UniProtKB - Q8TDM6 (DLG5_HUMAN)
Disks large homolog 5
DLG5
Functioni
GO - Molecular functioni
- beta-catenin binding Source: MGI
- cytoskeletal protein binding Source: MGI
- signaling receptor complex adaptor activity Source: UniProtKB
GO - Biological processi
- apical protein localization Source: Ensembl
- cell-cell adhesion Source: UniProtKB
- epithelial to mesenchymal transition Source: UniProtKB
- epithelial tube branching involved in lung morphogenesis Source: Ensembl
- establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
- intracellular signal transduction Source: UniProtKB
- maintenance of cell polarity Source: UniProtKB
- metanephric collecting duct development Source: Ensembl
- midbrain development Source: Ensembl
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cell population proliferation Source: ProtInc
- negative regulation of hippo signaling Source: UniProtKB
- negative regulation of T cell proliferation Source: UniProtKB
- polarized epithelial cell differentiation Source: Ensembl
- positive regulation of dendritic spine development Source: UniProtKB
- positive regulation of hippo signaling Source: UniProtKB
- positive regulation of smoothened signaling pathway Source: UniProtKB
- positive regulation of synapse assembly Source: UniProtKB
- protein-containing complex assembly Source: Ensembl
- protein localization to adherens junction Source: Ensembl
- regulation of apoptotic process Source: InterPro
- signal transduction Source: ProtInc
- zonula adherens assembly Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q8TDM6 |
Names & Taxonomyi
Protein namesi | Recommended name: Disks large homolog 5Alternative name(s): Discs large protein P-dlg Placenta and prostate DLG |
Gene namesi | Name:DLG5 Synonyms:KIAA0583, PDLG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2904, DLG5 |
MIMi | 604090, gene |
neXtProti | NX_Q8TDM6 |
VEuPathDBi | HostDB:ENSG00000151208.16 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytoskeleton
- cilium basal body By similarity
Other locations
- Cell junction 2 Publications
- postsynaptic density By similarity
Note: Localized at sites of cell-cell contact.
Cytoskeleton
- ciliary basal body Source: UniProtKB
Plasma Membrane
- plasma membrane Source: ProtInc
Other locations
- adherens junction Source: Ensembl
- cell junction Source: UniProtKB
- cytoplasm Source: ProtInc
- postsynaptic density Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 9231 |
OpenTargetsi | ENSG00000151208 |
PharmGKBi | PA27360 |
Miscellaneous databases
Pharosi | Q8TDM6, Tbio |
Genetic variation databases
BioMutai | DLG5 |
DMDMi | 158939323 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094564 | 1 – 1919 | Disks large homolog 5Add BLAST | 1919 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 264 | PhosphoserineCombined sources | 1 | |
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Modified residuei | 900 | PhosphoserineCombined sources | 1 | |
Modified residuei | 984 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1000 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1011 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1021 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1183 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1209 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1263 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1334 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1666 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8TDM6 |
jPOSTi | Q8TDM6 |
MassIVEi | Q8TDM6 |
MaxQBi | Q8TDM6 |
PaxDbi | Q8TDM6 |
PeptideAtlasi | Q8TDM6 |
PRIDEi | Q8TDM6 |
ProteomicsDBi | 74302 [Q8TDM6-1] 74303 [Q8TDM6-2] 74304 [Q8TDM6-3] 74305 [Q8TDM6-4] 74306 [Q8TDM6-5] |
PTM databases
iPTMneti | Q8TDM6 |
PhosphoSitePlusi | Q8TDM6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000151208, Expressed in forebrain and 243 other tissues |
ExpressionAtlasi | Q8TDM6, baseline and differential |
Genevisiblei | Q8TDM6, HS |
Organism-specific databases
HPAi | ENSG00000151208, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MPP1 (PubMed:9738934).
Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex (PubMed:12657639).
Interacts (via coiled-coil domain) with MARK3.
Interacts (via PDZ domain 3) with STK3/MST2 and STK4/MST1 (PubMed:28087714).
Interacts with SCRIB (PubMed:28169360).
Interacts with CTNB1, SMO and (via PDZ4 or guanylate kinase-like domain) with KIF7 (By similarity).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ8TDM6
With | #Exp. | IntAct |
---|---|---|
Tgfbr1 [Q64729] from Mus musculus. | 3 | EBI-715138,EBI-2899393 |
Tgfbr2 [Q62312] from Mus musculus. | 3 | EBI-715138,EBI-2899332 |
GO - Molecular functioni
- beta-catenin binding Source: MGI
- cytoskeletal protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 114662, 52 interactors |
ComplexPortali | CPX-6187, Scribble cell polarity complex, DLG5-LLGL2-SCRIB variant CPX-6188, Scribble cell polarity complex, DLG5-LLGL1-SCRIB variant |
CORUMi | Q8TDM6 |
DIPi | DIP-41450N |
IntActi | Q8TDM6, 40 interactors |
MINTi | Q8TDM6 |
STRINGi | 9606.ENSP00000361467 |
Miscellaneous databases
RNActi | Q8TDM6, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8TDM6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TDM6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 620 – 710 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 705 – 796 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 1350 – 1429 | PDZ 3PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 1501 – 1582 | PDZ 4PROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 1593 – 1661 | SH3PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 1722 – 1905 | Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST | 184 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 383 – 599 | Sequence analysisAdd BLAST | 217 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 113 – 123 | Poly-SerAdd BLAST | 11 | |
Compositional biasi | 982 – 1066 | Pro-richAdd BLAST | 85 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG0708, Eukaryota KOG3528, Eukaryota |
GeneTreei | ENSGT00940000155303 |
HOGENOMi | CLU_002448_1_0_1 |
InParanoidi | Q8TDM6 |
OMAi | KSRESSW |
OrthoDBi | 123652at2759 |
PhylomeDBi | Q8TDM6 |
TreeFami | TF323171 |
Family and domain databases
CDDi | cd11860, SH3_DLG5, 1 hit |
Gene3Di | 2.30.42.10, 4 hits |
InterProi | View protein in InterPro IPR001315, CARD IPR011029, DEATH-like_dom_sf IPR035537, DLG5_SH3 IPR006907, DUF622 IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF04822, Takusan, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 4 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 4 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 4 hits PS50002, SH3, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG
60 70 80 90 100
AKAELLLKLL LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG
110 120 130 140 150
AGSTYSVLST MPSDSESSSS LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS
160 170 180 190 200
IQLRLMTRER NELRKRLAFA THGTAFDKRP YHRLNPDYER LKIQCVRAMS
210 220 230 240 250
DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTRL KDDVDMLRRE
260 270 280 290 300
NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN
310 320 330 340 350
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK
360 370 380 390 400
QTEMLTQQRD TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL
410 420 430 440 450
QSELTELRTT QVKTAKESEK YREERDAVYS EYKLIMSERD QVISELDKLQ
460 470 480 490 500
TEVELAESKL KSSTSEKKAA NEEMEALRQI KDTVTMDAGR ANKEVEILRK
510 520 530 540 550
QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE
560 570 580 590 600
RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM
610 620 630 640 650
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG
660 670 680 690 700
DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG
710 720 730 740 750
AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVLPGSPAA
760 770 780 790 800
KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS
810 820 830 840 850
SWSGQNIFEN IKDSDKMLSF RAHGPEVQAH NKRNLIQHNN STQTDIFYTD
860 870 880 890 900
RLEDRKEPGP PGGSSSFLHK PFPGGPLQVC PQACPSASER SLSSFRSDAS
910 920 930 940 950
GDRGFGLVDV RGRRPLLPFE TEVGPCGVGE ASLDKADSEG SNSGGTWPKA
960 970 980 990 1000
MLSSTAVPEK LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGPAHS
1010 1020 1030 1040 1050
PQPSKRAGPL TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA
1060 1070 1080 1090 1100
LPPDVDPGEP MHASPPRKAR VRIASSYYPE GDGDSSHLPA KKSCDEDLTS
1110 1120 1130 1140 1150
QKVDELGQKR RRPKSAPSFR PKLAPVVIPA QFLEEQKCVP ASGELSPELQ
1160 1170 1180 1190 1200
EWAPYSPGHS SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS ILRNPIYTVR
1210 1220 1230 1240 1250
SHRVGPCSSP PAARDAGPQG LHPSVQHQGR LSLDLSHRTC SDYSEMRATH
1260 1270 1280 1290 1300
GSNSLPSSAR LGSSSNLQFK AERIKIPSTP RYPRSVVGSE RGSVSHSECS
1310 1320 1330 1340 1350
TPPQSPLNID TLSSCSQSQT SASTLPRIAV NPASLGERRK DRPYVEEPRH
1360 1370 1380 1390 1400
VKVQKGSEPL GISIVSGEKG GIYVSKVTVG SIAHQAGLEY GDQLLEFNGI
1410 1420 1430 1440 1450
NLRSATEQQA RLIIGQQCDT ITILAQYNPH VHQLSSHSRS SSHLDPAGTH
1460 1470 1480 1490 1500
STLQGSGTTT PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA GDANKKTLEP
1510 1520 1530 1540 1550
RVVFIKKSQL ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG LVPGDLILEY
1560 1570 1580 1590 1600
GSLDVRNKTV EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG LPGDSFYIRA
1610 1620 1630 1640 1650
LYDRLADVEQ ELSFKKDDIL YVDDTLPQGT FGSWMAWQLD ENAQKIQRGQ
1660 1670 1680 1690 1700
IPSKYVMDQE FSRRLSMSEV KDDNSATKTL SAAARRSFFR RKHKHKRSGS
1710 1720 1730 1740 1750
KDGKDLLALD AFSSDSIPLF EDSVSLAYQR VQKVDCTALR PVLILGPLLD
1760 1770 1780 1790 1800
VVKEMLVNEA PGKFCRCPLE VMKASQQAIE RGVKDCLFVD YKRRSGHFDV
1810 1820 1830 1840 1850
TTVASIKEIT EKNRHCLLDI APHAIERLHH MHIYPIVIFI HYKSAKHIKE
1860 1870 1880 1890 1900
QRDPIYLRDK VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG GALSSICTQI
1910
LAMVNQEQNK VLWIPACPL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSL1 | A0A0A0MSL1_HUMAN | Disks large homolog 5 | DLG5 | 880 | Annotation score: | ||
R4GMQ2 | R4GMQ2_HUMAN | Disks large homolog 5 | DLG5 | 214 | Annotation score: | ||
A0A0J9YYG8 | A0A0J9YYG8_HUMAN | Disks large homolog 5 | DLG5 | 598 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027897 | 140 | Q → R4 PublicationsCorresponds to variant dbSNP:rs1248696Ensembl. | 1 | |
Natural variantiVAR_027898 | 1481 | P → Q1 PublicationCorresponds to variant dbSNP:rs2289310Ensembl. | 1 | |
Natural variantiVAR_027899 | 1600 | A → V. Corresponds to variant dbSNP:rs4979794EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027198 | 1 – 1245 | Missing in isoform 5. 1 PublicationAdd BLAST | 1245 | |
Alternative sequenceiVSP_027197 | 1 – 110 | Missing in isoform 4. 1 PublicationAdd BLAST | 110 | |
Alternative sequenceiVSP_027199 | 130 – 580 | Missing in isoform 3. 1 PublicationAdd BLAST | 451 | |
Alternative sequenceiVSP_016349 | 795 – 1134 | Missing in isoform 2. CuratedAdd BLAST | 340 | |
Alternative sequenceiVSP_027200 | 1135 | E → V in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_027201 | 1136 – 1919 | Missing in isoform 3. 1 PublicationAdd BLAST | 784 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61843 mRNA Translation: AAC61295.1 AF352033 Genomic DNA Translation: AAL83937.1 AF352034 mRNA Translation: AAL83938.1 AB011155 mRNA Translation: BAA25509.2 Different initiation. AL391421 Genomic DNA No translation available. AL450306 Genomic DNA No translation available. BC073996 mRNA Translation: AAH73996.1 BC117695 mRNA Translation: AAI17696.1 Different initiation. BC146794 mRNA Translation: AAI46795.1 AB091676 mRNA Translation: BAC65420.1 |
CCDSi | CCDS7353.2 [Q8TDM6-1] |
PIRi | T00346 |
RefSeqi | NP_004738.3, NM_004747.3 [Q8TDM6-1] XP_006718119.1, XM_006718056.3 [Q8TDM6-2] XP_011538647.1, XM_011540345.1 XP_016872403.1, XM_017016914.1 [Q8TDM6-4] |
Genome annotation databases
Ensembli | ENST00000372391; ENSP00000361467; ENSG00000151208 [Q8TDM6-1] ENST00000614211; ENSP00000484894; ENSG00000274429 [Q8TDM6-1] |
GeneIDi | 9231 |
KEGGi | hsa:9231 |
UCSCi | uc001jzk.4, human [Q8TDM6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61843 mRNA Translation: AAC61295.1 AF352033 Genomic DNA Translation: AAL83937.1 AF352034 mRNA Translation: AAL83938.1 AB011155 mRNA Translation: BAA25509.2 Different initiation. AL391421 Genomic DNA No translation available. AL450306 Genomic DNA No translation available. BC073996 mRNA Translation: AAH73996.1 BC117695 mRNA Translation: AAI17696.1 Different initiation. BC146794 mRNA Translation: AAI46795.1 AB091676 mRNA Translation: BAC65420.1 |
CCDSi | CCDS7353.2 [Q8TDM6-1] |
PIRi | T00346 |
RefSeqi | NP_004738.3, NM_004747.3 [Q8TDM6-1] XP_006718119.1, XM_006718056.3 [Q8TDM6-2] XP_011538647.1, XM_011540345.1 XP_016872403.1, XM_017016914.1 [Q8TDM6-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UIT | NMR | - | A | 1336-1439 | [»] | |
SMRi | Q8TDM6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114662, 52 interactors |
ComplexPortali | CPX-6187, Scribble cell polarity complex, DLG5-LLGL2-SCRIB variant CPX-6188, Scribble cell polarity complex, DLG5-LLGL1-SCRIB variant |
CORUMi | Q8TDM6 |
DIPi | DIP-41450N |
IntActi | Q8TDM6, 40 interactors |
MINTi | Q8TDM6 |
STRINGi | 9606.ENSP00000361467 |
PTM databases
iPTMneti | Q8TDM6 |
PhosphoSitePlusi | Q8TDM6 |
Genetic variation databases
BioMutai | DLG5 |
DMDMi | 158939323 |
Proteomic databases
EPDi | Q8TDM6 |
jPOSTi | Q8TDM6 |
MassIVEi | Q8TDM6 |
MaxQBi | Q8TDM6 |
PaxDbi | Q8TDM6 |
PeptideAtlasi | Q8TDM6 |
PRIDEi | Q8TDM6 |
ProteomicsDBi | 74302 [Q8TDM6-1] 74303 [Q8TDM6-2] 74304 [Q8TDM6-3] 74305 [Q8TDM6-4] 74306 [Q8TDM6-5] |
Protocols and materials databases
Antibodypediai | 618, 90 antibodies |
DNASUi | 9231 |
Genome annotation databases
Ensembli | ENST00000372391; ENSP00000361467; ENSG00000151208 [Q8TDM6-1] ENST00000614211; ENSP00000484894; ENSG00000274429 [Q8TDM6-1] |
GeneIDi | 9231 |
KEGGi | hsa:9231 |
UCSCi | uc001jzk.4, human [Q8TDM6-1] |
Organism-specific databases
CTDi | 9231 |
DisGeNETi | 9231 |
GeneCardsi | DLG5 |
HGNCi | HGNC:2904, DLG5 |
HPAi | ENSG00000151208, Low tissue specificity |
MIMi | 604090, gene |
neXtProti | NX_Q8TDM6 |
OpenTargetsi | ENSG00000151208 |
PharmGKBi | PA27360 |
VEuPathDBi | HostDB:ENSG00000151208.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0708, Eukaryota KOG3528, Eukaryota |
GeneTreei | ENSGT00940000155303 |
HOGENOMi | CLU_002448_1_0_1 |
InParanoidi | Q8TDM6 |
OMAi | KSRESSW |
OrthoDBi | 123652at2759 |
PhylomeDBi | Q8TDM6 |
TreeFami | TF323171 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDM6 |
Miscellaneous databases
BioGRID-ORCSi | 9231, 91 hits in 995 CRISPR screens |
ChiTaRSi | DLG5, human |
EvolutionaryTracei | Q8TDM6 |
GeneWikii | DLG5 |
GenomeRNAii | 9231 |
Pharosi | Q8TDM6, Tbio |
PROi | PR:Q8TDM6 |
RNActi | Q8TDM6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151208, Expressed in forebrain and 243 other tissues |
ExpressionAtlasi | Q8TDM6, baseline and differential |
Genevisiblei | Q8TDM6, HS |
Family and domain databases
CDDi | cd11860, SH3_DLG5, 1 hit |
Gene3Di | 2.30.42.10, 4 hits |
InterProi | View protein in InterPro IPR001315, CARD IPR011029, DEATH-like_dom_sf IPR035537, DLG5_SH3 IPR006907, DUF622 IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF04822, Takusan, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 4 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 4 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 4 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DLG5_HUMAN | |
Accessioni | Q8TDM6Primary (citable) accession number: Q8TDM6 Secondary accession number(s): A6H8Y3 Q9Y4E3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | July 24, 2007 | |
Last modified: | April 7, 2021 | |
This is version 198 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families