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Protein

BPI fold-containing family B member 1

Gene

BPIFB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803157 Antimicrobial peptides

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BPI fold-containing family B member 1
Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 1
von Ebner minor salivary gland protein
Short name:
VEMSGP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BPIFB1
Synonyms:C20orf114, LPLUNC1
ORF Names:UNQ706/PRO1357
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000125999.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16108 BPIFB1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDL5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92747

Open Targets

More...
OpenTargetsi
ENSG00000125999

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25654

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BPIFB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395685

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001718022 – 484BPI fold-containing family B member 1Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi158 ↔ 201By similarity
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDL5

PeptideAtlas

More...
PeptideAtlasi
Q8TDL5

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDL5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74296
74297 [Q8TDL5-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8TDL5-1 [Q8TDL5-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1047

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125999 Expressed in 52 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_C20orf114

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TDL5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDL5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024256

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124975, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TDL5, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8TDL5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253354

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TDL5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4160 Eukaryota
ENOG410Z88E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153099

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052339

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDL5

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCPVIKA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0CAE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDL5

TreeFam database of animal gene trees

More...
TreeFami
TF338541

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR021193 Bpifb1
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N

The PANTHER Classification System

More...
PANTHERi
PTHR10504 PTHR10504, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037186 PLUNC_long_form, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00328 BPI1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55394 SSF55394, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPWTFTLL CGLLAATLIQ ATLSPTAVLI LGPKVIKEKL TQELKDHNAT
60 70 80 90 100
SILQQLPLLS AMREKPAGGI PVLGSLVNTV LKHIIWLKVI TANILQLQVK
110 120 130 140 150
PSANDQELLV KIPLDMVAGF NTPLVKTIVE FHMTTEAQAT IRMDTSASGP
160 170 180 190 200
TRLVLSDCAT SHGSLRIQLL HKLSFLVNAL AKQVMNLLVP SLPNLVKNQL
210 220 230 240 250
CPVIEASFNG MYADLLQLVK VPISLSIDRL EFDLLYPAIK GDTIQLYLGA
260 270 280 290 300
KLLDSQGKVT KWFNNSAASL TMPTLDNIPF SLIVSQDVVK AAVAAVLSPE
310 320 330 340 350
EFMVLLDSVL PESAHRLKSS IGLINEKAAD KLGSTQIVKI LTQDTPEFFI
360 370 380 390 400
DQGHAKVAQL IVLEVFPSSE ALRPLFTLGI EASSEAQFYT KGDQLILNLN
410 420 430 440 450
NISSDRIQLM NSGIGWFQPD VLKNIITEII HSILLPNQNG KLRSGVPVSL
460 470 480
VKALGFEAAE SSLTKDALVL TPASLWKPSS PVSQ
Length:484
Mass (Da):52,442
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA32A85F74D544E81
GO
Isoform 2 (identifier: Q8TDL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.
     170-220: LHKLSFLVNA...MYADLLQLVK → MCCPGGHYTL...RGRARRSPWS
     328-329: AA → LQ
     330-484: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):17,695
Checksum:i235B7A2830539689
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2R0A2A2R0_HUMAN
BPI fold-containing family B member...
BPIFB1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171H → Y in AAQ88958 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01675684I → V1 PublicationCorresponds to variant dbSNP:rs1078761Ensembl.1
Natural variantiVAR_049747140T → A. Corresponds to variant dbSNP:rs34578060Ensembl.1
Natural variantiVAR_049748284V → M. Corresponds to variant dbSNP:rs6141383Ensembl.1
Natural variantiVAR_049749287D → H. Corresponds to variant dbSNP:rs34548457Ensembl.1
Natural variantiVAR_023361298S → P. Corresponds to variant dbSNP:rs6120221Ensembl.1
Natural variantiVAR_023362313S → I. Corresponds to variant dbSNP:rs6120222Ensembl.1
Natural variantiVAR_049750464T → S1 PublicationCorresponds to variant dbSNP:rs17856249Ensembl.1
Natural variantiVAR_016757479S → T2 PublicationsCorresponds to variant dbSNP:rs1999663Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152851 – 169Missing in isoform 2. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_015286170 – 220LHKLS…LQLVK → MCCPGGHYTLILRRGNRFRR EKRPAKVTGAQTEVQLAPPL PRGRARRSPWS in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_015287328 – 329AA → LQ in isoform 2. 1 Publication2
Alternative sequenceiVSP_015288330 – 484Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF364078 mRNA Translation: AAM00283.1
AY358595 mRNA Translation: AAQ88958.1
AK127971 mRNA Translation: BAC87212.1
AK290243 mRNA Translation: BAF82932.1
AL121901 Genomic DNA No translation available.
AL355392 Genomic DNA No translation available.
BC008429 mRNA Translation: AAH08429.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13218.1 [Q8TDL5-1]

NCBI Reference Sequences

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RefSeqi
NP_149974.2, NM_033197.2 [Q8TDL5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.65551

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253354; ENSP00000253354; ENSG00000125999 [Q8TDL5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92747

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92747

UCSC genome browser

More...
UCSCi
uc002wyw.1 human [Q8TDL5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364078 mRNA Translation: AAM00283.1
AY358595 mRNA Translation: AAQ88958.1
AK127971 mRNA Translation: BAC87212.1
AK290243 mRNA Translation: BAF82932.1
AL121901 Genomic DNA No translation available.
AL355392 Genomic DNA No translation available.
BC008429 mRNA Translation: AAH08429.1
CCDSiCCDS13218.1 [Q8TDL5-1]
RefSeqiNP_149974.2, NM_033197.2 [Q8TDL5-1]
UniGeneiHs.65551

3D structure databases

ProteinModelPortaliQ8TDL5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124975, 18 interactors
IntActiQ8TDL5, 2 interactors
MINTiQ8TDL5
STRINGi9606.ENSP00000253354

PTM databases

GlyConnecti1047
iPTMnetiQ8TDL5
PhosphoSitePlusiQ8TDL5

Polymorphism and mutation databases

BioMutaiBPIFB1
DMDMi34395685

Proteomic databases

PaxDbiQ8TDL5
PeptideAtlasiQ8TDL5
PRIDEiQ8TDL5
ProteomicsDBi74296
74297 [Q8TDL5-2]
TopDownProteomicsiQ8TDL5-1 [Q8TDL5-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
92747
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253354; ENSP00000253354; ENSG00000125999 [Q8TDL5-1]
GeneIDi92747
KEGGihsa:92747
UCSCiuc002wyw.1 human [Q8TDL5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92747
DisGeNETi92747
EuPathDBiHostDB:ENSG00000125999.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BPIFB1
HGNCiHGNC:16108 BPIFB1
HPAiHPA024256
neXtProtiNX_Q8TDL5
OpenTargetsiENSG00000125999
PharmGKBiPA25654

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00940000153099
HOVERGENiHBG052339
InParanoidiQ8TDL5
OMAiLCPVIKA
OrthoDBiEOG091G0CAE
PhylomeDBiQ8TDL5
TreeFamiTF338541

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BPIFB1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92747

Protein Ontology

More...
PROi
PR:Q8TDL5

Gene expression databases

BgeeiENSG00000125999 Expressed in 52 organ(s), highest expression level in lung
CleanExiHS_C20orf114
ExpressionAtlasiQ8TDL5 baseline and differential
GenevisibleiQ8TDL5 HS

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR021193 Bpifb1
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF037186 PLUNC_long_form, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBPIB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDL5
Secondary accession number(s): A8K2H8
, Q5QP43, Q6UWY1, Q6ZRU7, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: December 5, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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