Disks large homolog 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12657639
• cytoskeletal protein binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12657639
• receptor signaling complex scaffold activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12353226

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• apical protein localization Source: Ensembl
• cell-cell adhesion Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12353226
• epithelial to mesenchymal transition Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 28169360
• epithelial tube branching involved in lung morphogenesis Source: Ensembl
• establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
• intracellular signal transduction Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12353226
• maintenance of cell polarity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 28169360
• metanephric collecting duct development Source: Ensembl
• midbrain development Source: Ensembl
• negative regulation of cell migration Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 28169360
• negative regulation of cell proliferation Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 9738934
• negative regulation of hippo signaling Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 28087714
• negative regulation of T cell proliferation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 28169360
• polarized epithelial cell differentiation Source: Ensembl
• positive regulation of dendritic spine development Source: UniProtKB
• positive regulation of hippo signaling Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 28169360
• positive regulation of smoothened signaling pathway Source: UniProtKB
• positive regulation of synapse assembly Source: UniProtKB
• protein-containing complex assembly Source: Ensembl
• protein localization to adherens junction Source: Ensembl
• regulation of apoptotic process Source: InterPro
• signal transduction Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 9738934
• zonula adherens assembly Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12657639
• cytoskeletal protein binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12657639
• receptor signaling complex scaffold activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12353226

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG 
        60         70         80         90        100
AKAELLLKLL LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG 
       110        120        130        140        150
AGSTYSVLST MPSDSESSSS LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS 
       160        170        180        190        200
IQLRLMTRER NELRKRLAFA THGTAFDKRP YHRLNPDYER LKIQCVRAMS 
       210        220        230        240        250
DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTRL KDDVDMLRRE 
       260        270        280        290        300
NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN 
       310        320        330        340        350
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK 
       360        370        380        390        400
QTEMLTQQRD TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL 
       410        420        430        440        450
QSELTELRTT QVKTAKESEK YREERDAVYS EYKLIMSERD QVISELDKLQ 
       460        470        480        490        500
TEVELAESKL KSSTSEKKAA NEEMEALRQI KDTVTMDAGR ANKEVEILRK 
       510        520        530        540        550
QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE 
       560        570        580        590        600
RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM 
       610        620        630        640        650
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG 
       660        670        680        690        700
DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG 
       710        720        730        740        750
AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVLPGSPAA 
       760        770        780        790        800
KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS 
       810        820        830        840        850
SWSGQNIFEN IKDSDKMLSF RAHGPEVQAH NKRNLIQHNN STQTDIFYTD 
       860        870        880        890        900
RLEDRKEPGP PGGSSSFLHK PFPGGPLQVC PQACPSASER SLSSFRSDAS 
       910        920        930        940        950
GDRGFGLVDV RGRRPLLPFE TEVGPCGVGE ASLDKADSEG SNSGGTWPKA 
       960        970        980        990       1000
MLSSTAVPEK LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGPAHS 
      1010       1020       1030       1040       1050
PQPSKRAGPL TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA 
      1060       1070       1080       1090       1100
LPPDVDPGEP MHASPPRKAR VRIASSYYPE GDGDSSHLPA KKSCDEDLTS 
      1110       1120       1130       1140       1150
QKVDELGQKR RRPKSAPSFR PKLAPVVIPA QFLEEQKCVP ASGELSPELQ 
      1160       1170       1180       1190       1200
EWAPYSPGHS SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS ILRNPIYTVR 
      1210       1220       1230       1240       1250
SHRVGPCSSP PAARDAGPQG LHPSVQHQGR LSLDLSHRTC SDYSEMRATH 
      1260       1270       1280       1290       1300
GSNSLPSSAR LGSSSNLQFK AERIKIPSTP RYPRSVVGSE RGSVSHSECS 
      1310       1320       1330       1340       1350
TPPQSPLNID TLSSCSQSQT SASTLPRIAV NPASLGERRK DRPYVEEPRH 
      1360       1370       1380       1390       1400
VKVQKGSEPL GISIVSGEKG GIYVSKVTVG SIAHQAGLEY GDQLLEFNGI 
      1410       1420       1430       1440       1450
NLRSATEQQA RLIIGQQCDT ITILAQYNPH VHQLSSHSRS SSHLDPAGTH 
      1460       1470       1480       1490       1500
STLQGSGTTT PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA GDANKKTLEP 
      1510       1520       1530       1540       1550
RVVFIKKSQL ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG LVPGDLILEY 
      1560       1570       1580       1590       1600
GSLDVRNKTV EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG LPGDSFYIRA 
      1610       1620       1630       1640       1650
LYDRLADVEQ ELSFKKDDIL YVDDTLPQGT FGSWMAWQLD ENAQKIQRGQ 
      1660       1670       1680       1690       1700
IPSKYVMDQE FSRRLSMSEV KDDNSATKTL SAAARRSFFR RKHKHKRSGS 
      1710       1720       1730       1740       1750
KDGKDLLALD AFSSDSIPLF EDSVSLAYQR VQKVDCTALR PVLILGPLLD 
      1760       1770       1780       1790       1800
VVKEMLVNEA PGKFCRCPLE VMKASQQAIE RGVKDCLFVD YKRRSGHFDV 
      1810       1820       1830       1840       1850
TTVASIKEIT EKNRHCLLDI APHAIERLHH MHIYPIVIFI HYKSAKHIKE 
      1860       1870       1880       1890       1900
QRDPIYLRDK VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG GALSSICTQI 
      1910 
LAMVNQEQNK VLWIPACPL                                   

        10         20         30         40         50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG 
        60         70         80         90        100
AKAELLLKLL LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG 
       110        120        130        140        150
AGSTYSVLST MPSDSESSSS LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS 
       160        170        180        190        200
IQLRLMTRER NELRKRLAFA THGTAFDKRP YHRLNPDYER LKIQCVRAMS 
       210        220        230        240        250
DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTRL KDDVDMLRRE 
       260        270        280        290        300
NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN 
       310        320        330        340        350
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK 
       360        370        380        390        400
QTEMLTQQRD TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL 
       410        420        430        440        450
QSELTELRTT QVKTAKESEK YREERDAVYS EYKLIMSERD QVISELDKLQ 
       460        470        480        490        500
TEVELAESKL KSSTSEKKAA NEEMEALRQI KDTVTMDAGR ANKEVEILRK 
       510        520        530        540        550
QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE 
       560        570        580        590        600
RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM 
       610        620        630        640        650
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG 
       660        670        680        690        700
DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG 
       710        720        730        740        750
AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVLPGSPAA 
       760        770        780        790        800
KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKEQKCVP 
       810        820        830        840        850
ASGELSPELQ EWAPYSPGHS SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS 
       860        870        880        890        900
ILRNPIYTVR SHRVGPCSSP PAARDAGPQG LHPSVQHQGR LSLDLSHRTC 
       910        920        930        940        950
SDYSEMRATH GSNSLPSSAR LGSSSNLQFK AERIKIPSTP RYPRSVVGSE 
       960        970        980        990       1000
RGSVSHSECS TPPQSPLNID TLSSCSQSQT SASTLPRIAV NPASLGERRK 
      1010       1020       1030       1040       1050
DRPYVEEPRH VKVQKGSEPL GISIVSGEKG GIYVSKVTVG SIAHQAGLEY 
      1060       1070       1080       1090       1100
GDQLLEFNGI NLRSATEQQA RLIIGQQCDT ITILAQYNPH VHQLSSHSRS 
      1110       1120       1130       1140       1150
SSHLDPAGTH STLQGSGTTT PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA 
      1160       1170       1180       1190       1200
GDANKKTLEP RVVFIKKSQL ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG 
      1210       1220       1230       1240       1250
LVPGDLILEY GSLDVRNKTV EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG 
      1260       1270       1280       1290       1300
LPGDSFYIRA LYDRLADVEQ ELSFKKDDIL YVDDTLPQGT FGSWMAWQLD 
      1310       1320       1330       1340       1350
ENAQKIQRGQ IPSKYVMDQE FSRRLSMSEV KDDNSATKTL SAAARRSFFR 
      1360       1370       1380       1390       1400
RKHKHKRSGS KDGKDLLALD AFSSDSIPLF EDSVSLAYQR VQKVDCTALR 
      1410       1420       1430       1440       1450
PVLILGPLLD VVKEMLVNEA PGKFCRCPLE VMKASQQAIE RGVKDCLFVD 
      1460       1470       1480       1490       1500
YKRRSGHFDV TTVASIKEIT EKNRHCLLDI APHAIERLHH MHIYPIVIFI 
      1510       1520       1530       1540       1550
HYKSAKHIKE QRDPIYLRDK VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG 
      1560       1570 
GALSSICTQI LAMVNQEQNK VLWIPACPL                        

        10         20         30         40         50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG 
        60         70         80         90        100
AKAELLLKLL LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG 
       110        120        130        140        150
AGSTYSVLST MPSDSESSSS LSSVGTTGKE LKEQMESQLE KEARFRQLMA 
       160        170        180        190        200
HSSHDSAIDT DSMEWETEVV EFERETEDID LKALGFDMAE GVNEPCFPGD 
       210        220        230        240        250
CGIFVTKVDK GSIADGRLRV NDWLLRINDV DLINKDKKQA IKALLNGEGA 
       260        270        280        290        300
INMVVRRRKS LGGKVVTPLH INLSGQKDSG ISLENGVYAA AVLPGSPAAK 
       310        320        330        340        350
EGSLAVGDRI VAINGIALDN KSLNECESLL RSCQDSLTLS LLKVFPQSSS 
       360        370        380        390        400
WSGQNIFENI KDSDKMLSFR AHGPEVQAHN KRNLIQHNNS TQTDIFYTDR 
       410        420        430        440        450
LEDRKEPGPP GGSSSFLHKP FPGGPLQVCP QACPSASERS LSSFRSDASG 
       460        470        480        490        500
DRGFGLVDVR GRRPLLPFET EVGPCGVGEA SLDKADSEGS NSGGTWPKAM 
       510        520        530        540        550
LSSTAVPEKL SVYKKPKQRK SIFDPNTFKR PQTPPKIDYL LPGPGPAHSP 
       560        570        580        590        600
QPSKRAGPLT PPKPPRRSDS IKFQHRLETS SESEATLVGS SPSTSPPSAL 
       610        620        630        640        650
PPDVDPGEPM HASPPRKARV RIASSYYPEG DGDSSHLPAK KSCDEDLTSQ 
       660        670        680 
KVDELGQKRR RPKSAPSFRP KLAPVVIPAQ FLEV                  

        10         20         30         40         50
MPSDSESSSS LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS IQLRLMTRER 
        60         70         80         90        100
NELRKRLAFA THGTAFDKRP YHRLNPDYER LKIQCVRAMS DLQSLQNQHT 
       110        120        130        140        150
NALKRCEEVA KETDFYHTLH SRLLSDQTRL KDDVDMLRRE NGQLLRERNL 
       160        170        180        190        200
LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN KLYDTAMDKL 
       210        220        230        240        250
EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK QTEMLTQQRD 
       260        270        280        290        300
TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL QSELTELRTT 
       310        320        330        340        350
QVKTAKESEK YREERDAVYS EYKLIMSERD QVISELDKLQ TEVELAESKL 
       360        370        380        390        400
KSSTSEKKAA NEEMEALRQI KDTVTMDAGR ANKEVEILRK QCKALCQELK 
       410        420        430        440        450
EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE RDRAVSELAE 
       460        470        480        490        500
ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM AHSSHDSAID 
       510        520        530        540        550
TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG DCGIFVTKVD 
       560        570        580        590        600
KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG AINMVVRRRK 
       610        620        630        640        650
SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVLPGSPAA KEGSLAVGDR 
       660        670        680        690        700
IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS SWSGQNIFEN 
       710        720        730        740        750
IKDSDKMLSF RAHGPEVQAH NKRNLIQHNN STQTDIFYTD RLEDRKEPGP 
       760        770        780        790        800
PGGSSSFLHK PFPGGPLQVC PQACPSASER SLSSFRSDAS GDRGFGLVDV 
       810        820        830        840        850
RGRRPLLPFE TEVGPCGVGE ASLDKADSEG SNSGGTWPKA MLSSTAVPEK 
       860        870        880        890        900
LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGPAHS PQPSKRAGPL 
       910        920        930        940        950
TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA LPPDVDPGEP 
       960        970        980        990       1000
MHASPPRKAR VRIASSYYPE GDGDSSHLPA KKSCDEDLTS QKVDELGQKR 
      1010       1020       1030       1040       1050
RRPKSAPSFR PKLAPVVIPA QFLEEQKCVP ASGELSPELQ EWAPYSPGHS 
      1060       1070       1080       1090       1100
SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS ILRNPIYTVR SHRVGPCSSP 
      1110       1120       1130       1140       1150
PAARDAGPQG LHPSVQHQGR LSLDLSHRTC SDYSEMRATH GSNSLPSSAR 
      1160       1170       1180       1190       1200
LGSSSNLQFK AERIKIPSTP RYPRSVVGSE RGSVSHSECS TPPQSPLNID 
      1210       1220       1230       1240       1250
TLSSCSQSQT SASTLPRIAV NPASLGERRK DRPYVEEPRH VKVQKGSEPL 
      1260       1270       1280       1290       1300
GISIVSGEKG GIYVSKVTVG SIAHQAGLEY GDQLLEFNGI NLRSATEQQA 
      1310       1320       1330       1340       1350
RLIIGQQCDT ITILAQYNPH VHQLSSHSRS SSHLDPAGTH STLQGSGTTT 
      1360       1370       1380       1390       1400
PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA GDANKKTLEP RVVFIKKSQL 
      1410       1420       1430       1440       1450
ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG LVPGDLILEY GSLDVRNKTV 
      1460       1470       1480       1490       1500
EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG LPGDSFYIRA LYDRLADVEQ 
      1510       1520       1530       1540       1550
ELSFKKDDIL YVDDTLPQGT FGSWMAWQLD ENAQKIQRGQ IPSKYVMDQE 
      1560       1570       1580       1590       1600
FSRRLSMSEV KDDNSATKTL SAAARRSFFR RKHKHKRSGS KDGKDLLALD 
      1610       1620       1630       1640       1650
AFSSDSIPLF EDSVSLAYQR VQKVDCTALR PVLILGPLLD VVKEMLVNEA 
      1660       1670       1680       1690       1700
PGKFCRCPLE VMKASQQAIE RGVKDCLFVD YKRRSGHFDV TTVASIKEIT 
      1710       1720       1730       1740       1750
EKNRHCLLDI APHAIERLHH MHIYPIVIFI HYKSAKHIKE QRDPIYLRDK 
      1760       1770       1780       1790       1800
VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG GALSSICTQI LAMVNQEQNK 

VLWIPACPL                                              

        10         20         30         40         50
MRATHGSNSL PSSARLGSSS NLQFKAERIK IPSTPRYPRS VVGSERGSVS 
        60         70         80         90        100
HSECSTPPQS PLNIDTLSSC SQSQTSASTL PRIAVNPASL GERRKDRPYV 
       110        120        130        140        150
EEPRHVKVQK GSEPLGISIV SGEKGGIYVS KVTVGSIAHQ AGLEYGDQLL 
       160        170        180        190        200
EFNGINLRSA TEQQARLIIG QQCDTITILA QYNPHVHQLS SHSRSSSHLD 
       210        220        230        240        250
PAGTHSTLQG SGTTTPEHPS VIDPLMEQDE GPSTPPAKQS SSRIAGDANK 
       260        270        280        290        300
KTLEPRVVFI KKSQLELGVH LCGGNLHGVF VAEVEDDSPA KGPDGLVPGD 
       310        320        330        340        350
LILEYGSLDV RNKTVEEVYV EMLKPRDGVR LKVQYRPEEF TKAKGLPGDS 
       360        370        380        390        400
FYIRALYDRL ADVEQELSFK KDDILYVDDT LPQGTFGSWM AWQLDENAQK 
       410        420        430        440        450
IQRGQIPSKY VMDQEFSRRL SMSEVKDDNS ATKTLSAAAR RSFFRRKHKH 
       460        470        480        490        500
KRSGSKDGKD LLALDAFSSD SIPLFEDSVS LAYQRVQKVD CTALRPVLIL 
       510        520        530        540        550
GPLLDVVKEM LVNEAPGKFC RCPLEVMKAS QQAIERGVKD CLFVDYKRRS 
       560        570        580        590        600
GHFDVTTVAS IKEITEKNRH CLLDIAPHAI ERLHHMHIYP IVIFIHYKSA 
       610        620        630        640        650
KHIKEQRDPI YLRDKVTQRH SKEQFEAAQK LEQEYSRYFT GVIQGGALSS 
       660        670 
ICTQILAMVN QEQNKVLWIP ACPL                             

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 10
   Human chromosome 10: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families