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Entry version 151 (10 Feb 2021)
Sequence version 1 (01 Jun 2002)
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Protein

BPI fold-containing family B member 1

Gene

BPIFB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TDL5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803157, Antimicrobial peptides

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BPI fold-containing family B member 1
Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 1
von Ebner minor salivary gland protein
Short name:
VEMSGP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BPIFB1
Synonyms:C20orf114, LPLUNC1
ORF Names:UNQ706/PRO1357
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16108, BPIFB1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDL5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000125999.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92747

Open Targets

More...
OpenTargetsi
ENSG00000125999

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25654

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TDL5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BPIFB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395685

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001718022 – 484BPI fold-containing family B member 1Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi158 ↔ 201By similarity
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1490

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TDL5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TDL5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDL5

PeptideAtlas

More...
PeptideAtlasi
Q8TDL5

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDL5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74296 [Q8TDL5-1]
74297 [Q8TDL5-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8TDL5-1 [Q8TDL5-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1047, 3 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8TDL5, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125999, Expressed in lung and 67 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TDL5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDL5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000125999, Tissue enhanced (cervix, uterine, lung, lymphoid tissue, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124975, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TDL5, 14 interactors

Molecular INTeraction database

More...
MINTi
Q8TDL5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253354

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TDL5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4160, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000193386

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_050473_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDL5

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNDMYAD

Database of Orthologous Groups

More...
OrthoDBi
1209764at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDL5

TreeFam database of animal gene trees

More...
TreeFami
TF338541

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017943, Bactericidal_perm-incr_a/b_dom
IPR021193, Bpifb1
IPR001124, Lipid-bd_serum_glycop_C
IPR017942, Lipid-bd_serum_glycop_N

The PANTHER Classification System

More...
PANTHERi
PTHR47395, PTHR47395, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01273, LBP_BPI_CETP, 1 hit
PF02886, LBP_BPI_CETP_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037186, PLUNC_long_form, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00328, BPI1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55394, SSF55394, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT
60 70 80 90 100
SILQQLPLLS AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK
110 120 130 140 150
PSANDQELLV KIPLDMVAGF NTPLVKTIVE FHMTTEAQAT IRMDTSASGP
160 170 180 190 200
TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL AKQVMNLLVP SLPNLVKNQL
210 220 230 240 250
CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK GDTIQLYLGA
260 270 280 290 300
KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE
310 320 330 340 350
EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI
360 370 380 390 400
DQGHAKVAQL IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN
410 420 430 440 450
NISSDRIQLM NSGIGWFQPD VLKNIITEII HSILLPNQNG KLRSGVPVSL
460 470 480
VKALGFEAAE SSLTKDALVL TPASLWKPSS PVSQ
Length:484
Mass (Da):52,442
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA32A85F74D544E81
GO
Isoform 2 (identifier: Q8TDL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.
     170-220: LHKLSFLVNA...MYADLLQLVK → MCCPGGHYTL...RGRARRSPWS
     328-329: AA → LQ
     330-484: Missing.

Show »
Length:160
Mass (Da):17,695
Checksum:i235B7A2830539689
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2R0A2A2R0_HUMAN
BPI fold-containing family B member...
BPIFB1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171H → Y in AAQ88958 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01675684I → V1 PublicationCorresponds to variant dbSNP:rs1078761Ensembl.1
Natural variantiVAR_049747140T → A. Corresponds to variant dbSNP:rs34578060EnsemblClinVar.1
Natural variantiVAR_049748284V → M. Corresponds to variant dbSNP:rs6141383Ensembl.1
Natural variantiVAR_049749287D → H. Corresponds to variant dbSNP:rs34548457Ensembl.1
Natural variantiVAR_023361298S → P. Corresponds to variant dbSNP:rs6120221Ensembl.1
Natural variantiVAR_023362313S → I. Corresponds to variant dbSNP:rs6120222Ensembl.1
Natural variantiVAR_049750464T → S1 PublicationCorresponds to variant dbSNP:rs17856249Ensembl.1
Natural variantiVAR_016757479S → T2 PublicationsCorresponds to variant dbSNP:rs1999663Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152851 – 169Missing in isoform 2. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_015286170 – 220LHKLS…LQLVK → MCCPGGHYTLILRRGNRFRR EKRPAKVTGAQTEVQLAPPL PRGRARRSPWS in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_015287328 – 329AA → LQ in isoform 2. 1 Publication2
Alternative sequenceiVSP_015288330 – 484Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF364078 mRNA Translation: AAM00283.1
AY358595 mRNA Translation: AAQ88958.1
AK127971 mRNA Translation: BAC87212.1
AK290243 mRNA Translation: BAF82932.1
AL121901 Genomic DNA No translation available.
AL355392 Genomic DNA No translation available.
BC008429 mRNA Translation: AAH08429.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13218.1 [Q8TDL5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_149974.2, NM_033197.2 [Q8TDL5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253354; ENSP00000253354; ENSG00000125999 [Q8TDL5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92747

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92747

UCSC genome browser

More...
UCSCi
uc002wyw.1, human [Q8TDL5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364078 mRNA Translation: AAM00283.1
AY358595 mRNA Translation: AAQ88958.1
AK127971 mRNA Translation: BAC87212.1
AK290243 mRNA Translation: BAF82932.1
AL121901 Genomic DNA No translation available.
AL355392 Genomic DNA No translation available.
BC008429 mRNA Translation: AAH08429.1
CCDSiCCDS13218.1 [Q8TDL5-1]
RefSeqiNP_149974.2, NM_033197.2 [Q8TDL5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124975, 22 interactors
IntActiQ8TDL5, 14 interactors
MINTiQ8TDL5
STRINGi9606.ENSP00000253354

PTM databases

GlyConnecti1047, 3 N-Linked glycans (2 sites)
GlyGeniQ8TDL5, 3 sites
iPTMnetiQ8TDL5
PhosphoSitePlusiQ8TDL5

Genetic variation databases

BioMutaiBPIFB1
DMDMi34395685

Proteomic databases

CPTACiCPTAC-1490
jPOSTiQ8TDL5
MassIVEiQ8TDL5
PaxDbiQ8TDL5
PeptideAtlasiQ8TDL5
PRIDEiQ8TDL5
ProteomicsDBi74296 [Q8TDL5-1]
74297 [Q8TDL5-2]
TopDownProteomicsiQ8TDL5-1 [Q8TDL5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10629, 185 antibodies

The DNASU plasmid repository

More...
DNASUi
92747

Genome annotation databases

EnsembliENST00000253354; ENSP00000253354; ENSG00000125999 [Q8TDL5-1]
GeneIDi92747
KEGGihsa:92747
UCSCiuc002wyw.1, human [Q8TDL5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92747
DisGeNETi92747

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BPIFB1
HGNCiHGNC:16108, BPIFB1
HPAiENSG00000125999, Tissue enhanced (cervix, uterine, lung, lymphoid tissue, stomach)
neXtProtiNX_Q8TDL5
OpenTargetsiENSG00000125999
PharmGKBiPA25654
VEuPathDBiHostDB:ENSG00000125999.10

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4160, Eukaryota
GeneTreeiENSGT00970000193386
HOGENOMiCLU_050473_0_0_1
InParanoidiQ8TDL5
OMAiFNDMYAD
OrthoDBi1209764at2759
PhylomeDBiQ8TDL5
TreeFamiTF338541

Enzyme and pathway databases

PathwayCommonsiQ8TDL5
ReactomeiR-HSA-6803157, Antimicrobial peptides

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
92747, 3 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BPIFB1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
92747
PharosiQ8TDL5, Tbio

Protein Ontology

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PROi
PR:Q8TDL5
RNActiQ8TDL5, protein

Gene expression databases

BgeeiENSG00000125999, Expressed in lung and 67 other tissues
ExpressionAtlasiQ8TDL5, baseline and differential
GenevisibleiQ8TDL5, HS

Family and domain databases

InterProiView protein in InterPro
IPR017943, Bactericidal_perm-incr_a/b_dom
IPR021193, Bpifb1
IPR001124, Lipid-bd_serum_glycop_C
IPR017942, Lipid-bd_serum_glycop_N
PANTHERiPTHR47395, PTHR47395, 1 hit
PfamiView protein in Pfam
PF01273, LBP_BPI_CETP, 1 hit
PF02886, LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF037186, PLUNC_long_form, 1 hit
SMARTiView protein in SMART
SM00328, BPI1, 1 hit
SUPFAMiSSF55394, SSF55394, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBPIB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDL5
Secondary accession number(s): A8K2H8
, Q5QP43, Q6UWY1, Q6ZRU7, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: February 10, 2021
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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