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Protein

Glucosamine-6-phosphate isomerase 2

Gene

GNPDA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptor; for enolization stepBy similarity1
Active sitei141For ring-opening stepBy similarity1
Active sitei143Proton acceptor; for ring-opening stepBy similarity1
Active sitei148For ring-opening stepBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BRENDAi3.5.99.6 2681
ReactomeiR-HSA-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosamine-6-phosphate isomerase 2 (EC:3.5.99.6)
Alternative name(s):
Glucosamine-6-phosphate deaminase 2
Short name:
GNPDA 2
Short name:
GlcN6P deaminase 2
Glucosamine-6-phosphate isomerase SB52
Gene namesi
Name:GNPDA2
Synonyms:GNP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163281.11
HGNCiHGNC:21526 GNPDA2
MIMi613222 gene
neXtProtiNX_Q8TDQ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi132789
OpenTargetsiENSG00000163281
PharmGKBiPA134939177

Polymorphism and mutation databases

DMDMi74723936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003432051 – 276Glucosamine-6-phosphate isomerase 2Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TDQ7
MaxQBiQ8TDQ7
PaxDbiQ8TDQ7
PeptideAtlasiQ8TDQ7
PRIDEiQ8TDQ7
ProteomicsDBi74327
74328 [Q8TDQ7-2]
74329 [Q8TDQ7-3]
TopDownProteomicsiQ8TDQ7-2 [Q8TDQ7-2]

PTM databases

iPTMnetiQ8TDQ7
PhosphoSitePlusiQ8TDQ7

Expressioni

Gene expression databases

BgeeiENSG00000163281 Expressed in 161 organ(s), highest expression level in secondary oocyte
CleanExiHS_GNPDA2
ExpressionAtlasiQ8TDQ7 baseline and differential
GenevisibleiQ8TDQ7 HS

Organism-specific databases

HPAiHPA000499
HPA046891

Interactioni

Subunit structurei

Homohexamer.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi126335, 15 interactors
DIPiDIP-62122N
IntActiQ8TDQ7, 5 interactors
STRINGi9606.ENSP00000295448

Structurei

3D structure databases

ProteinModelPortaliQ8TDQ7
SMRiQ8TDQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili105 – 130Sequence analysisAdd BLAST26

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3148 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00390000014316
HOGENOMiHOG000064979
HOVERGENiHBG002546
InParanoidiQ8TDQ7
KOiK02564
OMAiPLHSMKE
OrthoDBiEOG091G0LJF
PhylomeDBiQ8TDQ7
TreeFamiTF300841

Family and domain databases

CDDicd01399 GlcN6P_deaminase, 1 hit
HAMAPiMF_01241 GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR11280 PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00502 nagB, 1 hit
PROSITEiView protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLVILDNYD LASEWAAKYI CNRIIQFKPG QDRYFTLGLP TGSTPLGCYK
60 70 80 90 100
KLIEYHKNGH LSFKYVKTFN MDEYVGLPRN HPESYHSYMW NNFFKHIDID
110 120 130 140 150
PNNAHILDGN AADLQAECDA FENKIKEAGG IDLFVGGIGP DGHIAFNEPG
160 170 180 190 200
SSLVSRTRLK TLAMDTILAN AKYFDGDLSK VPTMALTVGV GTVMDAREVM
210 220 230 240 250
ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTIFVCD EDATLELRVK
260 270
TVKYFKGLMH VHNKLVDPLF SMKDGN
Length:276
Mass (Da):31,085
Last modified:June 1, 2002 - v1
Checksum:i2BCFD72F734639D0
GO
Isoform 2 (identifier: Q8TDQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-217: Missing.

Show »
Length:275
Mass (Da):30,956
Checksum:i6DB65CA86569D445
GO
Isoform 3 (identifier: Q8TDQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-276: LMHVHNKLVDPLFSMKDGN → EH

Show »
Length:259
Mass (Da):29,173
Checksum:i1C0DB9A7FFDB5C92
GO
Isoform 4 (identifier: Q8TDQ7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:206
Mass (Da):22,912
Checksum:iE3D8A72A584D3F06
GO
Isoform 5 (identifier: Q8TDQ7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-76: Missing.

Show »
Length:242
Mass (Da):27,091
Checksum:iBA5F01D6E1F5C015
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYK3V9GYK3_HUMAN
Glucosamine-6-phosphate isomerase 2
GNPDA2
117Annotation score:
V9GYW0V9GYW0_HUMAN
Glucosamine-6-phosphate isomerase 2
GNPDA2
63Annotation score:

Sequence cautioni

The sequence BAD93141 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37L → P in BAB70977 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044348182P → S1 PublicationCorresponds to variant dbSNP:rs17851302Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470331 – 70Missing in isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_04703443 – 76Missing in isoform 5. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_034579217Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_034580258 – 276LMHVH…MKDGN → EH in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247786 mRNA Translation: AAL95691.1
AY173948 mRNA Translation: AAO49718.1
AK055639 mRNA Translation: BAB70977.1
AK296051 mRNA Translation: BAG58815.1
AB209904 mRNA Translation: BAD93141.1 Different initiation.
AC096586 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93019.1
BC015532 mRNA Translation: AAH15532.1
AL834506 mRNA Translation: CAD39163.1
CCDSiCCDS3469.1 [Q8TDQ7-1]
CCDS59472.1 [Q8TDQ7-4]
CCDS59473.1 [Q8TDQ7-5]
RefSeqiNP_001257809.1, NM_001270880.1 [Q8TDQ7-5]
NP_001257810.1, NM_001270881.1 [Q8TDQ7-4]
NP_612208.1, NM_138335.2 [Q8TDQ7-1]
UniGeneiHs.21398
Hs.597934
Hs.619562

Genome annotation databases

EnsembliENST00000295448; ENSP00000295448; ENSG00000163281 [Q8TDQ7-1]
ENST00000507534; ENSP00000427423; ENSG00000163281 [Q8TDQ7-4]
ENST00000507917; ENSP00000425868; ENSG00000163281 [Q8TDQ7-5]
ENST00000509756; ENSP00000424061; ENSG00000163281 [Q8TDQ7-3]
GeneIDi132789
KEGGihsa:132789
UCSCiuc003gwy.5 human [Q8TDQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247786 mRNA Translation: AAL95691.1
AY173948 mRNA Translation: AAO49718.1
AK055639 mRNA Translation: BAB70977.1
AK296051 mRNA Translation: BAG58815.1
AB209904 mRNA Translation: BAD93141.1 Different initiation.
AC096586 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93019.1
BC015532 mRNA Translation: AAH15532.1
AL834506 mRNA Translation: CAD39163.1
CCDSiCCDS3469.1 [Q8TDQ7-1]
CCDS59472.1 [Q8TDQ7-4]
CCDS59473.1 [Q8TDQ7-5]
RefSeqiNP_001257809.1, NM_001270880.1 [Q8TDQ7-5]
NP_001257810.1, NM_001270881.1 [Q8TDQ7-4]
NP_612208.1, NM_138335.2 [Q8TDQ7-1]
UniGeneiHs.21398
Hs.597934
Hs.619562

3D structure databases

ProteinModelPortaliQ8TDQ7
SMRiQ8TDQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126335, 15 interactors
DIPiDIP-62122N
IntActiQ8TDQ7, 5 interactors
STRINGi9606.ENSP00000295448

PTM databases

iPTMnetiQ8TDQ7
PhosphoSitePlusiQ8TDQ7

Polymorphism and mutation databases

DMDMi74723936

Proteomic databases

EPDiQ8TDQ7
MaxQBiQ8TDQ7
PaxDbiQ8TDQ7
PeptideAtlasiQ8TDQ7
PRIDEiQ8TDQ7
ProteomicsDBi74327
74328 [Q8TDQ7-2]
74329 [Q8TDQ7-3]
TopDownProteomicsiQ8TDQ7-2 [Q8TDQ7-2]

Protocols and materials databases

DNASUi132789
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295448; ENSP00000295448; ENSG00000163281 [Q8TDQ7-1]
ENST00000507534; ENSP00000427423; ENSG00000163281 [Q8TDQ7-4]
ENST00000507917; ENSP00000425868; ENSG00000163281 [Q8TDQ7-5]
ENST00000509756; ENSP00000424061; ENSG00000163281 [Q8TDQ7-3]
GeneIDi132789
KEGGihsa:132789
UCSCiuc003gwy.5 human [Q8TDQ7-1]

Organism-specific databases

CTDi132789
DisGeNETi132789
EuPathDBiHostDB:ENSG00000163281.11
GeneCardsiGNPDA2
HGNCiHGNC:21526 GNPDA2
HPAiHPA000499
HPA046891
MIMi613222 gene
neXtProtiNX_Q8TDQ7
OpenTargetsiENSG00000163281
PharmGKBiPA134939177
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3148 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00390000014316
HOGENOMiHOG000064979
HOVERGENiHBG002546
InParanoidiQ8TDQ7
KOiK02564
OMAiPLHSMKE
OrthoDBiEOG091G0LJF
PhylomeDBiQ8TDQ7
TreeFamiTF300841

Enzyme and pathway databases

BRENDAi3.5.99.6 2681
ReactomeiR-HSA-70171 Glycolysis

Miscellaneous databases

ChiTaRSiGNPDA2 human
GeneWikiiGNPDA2
GenomeRNAii132789
PROiPR:Q8TDQ7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163281 Expressed in 161 organ(s), highest expression level in secondary oocyte
CleanExiHS_GNPDA2
ExpressionAtlasiQ8TDQ7 baseline and differential
GenevisibleiQ8TDQ7 HS

Family and domain databases

CDDicd01399 GlcN6P_deaminase, 1 hit
HAMAPiMF_01241 GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR11280 PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00502 nagB, 1 hit
PROSITEiView protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNPI2_HUMAN
AccessioniPrimary (citable) accession number: Q8TDQ7
Secondary accession number(s): B4DJF3
, Q2VYF1, Q59EA7, Q8NCZ8, Q96BJ4, Q96NC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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