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UniProtKB - Q8TDQ7 (GNPI2_HUMAN)

Entry version 144 (02 Dec 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Glucosamine-6-phosphate isomerase 2

Gene

GNPDA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei72Proton acceptor; for enolization stepBy similarity1
Active sitei141For ring-opening stepBy similarity1
Active sitei143Proton acceptor; for ring-opening stepBy similarity1
Active sitei148For ring-opening stepBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.5.99.6, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TDQ7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-70171, Glycolysis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucosamine-6-phosphate isomerase 2 (EC:3.5.99.6)
Alternative name(s):
Glucosamine-6-phosphate deaminase 2
Short name:
GNPDA 2
Short name:
GlcN6P deaminase 2
Glucosamine-6-phosphate isomerase SB52
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNPDA2
Synonyms:GNP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000163281.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:21526, GNPDA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613222, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		132789

Open Targets

More...OpenTargetsi		ENSG00000163281

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134939177

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TDQ7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GNPDA2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74723936

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003432051 – 276Glucosamine-6-phosphate isomerase 2Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei161PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TDQ7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TDQ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TDQ7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TDQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDQ7

PeptideAtlas

More...PeptideAtlasi		Q8TDQ7

PRoteomics IDEntifications database

More...PRIDEi		Q8TDQ7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4374
61529
74327 [Q8TDQ7-1]
74328 [Q8TDQ7-2]
74329 [Q8TDQ7-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q8TDQ7-2 [Q8TDQ7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDQ7

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q8TDQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163281, Expressed in secondary oocyte and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TDQ7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDQ7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163281, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126335, 17 interactors

Database of interacting proteins

More...DIPi		DIP-62122N

Protein interaction database and analysis system

More...IntActi		Q8TDQ7, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295448

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TDQ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDQ7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili105 – 130Sequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3148, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014316

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049611_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDQ7

Identification of Orthologs from Complete Genome Data

More...OMAi		PLHSMKE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDQ7

TreeFam database of animal gene trees

More...TreeFami		TF300841

Family and domain databases

Conserved Domains Database

More...CDDi		cd01399, GlcN6P_deaminase, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01241, GlcN6P_deamin, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006148, Glc/Gal-6P_isomerase
IPR004547, Glucosamine6P_isomerase
IPR018321, Glucosamine6P_isomerase_CS
IPR037171, NagB/RpiA_transferase-like

The PANTHER Classification System

More...PANTHERi		PTHR11280, PTHR11280, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01182, Glucosamine_iso, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100950, SSF100950, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00502, nagB, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01161, GLC_GALNAC_ISOMERASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLVILDNYD LASEWAAKYI CNRIIQFKPG QDRYFTLGLP TGSTPLGCYK 
        60         70         80         90        100
KLIEYHKNGH LSFKYVKTFN MDEYVGLPRN HPESYHSYMW NNFFKHIDID 
       110        120        130        140        150
PNNAHILDGN AADLQAECDA FENKIKEAGG IDLFVGGIGP DGHIAFNEPG 
       160        170        180        190        200
SSLVSRTRLK TLAMDTILAN AKYFDGDLSK VPTMALTVGV GTVMDAREVM 
       210        220        230        240        250
ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTIFVCD EDATLELRVK 
       260        270 
TVKYFKGLMH VHNKLVDPLF SMKDGN
Length:276
Mass (Da):31,085
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BCFD72F734639D0
GO
Isoform 2 (identifier: Q8TDQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-217: Missing.

Show »
Length:275
Mass (Da):30,956
Checksum:i6DB65CA86569D445
GO
Isoform 3 (identifier: Q8TDQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-276: LMHVHNKLVDPLFSMKDGN → EH

Show »
Length:259
Mass (Da):29,173
Checksum:i1C0DB9A7FFDB5C92
GO
Isoform 4 (identifier: Q8TDQ7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:206
Mass (Da):22,912
Checksum:iE3D8A72A584D3F06
GO
Isoform 5 (identifier: Q8TDQ7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-76: Missing.

Show »
Length:242
Mass (Da):27,091
Checksum:iBA5F01D6E1F5C015
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYK3V9GYK3_HUMAN
Glucosamine-6-phosphate isomerase 2
GNPDA2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYW0V9GYW0_HUMAN
Glucosamine-6-phosphate isomerase 2
GNPDA2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93141 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37L → P in BAB70977 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044348182P → S1 PublicationCorresponds to variant dbSNP:rs17851302Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470331 – 70Missing in isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_04703443 – 76Missing in isoform 5. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_034579217Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_034580258 – 276LMHVH…MKDGN → EH in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF247786 mRNA Translation: AAL95691.1
AY173948 mRNA Translation: AAO49718.1
AK055639 mRNA Translation: BAB70977.1
AK296051 mRNA Translation: BAG58815.1
AB209904 mRNA Translation: BAD93141.1 Different initiation.
AC096586 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93019.1
BC015532 mRNA Translation: AAH15532.1
AL834506 mRNA Translation: CAD39163.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3469.1 [Q8TDQ7-1]
CCDS59472.1 [Q8TDQ7-4]
CCDS59473.1 [Q8TDQ7-5]

NCBI Reference Sequences

More...RefSeqi		NP_001257809.1, NM_001270880.1 [Q8TDQ7-5]
NP_001257810.1, NM_001270881.1 [Q8TDQ7-4]
NP_612208.1, NM_138335.2 [Q8TDQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295448; ENSP00000295448; ENSG00000163281 [Q8TDQ7-1]
ENST00000507534; ENSP00000427423; ENSG00000163281 [Q8TDQ7-4]
ENST00000507917; ENSP00000425868; ENSG00000163281 [Q8TDQ7-5]
ENST00000509756; ENSP00000424061; ENSG00000163281 [Q8TDQ7-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		132789

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:132789

UCSC genome browser

More...UCSCi		uc003gwy.5, human [Q8TDQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247786 mRNA Translation: AAL95691.1
AY173948 mRNA Translation: AAO49718.1
AK055639 mRNA Translation: BAB70977.1
AK296051 mRNA Translation: BAG58815.1
AB209904 mRNA Translation: BAD93141.1 Different initiation.
AC096586 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93019.1
BC015532 mRNA Translation: AAH15532.1
AL834506 mRNA Translation: CAD39163.1
CCDSiCCDS3469.1 [Q8TDQ7-1]
CCDS59472.1 [Q8TDQ7-4]
CCDS59473.1 [Q8TDQ7-5]
RefSeqiNP_001257809.1, NM_001270880.1 [Q8TDQ7-5]
NP_001257810.1, NM_001270881.1 [Q8TDQ7-4]
NP_612208.1, NM_138335.2 [Q8TDQ7-1]

3D structure databases

SMRiQ8TDQ7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126335, 17 interactors
DIPiDIP-62122N
IntActiQ8TDQ7, 6 interactors
STRINGi9606.ENSP00000295448

PTM databases

iPTMnetiQ8TDQ7
MetOSiteiQ8TDQ7
PhosphoSitePlusiQ8TDQ7

Polymorphism and mutation databases

BioMutaiGNPDA2
DMDMi74723936

Proteomic databases

EPDiQ8TDQ7
jPOSTiQ8TDQ7
MassIVEiQ8TDQ7
MaxQBiQ8TDQ7
PaxDbiQ8TDQ7
PeptideAtlasiQ8TDQ7
PRIDEiQ8TDQ7
ProteomicsDBi4374
61529
74327 [Q8TDQ7-1]
74328 [Q8TDQ7-2]
74329 [Q8TDQ7-3]
TopDownProteomicsiQ8TDQ7-2 [Q8TDQ7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23728, 121 antibodies

The DNASU plasmid repository

More...DNASUi		132789

Genome annotation databases

EnsembliENST00000295448; ENSP00000295448; ENSG00000163281 [Q8TDQ7-1]
ENST00000507534; ENSP00000427423; ENSG00000163281 [Q8TDQ7-4]
ENST00000507917; ENSP00000425868; ENSG00000163281 [Q8TDQ7-5]
ENST00000509756; ENSP00000424061; ENSG00000163281 [Q8TDQ7-3]
GeneIDi132789
KEGGihsa:132789
UCSCiuc003gwy.5, human [Q8TDQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		132789
DisGeNETi132789
EuPathDBiHostDB:ENSG00000163281.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		GNPDA2
HGNCiHGNC:21526, GNPDA2
HPAiENSG00000163281, Low tissue specificity
MIMi613222, gene
neXtProtiNX_Q8TDQ7
OpenTargetsiENSG00000163281
PharmGKBiPA134939177

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3148, Eukaryota
GeneTreeiENSGT00390000014316
HOGENOMiCLU_049611_0_1_1
InParanoidiQ8TDQ7
OMAiPLHSMKE
PhylomeDBiQ8TDQ7
TreeFamiTF300841

Enzyme and pathway databases

BRENDAi3.5.99.6, 2681
PathwayCommonsiQ8TDQ7
ReactomeiR-HSA-70171, Glycolysis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		132789, 12 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GNPDA2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GNPDA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		132789
PharosiQ8TDQ7, Tbio

Protein Ontology

More...PROi		PR:Q8TDQ7
RNActiQ8TDQ7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163281, Expressed in secondary oocyte and 179 other tissues
ExpressionAtlasiQ8TDQ7, baseline and differential
GenevisibleiQ8TDQ7, HS

Family and domain databases

CDDicd01399, GlcN6P_deaminase, 1 hit
HAMAPiMF_01241, GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148, Glc/Gal-6P_isomerase
IPR004547, Glucosamine6P_isomerase
IPR018321, Glucosamine6P_isomerase_CS
IPR037171, NagB/RpiA_transferase-like
PANTHERiPTHR11280, PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182, Glucosamine_iso, 1 hit
SUPFAMiSSF100950, SSF100950, 1 hit
TIGRFAMsiTIGR00502, nagB, 1 hit
PROSITEiView protein in PROSITE
PS01161, GLC_GALNAC_ISOMERASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNPI2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDQ7
Secondary accession number(s): B4DJF3
, Q2VYF1, Q59EA7, Q8NCZ8, Q96BJ4, Q96NC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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