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UniProtKB - Q8TDN2 (KCNV2_HUMAN)

Entry version 149 (08 May 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Potassium voltage-gated channel subfamily V member 2

Gene

KCNV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • voltage-gated potassium channel activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296072 Voltage gated Potassium channels

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.2.23 the voltage-gated ion channel (vic) superfamily
1.A.1.2.24 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 2
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNV2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19698 KCNV2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607604 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDN2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 155CytoplasmicSequence analysisAdd BLAST155
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei156 – 176Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini177 – 261ExtracellularSequence analysisAdd BLAST85
Transmembranei262 – 282Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini283 – 336CytoplasmicSequence analysisAdd BLAST54
Transmembranei337 – 357Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini358 – 374ExtracellularSequence analysisAdd BLAST17
Transmembranei375 – 395Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini396 – 410CytoplasmicSequence analysisAdd BLAST15
Transmembranei411 – 431Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini432 – 444ExtracellularSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei445 – 465Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini466 – 471ExtracellularSequence analysis6
Transmembranei472 – 492Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini493 – 545CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cone dystrophy retinal 3B (RCD3B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.
See also OMIM:610356
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027632126L → Q in RCD3B. 1 PublicationCorresponds to variant dbSNP:rs776275880Ensembl.1
Natural variantiVAR_027633188W → C in RCD3B. 1 PublicationCorresponds to variant dbSNP:rs772921412Ensembl.1
Natural variantiVAR_027634256S → W in RCD3B. 1 PublicationCorresponds to variant dbSNP:rs104894116EnsemblClinVar.1
Natural variantiVAR_027635259A → V in RCD3B. 1 Publication1
Natural variantiVAR_027636339 – 341Missing in RCD3B. 1 Publication3
Natural variantiVAR_027637459G → D in RCD3B. 1 PublicationCorresponds to variant dbSNP:rs104894115EnsemblClinVar.1

Keywords - Diseasei

Cone-rod dystrophy, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		169522

MalaCards human disease database

More...MalaCardsi		KCNV2
MIMi610356 phenotype

Open Targets

More...OpenTargetsi		ENSG00000168263

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		209932 Cone dystrophy with supernormal rod response

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134992655

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2362996

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNV2

Domain mapping of disease mutations (DMDM)

More...DMDMi		26006804

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540941 – 545Potassium voltage-gated channel subfamily V member 2Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDN2

PeptideAtlas

More...PeptideAtlasi		Q8TDN2

PRoteomics IDEntifications database

More...PRIDEi		Q8TDN2

ProteomicsDB human proteome resource

More...ProteomicsDBi		74309

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDN2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168263 Expressed in 26 organ(s), highest expression level in sperm

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDN2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA031131

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		127982, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q8TDN2, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000371514

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi457 – 462Selectivity filterBy similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3713 Eukaryota
COG1226 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157438

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231016

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDN2

KEGG Orthology (KO)

More...KOi		K04935

Identification of Orthologs from Complete Genome Data

More...OMAi		QLVYNFY

Database of Orthologous Groups

More...OrthoDBi		818306at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDN2

TreeFam database of animal gene trees

More...TreeFami		TF313103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11537 PTHR11537, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01494 KV9CHANNEL
PR01491 KVCHANNEL

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54695 SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TDN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKQSERRRS WSYRPWNTTE NEGSQHRRSI CSLGARSGSQ ASIHGWTEGN 
        60         70         80         90        100
YNYYIEEDED GEEEDQWKDD LAEEDQQAGE VTTAKPEGPS DPPALLSTLN 
       110        120        130        140        150
VNVGGHSYQL DYCELAGFPK TRLGRLATST SRSRQLSLCD DYEEQTDEYF 
       160        170        180        190        200
FDRDPAVFQL VYNFYLSGVL LVLDGLCPRR FLEELGYWGV RLKYTPRCCR 
       210        220        230        240        250
ICFEERRDEL SERLKIQHEL RAQAQVEEAE ELFRDMRFYG PQRRRLWNLM 
       260        270        280        290        300
EKPFSSVAAK AIGVASSTFV LVSVVALALN TVEEMQQHSG QGEGGPDLRP 
       310        320        330        340        350
ILEHVEMLCM GFFTLEYLLR LASTPDLRRF ARSALNLVDL VAILPLYLQL 
       360        370        380        390        400
LLECFTGEGH QRGQTVGSVG KVGQVLRVMR LMRIFRILKL ARHSTGLRAF 
       410        420        430        440        450
GFTLRQCYQQ VGCLLLFIAM GIFTFSAAVY SVEHDVPSTN FTTIPHSWWW 
       460        470        480        490        500
AAVSISTVGY GDMYPETHLG RFFAFLCIAF GIILNGMPIS ILYNKFSDYY 
       510        520        530        540 
SKLKAYEYTT IRRERGEVNF MQRARKKIAE CLLGSNPQLT PRQEN
Length:545
Mass (Da):62,459
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72D175B4C0C6B1DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027632126L → Q in RCD3B. 1 PublicationCorresponds to variant dbSNP:rs776275880Ensembl.1
Natural variantiVAR_027633188W → C in RCD3B. 1 PublicationCorresponds to variant dbSNP:rs772921412Ensembl.1
Natural variantiVAR_027634256S → W in RCD3B. 1 PublicationCorresponds to variant dbSNP:rs104894116EnsemblClinVar.1
Natural variantiVAR_027635259A → V in RCD3B. 1 Publication1
Natural variantiVAR_027636339 – 341Missing in RCD3B. 1 Publication3
Natural variantiVAR_027637459G → D in RCD3B. 1 PublicationCorresponds to variant dbSNP:rs104894115EnsemblClinVar.1
Natural variantiVAR_027638533L → V1 PublicationCorresponds to variant dbSNP:rs12352254EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF348983 mRNA Translation: AAL83910.1
AL354723 Genomic DNA No translation available.
BC101352 mRNA Translation: AAI01353.1
BC101353 mRNA Translation: AAI01354.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6447.1

NCBI Reference Sequences

More...RefSeqi		NP_598004.1, NM_133497.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000382082; ENSP00000371514; ENSG00000168263

Database of genes from NCBI RefSeq genomes

More...GeneIDi		169522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:169522

UCSC genome browser

More...UCSCi		uc003zho.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348983 mRNA Translation: AAL83910.1
AL354723 Genomic DNA No translation available.
BC101352 mRNA Translation: AAI01353.1
BC101353 mRNA Translation: AAI01354.1
CCDSiCCDS6447.1
RefSeqiNP_598004.1, NM_133497.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi127982, 6 interactors
IntActiQ8TDN2, 1 interactor
STRINGi9606.ENSP00000371514

Chemistry databases

ChEMBLiCHEMBL2362996

Protein family/group databases

TCDBi1.A.1.2.23 the voltage-gated ion channel (vic) superfamily
1.A.1.2.24 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ8TDN2
PhosphoSitePlusiQ8TDN2

Polymorphism and mutation databases

BioMutaiKCNV2
DMDMi26006804

Proteomic databases

PaxDbiQ8TDN2
PeptideAtlasiQ8TDN2
PRIDEiQ8TDN2
ProteomicsDBi74309

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382082; ENSP00000371514; ENSG00000168263
GeneIDi169522
KEGGihsa:169522
UCSCiuc003zho.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		169522
DisGeNETi169522

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNV2

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0035118
HGNCiHGNC:19698 KCNV2
HPAiHPA031131
MalaCardsiKCNV2
MIMi607604 gene
610356 phenotype
neXtProtiNX_Q8TDN2
OpenTargetsiENSG00000168263
Orphaneti209932 Cone dystrophy with supernormal rod response
PharmGKBiPA134992655

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000157438
HOGENOMiHOG000231016
InParanoidiQ8TDN2
KOiK04935
OMAiQLVYNFY
OrthoDBi818306at2759
PhylomeDBiQ8TDN2
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNV2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		169522

Protein Ontology

More...PROi		PR:Q8TDN2

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168263 Expressed in 26 organ(s), highest expression level in sperm
GenevisibleiQ8TDN2 HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01494 KV9CHANNEL
PR01491 KVCHANNEL
SUPFAMiSSF54695 SSF54695, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNV2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDN2
Secondary accession number(s): Q5T6X0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 2002
Last modified: May 8, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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