UniProtKB - Q8TDR0 (MIPT3_HUMAN)
TRAF3-interacting protein 1
TRAF3IP1
Functioni
Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268).
Involved in ciliogenesis (By similarity).
By similarity4 PublicationsGO - Molecular functioni
- microtubule binding Source: InterPro
GO - Biological processi
- cilium assembly Source: GO_Central
- intraciliary transport Source: GO_Central
- kidney development Source: UniProtKB
- morphogenesis of a polarized epithelium Source: UniProtKB
- negative regulation of defense response to virus Source: CACAO
- negative regulation of protein-containing complex assembly Source: CACAO
- negative regulation of protein phosphorylation Source: CACAO
- negative regulation of type I interferon production Source: CACAO
- regulation of microtubule cytoskeleton organization Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q8TDR0 |
Reactomei | R-HSA-5620924, Intraflagellar transport |
SignaLinki | Q8TDR0 |
Names & Taxonomyi
Protein namesi | Recommended name: TRAF3-interacting protein 1Alternative name(s): Interleukin-13 receptor alpha 1-binding protein 1 Intraflagellar transport protein 54 homolog Microtubule-interacting protein associated with TRAF3 Short name: MIP-T3 |
Gene namesi | Name:TRAF3IP1 Synonyms:IFT54, MIPT3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17861, TRAF3IP1 |
MIMi | 607380, gene |
neXtProti | NX_Q8TDR0 |
VEuPathDBi | HostDB:ENSG00000204104 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
- cilium axoneme By similarity
- cilium basal body By similarity
Other locations
- cilium 1 Publication
Note: Microtubules (PubMed:12935900). In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip (PubMed:26487268).2 Publications
Cytoskeleton
- axoneme Source: GO_Central
- centrosome Source: GO_Central
- ciliary basal body Source: GO_Central
Other locations
- ciliary base Source: UniProtKB
- ciliary tip Source: UniProtKB
- ciliary transition zone Source: UniProtKB
- cilium Source: Reactome
- intraciliary transport particle B Source: ComplexPortal
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Senior-Loken syndrome 9 (SLSN9)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075068 | 17 | I → S in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 Publication | 1 | |
Natural variantiVAR_075069 | 125 | V → A in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037896EnsemblClinVar. | 1 | |
Natural variantiVAR_075070 | 125 | V → M in SLSN9; results in altered folding of the N-terminus; does not localize to the ciliary tip and transition zone; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037898EnsemblClinVar. | 1 | |
Natural variantiVAR_075071 | 520 | M → R in SLSN9; does not localize to the ciliary tip. 1 PublicationCorresponds to variant dbSNP:rs750055952EnsemblClinVar. | 1 |
Keywords - Diseasei
Ciliopathy, Disease variant, Leber congenital amaurosis, Nephronophthisis, Senior-Loken syndromeOrganism-specific databases
DisGeNETi | 26146 |
MalaCardsi | TRAF3IP1 |
MIMi | 616629, phenotype |
OpenTargetsi | ENSG00000204104 |
Orphaneti | 3156, Senior-Loken syndrome 93269, Short rib-polydactyly syndrome, Majewski type |
PharmGKBi | PA134943602 |
Miscellaneous databases
Pharosi | Q8TDR0, Tbio |
Genetic variation databases
BioMutai | TRAF3IP1 |
DMDMi | 74727348 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299544 | 1 – 691 | TRAF3-interacting protein 1Add BLAST | 691 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 317 | PhosphoserineBy similarity | 1 | |
Modified residuei | 476 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8TDR0 |
jPOSTi | Q8TDR0 |
MassIVEi | Q8TDR0 |
MaxQBi | Q8TDR0 |
PaxDbi | Q8TDR0 |
PeptideAtlasi | Q8TDR0 |
PRIDEi | Q8TDR0 |
ProteomicsDBi | 74330 [Q8TDR0-1] 74331 [Q8TDR0-2] |
PTM databases
GlyGeni | Q8TDR0, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q8TDR0 |
PhosphoSitePlusi | Q8TDR0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000204104, Expressed in testis and 219 other tissues |
ExpressionAtlasi | Q8TDR0, baseline and differential |
Genevisiblei | Q8TDR0, HS |
Organism-specific databases
HPAi | ENSG00000204104, Low tissue specificity |
Interactioni
Subunit structurei
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88.
Interacts with IFT88 (By similarity).
Interacts with IL13RA1 (PubMed:10791955). Binds to microtubules, TRAF3 and DISC1 (PubMed:12812986, PubMed:12935900).
Interacts with MAP4 (By similarity).
By similarity3 PublicationsBinary interactionsi
Q8TDR0
With | #Exp. | IntAct |
---|---|---|
DISC1 [Q9NRI5] | 11 | EBI-928811,EBI-529989 |
HSPA8 [P11142] | 3 | EBI-928811,EBI-351896 |
IL13RA1 [P78552] | 3 | EBI-928811,EBI-1391535 |
TRAF3 [Q13114] | 8 | EBI-928811,EBI-357631 |
Isoform 2 [Q8TDR0-2]
With | #Exp. | IntAct |
---|---|---|
SGF29 [Q96ES7] | 3 | EBI-11946508,EBI-743117 |
GO - Molecular functioni
- microtubule binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 117577, 92 interactors |
ComplexPortali | CPX-5022, IFT-B complex |
CORUMi | Q8TDR0 |
IntActi | Q8TDR0, 133 interactors |
STRINGi | 9606.ENSP00000362424 |
Miscellaneous databases
RNActi | Q8TDR0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8TDR0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TDR0 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 323 | Abolishes microtubules-binding when missingAdd BLAST | 323 | |
Regioni | 136 – 508 | DisorderedSequence analysisAdd BLAST | 373 | |
Regioni | 223 – 691 | DISC1-interaction domainAdd BLAST | 469 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 571 – 666 | Sequence analysisAdd BLAST | 96 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 149 – 332 | Basic and acidic residuesSequence analysisAdd BLAST | 184 | |
Compositional biasi | 347 – 363 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 364 – 420 | Polar residuesSequence analysisAdd BLAST | 57 | |
Compositional biasi | 480 – 498 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3809, Eukaryota |
GeneTreei | ENSGT00720000108822 |
HOGENOMi | CLU_023216_0_0_1 |
InParanoidi | Q8TDR0 |
OMAi | FLQKMID |
OrthoDBi | 1008610at2759 |
PhylomeDBi | Q8TDR0 |
TreeFami | TF315473 |
Family and domain databases
Gene3Di | 1.10.418.50, 1 hit |
InterProi | View protein in InterPro IPR018799, TRAF3IP1 IPR041476, TRAF3IP1_C IPR040468, TRAF3IP1_N IPR042576, TRAF3IP1_N_sf |
PANTHERi | PTHR31363, PTHR31363, 1 hit |
Pfami | View protein in Pfam PF10243, MIP-T3, 1 hit PF17749, MIP-T3_C, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK
60 70 80 90 100
GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE
110 120 130 140 150
PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD
160 170 180 190 200
NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD
210 220 230 240 250
KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD RDSERKKETE
260 270 280 290 300
RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD
310 320 330 340 350
KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK
360 370 380 390 400
NSVEGRKEDN ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD
410 420 430 440 450
DNSASLRCEN IQPNPTEKQK GDSTSDAEGD AGPAGQDKSE VPETPEIPNE
460 470 480 490 500
LSSNIRRIPR PGSARPAPPR VKRQDSMEAL QMDRSGSGKT VSNVITESHN
510 520 530 540 550
SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL VKKILETKKD
560 570 580 590 600
YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL
610 620 630 640 650
GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL
660 670 680 690
AELEQLIKDQ QDKICAVKAN ILKNEEKIQK MVYSINLTSR R
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7BZ10 | H7BZ10_HUMAN | TRAF3-interacting protein 1 | TRAF3IP1 | 52 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075068 | 17 | I → S in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 Publication | 1 | |
Natural variantiVAR_075069 | 125 | V → A in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037896EnsemblClinVar. | 1 | |
Natural variantiVAR_075070 | 125 | V → M in SLSN9; results in altered folding of the N-terminus; does not localize to the ciliary tip and transition zone; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037898EnsemblClinVar. | 1 | |
Natural variantiVAR_034841 | 228 | N → S1 PublicationCorresponds to variant dbSNP:rs3769110Ensembl. | 1 | |
Natural variantiVAR_034842 | 239 | R → W. Corresponds to variant dbSNP:rs34723381Ensembl. | 1 | |
Natural variantiVAR_051185 | 295 | K → N. Corresponds to variant dbSNP:rs12464423Ensembl. | 1 | |
Natural variantiVAR_061685 | 416 | T → S. Corresponds to variant dbSNP:rs58277463Ensembl. | 1 | |
Natural variantiVAR_075071 | 520 | M → R in SLSN9; does not localize to the ciliary tip. 1 PublicationCorresponds to variant dbSNP:rs750055952EnsemblClinVar. | 1 | |
Natural variantiVAR_034843 | 620 | M → L. Corresponds to variant dbSNP:rs3739070EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027734 | 355 – 420 | Missing in isoform 2. 3 PublicationsAdd BLAST | 66 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230877 mRNA Translation: AAF76984.1 AF242456 mRNA Translation: AAL90444.1 AC012485 Genomic DNA Translation: AAX88977.1 CH471063 Genomic DNA Translation: EAW71157.1 BC059174 mRNA Translation: AAH59174.1 AL080153 mRNA Translation: CAB45744.1 |
CCDSi | CCDS33415.1 [Q8TDR0-1] CCDS46557.1 [Q8TDR0-2] |
PIRi | T12536 |
RefSeqi | NP_001132962.1, NM_001139490.1 [Q8TDR0-2] NP_056465.2, NM_015650.3 [Q8TDR0-1] |
Genome annotation databases
Ensembli | ENST00000373327; ENSP00000362424; ENSG00000204104 ENST00000391993; ENSP00000375851; ENSG00000204104 [Q8TDR0-2] |
GeneIDi | 26146 |
KEGGi | hsa:26146 |
MANE-Selecti | ENST00000373327.5; ENSP00000362424.4; NM_015650.4; NP_056465.2 |
UCSCi | uc002vye.4, human [Q8TDR0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF230877 mRNA Translation: AAF76984.1 AF242456 mRNA Translation: AAL90444.1 AC012485 Genomic DNA Translation: AAX88977.1 CH471063 Genomic DNA Translation: EAW71157.1 BC059174 mRNA Translation: AAH59174.1 AL080153 mRNA Translation: CAB45744.1 |
CCDSi | CCDS33415.1 [Q8TDR0-1] CCDS46557.1 [Q8TDR0-2] |
PIRi | T12536 |
RefSeqi | NP_001132962.1, NM_001139490.1 [Q8TDR0-2] NP_056465.2, NM_015650.3 [Q8TDR0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EQO | NMR | - | A | 1-133 | [»] | |
SMRi | Q8TDR0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117577, 92 interactors |
ComplexPortali | CPX-5022, IFT-B complex |
CORUMi | Q8TDR0 |
IntActi | Q8TDR0, 133 interactors |
STRINGi | 9606.ENSP00000362424 |
PTM databases
GlyGeni | Q8TDR0, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q8TDR0 |
PhosphoSitePlusi | Q8TDR0 |
Genetic variation databases
BioMutai | TRAF3IP1 |
DMDMi | 74727348 |
Proteomic databases
EPDi | Q8TDR0 |
jPOSTi | Q8TDR0 |
MassIVEi | Q8TDR0 |
MaxQBi | Q8TDR0 |
PaxDbi | Q8TDR0 |
PeptideAtlasi | Q8TDR0 |
PRIDEi | Q8TDR0 |
ProteomicsDBi | 74330 [Q8TDR0-1] 74331 [Q8TDR0-2] |
Protocols and materials databases
Antibodypediai | 34501, 231 antibodies from 28 providers |
DNASUi | 26146 |
Genome annotation databases
Ensembli | ENST00000373327; ENSP00000362424; ENSG00000204104 ENST00000391993; ENSP00000375851; ENSG00000204104 [Q8TDR0-2] |
GeneIDi | 26146 |
KEGGi | hsa:26146 |
MANE-Selecti | ENST00000373327.5; ENSP00000362424.4; NM_015650.4; NP_056465.2 |
UCSCi | uc002vye.4, human [Q8TDR0-1] |
Organism-specific databases
CTDi | 26146 |
DisGeNETi | 26146 |
GeneCardsi | TRAF3IP1 |
HGNCi | HGNC:17861, TRAF3IP1 |
HPAi | ENSG00000204104, Low tissue specificity |
MalaCardsi | TRAF3IP1 |
MIMi | 607380, gene 616629, phenotype |
neXtProti | NX_Q8TDR0 |
OpenTargetsi | ENSG00000204104 |
Orphaneti | 3156, Senior-Loken syndrome 93269, Short rib-polydactyly syndrome, Majewski type |
PharmGKBi | PA134943602 |
VEuPathDBi | HostDB:ENSG00000204104 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3809, Eukaryota |
GeneTreei | ENSGT00720000108822 |
HOGENOMi | CLU_023216_0_0_1 |
InParanoidi | Q8TDR0 |
OMAi | FLQKMID |
OrthoDBi | 1008610at2759 |
PhylomeDBi | Q8TDR0 |
TreeFami | TF315473 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDR0 |
Reactomei | R-HSA-5620924, Intraflagellar transport |
SignaLinki | Q8TDR0 |
Miscellaneous databases
BioGRID-ORCSi | 26146, 17 hits in 1049 CRISPR screens |
ChiTaRSi | TRAF3IP1, human |
EvolutionaryTracei | Q8TDR0 |
GenomeRNAii | 26146 |
Pharosi | Q8TDR0, Tbio |
PROi | PR:Q8TDR0 |
RNActi | Q8TDR0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204104, Expressed in testis and 219 other tissues |
ExpressionAtlasi | Q8TDR0, baseline and differential |
Genevisiblei | Q8TDR0, HS |
Family and domain databases
Gene3Di | 1.10.418.50, 1 hit |
InterProi | View protein in InterPro IPR018799, TRAF3IP1 IPR041476, TRAF3IP1_C IPR040468, TRAF3IP1_N IPR042576, TRAF3IP1_N_sf |
PANTHERi | PTHR31363, PTHR31363, 1 hit |
Pfami | View protein in Pfam PF10243, MIP-T3, 1 hit PF17749, MIP-T3_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MIPT3_HUMAN | |
Accessioni | Q8TDR0Primary (citable) accession number: Q8TDR0 Secondary accession number(s): Q6PCT1 Q9Y4Q1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families