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Protein

Probable G-protein coupled receptor 152

Gene

GPR152

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 152
Alternative name(s):
G-protein coupled receptor PGR5
Gene namesi
Name:GPR152
Synonyms:PGR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175514.2
HGNCiHGNC:23622 GPR152
neXtProtiNX_Q8TDT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 65CytoplasmicSequence analysisAdd BLAST11
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 105ExtracellularSequence analysisAdd BLAST19
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 148CytoplasmicSequence analysisAdd BLAST22
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 194ExtracellularSequence analysisAdd BLAST25
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 257CytoplasmicSequence analysisAdd BLAST42
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 281ExtracellularSequence analysis3
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 470CytoplasmicSequence analysisAdd BLAST168

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175514
PharmGKBiPA134897297

Polymorphism and mutation databases

BioMutaiGPR152
DMDMi48428096

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696351 – 470Probable G-protein coupled receptor 152Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TDT2
PRIDEiQ8TDT2
ProteomicsDBi74338

PTM databases

iPTMnetiQ8TDT2
PhosphoSitePlusiQ8TDT2

Expressioni

Gene expression databases

BgeeiENSG00000175514
CleanExiHS_GPR152
ExpressionAtlasiQ8TDT2 baseline and differential

Organism-specific databases

HPAiHPA035078

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC7A1P308254EBI-13345167,EBI-4289564

Protein-protein interaction databases

IntActiQ8TDT2, 189 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8TDT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEY Eukaryota
ENOG410XYP4 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000112775
HOVERGENiHBG051788
InParanoidiQ8TDT2
KOiK08436
OMAiYYFLWGV
OrthoDBiEOG091G0A6G
PhylomeDBiQ8TDT2
TreeFamiTF338313

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027313 GPR152_orphan_prd
IPR026234 MRGPCRFAMILY
PANTHERiPTHR11334 PTHR11334, 1 hit
PTHR11334:SF1 PTHR11334:SF1, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TDT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTMEADLG ATGHRPRTEL DDEDSYPQGG WDTVFLVALL LLGLPANGLM
60 70 80 90 100
AWLAGSQARH GAGTRLALLL LSLALSDFLF LAAAAFQILE IRHGGHWPLG
110 120 130 140 150
TAACRFYYFL WGVSYSSGLF LLAALSLDRC LLALCPHWYP GHRPVRLPLW
160 170 180 190 200
VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV ICLDFWDSEE LSLRMLEVLG
210 220 230 240 250
GFLPFLLLLV CHVLTQATAC RTCHRQQQPA ACRGFARVAR TILSAYVVLR
260 270 280 290 300
LPYQLAQLLY LAFLWDVYSG YLLWEALVYS DYLILLNSCL SPFLCLMASA
310 320 330 340 350
DLRTLLRSVL SSFAAALCEE RPGSFTPTEP QTQLDSEGPT LPEPMAEAQS
360 370 380 390 400
QMDPVAQPQV NPTLQPRSDP TAQPQLNPTA QPQSDPTAQP QLNLMAQPQS
410 420 430 440 450
DSVAQPQADT NVQTPAPAAS SVPSPCDEAS PTPSSHPTPG ALEDPATPPA
460 470
SEGESPSSTP PEAAPGAGPT
Length:470
Mass (Da):50,962
Last modified:June 1, 2002 - v1
Checksum:i8B566AE95D9D79B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059323317L → V. Corresponds to variant dbSNP:rs1638559Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569571 mRNA Translation: AAS76893.1
AB083620 Genomic DNA Translation: BAB89333.1
AB065853 Genomic DNA Translation: BAC06071.1
BC119779 mRNA Translation: AAI19780.1
BC122869 mRNA Translation: AAI22870.1
AY255600 mRNA Translation: AAO85112.1
CCDSiCCDS8165.1
RefSeqiNP_996880.1, NM_206997.1
UniGeneiHs.567997

Genome annotation databases

EnsembliENST00000312457; ENSP00000310255; ENSG00000175514
GeneIDi390212
KEGGihsa:390212
UCSCiuc001olm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGP152_HUMAN
AccessioniPrimary (citable) accession number: Q8TDT2
Secondary accession number(s): Q0VD88, Q86SM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: July 18, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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