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Protein

TRAF3-interacting protein 1

Gene

TRAF3IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
TRAF3-interacting protein 1
Alternative name(s):
Interleukin-13 receptor alpha 1-binding protein 1
Intraflagellar transport protein 54 homolog
Microtubule-interacting protein associated with TRAF3
Short name:
MIP-T3
Gene namesi
Name:TRAF3IP1
Synonyms:IFT54, MIPT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000204104.11
HGNCiHGNC:17861 TRAF3IP1
MIMi607380 gene
neXtProtiNX_Q8TDR0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Senior-Loken syndrome 9 (SLSN9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life.
See also OMIM:616629
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07506817I → S in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 Publication1
Natural variantiVAR_075069125V → A in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037896EnsemblClinVar.1
Natural variantiVAR_075070125V → M in SLSN9; results in altered folding of the N-terminus; does not localize to the ciliary tip and transition zone; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037898EnsemblClinVar.1
Natural variantiVAR_075071520M → R in SLSN9; does not localize to the ciliary tip. 1 PublicationCorresponds to variant dbSNP:rs750055952EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation, Leber congenital amaurosis, Nephronophthisis, Senior-Loken syndrome

Organism-specific databases

DisGeNETi26146
MalaCardsiTRAF3IP1
MIMi616629 phenotype
OpenTargetsiENSG00000204104
Orphaneti3156 Senior-Loken syndrome
93269 Short rib-polydactyly syndrome, Majewski type
PharmGKBiPA134943602

Polymorphism and mutation databases

BioMutaiTRAF3IP1
DMDMi74727348

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995441 – 691TRAF3-interacting protein 1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei317PhosphoserineBy similarity1
Modified residuei476PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TDR0
MaxQBiQ8TDR0
PaxDbiQ8TDR0
PeptideAtlasiQ8TDR0
PRIDEiQ8TDR0
ProteomicsDBi74330
74331 [Q8TDR0-2]

PTM databases

GlyConnecti1828
iPTMnetiQ8TDR0
PhosphoSitePlusiQ8TDR0

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000204104 Expressed in 203 organ(s), highest expression level in testis
CleanExiHS_TRAF3IP1
ExpressionAtlasiQ8TDR0 baseline and differential
GenevisibleiQ8TDR0 HS

Organism-specific databases

HPAiHPA037857
HPA037858

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity). Interacts with IL13RA1 (PubMed:10791955). Binds to microtubules, TRAF3 and DISC1 (PubMed:12812986, PubMed:12935900). Interacts with MAP4 (By similarity).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117577, 85 interactors
CORUMiQ8TDR0
IntActiQ8TDR0, 68 interactors
STRINGi9606.ENSP00000362424

Structurei

Secondary structure

1691
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TDR0
SMRiQ8TDR0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TDR0

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 323Abolishes microtubules-binding when missingAdd BLAST323
Regioni223 – 691DISC1-interaction domainAdd BLAST469

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili571 – 666Sequence analysisAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 281Arg-richAdd BLAST71

Sequence similaritiesi

Belongs to the TRAF3IP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3809 Eukaryota
ENOG410ZHUT LUCA
GeneTreeiENSGT00720000108822
HOGENOMiHOG000007159
HOVERGENiHBG101388
InParanoidiQ8TDR0
KOiK19680
OMAiFLQKMID
OrthoDBiEOG091G0DXC
PhylomeDBiQ8TDR0
TreeFamiTF315473

Family and domain databases

InterProiView protein in InterPro
IPR018799 TRAF3IP1
PANTHERiPTHR31363 PTHR31363, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK
60 70 80 90 100
GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE
110 120 130 140 150
PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD
160 170 180 190 200
NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD
210 220 230 240 250
KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD RDSERKKETE
260 270 280 290 300
RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD
310 320 330 340 350
KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK
360 370 380 390 400
NSVEGRKEDN ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD
410 420 430 440 450
DNSASLRCEN IQPNPTEKQK GDSTSDAEGD AGPAGQDKSE VPETPEIPNE
460 470 480 490 500
LSSNIRRIPR PGSARPAPPR VKRQDSMEAL QMDRSGSGKT VSNVITESHN
510 520 530 540 550
SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL VKKILETKKD
560 570 580 590 600
YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL
610 620 630 640 650
GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL
660 670 680 690
AELEQLIKDQ QDKICAVKAN ILKNEEKIQK MVYSINLTSR R
Length:691
Mass (Da):78,632
Last modified:June 1, 2002 - v1
Checksum:i0675AA0E5319D2EB
GO
Isoform 2 (identifier: Q8TDR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-420: Missing.

Show »
Length:625
Mass (Da):71,529
Checksum:iFDF49249C140E026
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ10H7BZ10_HUMAN
TRAF3-interacting protein 1
TRAF3IP1
52Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07506817I → S in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 Publication1
Natural variantiVAR_075069125V → A in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037896EnsemblClinVar.1
Natural variantiVAR_075070125V → M in SLSN9; results in altered folding of the N-terminus; does not localize to the ciliary tip and transition zone; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037898EnsemblClinVar.1
Natural variantiVAR_034841228N → S1 PublicationCorresponds to variant dbSNP:rs3769110Ensembl.1
Natural variantiVAR_034842239R → W. Corresponds to variant dbSNP:rs34723381Ensembl.1
Natural variantiVAR_051185295K → N. Corresponds to variant dbSNP:rs12464423Ensembl.1
Natural variantiVAR_061685416T → S. Corresponds to variant dbSNP:rs58277463Ensembl.1
Natural variantiVAR_075071520M → R in SLSN9; does not localize to the ciliary tip. 1 PublicationCorresponds to variant dbSNP:rs750055952EnsemblClinVar.1
Natural variantiVAR_034843620M → L. Corresponds to variant dbSNP:rs3739070Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027734355 – 420Missing in isoform 2. 3 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230877 mRNA Translation: AAF76984.1
AF242456 mRNA Translation: AAL90444.1
AC012485 Genomic DNA Translation: AAX88977.1
CH471063 Genomic DNA Translation: EAW71157.1
BC059174 mRNA Translation: AAH59174.1
AL080153 mRNA Translation: CAB45744.1
CCDSiCCDS33415.1 [Q8TDR0-1]
CCDS46557.1 [Q8TDR0-2]
PIRiT12536
RefSeqiNP_001132962.1, NM_001139490.1 [Q8TDR0-2]
NP_056465.2, NM_015650.3 [Q8TDR0-1]
UniGeneiHs.631898

Genome annotation databases

EnsembliENST00000373327; ENSP00000362424; ENSG00000204104 [Q8TDR0-1]
ENST00000391993; ENSP00000375851; ENSG00000204104 [Q8TDR0-2]
GeneIDi26146
KEGGihsa:26146
UCSCiuc002vye.4 human [Q8TDR0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230877 mRNA Translation: AAF76984.1
AF242456 mRNA Translation: AAL90444.1
AC012485 Genomic DNA Translation: AAX88977.1
CH471063 Genomic DNA Translation: EAW71157.1
BC059174 mRNA Translation: AAH59174.1
AL080153 mRNA Translation: CAB45744.1
CCDSiCCDS33415.1 [Q8TDR0-1]
CCDS46557.1 [Q8TDR0-2]
PIRiT12536
RefSeqiNP_001132962.1, NM_001139490.1 [Q8TDR0-2]
NP_056465.2, NM_015650.3 [Q8TDR0-1]
UniGeneiHs.631898

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQONMR-A1-133[»]
ProteinModelPortaliQ8TDR0
SMRiQ8TDR0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117577, 85 interactors
CORUMiQ8TDR0
IntActiQ8TDR0, 68 interactors
STRINGi9606.ENSP00000362424

PTM databases

GlyConnecti1828
iPTMnetiQ8TDR0
PhosphoSitePlusiQ8TDR0

Polymorphism and mutation databases

BioMutaiTRAF3IP1
DMDMi74727348

Proteomic databases

EPDiQ8TDR0
MaxQBiQ8TDR0
PaxDbiQ8TDR0
PeptideAtlasiQ8TDR0
PRIDEiQ8TDR0
ProteomicsDBi74330
74331 [Q8TDR0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373327; ENSP00000362424; ENSG00000204104 [Q8TDR0-1]
ENST00000391993; ENSP00000375851; ENSG00000204104 [Q8TDR0-2]
GeneIDi26146
KEGGihsa:26146
UCSCiuc002vye.4 human [Q8TDR0-1]

Organism-specific databases

CTDi26146
DisGeNETi26146
EuPathDBiHostDB:ENSG00000204104.11
GeneCardsiTRAF3IP1
HGNCiHGNC:17861 TRAF3IP1
HPAiHPA037857
HPA037858
MalaCardsiTRAF3IP1
MIMi607380 gene
616629 phenotype
neXtProtiNX_Q8TDR0
OpenTargetsiENSG00000204104
Orphaneti3156 Senior-Loken syndrome
93269 Short rib-polydactyly syndrome, Majewski type
PharmGKBiPA134943602
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3809 Eukaryota
ENOG410ZHUT LUCA
GeneTreeiENSGT00720000108822
HOGENOMiHOG000007159
HOVERGENiHBG101388
InParanoidiQ8TDR0
KOiK19680
OMAiFLQKMID
OrthoDBiEOG091G0DXC
PhylomeDBiQ8TDR0
TreeFamiTF315473

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRSiTRAF3IP1 human
EvolutionaryTraceiQ8TDR0
GenomeRNAii26146
PROiPR:Q8TDR0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204104 Expressed in 203 organ(s), highest expression level in testis
CleanExiHS_TRAF3IP1
ExpressionAtlasiQ8TDR0 baseline and differential
GenevisibleiQ8TDR0 HS

Family and domain databases

InterProiView protein in InterPro
IPR018799 TRAF3IP1
PANTHERiPTHR31363 PTHR31363, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMIPT3_HUMAN
AccessioniPrimary (citable) accession number: Q8TDR0
Secondary accession number(s): Q6PCT1
, Q7L8N9, Q9NRD6, Q9Y4Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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