UniProtKB - Q8TDN1 (KCNG4_HUMAN)
Protein
Potassium voltage-gated channel subfamily G member 4
Gene
KCNG4
Organism
Homo sapiens (Human)
Status
Functioni
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).1 Publication
GO - Molecular functioni
- delayed rectifier potassium channel activity Source: UniProtKB
- ion channel binding Source: UniProtKB
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- potassium ion transmembrane transport Source: UniProtKB
- protein homooligomerization Source: InterPro
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q8TDN1 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Protein family/group databases
TCDBi | 1.A.1.2.26, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily G member 4Alternative name(s): Voltage-gated potassium channel subunit Kv6.4 |
Gene namesi | Name:KCNG4 Synonyms:KCNG3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19697, KCNG4 |
MIMi | 607603, gene |
neXtProti | NX_Q8TDN1 |
VEuPathDBi | HostDB:ENSG00000168418.7 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1 (PubMed:19074135).1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB
- voltage-gated potassium channel complex Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 218 | CytoplasmicBy similarityAdd BLAST | 218 | |
Transmembranei | 219 – 240 | Helical; Name=Segment S1By similarityAdd BLAST | 22 | |
Topological domaini | 241 – 261 | ExtracellularBy similarityAdd BLAST | 21 | |
Transmembranei | 262 – 283 | Helical; Name=Segment S2By similarityAdd BLAST | 22 | |
Topological domaini | 284 – 294 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 295 – 314 | Helical; Name=Segment S3By similarityAdd BLAST | 20 | |
Topological domaini | 315 – 328 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 329 – 353 | Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST | 25 | |
Topological domaini | 354 – 368 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 369 – 390 | Helical; Name=Segment S5By similarityAdd BLAST | 22 | |
Topological domaini | 391 – 405 | ExtracellularBy similarityAdd BLAST | 15 | |
Intramembranei | 406 – 417 | Helical; Name=Pore helixBy similarityAdd BLAST | 12 | |
Intramembranei | 418 – 425 | By similarity | 8 | |
Topological domaini | 426 – 432 | ExtracellularBy similarity | 7 | |
Transmembranei | 433 – 461 | Helical; Name=Segment S6By similarityAdd BLAST | 29 | |
Topological domaini | 462 – 519 | CytoplasmicBy similarityAdd BLAST | 58 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 93107 |
OpenTargetsi | ENSG00000168418 |
PharmGKBi | PA134989953 |
Miscellaneous databases
Pharosi | Q8TDN1, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2362996 |
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q8TDN1 |
Genetic variation databases
BioMutai | KCNG4 |
DMDMi | 26006803 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054080 | 1 – 519 | Potassium voltage-gated channel subfamily G member 4Add BLAST | 519 |
Proteomic databases
PaxDbi | Q8TDN1 |
PeptideAtlasi | Q8TDN1 |
PRIDEi | Q8TDN1 |
ProteomicsDBi | 74307 [Q8TDN1-1] 74308 [Q8TDN1-2] |
PTM databases
PhosphoSitePlusi | Q8TDN1 |
SwissPalmi | Q8TDN1 |
Expressioni
Tissue specificityi
Highly expressed in brain, and at lower levels in liver, small intestine and colon.
Gene expression databases
Bgeei | ENSG00000168418, Expressed in cerebellum and 26 other tissues |
ExpressionAtlasi | Q8TDN1, baseline and differential |
Genevisiblei | Q8TDN1, HS |
Organism-specific databases
HPAi | ENSG00000168418, Tissue enhanced (retina) |
Interactioni
Subunit structurei
Heterotetramer with KCNB1 (PubMed:19074135).
1 PublicationGO - Molecular functioni
- ion channel binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 125002, 7 interactors |
IntActi | Q8TDN1, 3 interactors |
STRINGi | 9606.ENSP00000312129 |
Miscellaneous databases
RNActi | Q8TDN1, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 418 – 423 | Selectivity filterBy similarity | 6 |
Domaini
The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity
Sequence similaritiesi
Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3713, Eukaryota |
GeneTreei | ENSGT00940000156938 |
HOGENOMi | CLU_011722_4_1_1 |
InParanoidi | Q8TDN1 |
OMAi | NKCQFFQ |
PhylomeDBi | Q8TDN1 |
TreeFami | TF313103 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003971, K_chnl_volt-dep_Kv9 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01494, KV9CHANNEL PR01491, KVCHANNEL |
SUPFAMi | SSF54695, SSF54695, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8TDN1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPMPSRDGGL HPRHHHYGSH SPWSQLLSSP METPSIKGLY YRRVRKVGAL
60 70 80 90 100
DASPVDLKKE ILINVGGRRY LLPWSTLDRF PLSRLSKLRL CRSYEEIVQL
110 120 130 140 150
CDDYDEDSQE FFFDRSPSAF GVIVSFLAAG KLVLLQEMCA LSFQEELAYW
160 170 180 190 200
GIEEAHLERC CLRKLLRKLE ELEELAKLHR EDVLRQQRET RRPASHSSRW
210 220 230 240 250
GLCMNRLREM VENPQSGLPG KVFACLSILF VATTAVSLCV STMPDLRAEE
260 270 280 290 300
DQGECSRKCY YIFIVETICV AWFSLEFCLR FVQAQDKCQF FQGPLNIIDI
310 320 330 340 350
LAISPYYVSL AVSEEPPEDG ERPSGSSYLE KVGLVLRVLR ALRILYVMRL
360 370 380 390 400
ARHSLGLQTL GLTVRRCTRE FGLLLLFLAV AITLFSPLVY VAEKESGRVL
410 420 430 440 450
EFTSIPASYW WAIISMTTVG YGDMVPRSVP GQMVALSSIL SGILIMAFPA
460 470 480 490 500
TSIFHTFSHS YLELKKEQEQ LQARLRHLQN TGPASECELL DPHVASEHEL
510
MNDVNDLILE GPALPIMHM
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053861 | 8 | G → W. Corresponds to variant dbSNP:rs35379218Ensembl. | 1 | |
Natural variantiVAR_053862 | 206 | R → W. Corresponds to variant dbSNP:rs11646443Ensembl. | 1 | |
Natural variantiVAR_053863 | 255 | C → Y. Corresponds to variant dbSNP:rs17736370Ensembl. | 1 | |
Natural variantiVAR_053864 | 321 | E → K. Corresponds to variant dbSNP:rs4782905Ensembl. | 1 | |
Natural variantiVAR_053865 | 325 | G → R. Corresponds to variant dbSNP:rs7196482Ensembl. | 1 | |
Natural variantiVAR_053866 | 427 | R → H. Corresponds to variant dbSNP:rs35649980Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001029 | 253 – 256 | GECS → VSGL in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_001030 | 257 – 519 | Missing in isoform 2. 1 PublicationAdd BLAST | 263 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF348984 mRNA Translation: AAL83911.1 BC008969 mRNA Translation: AAH08969.1 |
CCDSi | CCDS10945.1 [Q8TDN1-1] |
RefSeqi | NP_758857.1, NM_172347.2 [Q8TDN1-1] |
Genome annotation databases
Ensembli | ENST00000308251; ENSP00000312129; ENSG00000168418 [Q8TDN1-1] ENST00000568181; ENSP00000457897; ENSG00000168418 [Q8TDN1-2] |
GeneIDi | 93107 |
KEGGi | hsa:93107 |
UCSCi | uc002fhu.1, human [Q8TDN1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF348984 mRNA Translation: AAL83911.1 BC008969 mRNA Translation: AAH08969.1 |
CCDSi | CCDS10945.1 [Q8TDN1-1] |
RefSeqi | NP_758857.1, NM_172347.2 [Q8TDN1-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125002, 7 interactors |
IntActi | Q8TDN1, 3 interactors |
STRINGi | 9606.ENSP00000312129 |
Chemistry databases
ChEMBLi | CHEMBL2362996 |
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q8TDN1 |
Protein family/group databases
TCDBi | 1.A.1.2.26, the voltage-gated ion channel (vic) superfamily |
PTM databases
PhosphoSitePlusi | Q8TDN1 |
SwissPalmi | Q8TDN1 |
Genetic variation databases
BioMutai | KCNG4 |
DMDMi | 26006803 |
Proteomic databases
PaxDbi | Q8TDN1 |
PeptideAtlasi | Q8TDN1 |
PRIDEi | Q8TDN1 |
ProteomicsDBi | 74307 [Q8TDN1-1] 74308 [Q8TDN1-2] |
Protocols and materials databases
Antibodypediai | 30581, 101 antibodies |
DNASUi | 93107 |
Genome annotation databases
Ensembli | ENST00000308251; ENSP00000312129; ENSG00000168418 [Q8TDN1-1] ENST00000568181; ENSP00000457897; ENSG00000168418 [Q8TDN1-2] |
GeneIDi | 93107 |
KEGGi | hsa:93107 |
UCSCi | uc002fhu.1, human [Q8TDN1-1] |
Organism-specific databases
CTDi | 93107 |
DisGeNETi | 93107 |
GeneCardsi | KCNG4 |
HGNCi | HGNC:19697, KCNG4 |
HPAi | ENSG00000168418, Tissue enhanced (retina) |
MIMi | 607603, gene |
neXtProti | NX_Q8TDN1 |
OpenTargetsi | ENSG00000168418 |
PharmGKBi | PA134989953 |
VEuPathDBi | HostDB:ENSG00000168418.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3713, Eukaryota |
GeneTreei | ENSGT00940000156938 |
HOGENOMi | CLU_011722_4_1_1 |
InParanoidi | Q8TDN1 |
OMAi | NKCQFFQ |
PhylomeDBi | Q8TDN1 |
TreeFami | TF313103 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDN1 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Miscellaneous databases
BioGRID-ORCSi | 93107, 6 hits in 976 CRISPR screens |
GeneWikii | KCNG4 |
GenomeRNAii | 93107 |
Pharosi | Q8TDN1, Tclin |
PROi | PR:Q8TDN1 |
RNActi | Q8TDN1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168418, Expressed in cerebellum and 26 other tissues |
ExpressionAtlasi | Q8TDN1, baseline and differential |
Genevisiblei | Q8TDN1, HS |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003971, K_chnl_volt-dep_Kv9 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01494, KV9CHANNEL PR01491, KVCHANNEL |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNG4_HUMAN | |
Accessioni | Q8TDN1Primary (citable) accession number: Q8TDN1 Secondary accession number(s): Q96H24 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | June 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families