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UniProtKB - Q8TDR0 (MIPT3_HUMAN)

Entry version 130 (13 Feb 2019)
Sequence version 1 (01 Jun 2002)
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Protein

TRAF3-interacting protein 1

Gene

TRAF3IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5620924 Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TRAF3-interacting protein 1
Alternative name(s):
Interleukin-13 receptor alpha 1-binding protein 1
Intraflagellar transport protein 54 homolog
Microtubule-interacting protein associated with TRAF3
Short name:
MIP-T3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAF3IP1
Synonyms:IFT54, MIPT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000204104.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:17861 TRAF3IP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607380 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDR0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Senior-Loken syndrome 9 (SLSN9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life.
See also OMIM:616629
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07506817I → S in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 Publication1
Natural variantiVAR_075069125V → A in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037896EnsemblClinVar.1
Natural variantiVAR_075070125V → M in SLSN9; results in altered folding of the N-terminus; does not localize to the ciliary tip and transition zone; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037898EnsemblClinVar.1
Natural variantiVAR_075071520M → R in SLSN9; does not localize to the ciliary tip. 1 PublicationCorresponds to variant dbSNP:rs750055952EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation, Leber congenital amaurosis, Nephronophthisis, Senior-Loken syndrome

Organism-specific databases

DisGeNET

More...DisGeNETi		26146

MalaCards human disease database

More...MalaCardsi		TRAF3IP1
MIMi616629 phenotype

Open Targets

More...OpenTargetsi		ENSG00000204104

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		3156 Senior-Loken syndrome
93269 Short rib-polydactyly syndrome, Majewski type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134943602

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRAF3IP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74727348

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995441 – 691TRAF3-interacting protein 1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei317PhosphoserineBy similarity1
Modified residuei476PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TDR0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TDR0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TDR0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDR0

PeptideAtlas

More...PeptideAtlasi		Q8TDR0

PRoteomics IDEntifications database

More...PRIDEi		Q8TDR0

ProteomicsDB human proteome resource

More...ProteomicsDBi		74330
74331 [Q8TDR0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDR0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204104 Expressed in 203 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TDR0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDR0 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA037857
HPA037858

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity). Interacts with IL13RA1 (PubMed:10791955). Binds to microtubules, TRAF3 and DISC1 (PubMed:12812986, PubMed:12935900). Interacts with MAP4 (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117577, 85 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8TDR0

Protein interaction database and analysis system

More...IntActi		Q8TDR0, 69 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362424

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1691
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQONMR-A1-133[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8TDR0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDR0

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8TDR0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 323Abolishes microtubules-binding when missingAdd BLAST323
Regioni223 – 691DISC1-interaction domainAdd BLAST469

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili571 – 666Sequence analysisAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi211 – 281Arg-richAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAF3IP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3809 Eukaryota
ENOG410ZHUT LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00720000108822

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007159

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG101388

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDR0

KEGG Orthology (KO)

More...KOi		K19680

Identification of Orthologs from Complete Genome Data

More...OMAi		FLQKMID

Database of Orthologous Groups

More...OrthoDBi		1008610at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDR0

TreeFam database of animal gene trees

More...TreeFami		TF315473

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018799 TRAF3IP1
IPR040468 TRAF3IP1_N

The PANTHER Classification System

More...PANTHERi		PTHR31363 PTHR31363, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10243 MIP-T3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK 
        60         70         80         90        100
GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE 
       110        120        130        140        150
PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD 
       160        170        180        190        200
NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD 
       210        220        230        240        250
KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD RDSERKKETE 
       260        270        280        290        300
RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD 
       310        320        330        340        350
KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK 
       360        370        380        390        400
NSVEGRKEDN ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD 
       410        420        430        440        450
DNSASLRCEN IQPNPTEKQK GDSTSDAEGD AGPAGQDKSE VPETPEIPNE 
       460        470        480        490        500
LSSNIRRIPR PGSARPAPPR VKRQDSMEAL QMDRSGSGKT VSNVITESHN 
       510        520        530        540        550
SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL VKKILETKKD 
       560        570        580        590        600
YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL 
       610        620        630        640        650
GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL 
       660        670        680        690 
AELEQLIKDQ QDKICAVKAN ILKNEEKIQK MVYSINLTSR R
Length:691
Mass (Da):78,632
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0675AA0E5319D2EB
GO
Isoform 2 (identifier: Q8TDR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-420: Missing.

Show »
Length:625
Mass (Da):71,529
Checksum:iFDF49249C140E026
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ10H7BZ10_HUMAN
TRAF3-interacting protein 1
TRAF3IP1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07506817I → S in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 Publication1
Natural variantiVAR_075069125V → A in SLSN9; results in altered folding of the N-terminus; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037896EnsemblClinVar.1
Natural variantiVAR_075070125V → M in SLSN9; results in altered folding of the N-terminus; does not localize to the ciliary tip and transition zone; does not affect interaction with IFT20; loss of interaction with MAP4. 1 PublicationCorresponds to variant dbSNP:rs886037898EnsemblClinVar.1
Natural variantiVAR_034841228N → S1 PublicationCorresponds to variant dbSNP:rs3769110Ensembl.1
Natural variantiVAR_034842239R → W. Corresponds to variant dbSNP:rs34723381Ensembl.1
Natural variantiVAR_051185295K → N. Corresponds to variant dbSNP:rs12464423Ensembl.1
Natural variantiVAR_061685416T → S. Corresponds to variant dbSNP:rs58277463Ensembl.1
Natural variantiVAR_075071520M → R in SLSN9; does not localize to the ciliary tip. 1 PublicationCorresponds to variant dbSNP:rs750055952EnsemblClinVar.1
Natural variantiVAR_034843620M → L. Corresponds to variant dbSNP:rs3739070Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027734355 – 420Missing in isoform 2. 3 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF230877 mRNA Translation: AAF76984.1
AF242456 mRNA Translation: AAL90444.1
AC012485 Genomic DNA Translation: AAX88977.1
CH471063 Genomic DNA Translation: EAW71157.1
BC059174 mRNA Translation: AAH59174.1
AL080153 mRNA Translation: CAB45744.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33415.1 [Q8TDR0-1]
CCDS46557.1 [Q8TDR0-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T12536

NCBI Reference Sequences

More...RefSeqi		NP_001132962.1, NM_001139490.1 [Q8TDR0-2]
NP_056465.2, NM_015650.3 [Q8TDR0-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.631898

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373327; ENSP00000362424; ENSG00000204104 [Q8TDR0-1]
ENST00000391993; ENSP00000375851; ENSG00000204104 [Q8TDR0-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26146

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26146

UCSC genome browser

More...UCSCi		uc002vye.4 human [Q8TDR0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230877 mRNA Translation: AAF76984.1
AF242456 mRNA Translation: AAL90444.1
AC012485 Genomic DNA Translation: AAX88977.1
CH471063 Genomic DNA Translation: EAW71157.1
BC059174 mRNA Translation: AAH59174.1
AL080153 mRNA Translation: CAB45744.1
CCDSiCCDS33415.1 [Q8TDR0-1]
CCDS46557.1 [Q8TDR0-2]
PIRiT12536
RefSeqiNP_001132962.1, NM_001139490.1 [Q8TDR0-2]
NP_056465.2, NM_015650.3 [Q8TDR0-1]
UniGeneiHs.631898

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQONMR-A1-133[»]
ProteinModelPortaliQ8TDR0
SMRiQ8TDR0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117577, 85 interactors
CORUMiQ8TDR0
IntActiQ8TDR0, 69 interactors
STRINGi9606.ENSP00000362424

PTM databases

iPTMnetiQ8TDR0
PhosphoSitePlusiQ8TDR0

Polymorphism and mutation databases

BioMutaiTRAF3IP1
DMDMi74727348

Proteomic databases

EPDiQ8TDR0
jPOSTiQ8TDR0
MaxQBiQ8TDR0
PaxDbiQ8TDR0
PeptideAtlasiQ8TDR0
PRIDEiQ8TDR0
ProteomicsDBi74330
74331 [Q8TDR0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373327; ENSP00000362424; ENSG00000204104 [Q8TDR0-1]
ENST00000391993; ENSP00000375851; ENSG00000204104 [Q8TDR0-2]
GeneIDi26146
KEGGihsa:26146
UCSCiuc002vye.4 human [Q8TDR0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26146
DisGeNETi26146
EuPathDBiHostDB:ENSG00000204104.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRAF3IP1
HGNCiHGNC:17861 TRAF3IP1
HPAiHPA037857
HPA037858
MalaCardsiTRAF3IP1
MIMi607380 gene
616629 phenotype
neXtProtiNX_Q8TDR0
OpenTargetsiENSG00000204104
Orphaneti3156 Senior-Loken syndrome
93269 Short rib-polydactyly syndrome, Majewski type
PharmGKBiPA134943602

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3809 Eukaryota
ENOG410ZHUT LUCA
GeneTreeiENSGT00720000108822
HOGENOMiHOG000007159
HOVERGENiHBG101388
InParanoidiQ8TDR0
KOiK19680
OMAiFLQKMID
OrthoDBi1008610at2759
PhylomeDBiQ8TDR0
TreeFamiTF315473

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRAF3IP1 human
EvolutionaryTraceiQ8TDR0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26146

Protein Ontology

More...PROi		PR:Q8TDR0

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204104 Expressed in 203 organ(s), highest expression level in testis
ExpressionAtlasiQ8TDR0 baseline and differential
GenevisibleiQ8TDR0 HS

Family and domain databases

InterProiView protein in InterPro
IPR018799 TRAF3IP1
IPR040468 TRAF3IP1_N
PANTHERiPTHR31363 PTHR31363, 2 hits
PfamiView protein in Pfam
PF10243 MIP-T3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIPT3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDR0
Secondary accession number(s): Q6PCT1
, Q7L8N9, Q9NRD6, Q9Y4Q1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2002
Last modified: February 13, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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