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UniProtKB - Q8TDN1 (KCNG4_HUMAN)

Entry version 170 (07 Apr 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Potassium voltage-gated channel subfamily G member 4

Gene

KCNG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TDN1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296072, Voltage gated Potassium channels

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.2.26, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNG4
Synonyms:KCNG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19697, KCNG4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607603, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDN1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168418.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 218CytoplasmicBy similarityAdd BLAST218
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei219 – 240Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini241 – 261ExtracellularBy similarityAdd BLAST21
Transmembranei262 – 283Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini284 – 294CytoplasmicBy similarityAdd BLAST11
Transmembranei295 – 314Helical; Name=Segment S3By similarityAdd BLAST20
Topological domaini315 – 328ExtracellularBy similarityAdd BLAST14
Transmembranei329 – 353Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST25
Topological domaini354 – 368CytoplasmicBy similarityAdd BLAST15
Transmembranei369 – 390Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini391 – 405ExtracellularBy similarityAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei406 – 417Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei418 – 425By similarity8
Topological domaini426 – 432ExtracellularBy similarity7
Transmembranei433 – 461Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini462 – 519CytoplasmicBy similarityAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		93107

Open Targets

More...OpenTargetsi		ENSG00000168418

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134989953

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TDN1, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2362996

Drug and drug target database

More...DrugBanki		DB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine

DrugCentral

More...DrugCentrali		Q8TDN1

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNG4

Domain mapping of disease mutations (DMDM)

More...DMDMi		26006803

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540801 – 519Potassium voltage-gated channel subfamily G member 4Add BLAST519

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDN1

PeptideAtlas

More...PeptideAtlasi		Q8TDN1

PRoteomics IDEntifications database

More...PRIDEi		Q8TDN1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74307 [Q8TDN1-1]
74308 [Q8TDN1-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDN1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8TDN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, and at lower levels in liver, small intestine and colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168418, Expressed in cerebellum and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TDN1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDN1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168418, Tissue enhanced (retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer with KCNB1 (PubMed:19074135).

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125002, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q8TDN1, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000312129

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TDN1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi418 – 423Selectivity filterBy similarity6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3713, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156938

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011722_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDN1

Identification of Orthologs from Complete Genome Data

More...OMAi		NKCQFFQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDN1

TreeFam database of animal gene trees

More...TreeFami		TF313103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005821, Ion_trans_dom
IPR003968, K_chnl_volt-dep_Kv
IPR003971, K_chnl_volt-dep_Kv9
IPR011333, SKP1/BTB/POZ_sf
IPR003131, T1-type_BTB
IPR028325, VG_K_chnl
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11537, PTHR11537, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02214, BTB_2, 1 hit
PF00520, Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01494, KV9CHANNEL
PR01491, KVCHANNEL

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54695, SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TDN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPMPSRDGGL HPRHHHYGSH SPWSQLLSSP METPSIKGLY YRRVRKVGAL 
        60         70         80         90        100
DASPVDLKKE ILINVGGRRY LLPWSTLDRF PLSRLSKLRL CRSYEEIVQL 
       110        120        130        140        150
CDDYDEDSQE FFFDRSPSAF GVIVSFLAAG KLVLLQEMCA LSFQEELAYW 
       160        170        180        190        200
GIEEAHLERC CLRKLLRKLE ELEELAKLHR EDVLRQQRET RRPASHSSRW 
       210        220        230        240        250
GLCMNRLREM VENPQSGLPG KVFACLSILF VATTAVSLCV STMPDLRAEE 
       260        270        280        290        300
DQGECSRKCY YIFIVETICV AWFSLEFCLR FVQAQDKCQF FQGPLNIIDI 
       310        320        330        340        350
LAISPYYVSL AVSEEPPEDG ERPSGSSYLE KVGLVLRVLR ALRILYVMRL 
       360        370        380        390        400
ARHSLGLQTL GLTVRRCTRE FGLLLLFLAV AITLFSPLVY VAEKESGRVL 
       410        420        430        440        450
EFTSIPASYW WAIISMTTVG YGDMVPRSVP GQMVALSSIL SGILIMAFPA 
       460        470        480        490        500
TSIFHTFSHS YLELKKEQEQ LQARLRHLQN TGPASECELL DPHVASEHEL 
       510 
MNDVNDLILE GPALPIMHM
Length:519
Mass (Da):58,979
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5BBA354931AB0A4
GO
Isoform 2 (identifier: Q8TDN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-256: GECS → VSGL
     257-519: Missing.

Show »
Length:256
Mass (Da):29,334
Checksum:i5A48EFC68637F8B8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0538618G → W. Corresponds to variant dbSNP:rs35379218Ensembl.1
Natural variantiVAR_053862206R → W. Corresponds to variant dbSNP:rs11646443Ensembl.1
Natural variantiVAR_053863255C → Y. Corresponds to variant dbSNP:rs17736370Ensembl.1
Natural variantiVAR_053864321E → K. Corresponds to variant dbSNP:rs4782905Ensembl.1
Natural variantiVAR_053865325G → R. Corresponds to variant dbSNP:rs7196482Ensembl.1
Natural variantiVAR_053866427R → H. Corresponds to variant dbSNP:rs35649980Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001029253 – 256GECS → VSGL in isoform 2. 1 Publication4
Alternative sequenceiVSP_001030257 – 519Missing in isoform 2. 1 PublicationAdd BLAST263

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF348984 mRNA Translation: AAL83911.1
BC008969 mRNA Translation: AAH08969.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10945.1 [Q8TDN1-1]

NCBI Reference Sequences

More...RefSeqi		NP_758857.1, NM_172347.2 [Q8TDN1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308251; ENSP00000312129; ENSG00000168418 [Q8TDN1-1]
ENST00000568181; ENSP00000457897; ENSG00000168418 [Q8TDN1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		93107

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:93107

UCSC genome browser

More...UCSCi		uc002fhu.1, human [Q8TDN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348984 mRNA Translation: AAL83911.1
BC008969 mRNA Translation: AAH08969.1
CCDSiCCDS10945.1 [Q8TDN1-1]
RefSeqiNP_758857.1, NM_172347.2 [Q8TDN1-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125002, 7 interactors
IntActiQ8TDN1, 3 interactors
STRINGi9606.ENSP00000312129

Chemistry databases

ChEMBLiCHEMBL2362996
DrugBankiDB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine
DrugCentraliQ8TDN1

Protein family/group databases

TCDBi1.A.1.2.26, the voltage-gated ion channel (vic) superfamily

PTM databases

PhosphoSitePlusiQ8TDN1
SwissPalmiQ8TDN1

Genetic variation databases

BioMutaiKCNG4
DMDMi26006803

Proteomic databases

PaxDbiQ8TDN1
PeptideAtlasiQ8TDN1
PRIDEiQ8TDN1
ProteomicsDBi74307 [Q8TDN1-1]
74308 [Q8TDN1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30581, 101 antibodies

The DNASU plasmid repository

More...DNASUi		93107

Genome annotation databases

EnsembliENST00000308251; ENSP00000312129; ENSG00000168418 [Q8TDN1-1]
ENST00000568181; ENSP00000457897; ENSG00000168418 [Q8TDN1-2]
GeneIDi93107
KEGGihsa:93107
UCSCiuc002fhu.1, human [Q8TDN1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		93107
DisGeNETi93107

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNG4
HGNCiHGNC:19697, KCNG4
HPAiENSG00000168418, Tissue enhanced (retina)
MIMi607603, gene
neXtProtiNX_Q8TDN1
OpenTargetsiENSG00000168418
PharmGKBiPA134989953
VEuPathDBiHostDB:ENSG00000168418.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3713, Eukaryota
GeneTreeiENSGT00940000156938
HOGENOMiCLU_011722_4_1_1
InParanoidiQ8TDN1
OMAiNKCQFFQ
PhylomeDBiQ8TDN1
TreeFamiTF313103

Enzyme and pathway databases

PathwayCommonsiQ8TDN1
ReactomeiR-HSA-1296072, Voltage gated Potassium channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		93107, 6 hits in 976 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNG4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		93107
PharosiQ8TDN1, Tclin

Protein Ontology

More...PROi		PR:Q8TDN1
RNActiQ8TDN1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168418, Expressed in cerebellum and 26 other tissues
ExpressionAtlasiQ8TDN1, baseline and differential
GenevisibleiQ8TDN1, HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR003968, K_chnl_volt-dep_Kv
IPR003971, K_chnl_volt-dep_Kv9
IPR011333, SKP1/BTB/POZ_sf
IPR003131, T1-type_BTB
IPR028325, VG_K_chnl
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR11537, PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214, BTB_2, 1 hit
PF00520, Ion_trans, 1 hit
PRINTSiPR01494, KV9CHANNEL
PR01491, KVCHANNEL
SUPFAMiSSF54695, SSF54695, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNG4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDN1
Secondary accession number(s): Q96H24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 2002
Last modified: April 7, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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