UniProtKB - Q8TDR0 (MIPT3_HUMAN)

BLAST

>sp|Q8TDR0|MIPT3_HUMAN TRAF3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TRAF3IP1 PE=1 SV=1
MNAAVVRRTQEALGKVIRRPPLTEKLLSKPPFRYLHDIITEVIRMTGFMKGLYTDAEMKS
DNVKDKDAKISFLQKAIDVVVMVSGEPLLAKPARIVAGHEPERTNELLQIIGKCCLNKLS
SDDAVRRVLAGEKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSR
DRKQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERD
RDSERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHD
KPEKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVEGRKEDN
ISAKSLDSIVSGINNEPNQETTTSEIGTKEANINSTSISDDNSASLRCENIQPNPTEKQK
GDSTSDAEGDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEAL
QMDRSGSGKTVSNVITESHNSDNEEDDQFVVEAAPQLSEMSEIEMVTAVELEEEEKHGGL
VKKILETKKDYEKLQQSPKPGEKERSLFESAWKKEKDIVSKEIEKLRTSIQTLCKSALPL
GKIMDYIQEDVDAMQNELQMWHSENRQHAEALQQEQRITDCAVEPLKAELAELEQLIKDQ
QDKICAVKANILKNEEKIQKMVYSINLTSRR

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History
Entry version 128 (07 Nov 2018)
Sequence version 1 (01 Jun 2002)
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Protein

TRAF3-interacting protein 1

Gene

TRAF3IP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).By similarity4 Publications

GO - Molecular functionⁱ

microtubule binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

embryonic camera-type eye development Source: Ensembl
embryonic digit morphogenesis Source: Ensembl
embryonic heart tube development Source: Ensembl
intraciliary transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intraciliary transport involved in cilium assembly Source: Reactome
kidney development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26487268
morphogenesis of a polarized epithelium
Source: UniProtKB
Inferred from direct assayⁱ
- 26487268
negative regulation of defense response to virus
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22079989
negative regulation of interferon-beta production Source: Ensembl
negative regulation of protein complex assembly
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22079989
negative regulation of protein phosphorylation
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22079989
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
negative regulation of type I interferon production
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22079989
neural tube patterning Source: Ensembl
post-anal tail morphogenesis Source: Ensembl
regulation of microtubule cytoskeleton organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26487268

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation

Biological process

Cilium biogenesis/degradation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5620924 Intraflagellar transport

Reactomeⁱ

R-HSA-5620924 Intraflagellar transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TRAF3-interacting protein 1 Alternative name(s): Interleukin-13 receptor alpha 1-binding protein 1 Intraflagellar transport protein 54 homolog Microtubule-interacting protein associated with TRAF3 Short name: MIP-T3
Gene namesⁱ	Name:TRAF3IP1 Synonyms:IFT54, MIPT3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204104.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17861 TRAF3IP1
MIMⁱ	607380 gene
neXtProtⁱ	NX_Q8TDR0

Keywords - Cellular componentⁱ

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Senior-Loken syndrome 9 (SLSN9)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life.

Keywords - Diseaseⁱ

Ciliopathy, Disease mutation, Leber congenital amaurosis, Nephronophthisis, Senior-Loken syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26146
MalaCards human disease database More...MalaCardsⁱ	TRAF3IP1
MIMⁱ	616629 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000204104
Orphanetⁱ	3156 Senior-Loken syndrome 93269 Short rib-polydactyly syndrome, Majewski type
PharmGKBⁱ	PA134943602

Polymorphism and mutation databases

BioMutaⁱ	TRAF3IP1
DMDMⁱ	74727348

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000299544	1 – 691	TRAF3-interacting protein 1Add BLAST		691

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	317	PhosphoserineBy similarity		1
Modified residueⁱ	476	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8TDR0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TDR0
PaxDbⁱ	Q8TDR0
PeptideAtlas More...PeptideAtlasⁱ	Q8TDR0
PRIDEⁱ	Q8TDR0
ProteomicsDBⁱ	74330 74331 [Q8TDR0-2]

PTM databases

GlyConnectⁱ	1828
iPTMnetⁱ	Q8TDR0
PhosphoSitePlusⁱ	Q8TDR0

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000204104 Expressed in 203 organ(s), highest expression level in testis
CleanExⁱ	HS_TRAF3IP1
ExpressionAtlasⁱ	Q8TDR0 baseline and differential
Genevisibleⁱ	Q8TDR0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037857 HPA037858

HPAⁱ

HPA037857
HPA037858

Interactionⁱ

Subunit structureⁱ

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity). Interacts with IL13RA1 (PubMed:10791955). Binds to microtubules, TRAF3 and DISC1 (PubMed:12812986, PubMed:12935900). Interacts with MAP4 (By similarity).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DISC1	Q9NRI5	10	EBI-928811,EBI-529989
IL13RA1	P78552	3	EBI-928811,EBI-1391535
TRAF3	Q13114	8	EBI-928811,EBI-357631

GO - Molecular functionⁱ

microtubule binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117577, 85 interactors
CORUMⁱ	Q8TDR0
IntActⁱ	Q8TDR0, 68 interactors
STRINGⁱ	9606.ENSP00000362424

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 16	Combined sources	13
Turnⁱ	24 – 28	Combined sources	5
Helixⁱ	32 – 45	Combined sources	14
Turnⁱ	50 – 52	Combined sources	3
Helixⁱ	55 – 58	Combined sources	4
Helixⁱ	60 – 62	Combined sources	3
Helixⁱ	66 – 84	Combined sources	19
Helixⁱ	92 – 95	Combined sources	4
Turnⁱ	96 – 98	Combined sources	3
Helixⁱ	101 – 116	Combined sources	16
Helixⁱ	123 – 130	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8TDR0
SMRⁱ	Q8TDR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8TDR0

EvolutionaryTraceⁱ

Q8TDR0

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 323	Abolishes microtubules-binding when missingAdd BLAST		323
Regionⁱ	223 – 691	DISC1-interaction domainAdd BLAST		469

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	571 – 666	Sequence analysisAdd BLAST		96

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	211 – 281	Arg-richAdd BLAST		71

Sequence similaritiesⁱ

Belongs to the TRAF3IP1 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3809 Eukaryota ENOG410ZHUT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00720000108822
HOGENOMⁱ	HOG000007159
HOVERGENⁱ	HBG101388
InParanoidⁱ	Q8TDR0
KEGG Orthology (KO) More...KOⁱ	K19680
OMAⁱ	FLQKMID
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DXC
PhylomeDBⁱ	Q8TDR0
TreeFamⁱ	TF315473

Family and domain databases

InterProⁱ	View protein in InterPro IPR018799 TRAF3IP1
PANTHERⁱ	PTHR31363 PTHR31363, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TDR0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK 
        60         70         80         90        100
GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE 
       110        120        130        140        150
PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD 
       160        170        180        190        200
NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD 
       210        220        230        240        250
KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD RDSERKKETE 
       260        270        280        290        300
RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD 
       310        320        330        340        350
KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK 
       360        370        380        390        400
NSVEGRKEDN ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD 
       410        420        430        440        450
DNSASLRCEN IQPNPTEKQK GDSTSDAEGD AGPAGQDKSE VPETPEIPNE 
       460        470        480        490        500
LSSNIRRIPR PGSARPAPPR VKRQDSMEAL QMDRSGSGKT VSNVITESHN 
       510        520        530        540        550
SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL VKKILETKKD 
       560        570        580        590        600
YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL 
       610        620        630        640        650
GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL 
       660        670        680        690 
AELEQLIKDQ QDKICAVKAN ILKNEEKIQK MVYSINLTSR R

Length:691

Mass (Da):78,632

Last modified:June 1, 2002 - v1

Checksum:ⁱ0675AA0E5319D2EB

Isoform 2 (identifier: Q8TDR0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
355-420: Missing.

« Hide

        10         20         30         40         50
MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK 
        60         70         80         90        100
GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE 
       110        120        130        140        150
PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD 
       160        170        180        190        200
NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD 
       210        220        230        240        250
KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD RDSERKKETE 
       260        270        280        290        300
RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD 
       310        320        330        340        350
KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK 
       360        370        380        390        400
NSVEGDSTSD AEGDAGPAGQ DKSEVPETPE IPNELSSNIR RIPRPGSARP 
       410        420        430        440        450
APPRVKRQDS MEALQMDRSG SGKTVSNVIT ESHNSDNEED DQFVVEAAPQ 
       460        470        480        490        500
LSEMSEIEMV TAVELEEEEK HGGLVKKILE TKKDYEKLQQ SPKPGEKERS 
       510        520        530        540        550
LFESAWKKEK DIVSKEIEKL RTSIQTLCKS ALPLGKIMDY IQEDVDAMQN 
       560        570        580        590        600
ELQMWHSENR QHAEALQQEQ RITDCAVEPL KAELAELEQL IKDQQDKICA 
       610        620 
VKANILKNEE KIQKMVYSIN LTSRR

Show »

Length:625

Mass (Da):71,529

Checksum:ⁱFDF49249C140E026

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7BZ10	H7BZ10_HUMAN		TRAF3-interacting protein 1 TRAF3-interacting protein 1	TRAF3IP1	52	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_075068	17	I → S in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 Publication	1
Natural variantⁱVAR_075069	125	V → A in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037896EnsemblClinVar.	1
Natural variantⁱVAR_075070	125	V → M in SLSN9; results in altered folding of the N-terminus; does not localize to the ciliary tip and transition zone; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037898EnsemblClinVar.	1
Natural variantⁱVAR_034841	228	N → S1 PublicationCorresponds to variant dbSNP:rs3769110Ensembl.	1
Natural variantⁱVAR_034842	239	R → W. Corresponds to variant dbSNP:rs34723381Ensembl.	1
Natural variantⁱVAR_051185	295	K → N. Corresponds to variant dbSNP:rs12464423Ensembl.	1
Natural variantⁱVAR_061685	416	T → S. Corresponds to variant dbSNP:rs58277463Ensembl.	1
Natural variantⁱVAR_075071	520	M → R in SLSN9; does not localize to the ciliary tip. 1 PublicationCorresponds to variant dbSNP:rs750055952EnsemblClinVar.	1
Natural variantⁱVAR_034843	620	M → L. Corresponds to variant dbSNP:rs3739070Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_027734	355 – 420	Missing in isoform 2. 3 PublicationsAdd BLAST		66

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF230877 mRNA Translation: AAF76984.1 AF242456 mRNA Translation: AAL90444.1 AC012485 Genomic DNA Translation: AAX88977.1 CH471063 Genomic DNA Translation: EAW71157.1 BC059174 mRNA Translation: AAH59174.1 AL080153 mRNA Translation: CAB45744.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33415.1 [Q8TDR0-1] CCDS46557.1 [Q8TDR0-2]
PIRⁱ	T12536
NCBI Reference Sequences More...RefSeqⁱ	NP_001132962.1, NM_001139490.1 [Q8TDR0-2] NP_056465.2, NM_015650.3 [Q8TDR0-1]
UniGeneⁱ	Hs.631898

Genome annotation databases

Ensemblⁱ	ENST00000373327; ENSP00000362424; ENSG00000204104 [Q8TDR0-1] ENST00000391993; ENSP00000375851; ENSG00000204104 [Q8TDR0-2]
GeneIDⁱ	26146
KEGGⁱ	hsa:26146
UCSC genome browser More...UCSCⁱ	uc002vye.4 human [Q8TDR0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TDR0	TRAF3 interacting protein 1		PANTR		691	UniRef90_Q8TDR0
Uncharacterized protein		CERAT		691
Uncharacterized protein		PAPAN		691
Uncharacterized protein		NOMLE		691
TRAF3 interacting protein 1		GORGO		691
+15
Q8TDR0-2	Uncharacterized protein		PAPAN		635	UniRef90_Q8TDR0-2
TRAF3 interacting protein 1		GORGO		625
Uncharacterized protein		CERAT		625
TRAF3 interacting protein 1		MACMU		625
Uncharacterized protein		MACFA		625
+23

Protein	Similar proteins		Species	Score	Length	Source
Q8TDR0	TRAF3 interacting protein 1		GORGO		691	UniRef50_Q8TDR0
Uncharacterized protein		CERAT		691
TRAF3 interacting protein 1		PANTR		691
Uncharacterized protein		MACFA		691
Uncharacterized protein		NOMLE		691
+124
Q8TDR0-2	TRAF3-interacting protein 1	)	MOUSE		625	UniRef50_Q8TDR0-2
TRAF3-interacting protein 1		RAT		653
Uncharacterized protein		PAPAN		635
TRAF3 interacting protein 1		GORGO		625
TNF receptor-associated factor 3 interacting protein 1		PANTR		625
+244

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF230877 mRNA Translation: AAF76984.1 AF242456 mRNA Translation: AAL90444.1 AC012485 Genomic DNA Translation: AAX88977.1 CH471063 Genomic DNA Translation: EAW71157.1 BC059174 mRNA Translation: AAH59174.1 AL080153 mRNA Translation: CAB45744.1
CCDSⁱ	CCDS33415.1 [Q8TDR0-1] CCDS46557.1 [Q8TDR0-2]
PIRⁱ	T12536
RefSeqⁱ	NP_001132962.1, NM_001139490.1 [Q8TDR0-2] NP_056465.2, NM_015650.3 [Q8TDR0-1]
UniGeneⁱ	Hs.631898

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EQO	NMR	-	A	1-133	[»]
ProteinModelPortalⁱ	Q8TDR0
SMRⁱ	Q8TDR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117577, 85 interactors
CORUMⁱ	Q8TDR0
IntActⁱ	Q8TDR0, 68 interactors
STRINGⁱ	9606.ENSP00000362424

PTM databases

GlyConnectⁱ	1828
iPTMnetⁱ	Q8TDR0
PhosphoSitePlusⁱ	Q8TDR0

Polymorphism and mutation databases

BioMutaⁱ	TRAF3IP1
DMDMⁱ	74727348

Proteomic databases

EPDⁱ	Q8TDR0
MaxQBⁱ	Q8TDR0
PaxDbⁱ	Q8TDR0
PeptideAtlasⁱ	Q8TDR0
PRIDEⁱ	Q8TDR0
ProteomicsDBⁱ	74330 74331 [Q8TDR0-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000373327; ENSP00000362424; ENSG00000204104 [Q8TDR0-1] ENST00000391993; ENSP00000375851; ENSG00000204104 [Q8TDR0-2]
GeneIDⁱ	26146
KEGGⁱ	hsa:26146
UCSCⁱ	uc002vye.4 human [Q8TDR0-1]

Organism-specific databases

CTDⁱ	26146
DisGeNETⁱ	26146
EuPathDBⁱ	HostDB:ENSG00000204104.11
GeneCardsⁱ	TRAF3IP1
HGNCⁱ	HGNC:17861 TRAF3IP1
HPAⁱ	HPA037857 HPA037858
MalaCardsⁱ	TRAF3IP1
MIMⁱ	607380 gene 616629 phenotype
neXtProtⁱ	NX_Q8TDR0
OpenTargetsⁱ	ENSG00000204104
Orphanetⁱ	3156 Senior-Loken syndrome 93269 Short rib-polydactyly syndrome, Majewski type
PharmGKBⁱ	PA134943602
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3809 Eukaryota ENOG410ZHUT LUCA
GeneTreeⁱ	ENSGT00720000108822
HOGENOMⁱ	HOG000007159
HOVERGENⁱ	HBG101388
InParanoidⁱ	Q8TDR0
KOⁱ	K19680
OMAⁱ	FLQKMID
OrthoDBⁱ	EOG091G0DXC
PhylomeDBⁱ	Q8TDR0
TreeFamⁱ	TF315473

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5620924 Intraflagellar transport

Reactomeⁱ

R-HSA-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRSⁱ	TRAF3IP1 human
EvolutionaryTraceⁱ	Q8TDR0
GenomeRNAiⁱ	26146
Protein Ontology More...PROⁱ	PR:Q8TDR0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204104 Expressed in 203 organ(s), highest expression level in testis
CleanExⁱ	HS_TRAF3IP1
ExpressionAtlasⁱ	Q8TDR0 baseline and differential
Genevisibleⁱ	Q8TDR0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018799 TRAF3IP1
PANTHERⁱ	PTHR31363 PTHR31363, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MIPT3_HUMAN
Accessionⁱ	Q8TDR0Primary (citable) accession number: Q8TDR0 Secondary accession number(s): Q6PCT1 , Q7L8N9, Q9NRD6, Q9Y4Q1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q8TDR0 (MIPT3_HUMAN)

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TRAF3-interacting protein 1

TRAF3IP1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ