UniProtKB - Q8TDQ0 (HAVR2_HUMAN)
Hepatitis A virus cellular receptor 2
HAVCR2
Functioni
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777).
Regulates macrophage activation (PubMed:11823861).
Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005).
In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563).
In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity).
Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857).
Receptor for LGALS9 (PubMed:16286920, PubMed:24337741).
Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity).
However, the function as receptor for LGALS9 has been challenged (PubMed:23555261).
Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity).
Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity).
Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453).
In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801).
Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity).
By similarity1 Publication8 PublicationsCaution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 111 | PhosphatidylserineBy similarity | 1 | |
Metal bindingi | 116 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 118 | Phosphatidylserine; via amide nitrogenBy similarity | 1 | |
Metal bindingi | 119 | CalciumBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cellular response to lipopolysaccharide Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- macrophage activation involved in immune response Source: Ensembl
- maternal process involved in female pregnancy Source: UniProtKB
- natural killer cell tolerance induction Source: UniProtKB
- negative regulation of defense response to bacterium Source: Ensembl
- negative regulation of gene expression Source: UniProtKB
- negative regulation of granulocyte colony-stimulating factor production Source: UniProtKB
- negative regulation of immunological synapse formation Source: Ensembl
- negative regulation of interferon-alpha production Source: UniProtKB
- negative regulation of interferon-gamma production Source: UniProtKB
- negative regulation of interleukin-2 production Source: UniProtKB
- negative regulation of interleukin-3 production Source: UniProtKB
- negative regulation of interleukin-6 production Source: Ensembl
- negative regulation of myeloid dendritic cell activation Source: UniProtKB
- negative regulation of natural killer cell activation Source: Ensembl
- negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: UniProtKB
- negative regulation of T cell proliferation Source: Ensembl
- negative regulation of T-helper 1 type immune response Source: Ensembl
- negative regulation of tumor necrosis factor production Source: UniProtKB
- positive regulation of chemokine production Source: Ensembl
- positive regulation of defense response to bacterium Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of innate immune response Source: Ensembl
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-1 production Source: Ensembl
- positive regulation of interleukin-4 production Source: UniProtKB
- positive regulation of macrophage activation Source: Ensembl
- positive regulation of NIK/NF-kappaB signaling Source: Ensembl
- positive regulation of T cell proliferation Source: Ensembl
- positive regulation of tumor necrosis factor production Source: UniProtKB
- regulation of tolerance induction dependent upon immune response Source: Ensembl
- toll-like receptor 3 signaling pathway Source: Ensembl
- toll-like receptor 7 signaling pathway Source: Ensembl
- toll-like receptor 9 signaling pathway Source: Ensembl
Keywordsi
Biological process | Adaptive immunity, Immunity, Inflammatory response, Innate immunity |
Ligand | Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8TDQ0 |
Reactomei | R-HSA-451927, Interleukin-2 family signaling |
SignaLinki | Q8TDQ0 |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatitis A virus cellular receptor 2Short name: HAVcr-2 Alternative name(s): T-cell immunoglobulin and mucin domain-containing protein 3 Short name: TIMD-3 T-cell immunoglobulin mucin receptor 3 Short name: TIM-3 T-cell membrane protein 3 CD_antigen: CD366 |
Gene namesi | Name:HAVCR2 Synonyms:TIM3, TIMD3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18437, HAVCR2 |
MIMi | 606652, gene |
neXtProti | NX_Q8TDQ0 |
VEuPathDBi | HostDB:ENSG00000135077 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
- Cell junction 1 Publication
Note: Localizes to the immunological synapse between CD8+ T-cells and target cells.1 Publication
Endosome
- early endosome Source: Ensembl
Plasma Membrane
- immunological synapse Source: Ensembl
Other locations
- cell junction Source: UniProtKB-SubCell
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 202 | ExtracellularSequence analysisAdd BLAST | 181 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 224 – 301 | CytoplasmicSequence analysisAdd BLAST | 78 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
T-cell lymphoma, subcutaneous panniculitis-like (SPTCL)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_082211 | 82 | Y → C in SPTCL; associated with disease susceptibility; results in dysregulated secretion of inflammatory cytokines by macrophages; affects protein folding; decreased localization at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs184868814EnsemblClinVar. | 1 | |
Natural variantiVAR_082212 | 97 | I → M in SPTCL; associated with disease susceptibility; affects protein folding; decreased localization at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs35960726EnsemblClinVar. | 1 | |
Natural variantiVAR_082213 | 101 | T → I in SPTCL; may be associated with disease susceptibility. 2 PublicationsCorresponds to variant dbSNP:rs147827860EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 265 | Y → A: Abolishes TCR-induced NFAT activation; when associated with A-272. 1 Publication | 1 | |
Mutagenesisi | 265 | Y → E: No effect on TCR-induced NFAT activation (phosphomimetic mutation); when associated with E-272. 1 Publication | 1 | |
Mutagenesisi | 272 | Y → A: Abolishes TCR-induced NFAT activation; when associated with A-265. 1 Publication | 1 | |
Mutagenesisi | 272 | Y → E: No effect on TCR-induced NFAT activation (phosphomimetic mutation); when associated with E-265. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 84868 |
MalaCardsi | HAVCR2 |
MIMi | 618398, phenotype |
OpenTargetsi | ENSG00000135077 |
Orphaneti | 86884, Subcutaneous panniculitis-like T-cell lymphoma |
PharmGKBi | PA134883425 |
Miscellaneous databases
Pharosi | Q8TDQ0, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4630879 |
Genetic variation databases
BioMutai | HAVCR2 |
DMDMi | 311033536 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000042101 | 22 – 301 | Hepatitis A virus cellular receptor 2Add BLAST | 280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 110 | PROSITE-ProRule annotationBy similarity | ||
Disulfide bondi | 52 ↔ 63 | PROSITE-ProRule annotationBy similarity | ||
Disulfide bondi | 58 ↔ 109 | PROSITE-ProRule annotationBy similarity | ||
Glycosylationi | 145 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 265 | Phosphotyrosine; by ITK1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q8TDQ0 |
MassIVEi | Q8TDQ0 |
PaxDbi | Q8TDQ0 |
PeptideAtlasi | Q8TDQ0 |
PRIDEi | Q8TDQ0 |
ProteomicsDBi | 74319 [Q8TDQ0-1] 74320 [Q8TDQ0-2] |
PTM databases
GlyConnecti | 712, 5 O-Linked glycans (1 site) |
GlyGeni | Q8TDQ0, 4 sites, 6 O-linked glycans (3 sites) |
iPTMneti | Q8TDQ0 |
PhosphoSitePlusi | Q8TDQ0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000135077, Expressed in layer of synovial tissue and 176 other tissues |
ExpressionAtlasi | Q8TDQ0, baseline and differential |
Genevisiblei | Q8TDQ0, HS |
Organism-specific databases
HPAi | ENSG00000135077, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with HMGB1; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response (By similarity).
Interacts with BAG6 (By similarity).
Interacts (phosphorylated) with PIK3R1 and PIK3R2.
Interacts (not dependent on its phosphorylation status) with FYN (By similarity).
Interacts (in basal state T-cells) with VAV1; AKT1/2, LCP2, ZAP70, SYK, PIK3R1, FYN, SH3BP2 and SH2D2A.
Interacts (in activated T-cells) with LCK and PLCG (PubMed:26492563, PubMed:24337741).
Interacts with ILF3; this interaction promotes ILF3 ubiquitination and degradation (PubMed:34110282).
By similarity3 PublicationsBinary interactionsi
Q8TDQ0
With | #Exp. | IntAct |
---|---|---|
CEACAM1 [P13688] | 4 | EBI-11472922,EBI-4314481 |
SEC22A [Q96IW7] | 3 | EBI-11472922,EBI-8652744 |
TMEM86A [Q8N2M4] | 3 | EBI-11472922,EBI-12015604 |
Protein-protein interaction databases
BioGRIDi | 124313, 82 interactors |
DIPi | DIP-61459N |
IntActi | Q8TDQ0, 79 interactors |
STRINGi | 9606.ENSP00000312002 |
Miscellaneous databases
RNActi | Q8TDQ0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8TDQ0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 124 | Ig-like V-typeAdd BLAST | 103 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S454, Eukaryota |
GeneTreei | ENSGT00940000154444 |
InParanoidi | Q8TDQ0 |
OMAi | EHGPAET |
OrthoDBi | 1147868at2759 |
PhylomeDBi | Q8TDQ0 |
TreeFami | TF336163 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFSHLPFDCV LLLLLLLLTR SSEVEYRAEV GQNAYLPCFY TPAAPGNLVP
60 70 80 90 100
VCWGKGACPV FECGNVVLRT DERDVNYWTS RYWLNGDFRK GDVSLTIENV
110 120 130 140 150
TLADSGIYCC RIQIPGIMND EKFNLKLVIK PAKVTPAPTR QRDFTAAFPR
160 170 180 190 200
MLTTRGHGPA ETQTLGSLPD INLTQISTLA NELRDSRLAN DLRDSGATIR
210 220 230 240 250
IGIYIGAGIC AGLALALIFG ALIFKWYSHS KEKIQNLSLI SLANLPPSGL
260 270 280 290 300
ANAVAEGIRS EENIYTIEEN VYEVEEPNEY YCYVSSRQQP SQPLGCRFAM
P
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RHN3 | E5RHN3_HUMAN | Hepatitis A virus cellular receptor... | HAVCR2 | 273 | Annotation score: | ||
E5RFR4 | E5RFR4_HUMAN | Hepatitis A virus cellular receptor... | HAVCR2 | 74 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_082211 | 82 | Y → C in SPTCL; associated with disease susceptibility; results in dysregulated secretion of inflammatory cytokines by macrophages; affects protein folding; decreased localization at the cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs184868814EnsemblClinVar. | 1 | |
Natural variantiVAR_082212 | 97 | I → M in SPTCL; associated with disease susceptibility; affects protein folding; decreased localization at the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs35960726EnsemblClinVar. | 1 | |
Natural variantiVAR_082213 | 101 | T → I in SPTCL; may be associated with disease susceptibility. 2 PublicationsCorresponds to variant dbSNP:rs147827860EnsemblClinVar. | 1 | |
Natural variantiVAR_025342 | 140 | R → L6 PublicationsCorresponds to variant dbSNP:rs1036199Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017287 | 132 – 142 | AKVTPAPTRQR → GEWTFACHLYE in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_017288 | 143 – 301 | Missing in isoform 2. 1 PublicationAdd BLAST | 159 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF251707 mRNA Translation: AAM19100.1 AY069944 mRNA Translation: AAL55401.1 AK027334 mRNA Translation: BAB55044.1 AK314406 mRNA Translation: BAG37029.1 AC011377 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61614.1 BC020843 mRNA Translation: AAH20843.1 BC063431 mRNA Translation: AAH63431.1 |
CCDSi | CCDS4333.1 [Q8TDQ0-1] |
RefSeqi | NP_116171.3, NM_032782.4 [Q8TDQ0-1] |
Genome annotation databases
Ensembli | ENST00000307851; ENSP00000312002; ENSG00000135077 |
GeneIDi | 84868 |
KEGGi | hsa:84868 |
MANE-Selecti | ENST00000307851.9; ENSP00000312002.4; NM_032782.5; NP_116171.3 |
UCSCi | uc003lwk.3, human [Q8TDQ0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF251707 mRNA Translation: AAM19100.1 AY069944 mRNA Translation: AAL55401.1 AK027334 mRNA Translation: BAB55044.1 AK314406 mRNA Translation: BAG37029.1 AC011377 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61614.1 BC020843 mRNA Translation: AAH20843.1 BC063431 mRNA Translation: AAH63431.1 |
CCDSi | CCDS4333.1 [Q8TDQ0-1] |
RefSeqi | NP_116171.3, NM_032782.4 [Q8TDQ0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5DZL | X-ray | 3.40 | A/B | 22-126 | [»] | |
5F71 | X-ray | 2.40 | A/B | 22-130 | [»] | |
6DHB | X-ray | 1.70 | A | 24-130 | [»] | |
6TXZ | X-ray | 3.06 | A/B/C/D | 22-130 | [»] | |
7M3Y | X-ray | 1.69 | B | 22-130 | [»] | |
7M3Z | X-ray | 1.40 | A | 22-130 | [»] | |
7M41 | X-ray | 1.79 | A/B | 22-130 | [»] | |
SMRi | Q8TDQ0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124313, 82 interactors |
DIPi | DIP-61459N |
IntActi | Q8TDQ0, 79 interactors |
STRINGi | 9606.ENSP00000312002 |
Chemistry databases
ChEMBLi | CHEMBL4630879 |
PTM databases
GlyConnecti | 712, 5 O-Linked glycans (1 site) |
GlyGeni | Q8TDQ0, 4 sites, 6 O-linked glycans (3 sites) |
iPTMneti | Q8TDQ0 |
PhosphoSitePlusi | Q8TDQ0 |
Genetic variation databases
BioMutai | HAVCR2 |
DMDMi | 311033536 |
Proteomic databases
jPOSTi | Q8TDQ0 |
MassIVEi | Q8TDQ0 |
PaxDbi | Q8TDQ0 |
PeptideAtlasi | Q8TDQ0 |
PRIDEi | Q8TDQ0 |
ProteomicsDBi | 74319 [Q8TDQ0-1] 74320 [Q8TDQ0-2] |
Protocols and materials databases
ABCDi | Q8TDQ0, 1 sequenced antibody |
Antibodypediai | 2450, 1324 antibodies from 44 providers |
CPTCi | Q8TDQ0, 1 antibody |
DNASUi | 84868 |
Genome annotation databases
Ensembli | ENST00000307851; ENSP00000312002; ENSG00000135077 |
GeneIDi | 84868 |
KEGGi | hsa:84868 |
MANE-Selecti | ENST00000307851.9; ENSP00000312002.4; NM_032782.5; NP_116171.3 |
UCSCi | uc003lwk.3, human [Q8TDQ0-1] |
Organism-specific databases
CTDi | 84868 |
DisGeNETi | 84868 |
GeneCardsi | HAVCR2 |
HGNCi | HGNC:18437, HAVCR2 |
HPAi | ENSG00000135077, Tissue enhanced (lymphoid) |
MalaCardsi | HAVCR2 |
MIMi | 606652, gene 618398, phenotype |
neXtProti | NX_Q8TDQ0 |
OpenTargetsi | ENSG00000135077 |
Orphaneti | 86884, Subcutaneous panniculitis-like T-cell lymphoma |
PharmGKBi | PA134883425 |
VEuPathDBi | HostDB:ENSG00000135077 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S454, Eukaryota |
GeneTreei | ENSGT00940000154444 |
InParanoidi | Q8TDQ0 |
OMAi | EHGPAET |
OrthoDBi | 1147868at2759 |
PhylomeDBi | Q8TDQ0 |
TreeFami | TF336163 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDQ0 |
Reactomei | R-HSA-451927, Interleukin-2 family signaling |
SignaLinki | Q8TDQ0 |
Miscellaneous databases
BioGRID-ORCSi | 84868, 5 hits in 1041 CRISPR screens |
ChiTaRSi | HAVCR2, human |
GeneWikii | HAVCR2 |
GenomeRNAii | 84868 |
Pharosi | Q8TDQ0, Tbio |
PROi | PR:Q8TDQ0 |
RNActi | Q8TDQ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135077, Expressed in layer of synovial tissue and 176 other tissues |
ExpressionAtlasi | Q8TDQ0, baseline and differential |
Genevisiblei | Q8TDQ0, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HAVR2_HUMAN | |
Accessioni | Q8TDQ0Primary (citable) accession number: Q8TDQ0 Secondary accession number(s): B2RAY2, Q8WW60, Q96K94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families