UniProtKB - Q8TDN6 (BRX1_HUMAN)
Protein
Ribosome biogenesis protein BRX1 homolog
Gene
BRIX1
Organism
Homo sapiens (Human)
Status
Functioni
Required for biogenesis of the 60S ribosomal subunit.
GO - Molecular functioni
- RNA binding Source: UniProtKB
- rRNA binding Source: InterPro
GO - Biological processi
- ribosomal large subunit assembly Source: GO_Central
- rRNA processing Source: InterPro
Keywordsi
Biological process | Ribosome biogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q8TDN6 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosome biogenesis protein BRX1 homologAlternative name(s): Brix domain-containing protein 2 |
Gene namesi | Name:BRIX1 Synonyms:BRIX, BXDC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24170, BRIX1 |
MIMi | 618466, gene |
neXtProti | NX_Q8TDN6 |
VEuPathDBi | HostDB:ENSG00000113460.12 |
Subcellular locationi
Nucleus
Nucleus
- nucleolus Source: HPA
Other locations
- chromosome Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000113460 |
PharmGKBi | PA165660166 |
Miscellaneous databases
Pharosi | Q8TDN6, Tbio |
Genetic variation databases
BioMutai | BRIX1 |
DMDMi | 30580352 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120230 | 1 – 353 | Ribosome biogenesis protein BRX1 homologAdd BLAST | 353 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 160 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 261 | PhosphoserineCombined sources | 1 | |
Modified residuei | 276 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 314 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 322 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8TDN6 |
jPOSTi | Q8TDN6 |
MassIVEi | Q8TDN6 |
MaxQBi | Q8TDN6 |
PaxDbi | Q8TDN6 |
PeptideAtlasi | Q8TDN6 |
PRIDEi | Q8TDN6 |
ProteomicsDBi | 74313 |
PTM databases
iPTMneti | Q8TDN6 |
MetOSitei | Q8TDN6 |
PhosphoSitePlusi | Q8TDN6 |
SwissPalmi | Q8TDN6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000113460, Expressed in left coronary artery and 178 other tissues |
Genevisiblei | Q8TDN6, HS |
Organism-specific databases
HPAi | ENSG00000113460, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8TDN6
With | #Exp. | IntAct |
---|---|---|
EBNA1BP2 [Q99848] | 4 | EBI-1052326,EBI-1048111 |
HNRNPU [Q00839] | 2 | EBI-1052326,EBI-351126 |
Protein-protein interaction databases
BioGRIDi | 120586, 185 interactors |
CORUMi | Q8TDN6 |
IntActi | Q8TDN6, 79 interactors |
MINTi | Q8TDN6 |
STRINGi | 9606.ENSP00000338862 |
Miscellaneous databases
RNActi | Q8TDN6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 249 | BrixPROSITE-ProRule annotationAdd BLAST | 190 |
Sequence similaritiesi
Belongs to the BRX1 family.Curated
Phylogenomic databases
eggNOGi | KOG2971, Eukaryota |
GeneTreei | ENSGT00390000014467 |
HOGENOMi | CLU_048373_2_0_1 |
InParanoidi | Q8TDN6 |
OMAi | DHVMGFT |
OrthoDBi | 973436at2759 |
PhylomeDBi | Q8TDN6 |
TreeFami | TF105766 |
Family and domain databases
InterProi | View protein in InterPro IPR007109, Brix IPR026532, BRX1 |
PANTHERi | PTHR13634, PTHR13634, 1 hit |
Pfami | View protein in Pfam PF04427, Brix, 1 hit |
SMARTi | View protein in SMART SM00879, Brix, 1 hit |
PROSITEi | View protein in PROSITE PS50833, BRIX, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8TDN6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAATKRKRRG GFAVQAKKPK RNEIDAEPPA KRHATAEEVE EEERDRIPGP
60 70 80 90 100
VCKGKWKNKE RILIFSSRGI NFRTRHLMQD LRMLMPHSKA DTKMDRKDKL
110 120 130 140 150
FVINEVCEMK NCNKCIYFEA KKKQDLYMWL SNSPHGPSAK FLVQNIHTLA
160 170 180 190 200
ELKMTGNCLK GSRPLLSFDP AFDELPHYAL LKELLIQIFS TPRYHPKSQP
210 220 230 240 250
FVDHVFTFTI LDNRIWFRNF QIIEEDAALV EIGPRFVLNL IKIFQGSFGG
260 270 280 290 300
PTLYENPHYQ SPNMHRRVIR SITAAKYREK QQVKDVQKLR KKEPKTLLPH
310 320 330 340 350
DPTADVFVTP AEEKPIEIQW VKPEPKVDLK ARKKRIYKRQ RKMKQRMDSG
KTK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 – 27 | GFAVQ…EIDAE → RLCSSGEEAKKKRNRCG in AAL83818 (PubMed:11843177).CuratedAdd BLAST | 17 | |
Sequence conflicti | 34 | A → V in AAL83818 (PubMed:11843177).Curated | 1 | |
Sequence conflicti | 286 | V → VP in AAL83818 (PubMed:11843177).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF347667 mRNA Translation: AAL83818.1 AY364244 mRNA Translation: AAQ76803.1 AK289610 mRNA Translation: BAF82299.1 CH471119 Genomic DNA Translation: EAW55909.1 BC001546 mRNA Translation: AAH01546.2 BC036741 mRNA Translation: AAH36741.1 |
CCDSi | CCDS34143.1 |
RefSeqi | NP_060791.3, NM_018321.3 |
Genome annotation databases
Ensembli | ENST00000336767; ENSP00000338862; ENSG00000113460 |
GeneIDi | 55299 |
KEGGi | hsa:55299 |
UCSCi | uc003jja.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF347667 mRNA Translation: AAL83818.1 AY364244 mRNA Translation: AAQ76803.1 AK289610 mRNA Translation: BAF82299.1 CH471119 Genomic DNA Translation: EAW55909.1 BC001546 mRNA Translation: AAH01546.2 BC036741 mRNA Translation: AAH36741.1 |
CCDSi | CCDS34143.1 |
RefSeqi | NP_060791.3, NM_018321.3 |
3D structure databases
SMRi | Q8TDN6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120586, 185 interactors |
CORUMi | Q8TDN6 |
IntActi | Q8TDN6, 79 interactors |
MINTi | Q8TDN6 |
STRINGi | 9606.ENSP00000338862 |
PTM databases
iPTMneti | Q8TDN6 |
MetOSitei | Q8TDN6 |
PhosphoSitePlusi | Q8TDN6 |
SwissPalmi | Q8TDN6 |
Genetic variation databases
BioMutai | BRIX1 |
DMDMi | 30580352 |
Proteomic databases
EPDi | Q8TDN6 |
jPOSTi | Q8TDN6 |
MassIVEi | Q8TDN6 |
MaxQBi | Q8TDN6 |
PaxDbi | Q8TDN6 |
PeptideAtlasi | Q8TDN6 |
PRIDEi | Q8TDN6 |
ProteomicsDBi | 74313 |
Protocols and materials databases
Antibodypediai | 10048, 200 antibodies |
DNASUi | 55299 |
Genome annotation databases
Ensembli | ENST00000336767; ENSP00000338862; ENSG00000113460 |
GeneIDi | 55299 |
KEGGi | hsa:55299 |
UCSCi | uc003jja.4, human |
Organism-specific databases
CTDi | 55299 |
GeneCardsi | BRIX1 |
HGNCi | HGNC:24170, BRIX1 |
HPAi | ENSG00000113460, Low tissue specificity |
MIMi | 618466, gene |
neXtProti | NX_Q8TDN6 |
OpenTargetsi | ENSG00000113460 |
PharmGKBi | PA165660166 |
VEuPathDBi | HostDB:ENSG00000113460.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2971, Eukaryota |
GeneTreei | ENSGT00390000014467 |
HOGENOMi | CLU_048373_2_0_1 |
InParanoidi | Q8TDN6 |
OMAi | DHVMGFT |
OrthoDBi | 973436at2759 |
PhylomeDBi | Q8TDN6 |
TreeFami | TF105766 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDN6 |
Miscellaneous databases
BioGRID-ORCSi | 55299, 709 hits in 996 CRISPR screens |
ChiTaRSi | BRIX1, human |
GeneWikii | BXDC2 |
GenomeRNAii | 55299 |
Pharosi | Q8TDN6, Tbio |
PROi | PR:Q8TDN6 |
RNActi | Q8TDN6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113460, Expressed in left coronary artery and 178 other tissues |
Genevisiblei | Q8TDN6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007109, Brix IPR026532, BRX1 |
PANTHERi | PTHR13634, PTHR13634, 1 hit |
Pfami | View protein in Pfam PF04427, Brix, 1 hit |
SMARTi | View protein in SMART SM00879, Brix, 1 hit |
PROSITEi | View protein in PROSITE PS50833, BRIX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BRX1_HUMAN | |
Accessioni | Q8TDN6Primary (citable) accession number: Q8TDN6 Secondary accession number(s): A8K0P5 Q96DH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 9, 2003 |
Last sequence update: | May 9, 2003 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families