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Entry version 153 (03 Jul 2019)
Sequence version 2 (09 May 2003)
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Protein

Ribosome biogenesis protein BRX1 homolog

Gene

BRIX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for biogenesis of the 60S ribosomal subunit.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome biogenesis protein BRX1 homolog
Alternative name(s):
Brix domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRIX1
Synonyms:BRIX, BXDC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24170 BRIX1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDN6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000113460

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165660166

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRIX1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30580352

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001202301 – 353Ribosome biogenesis protein BRX1 homologAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki160Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei261PhosphoserineCombined sources1
Modified residuei276N6-acetyllysineCombined sources1
Cross-linki314Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki322Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TDN6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TDN6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TDN6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDN6

PeptideAtlas

More...
PeptideAtlasi
Q8TDN6

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDN6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74313

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDN6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TDN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113460 Expressed in 168 organ(s), highest expression level in left coronary artery

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDN6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039614

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPUQ008392EBI-1052326,EBI-351126

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120586, 136 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8TDN6

Protein interaction database and analysis system

More...
IntActi
Q8TDN6, 37 interactors

Molecular INTeraction database

More...
MINTi
Q8TDN6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338862

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TDN6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 249BrixPROSITE-ProRule annotationAdd BLAST190

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BRX1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2971 Eukaryota
COG5154 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014467

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000212937

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDN6

KEGG Orthology (KO)

More...
KOi
K14820

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWIRNYQ

Database of Orthologous Groups

More...
OrthoDBi
973436at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDN6

TreeFam database of animal gene trees

More...
TreeFami
TF105766

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007109 Brix
IPR026532 BRX1

The PANTHER Classification System

More...
PANTHERi
PTHR13634 PTHR13634, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04427 Brix, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00879 Brix, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50833 BRIX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TDN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATKRKRRG GFAVQAKKPK RNEIDAEPPA KRHATAEEVE EEERDRIPGP
60 70 80 90 100
VCKGKWKNKE RILIFSSRGI NFRTRHLMQD LRMLMPHSKA DTKMDRKDKL
110 120 130 140 150
FVINEVCEMK NCNKCIYFEA KKKQDLYMWL SNSPHGPSAK FLVQNIHTLA
160 170 180 190 200
ELKMTGNCLK GSRPLLSFDP AFDELPHYAL LKELLIQIFS TPRYHPKSQP
210 220 230 240 250
FVDHVFTFTI LDNRIWFRNF QIIEEDAALV EIGPRFVLNL IKIFQGSFGG
260 270 280 290 300
PTLYENPHYQ SPNMHRRVIR SITAAKYREK QQVKDVQKLR KKEPKTLLPH
310 320 330 340 350
DPTADVFVTP AEEKPIEIQW VKPEPKVDLK ARKKRIYKRQ RKMKQRMDSG

KTK
Length:353
Mass (Da):41,401
Last modified:May 9, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF05597673A13B7CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11 – 27GFAVQ…EIDAE → RLCSSGEEAKKKRNRCG in AAL83818 (PubMed:11843177).CuratedAdd BLAST17
Sequence conflicti34A → V in AAL83818 (PubMed:11843177).Curated1
Sequence conflicti286V → VP in AAL83818 (PubMed:11843177).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF347667 mRNA Translation: AAL83818.1
AY364244 mRNA Translation: AAQ76803.1
AK289610 mRNA Translation: BAF82299.1
CH471119 Genomic DNA Translation: EAW55909.1
BC001546 mRNA Translation: AAH01546.2
BC036741 mRNA Translation: AAH36741.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34143.1

NCBI Reference Sequences

More...
RefSeqi
NP_060791.3, NM_018321.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336767; ENSP00000338862; ENSG00000113460

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55299

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55299

UCSC genome browser

More...
UCSCi
uc003jja.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347667 mRNA Translation: AAL83818.1
AY364244 mRNA Translation: AAQ76803.1
AK289610 mRNA Translation: BAF82299.1
CH471119 Genomic DNA Translation: EAW55909.1
BC001546 mRNA Translation: AAH01546.2
BC036741 mRNA Translation: AAH36741.1
CCDSiCCDS34143.1
RefSeqiNP_060791.3, NM_018321.3

3D structure databases

SMRiQ8TDN6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120586, 136 interactors
CORUMiQ8TDN6
IntActiQ8TDN6, 37 interactors
MINTiQ8TDN6
STRINGi9606.ENSP00000338862

PTM databases

iPTMnetiQ8TDN6
PhosphoSitePlusiQ8TDN6
SwissPalmiQ8TDN6

Polymorphism and mutation databases

BioMutaiBRIX1
DMDMi30580352

Proteomic databases

EPDiQ8TDN6
jPOSTiQ8TDN6
MaxQBiQ8TDN6
PaxDbiQ8TDN6
PeptideAtlasiQ8TDN6
PRIDEiQ8TDN6
ProteomicsDBi74313

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55299
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336767; ENSP00000338862; ENSG00000113460
GeneIDi55299
KEGGihsa:55299
UCSCiuc003jja.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55299

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BRIX1
HGNCiHGNC:24170 BRIX1
HPAiHPA039614
neXtProtiNX_Q8TDN6
OpenTargetsiENSG00000113460
PharmGKBiPA165660166

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2971 Eukaryota
COG5154 LUCA
GeneTreeiENSGT00390000014467
HOGENOMiHOG000212937
InParanoidiQ8TDN6
KOiK14820
OMAiIWIRNYQ
OrthoDBi973436at2759
PhylomeDBiQ8TDN6
TreeFamiTF105766

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BXDC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55299

Protein Ontology

More...
PROi
PR:Q8TDN6

Gene expression databases

BgeeiENSG00000113460 Expressed in 168 organ(s), highest expression level in left coronary artery
GenevisibleiQ8TDN6 HS

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
IPR026532 BRX1
PANTHERiPTHR13634 PTHR13634, 1 hit
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRX1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDN6
Secondary accession number(s): A8K0P5
, Q3ZTT4, Q8N453, Q96DH1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: July 3, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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