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Protein

T-complex protein 10A homolog 1

Gene

TCP10L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB
  • repressing transcription factor binding Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 10A homolog 1
Short name:
T-complex protein 10A-1
Short name:
TCP10A-1
Alternative name(s):
TCP10-like
Gene namesi
Name:TCP10L
ORF Names:PRED77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000242220.6
HGNCiHGNC:11657 TCP10L
MIMi608365 gene
neXtProtiNX_Q8TDR4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82L → F: Greatly decreases in vitro transcription inhibition activity. 1 Publication1
Mutagenesisi89L → P: Disrupts self-association. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

OpenTargetsiENSG00000242220
PharmGKBiPA36408

Polymorphism and mutation databases

BioMutaiTCP10L
DMDMi23822246

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724621 – 215T-complex protein 10A homolog 1Add BLAST215

Proteomic databases

PaxDbiQ8TDR4
PeptideAtlasiQ8TDR4
PRIDEiQ8TDR4
ProteomicsDBi74333

PTM databases

iPTMnetiQ8TDR4
PhosphoSitePlusiQ8TDR4

Expressioni

Tissue specificityi

Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000242220 Expressed in 88 organ(s), highest expression level in right testis
CleanExiHS_TCP10L
ExpressionAtlasiQ8TDR4 baseline and differential
GenevisibleiQ8TDR4 HS

Organism-specific databases

HPAiHPA044709

Interactioni

Subunit structurei

Self-associates (via leucine zipper). Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper). Interacts with MAD4.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126602, 45 interactors
IntActiQ8TDR4, 24 interactors
STRINGi9606.ENSP00000300258

Structurei

3D structure databases

ProteinModelPortaliQ8TDR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 96Leucine-zipperAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 110Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the TCP10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410KII0 Eukaryota
ENOG4110Q7Q LUCA
GeneTreeiENSGT00530000064597
HOGENOMiHOG000136328
HOVERGENiHBG082781
InParanoidiQ8TDR4
OMAiTPCAERR
OrthoDBiEOG091G00Z1
PhylomeDBiQ8TDR4

Family and domain databases

InterProiView protein in InterPro
IPR026581 TCP10_fam
PANTHERiPTHR10331 PTHR10331, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8TDR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAGQLEARD PKEGTHPEDP CPGAGAVMEK TAVAAEVLTE DCNTGEMPPL
60 70 80 90 100
QQQIIRLHQE LGRQKSLWAD VHGKLRSHID ALREQNMELR EKLRALQLQR
110 120 130 140 150
WKARKKSAAS PHAGQESHTL ALEPAFGKIS PLSADEETIP KYAGHKNQSA
160 170 180 190 200
TLLGQRSSSN NSAPPKPMSL KIERISSWKT PPQENRDKNL SRRRQDRRAT
210
PTGRPTPCAE RRGGV
Length:215
Mass (Da):23,863
Last modified:June 1, 2002 - v1
Checksum:iCF3F74AB520F55FE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTL9J3KTL9_HUMAN
T-complex protein 10A homolog 1
TCP10L
191Annotation score:
V9GY77V9GY77_HUMAN
T-complex protein 10A homolog 1
TCP10L
129Annotation score:
V9GYF3V9GYF3_HUMAN
T-complex protein 10A homolog 1
TCP10L
108Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016099145H → R2 PublicationsCorresponds to variant dbSNP:rs9622Ensembl.1
Natural variantiVAR_049089194R → H. Corresponds to variant dbSNP:rs16989521Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115967 mRNA Translation: AAM18531.1
AK058078 mRNA Translation: BAB71653.1
AK223529 mRNA Translation: BAD97249.1
AP001714 Genomic DNA No translation available.
BC033855 mRNA Translation: AAH33855.1
CCDSiCCDS13616.1
RefSeqiNP_653260.1, NM_144659.5
UniGeneiHs.728804

Genome annotation databases

EnsembliENST00000300258; ENSP00000300258; ENSG00000242220
GeneIDi140290
KEGGihsa:140290
UCSCiuc002ypw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115967 mRNA Translation: AAM18531.1
AK058078 mRNA Translation: BAB71653.1
AK223529 mRNA Translation: BAD97249.1
AP001714 Genomic DNA No translation available.
BC033855 mRNA Translation: AAH33855.1
CCDSiCCDS13616.1
RefSeqiNP_653260.1, NM_144659.5
UniGeneiHs.728804

3D structure databases

ProteinModelPortaliQ8TDR4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126602, 45 interactors
IntActiQ8TDR4, 24 interactors
STRINGi9606.ENSP00000300258

PTM databases

iPTMnetiQ8TDR4
PhosphoSitePlusiQ8TDR4

Polymorphism and mutation databases

BioMutaiTCP10L
DMDMi23822246

Proteomic databases

PaxDbiQ8TDR4
PeptideAtlasiQ8TDR4
PRIDEiQ8TDR4
ProteomicsDBi74333

Protocols and materials databases

DNASUi140290
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300258; ENSP00000300258; ENSG00000242220
GeneIDi140290
KEGGihsa:140290
UCSCiuc002ypw.5 human

Organism-specific databases

CTDi140290
EuPathDBiHostDB:ENSG00000242220.6
GeneCardsiTCP10L
HGNCiHGNC:11657 TCP10L
HPAiHPA044709
MIMi608365 gene
neXtProtiNX_Q8TDR4
OpenTargetsiENSG00000242220
PharmGKBiPA36408
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KII0 Eukaryota
ENOG4110Q7Q LUCA
GeneTreeiENSGT00530000064597
HOGENOMiHOG000136328
HOVERGENiHBG082781
InParanoidiQ8TDR4
OMAiTPCAERR
OrthoDBiEOG091G00Z1
PhylomeDBiQ8TDR4

Miscellaneous databases

GeneWikiiTCP10L
GenomeRNAii140290
PROiPR:Q8TDR4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242220 Expressed in 88 organ(s), highest expression level in right testis
CleanExiHS_TCP10L
ExpressionAtlasiQ8TDR4 baseline and differential
GenevisibleiQ8TDR4 HS

Family and domain databases

InterProiView protein in InterPro
IPR026581 TCP10_fam
PANTHERiPTHR10331 PTHR10331, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCP1L_HUMAN
AccessioniPrimary (citable) accession number: Q8TDR4
Secondary accession number(s): Q53EW0, Q96LN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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