UniProtKB - Q8TDQ7 (GNPI2_HUMAN)
Protein
Glucosamine-6-phosphate isomerase 2
Gene
GNPDA2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.5.99.6
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 72 | Proton acceptor; for enolization stepBy similarity | 1 | |
Active sitei | 141 | For ring-opening stepBy similarity | 1 | |
Active sitei | 143 | Proton acceptor; for ring-opening stepBy similarity | 1 | |
Active sitei | 148 | For ring-opening stepBy similarity | 1 |
GO - Molecular functioni
- glucosamine-6-phosphate deaminase activity Source: GO_Central
- identical protein binding Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB-KW
- glucosamine catabolic process Source: GO_Central
- N-acetylglucosamine catabolic process Source: GO_Central
- N-acetylneuraminate catabolic process Source: GO_Central
- UDP-N-acetylglucosamine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | Carbohydrate metabolism |
Enzyme and pathway databases
BRENDAi | 3.5.99.6, 2681 |
PathwayCommonsi | Q8TDQ7 |
Reactomei | R-HSA-70171, Glycolysis |
Names & Taxonomyi
Protein namesi | Recommended name: Glucosamine-6-phosphate isomerase 2 (EC:3.5.99.6)Alternative name(s): Glucosamine-6-phosphate deaminase 2 Short name: GNPDA 2 Short name: GlcN6P deaminase 2 Glucosamine-6-phosphate isomerase SB52 |
Gene namesi | Name:GNPDA2 Synonyms:GNP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163281.11 |
HGNCi | HGNC:21526, GNPDA2 |
MIMi | 613222, gene |
neXtProti | NX_Q8TDQ7 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 132789 |
OpenTargetsi | ENSG00000163281 |
PharmGKBi | PA134939177 |
Miscellaneous databases
Pharosi | Q8TDQ7, Tbio |
Polymorphism and mutation databases
BioMutai | GNPDA2 |
DMDMi | 74723936 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000343205 | 1 – 276 | Glucosamine-6-phosphate isomerase 2Add BLAST | 276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 161 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8TDQ7 |
jPOSTi | Q8TDQ7 |
MassIVEi | Q8TDQ7 |
MaxQBi | Q8TDQ7 |
PaxDbi | Q8TDQ7 |
PeptideAtlasi | Q8TDQ7 |
PRIDEi | Q8TDQ7 |
ProteomicsDBi | 4374 61529 74327 [Q8TDQ7-1] 74328 [Q8TDQ7-2] 74329 [Q8TDQ7-3] |
TopDownProteomicsi | Q8TDQ7-2 [Q8TDQ7-2] |
PTM databases
iPTMneti | Q8TDQ7 |
MetOSitei | Q8TDQ7 |
PhosphoSitePlusi | Q8TDQ7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163281, Expressed in secondary oocyte and 179 other tissues |
ExpressionAtlasi | Q8TDQ7, baseline and differential |
Genevisiblei | Q8TDQ7, HS |
Organism-specific databases
HPAi | ENSG00000163281, Low tissue specificity |
Interactioni
Subunit structurei
Homohexamer.
By similarityBinary interactionsi
Hide detailsQ8TDQ7
With | #Exp. | IntAct |
---|---|---|
AMDHD2 [Q9Y303] | 4 | EBI-10275006,EBI-2798672 |
TRIM27 [P14373] | 4 | EBI-10275006,EBI-719493 |
Isoform 2 [Q8TDQ7-2]
With | #Exp. | IntAct |
---|---|---|
AMDHD2 - isoform 2 [Q9Y303-2] | 3 | EBI-12197555,EBI-12323557 |
MAGOHB [Q96A72] | 3 | EBI-12197555,EBI-746778 |
NTAQ1 [Q96HA8] | 3 | EBI-12197555,EBI-741158 |
TRIM27 [P14373] | 3 | EBI-12197555,EBI-719493 |
GO - Molecular functioni
- identical protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 126335, 17 interactors |
DIPi | DIP-62122N |
IntActi | Q8TDQ7, 6 interactors |
STRINGi | 9606.ENSP00000295448 |
Miscellaneous databases
RNActi | Q8TDQ7, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 105 – 130 | Sequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3148, Eukaryota |
GeneTreei | ENSGT00390000014316 |
HOGENOMi | CLU_049611_0_1_1 |
InParanoidi | Q8TDQ7 |
OMAi | PLHSMKE |
PhylomeDBi | Q8TDQ7 |
TreeFami | TF300841 |
Family and domain databases
CDDi | cd01399, GlcN6P_deaminase, 1 hit |
HAMAPi | MF_01241, GlcN6P_deamin, 1 hit |
InterProi | View protein in InterPro IPR006148, Glc/Gal-6P_isomerase IPR004547, Glucosamine6P_isomerase IPR018321, Glucosamine6P_isomerase_CS IPR037171, NagB/RpiA_transferase-like |
PANTHERi | PTHR11280, PTHR11280, 1 hit |
Pfami | View protein in Pfam PF01182, Glucosamine_iso, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00502, nagB, 1 hit |
PROSITEi | View protein in PROSITE PS01161, GLC_GALNAC_ISOMERASE, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TDQ7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLVILDNYD LASEWAAKYI CNRIIQFKPG QDRYFTLGLP TGSTPLGCYK
60 70 80 90 100
KLIEYHKNGH LSFKYVKTFN MDEYVGLPRN HPESYHSYMW NNFFKHIDID
110 120 130 140 150
PNNAHILDGN AADLQAECDA FENKIKEAGG IDLFVGGIGP DGHIAFNEPG
160 170 180 190 200
SSLVSRTRLK TLAMDTILAN AKYFDGDLSK VPTMALTVGV GTVMDAREVM
210 220 230 240 250
ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTIFVCD EDATLELRVK
260 270
TVKYFKGLMH VHNKLVDPLF SMKDGN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketV9GYK3 | V9GYK3_HUMAN | Glucosamine-6-phosphate isomerase 2 | GNPDA2 | 117 | Annotation score: | ||
V9GYW0 | V9GYW0_HUMAN | Glucosamine-6-phosphate isomerase 2 | GNPDA2 | 63 | Annotation score: |
Sequence cautioni
The sequence BAD93141 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | L → P in BAB70977 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044348 | 182 | P → S1 PublicationCorresponds to variant dbSNP:rs17851302Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047033 | 1 – 70 | Missing in isoform 4. 1 PublicationAdd BLAST | 70 | |
Alternative sequenceiVSP_047034 | 43 – 76 | Missing in isoform 5. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_034579 | 217 | Missing in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_034580 | 258 – 276 | LMHVH…MKDGN → EH in isoform 3. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF247786 mRNA Translation: AAL95691.1 AY173948 mRNA Translation: AAO49718.1 AK055639 mRNA Translation: BAB70977.1 AK296051 mRNA Translation: BAG58815.1 AB209904 mRNA Translation: BAD93141.1 Different initiation. AC096586 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW93019.1 BC015532 mRNA Translation: AAH15532.1 AL834506 mRNA Translation: CAD39163.1 |
CCDSi | CCDS3469.1 [Q8TDQ7-1] CCDS59472.1 [Q8TDQ7-4] CCDS59473.1 [Q8TDQ7-5] |
RefSeqi | NP_001257809.1, NM_001270880.1 [Q8TDQ7-5] NP_001257810.1, NM_001270881.1 [Q8TDQ7-4] NP_612208.1, NM_138335.2 [Q8TDQ7-1] |
Genome annotation databases
Ensembli | ENST00000295448; ENSP00000295448; ENSG00000163281 [Q8TDQ7-1] ENST00000507534; ENSP00000427423; ENSG00000163281 [Q8TDQ7-4] ENST00000507917; ENSP00000425868; ENSG00000163281 [Q8TDQ7-5] ENST00000509756; ENSP00000424061; ENSG00000163281 [Q8TDQ7-3] |
GeneIDi | 132789 |
KEGGi | hsa:132789 |
UCSCi | uc003gwy.5, human [Q8TDQ7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF247786 mRNA Translation: AAL95691.1 AY173948 mRNA Translation: AAO49718.1 AK055639 mRNA Translation: BAB70977.1 AK296051 mRNA Translation: BAG58815.1 AB209904 mRNA Translation: BAD93141.1 Different initiation. AC096586 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW93019.1 BC015532 mRNA Translation: AAH15532.1 AL834506 mRNA Translation: CAD39163.1 |
CCDSi | CCDS3469.1 [Q8TDQ7-1] CCDS59472.1 [Q8TDQ7-4] CCDS59473.1 [Q8TDQ7-5] |
RefSeqi | NP_001257809.1, NM_001270880.1 [Q8TDQ7-5] NP_001257810.1, NM_001270881.1 [Q8TDQ7-4] NP_612208.1, NM_138335.2 [Q8TDQ7-1] |
3D structure databases
SMRi | Q8TDQ7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126335, 17 interactors |
DIPi | DIP-62122N |
IntActi | Q8TDQ7, 6 interactors |
STRINGi | 9606.ENSP00000295448 |
PTM databases
iPTMneti | Q8TDQ7 |
MetOSitei | Q8TDQ7 |
PhosphoSitePlusi | Q8TDQ7 |
Polymorphism and mutation databases
BioMutai | GNPDA2 |
DMDMi | 74723936 |
Proteomic databases
EPDi | Q8TDQ7 |
jPOSTi | Q8TDQ7 |
MassIVEi | Q8TDQ7 |
MaxQBi | Q8TDQ7 |
PaxDbi | Q8TDQ7 |
PeptideAtlasi | Q8TDQ7 |
PRIDEi | Q8TDQ7 |
ProteomicsDBi | 4374 61529 74327 [Q8TDQ7-1] 74328 [Q8TDQ7-2] 74329 [Q8TDQ7-3] |
TopDownProteomicsi | Q8TDQ7-2 [Q8TDQ7-2] |
Protocols and materials databases
Antibodypediai | 23728, 121 antibodies |
DNASUi | 132789 |
Genome annotation databases
Ensembli | ENST00000295448; ENSP00000295448; ENSG00000163281 [Q8TDQ7-1] ENST00000507534; ENSP00000427423; ENSG00000163281 [Q8TDQ7-4] ENST00000507917; ENSP00000425868; ENSG00000163281 [Q8TDQ7-5] ENST00000509756; ENSP00000424061; ENSG00000163281 [Q8TDQ7-3] |
GeneIDi | 132789 |
KEGGi | hsa:132789 |
UCSCi | uc003gwy.5, human [Q8TDQ7-1] |
Organism-specific databases
CTDi | 132789 |
DisGeNETi | 132789 |
EuPathDBi | HostDB:ENSG00000163281.11 |
GeneCardsi | GNPDA2 |
HGNCi | HGNC:21526, GNPDA2 |
HPAi | ENSG00000163281, Low tissue specificity |
MIMi | 613222, gene |
neXtProti | NX_Q8TDQ7 |
OpenTargetsi | ENSG00000163281 |
PharmGKBi | PA134939177 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3148, Eukaryota |
GeneTreei | ENSGT00390000014316 |
HOGENOMi | CLU_049611_0_1_1 |
InParanoidi | Q8TDQ7 |
OMAi | PLHSMKE |
PhylomeDBi | Q8TDQ7 |
TreeFami | TF300841 |
Enzyme and pathway databases
BRENDAi | 3.5.99.6, 2681 |
PathwayCommonsi | Q8TDQ7 |
Reactomei | R-HSA-70171, Glycolysis |
Miscellaneous databases
BioGRID-ORCSi | 132789, 12 hits in 843 CRISPR screens |
ChiTaRSi | GNPDA2, human |
GeneWikii | GNPDA2 |
GenomeRNAii | 132789 |
Pharosi | Q8TDQ7, Tbio |
PROi | PR:Q8TDQ7 |
RNActi | Q8TDQ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163281, Expressed in secondary oocyte and 179 other tissues |
ExpressionAtlasi | Q8TDQ7, baseline and differential |
Genevisiblei | Q8TDQ7, HS |
Family and domain databases
CDDi | cd01399, GlcN6P_deaminase, 1 hit |
HAMAPi | MF_01241, GlcN6P_deamin, 1 hit |
InterProi | View protein in InterPro IPR006148, Glc/Gal-6P_isomerase IPR004547, Glucosamine6P_isomerase IPR018321, Glucosamine6P_isomerase_CS IPR037171, NagB/RpiA_transferase-like |
PANTHERi | PTHR11280, PTHR11280, 1 hit |
Pfami | View protein in Pfam PF01182, Glucosamine_iso, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00502, nagB, 1 hit |
PROSITEi | View protein in PROSITE PS01161, GLC_GALNAC_ISOMERASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNPI2_HUMAN | |
Accessioni | Q8TDQ7Primary (citable) accession number: Q8TDQ7 Secondary accession number(s): B4DJF3 Q96NC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations