - isoform 5 [Q9GZY8-5]3EBI-13345167,EBI-11956541
MFSD5 [Q6N075]3EBI-13345167,EBI-3920969
MFSD6 [Q6ZSS7]3EBI-13345167,EBI-2858252
MGLL [A0A0C4DFN3]3EBI-13345167,EBI-12866138
MGST3 [O14880]3EBI-13345167,EBI-724754
MMD [Q15546]3EBI-13345167,EBI-17873222
MOSPD3 [O75425]3EBI-13345167,EBI-12179105
MS4A13 [Q5J8X5]3EBI-13345167,EBI-12070086
MYADML2 [A6NDP7]3EBI-13345167,EBI-17641390
NAT8 [Q9UHE5]3EBI-13345167,EBI-2863634
NDUFB11 [Q9NX14]3EBI-13345167,EBI-1246182
NEU1 [Q99519]3EBI-13345167,EBI-721517
NINJ2 [Q9NZG7]3EBI-13345167,EBI-10317425
NIPAL4 [Q0D2K0]3EBI-13345167,EBI-9550165
NRAC [Q8N912]3EBI-13345167,EBI-12051377
ORMDL1 [Q9P0S3]3EBI-13345167,EBI-1054848
ORMDL3 [Q8N138]3EBI-13345167,EBI-721750
PEX16 [Q9Y5Y5]3EBI-13345167,EBI-981985
PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-13345167,EBI-12092917
PIGF [Q07326]3EBI-13345167,EBI-17180304
PIN1 [Q13526]3EBI-13345167,EBI-714158
PLN [P26678]3EBI-13345167,EBI-692836
PNLIPRP1 [P54315]3EBI-13345167,EBI-8652812
PRAF2 [O60831]3EBI-13345167,EBI-2506064
PROM2 [Q8N271]3EBI-13345167,EBI-18210782
PTPRN - isoform 3 [Q16849-3]3EBI-13345167,EBI-10200782
RABAC1 [Q9UI14]3EBI-13345167,EBI-712367
RBFA [Q8N0V3]3EBI-13345167,EBI-3232108
REEP6 - isoform 2 [Q96HR9-2]3EBI-13345167,EBI-14065960
ROBO2 [Q9HCK4]3EBI-13345167,EBI-399800
RTN3 - isoform 3 [O95197-3]3EBI-13345167,EBI-11525735
RTP2 [Q5QGT7]3EBI-13345167,EBI-10244780
SACM1L [Q9NTJ5]3EBI-13345167,EBI-3917235
SCAMP4 [Q969E2]3EBI-13345167,EBI-4403649
SCD [O00767]3EBI-13345167,EBI-2684237
SEC22B [O75396]3EBI-13345167,EBI-1058865
SERF1B [O75920]3EBI-13345167,EBI-2115181
SERP2 [Q8N6R1]3EBI-13345167,EBI-749270
SFT2D2 [O95562]3EBI-13345167,EBI-4402330
SFTPC [P11686]3EBI-13345167,EBI-10197617
SLC10A1 [Q14973]3EBI-13345167,EBI-3923031
SLC13A4 [Q9UKG4]3EBI-13345167,EBI-12808018
SLC30A3 [Q99726]3EBI-13345167,EBI-10294651
SLC35A4 [Q96G79]3EBI-13345167,EBI-12363689
SLC35B1 [P78383]3EBI-13345167,EBI-12147661
SLC35B4 [Q969S0]3EBI-13345167,EBI-10281213
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-13345167,EBI-17295964
SLC35F6 [Q8N357]3EBI-13345167,EBI-713484
SLC38A1 [Q9H2H9]3EBI-13345167,EBI-9978441
SLC38A7 [Q9NVC3]3EBI-13345167,EBI-10314552
SLC39A2 [Q9NP94]3EBI-13345167,EBI-12898013
SLC41A1 [Q8IVJ1]3EBI-13345167,EBI-12266234
SLC66A1 - isoform 3 [Q6ZP29-3]3EBI-13345167,EBI-12889586
SLC66A2 [Q8N2U9]3EBI-13345167,EBI-3907610
SLC7A1 [P30825]3EBI-13345167,EBI-4289564
SMCO4 [Q9NRQ5]3EBI-13345167,EBI-8640191
STATH [P02808]3EBI-13345167,EBI-738687
STX1B [P61266]3EBI-13345167,EBI-9071709
STX3 [Q13277]3EBI-13345167,EBI-1394295
STX4 [Q12846]3EBI-13345167,EBI-744942
STX5 [Q13190]3EBI-13345167,EBI-714206
STX8 [Q9UNK0]3EBI-13345167,EBI-727240
SYT15 - isoform 2 [Q9BQS2-2]3EBI-13345167,EBI-13373352
TAP1 [Q03518]3EBI-13345167,EBI-747259
TEX264 [Q9Y6I9]3EBI-13345167,EBI-10329860
TFRC [P02786]3EBI-13345167,EBI-355727
THSD7B [C9JKN6]3EBI-13345167,EBI-17192156
TIMMDC1 [Q9NPL8]3EBI-13345167,EBI-6268651
TM4SF19 [Q96DZ7]3EBI-13345167,EBI-6448756
TMEM100 [Q9NV29]3EBI-13345167,EBI-8644968
TMEM120B [A0PK00]3EBI-13345167,EBI-10171534
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-13345167,EBI-10694905
TMEM140 [Q9NV12]3EBI-13345167,EBI-2844246
TMEM14B [Q9NUH8]3EBI-13345167,EBI-8638294
TMEM14C [Q9P0S9]3EBI-13345167,EBI-2339195
TMEM189-UBE2V1 [I3L0A0]3EBI-13345167,EBI-12213001
TMEM201 - isoform 2 [Q5SNT2-2]3EBI-13345167,EBI-11994282
TMEM208 [Q9BTX3]3EBI-13345167,EBI-12876824
TMEM218 [A2RU14]3EBI-13345167,EBI-10173151
TMEM236 [Q5W0B7]3EBI-13345167,EBI-13378608
TMEM237 - isoform 2 [Q96Q45-2]3EBI-13345167,EBI-10982110
TMEM243 [Q9BU79]3EBI-13345167,EBI-12887458
TMEM254 [Q8TBM7]3EBI-13345167,EBI-11956809
TMEM42 [Q69YG0]3EBI-13345167,EBI-12038591
TMEM50B [P56557]3EBI-13345167,EBI-12366453
TMEM54 [Q969K7]3EBI-13345167,EBI-3922833
TMEM60 [Q9H2L4]3EBI-13345167,EBI-2852148
TMEM97 [Q5BJF2]3EBI-13345167,EBI-12111910
TMPPE [Q6ZT21]3EBI-13345167,EBI-11724433
TNFRSF10C [O14798]3EBI-13345167,EBI-717441
TSNARE1 [A0AVG3]3EBI-13345167,EBI-12003468
TSPAN33 [Q86UF1]3EBI-13345167,EBI-12045841
TSPAN7 [P41732]3EBI-13345167,EBI-1042779
TSPO2 [Q5TGU0]3EBI-13345167,EBI-12195249
UBIAD1 [Q9Y5Z9]3EBI-13345167,EBI-2819725
UNC50 [Q53HI1]3EBI-13345167,EBI-7601760
VAMP1 - isoform 2 [P23763-3]3EBI-13345167,EBI-12097582
VAMP4 [O75379]3EBI-13345167,EBI-744953
VAMP5 [O95183]3EBI-13345167,EBI-10191195
VKORC1 [Q9BQB6]3EBI-13345167,EBI-6256462
YIPF1 [Q9Y548]3EBI-13345167,EBI-7850136
YIPF4 [Q9BSR8]3EBI-13345167,EBI-751253
YIPF6 [Q96EC8]3EBI-13345167,EBI-751210
ZDHHC15 [Q96MV8]3EBI-13345167,EBI-12837904
Q96FB23EBI-13345167,EBI-2857623

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8TDT2, 190 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310255

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TDT2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVEY Eukaryota
ENOG410XYP4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182854

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_587370_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDT2

KEGG Orthology (KO)

More...
KOi
K08436

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYFLWGV

Database of Orthologous Groups

More...
OrthoDBi
1256901at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDT2

TreeFam database of animal gene trees

More...
TreeFami
TF338313

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027313 GPR152_orphan_prd
IPR026234 MRGPCRFAMILY

The PANTHER Classification System

More...
PANTHERi
PTHR11334 PTHR11334, 1 hit
PTHR11334:SF1 PTHR11334:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TDT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTTMEADLG ATGHRPRTEL DDEDSYPQGG WDTVFLVALL LLGLPANGLM
60 70 80 90 100
AWLAGSQARH GAGTRLALLL LSLALSDFLF LAAAAFQILE IRHGGHWPLG
110 120 130 140 150
TAACRFYYFL WGVSYSSGLF LLAALSLDRC LLALCPHWYP GHRPVRLPLW
160 170 180 190 200
VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV ICLDFWDSEE LSLRMLEVLG
210 220 230 240 250
GFLPFLLLLV CHVLTQATAC RTCHRQQQPA ACRGFARVAR TILSAYVVLR
260 270 280 290 300
LPYQLAQLLY LAFLWDVYSG YLLWEALVYS DYLILLNSCL SPFLCLMASA
310 320 330 340 350
DLRTLLRSVL SSFAAALCEE RPGSFTPTEP QTQLDSEGPT LPEPMAEAQS
360 370 380 390 400
QMDPVAQPQV NPTLQPRSDP TAQPQLNPTA QPQSDPTAQP QLNLMAQPQS
410 420 430 440 450
DSVAQPQADT NVQTPAPAAS SVPSPCDEAS PTPSSHPTPG ALEDPATPPA
460 470
SEGESPSSTP PEAAPGAGPT
Length:470
Mass (Da):50,962
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B566AE95D9D79B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059323317L → V. Corresponds to variant dbSNP:rs1638559Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY569571 mRNA Translation: AAS76893.1
AB083620 Genomic DNA Translation: BAB89333.1
AB065853 Genomic DNA Translation: BAC06071.1
BC119779 mRNA Translation: AAI19780.1
BC122869 mRNA Translation: AAI22870.1
AY255600 mRNA Translation: AAO85112.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8165.1

NCBI Reference Sequences

More...
RefSeqi
NP_996880.1, NM_206997.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312457; ENSP00000310255; ENSG00000175514

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
390212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:390212

UCSC genome browser

More...
UCSCi
uc001olm.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569571 mRNA Translation: AAS76893.1
AB083620 Genomic DNA Translation: BAB89333.1
AB065853 Genomic DNA Translation: BAC06071.1
BC119779 mRNA Translation: AAI19780.1
BC122869 mRNA Translation: AAI22870.1
AY255600 mRNA Translation: AAO85112.1
CCDSiCCDS8165.1
RefSeqiNP_996880.1, NM_206997.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8TDT2, 190 interactors
STRINGi9606.ENSP00000310255

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ8TDT2
PhosphoSitePlusiQ8TDT2

Polymorphism and mutation databases

BioMutaiGPR152
DMDMi48428096

Proteomic databases

PaxDbiQ8TDT2
PRIDEiQ8TDT2
ProteomicsDBi74338

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
16520 155 antibodies

The DNASU plasmid repository

More...
DNASUi
390212

Genome annotation databases

EnsembliENST00000312457; ENSP00000310255; ENSG00000175514
GeneIDi390212
KEGGihsa:390212
UCSCiuc001olm.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
390212
DisGeNETi390212
EuPathDBiHostDB:ENSG00000175514.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GPR152
HGNCiHGNC:23622 GPR152
HPAiENSG00000175514 Tissue enhanced (intestine, lymphoid tissue)
neXtProtiNX_Q8TDT2
OpenTargetsiENSG00000175514
PharmGKBiPA134897297

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVEY Eukaryota
ENOG410XYP4 LUCA
GeneTreeiENSGT00950000182854
HOGENOMiCLU_587370_0_0_1
InParanoidiQ8TDT2
KOiK08436
OMAiYYFLWGV
OrthoDBi1256901at2759
PhylomeDBiQ8TDT2
TreeFamiTF338313

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
390212 2 hits in 781 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GPR152

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
390212
PharosiQ8TDT2 Tbio

Protein Ontology

More...
PROi
PR:Q8TDT2
RNActiQ8TDT2 protein

Gene expression databases

BgeeiENSG00000175514 Expressed in adrenal gland and 4 other tissues
ExpressionAtlasiQ8TDT2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027313 GPR152_orphan_prd
IPR026234 MRGPCRFAMILY
PANTHERiPTHR11334 PTHR11334, 1 hit
PTHR11334:SF1 PTHR11334:SF1, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP152_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDT2
Secondary accession number(s): Q0VD88, Q86SM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: June 17, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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