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Entry version 137 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Ribonuclease H2 subunit C

Gene

RNASEH2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

2 Publications

Miscellaneous

The T6 pseudogene located upstream of SRY on chromosome Y is derived from the transcript of this gene.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS16149-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.26.4, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TDP1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease H2 subunit C
Short name:
RNase H2 subunit C
Alternative name(s):
Aicardi-Goutieres syndrome 3 protein
Short name:
AGS3
RNase H1 small subunit
Ribonuclease HI subunit C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASEH2C
Synonyms:AYP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24116, RNASEH2C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610330, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDP1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000172922.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aicardi-Goutieres syndrome 3 (AGS3)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07061813R → H in AGS3. 1 PublicationCorresponds to variant dbSNP:rs75328625Ensembl.1
Natural variantiVAR_07061939D → Y in AGS3. 1 PublicationCorresponds to variant dbSNP:rs773527127EnsemblClinVar.1
Natural variantiVAR_02728769R → W in AGS3. 3 PublicationsCorresponds to variant dbSNP:rs78635798Ensembl.1
Natural variantiVAR_07062076P → L in AGS3. 1 PublicationCorresponds to variant dbSNP:rs76091978EnsemblClinVar.1
Natural variantiVAR_070621138P → L in AGS3. 1 Publication1
Natural variantiVAR_027288143K → I in AGS3. 2 PublicationsCorresponds to variant dbSNP:rs75146158EnsemblClinVar.1
Natural variantiVAR_070622151P → S in AGS3. 1 PublicationCorresponds to variant dbSNP:rs78464826EnsemblClinVar.1

Keywords - Diseasei

Aicardi-Goutieres syndrome, Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
84153

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
RNASEH2C

MalaCards human disease database

More...
MalaCardsi
RNASEH2C
MIMi610329, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000172922

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
51, Aicardi-Goutieres syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162401445

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TDP1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNASEH2C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730607

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002483851 – 164Ribonuclease H2 subunit CAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TDP1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TDP1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TDP1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TDP1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDP1

PeptideAtlas

More...
PeptideAtlasi
Q8TDP1

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDP1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172922, Expressed in tendon of biceps brachii and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TDP1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDP1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000172922, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123916, 15 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-745, RNase H2 complex

Protein interaction database and analysis system

More...
IntActi
Q8TDP1, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308193

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TDP1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TDP1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TDP1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni91 – 112DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNase H2 subunit C family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SBKV, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001568

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDP1

Database of Orthologous Groups

More...
OrthoDBi
1542008at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDP1

TreeFam database of animal gene trees

More...
TreeFami
TF324370

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09271, RNase_H2-C, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID00602

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013924, RNase_H2_suC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08615, RNase_H2_suC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8TDP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESGDEAAIE RHRVHLRSAT LRDAVPATLH LLPCEVAVDG PAPVGRFFTP
60 70 80 90 100
AIRQGPEGLE VSFRGRCLRG EEVAVPPGLV GYVMVTEEKK VSMGKPDPLR
110 120 130 140 150
DSGTDDQEEE PLERDFDRFI GATANFSRFT LWGLETIPGP DAKVRGALTW
160
PSLAAAIHAQ VPED
Length:164
Mass (Da):17,840
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13D0F1D039963671
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PN81E9PN81_HUMAN
Ribonuclease H2 subunit C
RNASEH2C
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07061813R → H in AGS3. 1 PublicationCorresponds to variant dbSNP:rs75328625Ensembl.1
Natural variantiVAR_07061939D → Y in AGS3. 1 PublicationCorresponds to variant dbSNP:rs773527127EnsemblClinVar.1
Natural variantiVAR_02728769R → W in AGS3. 3 PublicationsCorresponds to variant dbSNP:rs78635798Ensembl.1
Natural variantiVAR_07062076P → L in AGS3. 1 PublicationCorresponds to variant dbSNP:rs76091978EnsemblClinVar.1
Natural variantiVAR_070621138P → L in AGS3. 1 Publication1
Natural variantiVAR_027288143K → I in AGS3. 2 PublicationsCorresponds to variant dbSNP:rs75146158EnsemblClinVar.1
Natural variantiVAR_070622151P → S in AGS3. 1 PublicationCorresponds to variant dbSNP:rs78464826EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF312034 mRNA Translation: AAL87739.1
AF346605 Genomic DNA Translation: AAO49176.1
AF346606 mRNA Translation: AAO49177.1
AK024627 mRNA Translation: BAB14937.1
BC023588 mRNA Translation: AAH23588.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8111.1

NCBI Reference Sequences

More...
RefSeqi
NP_115569.2, NM_032193.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308418; ENSP00000308193; ENSG00000172922
ENST00000531596; ENSP00000435717; ENSG00000172922
ENST00000534482; ENSP00000432081; ENSG00000172922
ENST00000644142; ENSP00000493695; ENSG00000172922

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84153

UCSC genome browser

More...
UCSCi
uc001ofn.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312034 mRNA Translation: AAL87739.1
AF346605 Genomic DNA Translation: AAO49176.1
AF346606 mRNA Translation: AAO49177.1
AK024627 mRNA Translation: BAB14937.1
BC023588 mRNA Translation: AAH23588.1
CCDSiCCDS8111.1
RefSeqiNP_115569.2, NM_032193.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P56X-ray4.06C/F1-164[»]
3PUFX-ray3.10C/F/I/L/O/R1-164[»]
SMRiQ8TDP1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123916, 15 interactors
ComplexPortaliCPX-745, RNase H2 complex
IntActiQ8TDP1, 7 interactors
STRINGi9606.ENSP00000308193

PTM databases

iPTMnetiQ8TDP1
PhosphoSitePlusiQ8TDP1

Genetic variation databases

BioMutaiRNASEH2C
DMDMi74730607

Proteomic databases

EPDiQ8TDP1
jPOSTiQ8TDP1
MassIVEiQ8TDP1
MaxQBiQ8TDP1
PaxDbiQ8TDP1
PeptideAtlasiQ8TDP1
PRIDEiQ8TDP1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
44295, 134 antibodies

The DNASU plasmid repository

More...
DNASUi
84153

Genome annotation databases

EnsembliENST00000308418; ENSP00000308193; ENSG00000172922
ENST00000531596; ENSP00000435717; ENSG00000172922
ENST00000534482; ENSP00000432081; ENSG00000172922
ENST00000644142; ENSP00000493695; ENSG00000172922
GeneIDi84153
KEGGihsa:84153
UCSCiuc001ofn.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84153
DisGeNETi84153

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RNASEH2C
GeneReviewsiRNASEH2C
HGNCiHGNC:24116, RNASEH2C
HPAiENSG00000172922, Low tissue specificity
MalaCardsiRNASEH2C
MIMi610329, phenotype
610330, gene
neXtProtiNX_Q8TDP1
OpenTargetsiENSG00000172922
Orphaneti51, Aicardi-Goutieres syndrome
PharmGKBiPA162401445
VEuPathDBiHostDB:ENSG00000172922.8

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SBKV, Eukaryota
GeneTreeiENSGT00390000001568
InParanoidiQ8TDP1
OrthoDBi1542008at2759
PhylomeDBiQ8TDP1
TreeFamiTF324370

Enzyme and pathway databases

BioCyciMetaCyc:HS16149-MONOMER
BRENDAi3.1.26.4, 2681
PathwayCommonsiQ8TDP1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84153, 187 hits in 1008 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RNASEH2C, human
EvolutionaryTraceiQ8TDP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84153
PharosiQ8TDP1, Tbio

Protein Ontology

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PROi
PR:Q8TDP1
RNActiQ8TDP1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000172922, Expressed in tendon of biceps brachii and 216 other tissues
ExpressionAtlasiQ8TDP1, baseline and differential
GenevisibleiQ8TDP1, HS

Family and domain databases

CDDicd09271, RNase_H2-C, 1 hit
IDEALiIID00602
InterProiView protein in InterPro
IPR013924, RNase_H2_suC
PfamiView protein in Pfam
PF08615, RNase_H2_suC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNH2C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDP1
Secondary accession number(s): Q9H7F5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2002
Last modified: June 2, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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