UniProtKB - Q8TDI0 (CHD5_HUMAN)
Protein
Chromodomain-helicase-DNA-binding protein 5
Gene
CHD5
Organism
Homo sapiens (Human)
Status
Functioni
Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.1 Publication
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 343 – 390 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 416 – 463 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 48 | |
Nucleotide bindingi | 725 – 732 | ATPPROSITE-ProRule annotationBy similarity | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA helicase activity Source: UniProtKB-EC
- H3K27me3 modified histone binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cerebral cortex neuron differentiation Source: UniProtKB
- histone H3-K27 trimethylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- positive regulation of signal transduction by p53 class mediator Source: UniProtKB
- regulation of transcription involved in cell fate commitment Source: UniProtKB
- spermatogenesis, exchange of chromosomal proteins Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Helicase, Hydrolase |
Biological process | Differentiation, Neurogenesis, Spermatogenesis, Transcription, Transcription regulation |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Chromodomain-helicase-DNA-binding protein 5 (EC:3.6.4.12)Short name: CHD-5 Alternative name(s): ATP-dependent helicase CHD5 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16816 CHD5 |
MIMi | 610771 gene |
neXtProti | NX_Q8TDI0 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Note: Associates with heterochromatin.By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- NuRD complex Source: UniProtKB
Other locations
- heterochromatin Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Defects in CHD5 may be a cause of the development of cancers from epithelial, neural and hematopoietic origin. CHD5 is one of the missing genes in the del(1p36), a deletion which is extremely common in this type of cancers. A decrease of its expression, results in increased susceptibility of cells to Ras-mediated transformation in vitro and in vivo (PubMed:17289567).1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 518 | L → A: Reduced affinity for trimethylated histone H3K27me3. 1 Publication | 1 | |
Mutagenesisi | 619 | Y → E: Reduced affinity for trimethylated histone H3K27me3. 1 Publication | 1 | |
Mutagenesisi | 1390 | Q → R: Abolishes methylation by N6AMT1. 1 Publication | 1 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 26038 |
OpenTargetsi | ENSG00000116254 |
PharmGKBi | PA134969178 |
Miscellaneous databases
Pharosi | Q8TDI0 |
Polymorphism and mutation databases
BioMutai | CHD5 |
DMDMi | 51701343 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080230 | 1 – 1954 | Chromodomain-helicase-DNA-binding protein 5Add BLAST | 1954 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1390 | N5-methylglutamine1 Publication | 1 | |
Modified residuei | 1554 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Methylated at Gln-1390 by N6AMT1.1 Publication
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q8TDI0 |
jPOSTi | Q8TDI0 |
MassIVEi | Q8TDI0 |
MaxQBi | Q8TDI0 |
PaxDbi | Q8TDI0 |
PeptideAtlasi | Q8TDI0 |
PRIDEi | Q8TDI0 |
ProteomicsDBi | 74289 |
PTM databases
iPTMneti | Q8TDI0 |
PhosphoSitePlusi | Q8TDI0 |
Expressioni
Tissue specificityi
Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis.2 Publications
Gene expression databases
Bgeei | ENSG00000116254 Expressed in 131 organ(s), highest expression level in frontal cortex |
ExpressionAtlasi | Q8TDI0 baseline and differential |
Genevisiblei | Q8TDI0 HS |
Organism-specific databases
HPAi | HPA015809 HPA055477 |
Interactioni
Subunit structurei
May be part of a nucleosome remodeling and histone deacetylation, NuRD-like, complex composed at least of GATAD2B, HDAC1, HDAC2 and MTA3.
By similarityGO - Molecular functioni
- H3K27me3 modified histone binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 117504, 22 interactors |
IntActi | Q8TDI0, 11 interactors |
MINTi | Q8TDI0 |
STRINGi | 9606.ENSP00000262450 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 497 – 554 | Chromo 1PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 592 – 653 | Chromo 2PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 712 – 896 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 185 | |
Domaini | 1028 – 1193 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 166 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 343 – 653 | Histone-bindingAdd BLAST | 311 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 847 – 850 | DEAH box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 116 | Lys-richAdd BLAST | 68 |
Domaini
The PHD domains mediate specific binding to histone H3 unmethylated at 'Lys-4' and may preferentially recruit the protein to transcriptionally inactive genes.By similarity
The chromo domains mediate specific binding to histone H3 trimethylated at 'Lys-27' (H3K27me3) and may be required in neuron differentiation for proper gene regulation.1 Publication
Sequence similaritiesi
Belongs to the SNF2/RAD54 helicase family.Sequence analysis
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 343 – 390 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 416 – 463 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG410IREB Eukaryota ENOG410XNUT LUCA |
GeneTreei | ENSGT00940000159249 |
HOGENOMi | HOG000231124 |
InParanoidi | Q8TDI0 |
KOi | K14435 |
OMAi | ITWRWAV |
OrthoDBi | 54215at2759 |
PhylomeDBi | Q8TDI0 |
TreeFami | TF106448 |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR028727 CHD5 IPR012957 CHD_C2 IPR012958 CHD_N IPR016197 Chromo-like_dom_sf IPR000953 Chromo/chromo_shadow_dom IPR023780 Chromo_domain IPR002464 DNA/RNA_helicase_DEAH_CS IPR009462 DUF1086 IPR009463 DUF1087 IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD |
PANTHERi | PTHR45623:SF6 PTHR45623:SF6, 1 hit |
Pfami | View protein in Pfam PF08074 CHDCT2, 1 hit PF08073 CHDNT, 1 hit PF00385 Chromo, 1 hit PF06461 DUF1086, 1 hit PF06465 DUF1087, 1 hit PF00271 Helicase_C, 1 hit PF00628 PHD, 2 hits PF00176 SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00298 CHROMO, 2 hits SM00487 DEXDc, 1 hit SM01146 DUF1086, 1 hit SM01147 DUF1087, 1 hit SM00490 HELICc, 1 hit SM00249 PHD, 2 hits |
SUPFAMi | SSF52540 SSF52540, 2 hits SSF54160 SSF54160, 2 hits SSF57903 SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50013 CHROMO_2, 2 hits PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS01359 ZF_PHD_1, 2 hits PS50016 ZF_PHD_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8TDI0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGPVGTEEE LPRLFAEEME NEDEMSEEED GGLEAFDDFF PVEPVSLPKK
60 70 80 90 100
KKPKKLKENK CKGKRKKKEG SNDELSENEE DLEEKSESEG SDYSPNKKKK
110 120 130 140 150
KKLKDKKEKK AKRKKKDEDE DDNDDGCLKE PKSSGQLMAE WGLDDVDYLF
160 170 180 190 200
SEEDYHTLTN YKAFSQFLRP LIAKKNPKIP MSKMMTVLGA KWREFSANNP
210 220 230 240 250
FKGSSAAAAA AAVAAAVETV TISPPLAVSP PQVPQPVPIR KAKTKEGKGP
260 270 280 290 300
GVRKKIKGSK DGKKKGKGKK TAGLKFRFGG ISNKRKKGSS SEEDEREESD
310 320 330 340 350
FDSASIHSAS VRSECSAALG KKSKRRRKKK RIDDGDGYET DHQDYCEVCQ
360 370 380 390 400
QGGEIILCDT CPRAYHLVCL DPELEKAPEG KWSCPHCEKE GIQWEPKDDD
410 420 430 440 450
DEEEEGGCEE EEDDHMEFCR VCKDGGELLC CDACPSSYHL HCLNPPLPEI
460 470 480 490 500
PNGEWLCPRC TCPPLKGKVQ RILHWRWTEP PAPFMVGLPG PDVEPSLPPP
510 520 530 540 550
KPLEGIPERE FFVKWAGLSY WHCSWVKELQ LELYHTVMYR NYQRKNDMDE
560 570 580 590 600
PPPFDYGSGD EDGKSEKRKN KDPLYAKMEE RFYRYGIKPE WMMIHRILNH
610 620 630 640 650
SFDKKGDVHY LIKWKDLPYD QCTWEIDDID IPYYDNLKQA YWGHRELMLG
660 670 680 690 700
EDTRLPKRLL KKGKKLRDDK QEKPPDTPIV DPTVKFDKQP WYIDSTGGTL
710 720 730 740 750
HPYQLEGLNW LRFSWAQGTD TILADEMGLG KTVQTIVFLY SLYKEGHSKG
760 770 780 790 800
PYLVSAPLST IINWEREFEM WAPDFYVVTY TGDKESRSVI RENEFSFEDN
810 820 830 840 850
AIRSGKKVFR MKKEVQIKFH VLLTSYELIT IDQAILGSIE WACLVVDEAH
860 870 880 890 900
RLKNNQSKFF RVLNSYKIDY KLLLTGTPLQ NNLEELFHLL NFLTPERFNN
910 920 930 940 950
LEGFLEEFAD ISKEDQIKKL HDLLGPHMLR RLKADVFKNM PAKTELIVRV
960 970 980 990 1000
ELSQMQKKYY KFILTRNFEA LNSKGGGNQV SLLNIMMDLK KCCNHPYLFP
1010 1020 1030 1040 1050
VAAVEAPVLP NGSYDGSSLV KSSGKLMLLQ KMLKKLRDEG HRVLIFSQMT
1060 1070 1080 1090 1100
KMLDLLEDFL EYEGYKYERI DGGITGGLRQ EAIDRFNAPG AQQFCFLLST
1110 1120 1130 1140 1150
RAGGLGINLA TADTVIIYDS DWNPHNDIQA FSRAHRIGQN KKVMIYRFVT
1160 1170 1180 1190 1200
RASVEERITQ VAKRKMMLTH LVVRPGLGSK SGSMTKQELD DILKFGTEEL
1210 1220 1230 1240 1250
FKDDVEGMMS QGQRPVTPIP DVQSSKGGNL AASAKKKHGS TPPGDNKDVE
1260 1270 1280 1290 1300
DSSVIHYDDA AISKLLDRNQ DATDDTELQN MNEYLSSFKV AQYVVREEDG
1310 1320 1330 1340 1350
VEEVEREIIK QEENVDPDYW EKLLRHHYEQ QQEDLARNLG KGKRIRKQVN
1360 1370 1380 1390 1400
YNDASQEDQE WQDELSDNQS EYSIGSEDED EDFEERPEGQ SGRRQSRRQL
1410 1420 1430 1440 1450
KSDRDKPLPP LLARVGGNIE VLGFNARQRK AFLNAIMRWG MPPQDAFNSH
1460 1470 1480 1490 1500
WLVRDLRGKS EKEFRAYVSL FMRHLCEPGA DGAETFADGV PREGLSRQHV
1510 1520 1530 1540 1550
LTRIGVMSLV RKKVQEFEHV NGKYSTPDLI PEGPEGKKSG EVISSDPNTP
1560 1570 1580 1590 1600
VPASPAHLLP APLGLPDKME AQLGYMDEKD PGAQKPRQPL EVQALPAALD
1610 1620 1630 1640 1650
RVESEDKHES PASKERAREE RPEETEKAPP SPEQLPREEV LPEKEKILDK
1660 1670 1680 1690 1700
LELSLIHSRG DSSELRPDDT KAEEKEPIET QQNGDKEEDD EGKKEDKKGK
1710 1720 1730 1740 1750
FKFMFNIADG GFTELHTLWQ NEERAAVSSG KIYDIWHRRH DYWLLAGIVT
1760 1770 1780 1790 1800
HGYARWQDIQ NDPRYMILNE PFKSEVHKGN YLEMKNKFLA RRFKLLEQAL
1810 1820 1830 1840 1850
VIEEQLRRAA YLNMTQDPNH PAMALNARLA EVECLAESHQ HLSKESLAGN
1860 1870 1880 1890 1900
KPANAVLHKV LNQLEELLSD MKADVTRLPS MLSRIPPVAA RLQMSERSIL
1910 1920 1930 1940 1950
SRLTNRAGDP TIQQGAFGSS QMYSNNFGPN FRGPGPGGIV NYNQMPLGPY
VTDI
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF2Z2R5 | F2Z2R5_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD5 | 1,225 | Annotation score: | ||
K7EMY3 | K7EMY3_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD5 | 1,060 | Annotation score: | ||
K7EMC0 | K7EMC0_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD5 | 90 | Annotation score: | ||
F6T542 | F6T542_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD5 | 110 | Annotation score: | ||
K7ESA5 | K7ESA5_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD5 | 127 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035475 | 45 | V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1470692239Ensembl. | 1 | |
Natural variantiVAR_035476 | 119 | D → N in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_035477 | 667 | R → G in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_048729 | 1253 | S → I. Corresponds to variant dbSNP:rs6657997Ensembl. | 1 | |
Natural variantiVAR_048730 | 1539 | S → P2 PublicationsCorresponds to variant dbSNP:rs2843493Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF425231 mRNA Translation: AAL98962.1 AL031847 Genomic DNA No translation available. AL035406 Genomic DNA No translation available. AL117491 mRNA Translation: CAB55959.1 AB007913 mRNA Translation: BAA32289.1 |
CCDSi | CCDS57.1 |
PIRi | T17269 |
RefSeqi | NP_056372.1, NM_015557.2 |
Genome annotation databases
Ensembli | ENST00000262450; ENSP00000262450; ENSG00000116254 |
GeneIDi | 26038 |
KEGGi | hsa:26038 |
UCSCi | uc001amb.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF425231 mRNA Translation: AAL98962.1 AL031847 Genomic DNA No translation available. AL035406 Genomic DNA No translation available. AL117491 mRNA Translation: CAB55959.1 AB007913 mRNA Translation: BAA32289.1 |
CCDSi | CCDS57.1 |
PIRi | T17269 |
RefSeqi | NP_056372.1, NM_015557.2 |
3D structure databases
SMRi | Q8TDI0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 117504, 22 interactors |
IntActi | Q8TDI0, 11 interactors |
MINTi | Q8TDI0 |
STRINGi | 9606.ENSP00000262450 |
PTM databases
iPTMneti | Q8TDI0 |
PhosphoSitePlusi | Q8TDI0 |
Polymorphism and mutation databases
BioMutai | CHD5 |
DMDMi | 51701343 |
Proteomic databases
EPDi | Q8TDI0 |
jPOSTi | Q8TDI0 |
MassIVEi | Q8TDI0 |
MaxQBi | Q8TDI0 |
PaxDbi | Q8TDI0 |
PeptideAtlasi | Q8TDI0 |
PRIDEi | Q8TDI0 |
ProteomicsDBi | 74289 |
Protocols and materials databases
DNASUi | 26038 |
Genome annotation databases
Ensembli | ENST00000262450; ENSP00000262450; ENSG00000116254 |
GeneIDi | 26038 |
KEGGi | hsa:26038 |
UCSCi | uc001amb.3 human |
Organism-specific databases
CTDi | 26038 |
DisGeNETi | 26038 |
GeneCardsi | CHD5 |
HGNCi | HGNC:16816 CHD5 |
HPAi | HPA015809 HPA055477 |
MIMi | 610771 gene |
neXtProti | NX_Q8TDI0 |
OpenTargetsi | ENSG00000116254 |
PharmGKBi | PA134969178 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IREB Eukaryota ENOG410XNUT LUCA |
GeneTreei | ENSGT00940000159249 |
HOGENOMi | HOG000231124 |
InParanoidi | Q8TDI0 |
KOi | K14435 |
OMAi | ITWRWAV |
OrthoDBi | 54215at2759 |
PhylomeDBi | Q8TDI0 |
TreeFami | TF106448 |
Miscellaneous databases
ChiTaRSi | CHD5 human |
GeneWikii | CHD5 |
GenomeRNAii | 26038 |
Pharosi | Q8TDI0 |
PROi | PR:Q8TDI0 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116254 Expressed in 131 organ(s), highest expression level in frontal cortex |
ExpressionAtlasi | Q8TDI0 baseline and differential |
Genevisiblei | Q8TDI0 HS |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR028727 CHD5 IPR012957 CHD_C2 IPR012958 CHD_N IPR016197 Chromo-like_dom_sf IPR000953 Chromo/chromo_shadow_dom IPR023780 Chromo_domain IPR002464 DNA/RNA_helicase_DEAH_CS IPR009462 DUF1086 IPR009463 DUF1087 IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR038718 SNF2-like_sf IPR000330 SNF2_N IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD |
PANTHERi | PTHR45623:SF6 PTHR45623:SF6, 1 hit |
Pfami | View protein in Pfam PF08074 CHDCT2, 1 hit PF08073 CHDNT, 1 hit PF00385 Chromo, 1 hit PF06461 DUF1086, 1 hit PF06465 DUF1087, 1 hit PF00271 Helicase_C, 1 hit PF00628 PHD, 2 hits PF00176 SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00298 CHROMO, 2 hits SM00487 DEXDc, 1 hit SM01146 DUF1086, 1 hit SM01147 DUF1087, 1 hit SM00490 HELICc, 1 hit SM00249 PHD, 2 hits |
SUPFAMi | SSF52540 SSF52540, 2 hits SSF54160 SSF54160, 2 hits SSF57903 SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50013 CHROMO_2, 2 hits PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS01359 ZF_PHD_1, 2 hits PS50016 ZF_PHD_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHD5_HUMAN | |
Accessioni | Q8TDI0Primary (citable) accession number: Q8TDI0 Secondary accession number(s): O75032 Q9UFR9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | October 16, 2019 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot