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UniProtKB - Q8TDM6 (DLG5_HUMAN)

Protein

Disks large homolog 5

Gene

DLG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).By similarity2 Publications

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • cytoskeletal protein binding Source: MGI
  • receptor signaling complex scaffold activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 5
Alternative name(s):
Discs large protein P-dlg
Placenta and prostate DLG
Gene namesi
Name:DLG5
Synonyms:KIAA0583, PDLG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151208.16
HGNCiHGNC:2904 DLG5
MIMi604090 gene
neXtProtiNX_Q8TDM6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9231
OpenTargetsiENSG00000151208
PharmGKBiPA27360

Polymorphism and mutation databases

BioMutaiDLG5
DMDMi158939323

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945641 – 1919Disks large homolog 5Add BLAST1919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei984PhosphothreonineCombined sources1
Modified residuei1000PhosphoserineCombined sources1
Modified residuei1011PhosphothreonineCombined sources1
Modified residuei1021PhosphoserineCombined sources1
Modified residuei1183PhosphothreonineCombined sources1
Modified residuei1209PhosphoserineCombined sources1
Modified residuei1263PhosphoserineCombined sources1
Modified residuei1334PhosphoserineCombined sources1
Modified residuei1666PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TDM6
MaxQBiQ8TDM6
PaxDbiQ8TDM6
PeptideAtlasiQ8TDM6
PRIDEiQ8TDM6
ProteomicsDBi74302
74303 [Q8TDM6-2]
74304 [Q8TDM6-3]
74305 [Q8TDM6-4]
74306 [Q8TDM6-5]

PTM databases

iPTMnetiQ8TDM6
PhosphoSitePlusiQ8TDM6

Expressioni

Tissue specificityi

Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.4 Publications

Gene expression databases

BgeeiENSG00000151208 Expressed in 233 organ(s), highest expression level in forebrain
ExpressionAtlasiQ8TDM6 baseline and differential
GenevisibleiQ8TDM6 HS

Organism-specific databases

HPAiHPA001746

Interactioni

Subunit structurei

Interacts with MPP1 (PubMed:9738934). Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex (PubMed:12657639). Interacts (via coiled-coil domain) with MARK3. Interacts (via PDZ domain 3) with STK3/MST2 and STK4/MST1 (PubMed:28087714). Interacts with SCRIB (PubMed:28169360). Interacts with CTNB1, SMO and (via PDZ4 or guanylate kinase-like domain) with KIF7 (By similarity).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114662, 33 interactors
CORUMiQ8TDM6
DIPiDIP-41450N
IntActiQ8TDM6, 30 interactors
MINTiQ8TDM6
STRINGi9606.ENSP00000361467

Structurei

Secondary structure

11919
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TDM6
SMRiQ8TDM6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TDM6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini620 – 710PDZ 1PROSITE-ProRule annotationAdd BLAST91
Domaini705 – 796PDZ 2PROSITE-ProRule annotationAdd BLAST92
Domaini1350 – 1429PDZ 3PROSITE-ProRule annotationAdd BLAST80
Domaini1501 – 1582PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini1593 – 1661SH3PROSITE-ProRule annotationAdd BLAST69
Domaini1722 – 1905Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili383 – 599Sequence analysisAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 123Poly-SerAdd BLAST11
Compositional biasi982 – 1066Pro-richAdd BLAST85

Domaini

The guanylate kinase-like domain interacts with the SH3 domain.By similarity

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA
GeneTreeiENSGT00760000118866
HOVERGENiHBG081446
InParanoidiQ8TDM6
OMAiEWAPYSP
OrthoDBiEOG091G00NF
PhylomeDBiQ8TDM6
TreeFamiTF323171

Family and domain databases

CDDicd11860 SH3_DLG5, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR035537 DLG5_SH3
IPR006907 DUF622
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF04822 Takusan, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG 
        60         70         80         90        100
AKAELLLKLL LAKERDHFQD LRAALEKTQP HLLPILYLNG VVGPPQPAEG 
       110        120        130        140        150
AGSTYSVLST MPSDSESSSS LSSVGTTGKA PSPPPLLTDQ QVNEKVENLS 
       160        170        180        190        200
IQLRLMTRER NELRKRLAFA THGTAFDKRP YHRLNPDYER LKIQCVRAMS 
       210        220        230        240        250
DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTRL KDDVDMLRRE 
       260        270        280        290        300
NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN 
       310        320        330        340        350
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HNADLSRLEQ LGEENQRLLK 
       360        370        380        390        400
QTEMLTQQRD TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL 
       410        420        430        440        450
QSELTELRTT QVKTAKESEK YREERDAVYS EYKLIMSERD QVISELDKLQ 
       460        470        480        490        500
TEVELAESKL KSSTSEKKAA NEEMEALRQI KDTVTMDAGR ANKEVEILRK 
       510        520        530        540        550
QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE 
       560        570        580        590        600
RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM 
       610        620        630        640        650
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG 
       660        670        680        690        700
DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG 
       710        720        730        740        750
AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVLPGSPAA 
       760        770        780        790        800
KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS 
       810        820        830        840        850
SWSGQNIFEN IKDSDKMLSF RAHGPEVQAH NKRNLIQHNN STQTDIFYTD 
       860        870        880        890        900
RLEDRKEPGP PGGSSSFLHK PFPGGPLQVC PQACPSASER SLSSFRSDAS 
       910        920        930        940        950
GDRGFGLVDV RGRRPLLPFE TEVGPCGVGE ASLDKADSEG SNSGGTWPKA 
       960        970        980        990       1000
MLSSTAVPEK LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGPAHS 
      1010       1020       1030       1040       1050
PQPSKRAGPL TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA 
      1060       1070       1080       1090       1100
LPPDVDPGEP MHASPPRKAR VRIASSYYPE GDGDSSHLPA KKSCDEDLTS 
      1110       1120       1130       1140       1150
QKVDELGQKR RRPKSAPSFR PKLAPVVIPA QFLEEQKCVP ASGELSPELQ 
      1160       1170       1180       1190       1200
EWAPYSPGHS SRHSNPPLYP SRPSVGTVPR SLTPSTTVSS ILRNPIYTVR 
      1210       1220       1230       1240       1250
SHRVGPCSSP PAARDAGPQG LHPSVQHQGR LSLDLSHRTC SDYSEMRATH 
      1260       1270       1280       1290       1300
GSNSLPSSAR LGSSSNLQFK AERIKIPSTP RYPRSVVGSE RGSVSHSECS 
      1310       1320       1330       1340       1350
TPPQSPLNID TLSSCSQSQT SASTLPRIAV NPASLGERRK DRPYVEEPRH 
      1360       1370       1380       1390       1400
VKVQKGSEPL GISIVSGEKG GIYVSKVTVG SIAHQAGLEY GDQLLEFNGI 
      1410       1420       1430       1440       1450
NLRSATEQQA RLIIGQQCDT ITILAQYNPH VHQLSSHSRS SSHLDPAGTH 
      1460       1470       1480       1490       1500
STLQGSGTTT PEHPSVIDPL MEQDEGPSTP PAKQSSSRIA GDANKKTLEP 
      1510       1520       1530       1540       1550
RVVFIKKSQL ELGVHLCGGN LHGVFVAEVE DDSPAKGPDG LVPGDLILEY 
      1560       1570       1580       1590       1600
GSLDVRNKTV EEVYVEMLKP RDGVRLKVQY RPEEFTKAKG LPGDSFYIRA 
      1610       1620       1630       1640       1650
LYDRLADVEQ ELSFKKDDIL YVDDTLPQGT FGSWMAWQLD ENAQKIQRGQ 
      1660       1670       1680       1690       1700
IPSKYVMDQE FSRRLSMSEV KDDNSATKTL SAAARRSFFR RKHKHKRSGS 
      1710       1720       1730       1740       1750
KDGKDLLALD AFSSDSIPLF EDSVSLAYQR VQKVDCTALR PVLILGPLLD 
      1760       1770       1780       1790       1800
VVKEMLVNEA PGKFCRCPLE VMKASQQAIE RGVKDCLFVD YKRRSGHFDV 
      1810       1820       1830       1840       1850
TTVASIKEIT EKNRHCLLDI APHAIERLHH MHIYPIVIFI HYKSAKHIKE 
      1860       1870       1880       1890       1900
QRDPIYLRDK VTQRHSKEQF EAAQKLEQEY SRYFTGVIQG GALSSICTQI 
      1910 
LAMVNQEQNK VLWIPACPL
Length:1,919
Mass (Da):213,868
Last modified:July 24, 2007 - v4
Checksum:iCC19273380260C92
GO
Isoform 2 (identifier: Q8TDM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-1134: Missing.

Note: No experimental confirmation available.
Show »
Length:1,579
Mass (Da):176,971
Checksum:iE1129566D56B6B6F
GO
Isoform 3 (identifier: Q8TDM6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-580: Missing.
     1135-1135: E → V
     1136-1919: Missing.

Note: No experimental confirmation available.
Show »
Length:684
Mass (Da):74,012
Checksum:i9E289C42E00A3C22
GO
Isoform 4 (identifier: Q8TDM6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:1,809
Mass (Da):202,058
Checksum:iB32E6DAD3F124833
GO
Isoform 5 (identifier: Q8TDM6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1245: Missing.

Show »
Length:674
Mass (Da):74,910
Checksum:i19F8FB067F9A400B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSL1A0A0A0MSL1_HUMAN
Disks large homolog 5
DLG5
880Annotation score:
R4GMQ2R4GMQ2_HUMAN
Disks large homolog 5
DLG5
214Annotation score:
A0A0J9YYG8A0A0J9YYG8_HUMAN
Disks large homolog 5
DLG5
598Annotation score:

Sequence cautioni

The sequence AAI17696 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA25509 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027897140Q → R4 PublicationsCorresponds to variant dbSNP:rs1248696Ensembl.1
Natural variantiVAR_0278981481P → Q1 PublicationCorresponds to variant dbSNP:rs2289310Ensembl.1
Natural variantiVAR_0278991600A → V. Corresponds to variant dbSNP:rs4979794Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0271981 – 1245Missing in isoform 5. 1 PublicationAdd BLAST1245
Alternative sequenceiVSP_0271971 – 110Missing in isoform 4. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_027199130 – 580Missing in isoform 3. 1 PublicationAdd BLAST451
Alternative sequenceiVSP_016349795 – 1134Missing in isoform 2. CuratedAdd BLAST340
Alternative sequenceiVSP_0272001135E → V in isoform 3. 1 Publication1
Alternative sequenceiVSP_0272011136 – 1919Missing in isoform 3. 1 PublicationAdd BLAST784

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61843 mRNA Translation: AAC61295.1
AF352033 Genomic DNA Translation: AAL83937.1
AF352034 mRNA Translation: AAL83938.1
AB011155 mRNA Translation: BAA25509.2 Different initiation.
AL391421 Genomic DNA No translation available.
AL450306 Genomic DNA No translation available.
BC073996 mRNA Translation: AAH73996.1
BC117695 mRNA Translation: AAI17696.1 Different initiation.
BC146794 mRNA Translation: AAI46795.1
AB091676 mRNA Translation: BAC65420.1
CCDSiCCDS7353.2 [Q8TDM6-1]
PIRiT00346
RefSeqiNP_004738.3, NM_004747.3 [Q8TDM6-1]
XP_006718119.1, XM_006718056.3 [Q8TDM6-2]
XP_011538647.1, XM_011540345.1
XP_016872403.1, XM_017016914.1 [Q8TDM6-4]
UniGeneiHs.652690

Genome annotation databases

EnsembliENST00000372391; ENSP00000361467; ENSG00000151208 [Q8TDM6-1]
ENST00000614211; ENSP00000484894; ENSG00000274429 [Q8TDM6-1]
GeneIDi9231
KEGGihsa:9231
UCSCiuc001jzk.4 human [Q8TDM6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61843 mRNA Translation: AAC61295.1
AF352033 Genomic DNA Translation: AAL83937.1
AF352034 mRNA Translation: AAL83938.1
AB011155 mRNA Translation: BAA25509.2 Different initiation.
AL391421 Genomic DNA No translation available.
AL450306 Genomic DNA No translation available.
BC073996 mRNA Translation: AAH73996.1
BC117695 mRNA Translation: AAI17696.1 Different initiation.
BC146794 mRNA Translation: AAI46795.1
AB091676 mRNA Translation: BAC65420.1
CCDSiCCDS7353.2 [Q8TDM6-1]
PIRiT00346
RefSeqiNP_004738.3, NM_004747.3 [Q8TDM6-1]
XP_006718119.1, XM_006718056.3 [Q8TDM6-2]
XP_011538647.1, XM_011540345.1
XP_016872403.1, XM_017016914.1 [Q8TDM6-4]
UniGeneiHs.652690

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UITNMR-A1336-1439[»]
ProteinModelPortaliQ8TDM6
SMRiQ8TDM6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114662, 33 interactors
CORUMiQ8TDM6
DIPiDIP-41450N
IntActiQ8TDM6, 30 interactors
MINTiQ8TDM6
STRINGi9606.ENSP00000361467

PTM databases

iPTMnetiQ8TDM6
PhosphoSitePlusiQ8TDM6

Polymorphism and mutation databases

BioMutaiDLG5
DMDMi158939323

Proteomic databases

EPDiQ8TDM6
MaxQBiQ8TDM6
PaxDbiQ8TDM6
PeptideAtlasiQ8TDM6
PRIDEiQ8TDM6
ProteomicsDBi74302
74303 [Q8TDM6-2]
74304 [Q8TDM6-3]
74305 [Q8TDM6-4]
74306 [Q8TDM6-5]

Protocols and materials databases

DNASUi9231
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372391; ENSP00000361467; ENSG00000151208 [Q8TDM6-1]
ENST00000614211; ENSP00000484894; ENSG00000274429 [Q8TDM6-1]
GeneIDi9231
KEGGihsa:9231
UCSCiuc001jzk.4 human [Q8TDM6-1]

Organism-specific databases

CTDi9231
DisGeNETi9231
EuPathDBiHostDB:ENSG00000151208.16
GeneCardsiDLG5
H-InvDBiHIX0008958
HIX0035651
HGNCiHGNC:2904 DLG5
HPAiHPA001746
MIMi604090 gene
neXtProtiNX_Q8TDM6
OpenTargetsiENSG00000151208
PharmGKBiPA27360
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA
GeneTreeiENSGT00760000118866
HOVERGENiHBG081446
InParanoidiQ8TDM6
OMAiEWAPYSP
OrthoDBiEOG091G00NF
PhylomeDBiQ8TDM6
TreeFamiTF323171

Miscellaneous databases

ChiTaRSiDLG5 human
EvolutionaryTraceiQ8TDM6
GeneWikiiDLG5
GenomeRNAii9231
PROiPR:Q8TDM6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151208 Expressed in 233 organ(s), highest expression level in forebrain
ExpressionAtlasiQ8TDM6 baseline and differential
GenevisibleiQ8TDM6 HS

Family and domain databases

CDDicd11860 SH3_DLG5, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR035537 DLG5_SH3
IPR006907 DUF622
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF04822 Takusan, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLG5_HUMAN
AccessioniPrimary (citable) accession number: Q8TDM6
Secondary accession number(s): A6H8Y3
, Q149N1, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 179 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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