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UniProtKB - Q8TDF6 (GRP4_HUMAN)

Entry version 149 (18 Sep 2019)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

RAS guanyl-releasing protein 4

Gene

RASGRP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri540 – 590Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processDifferentiation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5673001 RAF/MAP kinase cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RAS guanyl-releasing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASGRP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18958 RASGRP4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607320 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDF6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi548F → S: Loss of cell membrane targeting. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		115727

Open Targets

More...OpenTargetsi		ENSG00000171777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38770

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RASGRP4

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434529

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003152131 – 673RAS guanyl-releasing protein 4Add BLAST673

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TDF6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TDF6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDF6

PeptideAtlas

More...PeptideAtlasi		Q8TDF6

PRoteomics IDEntifications database

More...PRIDEi		Q8TDF6

ProteomicsDB human proteome resource

More...ProteomicsDBi		74276 [Q8TDF6-1]
74277 [Q8TDF6-2]
74278 [Q8TDF6-3]
74279 [Q8TDF6-5]
74280 [Q8TDF6-6]
74281 [Q8TDF6-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDF6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed early during development. Detected in all fetal tissues tested.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171777 Expressed in 91 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TDF6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDF6 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		125451, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q8TDF6, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000479844

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDF6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 175N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST127
Domaini201 – 432Ras-GEFPROSITE-ProRule annotationAdd BLAST232
Domaini466 – 501EF-handPROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RASGRP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri540 – 590Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IQ6I Eukaryota
ENOG410XQ12 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159883

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000293171

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDF6

KEGG Orthology (KO)

More...KOi		K12363

Identification of Orthologs from Complete Genome Data

More...OMAi		PETGCQL

Database of Orthologous Groups

More...OrthoDBi		355412at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDF6

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029 C1, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.840.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020454 DAG/PE-bd
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR23113 PTHR23113, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00130 C1_1, 1 hit
PF00617 RasGEF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00008 DAGPEDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109 C1, 1 hit
SM00147 RasGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48366 SSF48366, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL 
        60         70         80         90        100
LSEGGCSEDE LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA 
       110        120        130        140        150
RLLTSYQKAT GDTQELRRLQ ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW 
       160        170        180        190        200
ATVAREGNSA QRRLGDSSDL LSPGGPGPPL PMSSPGLGKK RKVSLLFDHL 
       210        220        230        240        250
ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL EGSVGLSNSV 
       260        270        280        290        300
SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS 
       310        320        330        340        350
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV 
       360        370        380        390        400
LGVHLKDLVS LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS 
       410        420        430        440        450
ANEDLLHLLT LSLDLFYTED EIYELSYARE PRCPKSLPPS PFNAPLVVEW 
       460        470        480        490        500
APGVTPKPDR VTLGRHVEQL VESVFKNYDP EGRGTISQED FERLSGNFPF 
       510        520        530        540        550
ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL HTFHEVTFRK 
       560        570        580        590        600
PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA 
       610        620        630        640        650
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS 
       660        670 
WETDTVPCPV MDPPSTASSK LDS
Length:673
Mass (Da):74,882
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C007F595E3C7A02
GO
Isoform 2 (identifier: Q8TDF6-2) [UniParc]FASTAAdd to basket
Also known as: variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     171-184: Missing.

Note: Probably inactive.
Show »
Length:659
Mass (Da):73,607
Checksum:iAF5CEEBD186384DF
GO
Isoform 3 (identifier: Q8TDF6-3) [UniParc]FASTAAdd to basket
Also known as: variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     171-673: Missing.

Note: Probably inactive.
Show »
Length:170
Mass (Da):19,325
Checksum:i81FA75D21C6780F0
GO
Isoform 4 (identifier: Q8TDF6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-410: Missing.

Show »
Length:581
Mass (Da):64,491
Checksum:iCD8BBDAC9FA2F7A5
GO
Isoform 5 (identifier: Q8TDF6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-409: Missing.

Show »
Length:484
Mass (Da):53,910
Checksum:iFCE47E98E739BF31
GO
Isoform 6 (identifier: Q8TDF6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-318: Missing.

Note: No experimental confirmation available.
Show »
Length:576
Mass (Da):64,301
Checksum:iCF155F3D646655EE
GO
Isoform 7 (identifier: Q8TDF6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-255: Missing.

Show »
Length:639
Mass (Da):71,254
Checksum:i2E9D215E40CA9F2C
GO
Isoform 8 (identifier: Q8TDF6-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-387: Missing.

Show »
Length:604
Mass (Da):66,972
Checksum:iA31300C9C32D900E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C0LTP6C0LTP6_HUMAN
RAS guanyl releasing protein 4 vari...
RASGRP4
617Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27V → A in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti73G → D in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti554C → R in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti671L → P in AAK85701 (PubMed:11956218).Curated1
Sequence conflicti671L → P in AAK85703 (PubMed:11956218).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03814418I → T3 PublicationsCorresponds to variant dbSNP:rs892055Ensembl.1
Natural variantiVAR_038145120Q → L1 Publication1
Natural variantiVAR_038146145V → A1 Publication1
Natural variantiVAR_038147261R → C1 Publication1
Natural variantiVAR_038148335R → G1 PublicationCorresponds to variant dbSNP:rs202008979Ensembl.1
Natural variantiVAR_057172620E → K. Corresponds to variant dbSNP:rs34377632Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030479171 – 673Missing in isoform 3. 1 PublicationAdd BLAST503
Alternative sequenceiVSP_030480171 – 184Missing in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_043176221 – 409Missing in isoform 5. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_043392222 – 318Missing in isoform 6. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_046907222 – 255Missing in isoform 7. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_043138319 – 410Missing in isoform 4. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_046908319 – 387Missing in isoform 8. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY048119 mRNA Translation: AAK85701.1
AY048120 mRNA Translation: AAK85702.1
AY048121 mRNA Translation: AAK85703.1
AF448437 mRNA Translation: AAL87858.1
FJ768677 mRNA Translation: ACN82414.1
FJ768678 mRNA Translation: ACN82415.1
FJ768679 mRNA Translation: ACN82416.1
FJ768680 mRNA Translation: ACN82417.1
FJ768682 mRNA Translation: ACN82419.1
AC005789 Genomic DNA No translation available.
AC011469 Genomic DNA No translation available.
AC093076 Genomic DNA No translation available.
BC146669 mRNA Translation: AAI46670.1
BC150202 mRNA Translation: AAI50203.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46068.1 [Q8TDF6-1]
CCDS54262.1 [Q8TDF6-6]
CCDS54263.1 [Q8TDF6-7]
CCDS54264.1 [Q8TDF6-5]
CCDS59382.1 [Q8TDF6-2]
CCDS59383.1 [Q8TDF6-8]
CCDS59384.1 [Q8TDF6-9]

NCBI Reference Sequences

More...RefSeqi		NP_001139674.1, NM_001146202.1 [Q8TDF6-2]
NP_001139675.1, NM_001146203.1 [Q8TDF6-5]
NP_001139676.1, NM_001146204.1 [Q8TDF6-9]
NP_001139677.1, NM_001146205.1 [Q8TDF6-8]
NP_001139678.1, NM_001146206.1 [Q8TDF6-6]
NP_001139679.1, NM_001146207.1 [Q8TDF6-7]
NP_733749.1, NM_170604.2 [Q8TDF6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000293062; ENSP00000293062; ENSG00000171777 [Q8TDF6-7]
ENST00000426920; ENSP00000445966; ENSG00000171777 [Q8TDF6-6]
ENST00000433821; ENSP00000411878; ENSG00000171777 [Q8TDF6-5]
ENST00000454404; ENSP00000416463; ENSG00000171777 [Q8TDF6-8]
ENST00000586305; ENSP00000467604; ENSG00000171777 [Q8TDF6-2]
ENST00000587738; ENSP00000465772; ENSG00000171777 [Q8TDF6-1]
ENST00000587753; ENSP00000468483; ENSG00000171777 [Q8TDF6-9]
ENST00000589358; ENSP00000465742; ENSG00000171777 [Q8TDF6-1]
ENST00000589474; ENSP00000466928; ENSG00000171777 [Q8TDF6-2]
ENST00000614135; ENSP00000479078; ENSG00000171777 [Q8TDF6-5]
ENST00000615439; ENSP00000479844; ENSG00000171777 [Q8TDF6-1]
ENST00000617966; ENSP00000479888; ENSG00000171777 [Q8TDF6-7]
ENST00000622174; ENSP00000484345; ENSG00000171777 [Q8TDF6-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		115727

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:115727

UCSC genome browser

More...UCSCi		uc010efz.4 human [Q8TDF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048119 mRNA Translation: AAK85701.1
AY048120 mRNA Translation: AAK85702.1
AY048121 mRNA Translation: AAK85703.1
AF448437 mRNA Translation: AAL87858.1
FJ768677 mRNA Translation: ACN82414.1
FJ768678 mRNA Translation: ACN82415.1
FJ768679 mRNA Translation: ACN82416.1
FJ768680 mRNA Translation: ACN82417.1
FJ768682 mRNA Translation: ACN82419.1
AC005789 Genomic DNA No translation available.
AC011469 Genomic DNA No translation available.
AC093076 Genomic DNA No translation available.
BC146669 mRNA Translation: AAI46670.1
BC150202 mRNA Translation: AAI50203.1
CCDSiCCDS46068.1 [Q8TDF6-1]
CCDS54262.1 [Q8TDF6-6]
CCDS54263.1 [Q8TDF6-7]
CCDS54264.1 [Q8TDF6-5]
CCDS59382.1 [Q8TDF6-2]
CCDS59383.1 [Q8TDF6-8]
CCDS59384.1 [Q8TDF6-9]
RefSeqiNP_001139674.1, NM_001146202.1 [Q8TDF6-2]
NP_001139675.1, NM_001146203.1 [Q8TDF6-5]
NP_001139676.1, NM_001146204.1 [Q8TDF6-9]
NP_001139677.1, NM_001146205.1 [Q8TDF6-8]
NP_001139678.1, NM_001146206.1 [Q8TDF6-6]
NP_001139679.1, NM_001146207.1 [Q8TDF6-7]
NP_733749.1, NM_170604.2 [Q8TDF6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6AXGX-ray3.30A/C/E/G/I/K46-460[»]
SMRiQ8TDF6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125451, 5 interactors
IntActiQ8TDF6, 9 interactors
STRINGi9606.ENSP00000479844

PTM databases

iPTMnetiQ8TDF6
PhosphoSitePlusiQ8TDF6

Polymorphism and mutation databases

BioMutaiRASGRP4
DMDMi296434529

Proteomic databases

EPDiQ8TDF6
MassIVEiQ8TDF6
PaxDbiQ8TDF6
PeptideAtlasiQ8TDF6
PRIDEiQ8TDF6
ProteomicsDBi74276 [Q8TDF6-1]
74277 [Q8TDF6-2]
74278 [Q8TDF6-3]
74279 [Q8TDF6-5]
74280 [Q8TDF6-6]
74281 [Q8TDF6-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293062; ENSP00000293062; ENSG00000171777 [Q8TDF6-7]
ENST00000426920; ENSP00000445966; ENSG00000171777 [Q8TDF6-6]
ENST00000433821; ENSP00000411878; ENSG00000171777 [Q8TDF6-5]
ENST00000454404; ENSP00000416463; ENSG00000171777 [Q8TDF6-8]
ENST00000586305; ENSP00000467604; ENSG00000171777 [Q8TDF6-2]
ENST00000587738; ENSP00000465772; ENSG00000171777 [Q8TDF6-1]
ENST00000587753; ENSP00000468483; ENSG00000171777 [Q8TDF6-9]
ENST00000589358; ENSP00000465742; ENSG00000171777 [Q8TDF6-1]
ENST00000589474; ENSP00000466928; ENSG00000171777 [Q8TDF6-2]
ENST00000614135; ENSP00000479078; ENSG00000171777 [Q8TDF6-5]
ENST00000615439; ENSP00000479844; ENSG00000171777 [Q8TDF6-1]
ENST00000617966; ENSP00000479888; ENSG00000171777 [Q8TDF6-7]
ENST00000622174; ENSP00000484345; ENSG00000171777 [Q8TDF6-6]
GeneIDi115727
KEGGihsa:115727
UCSCiuc010efz.4 human [Q8TDF6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		115727
DisGeNETi115727

GeneCards: human genes, protein and diseases

More...GeneCardsi		RASGRP4
HGNCiHGNC:18958 RASGRP4
MIMi607320 gene
neXtProtiNX_Q8TDF6
OpenTargetsiENSG00000171777
PharmGKBiPA38770

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IQ6I Eukaryota
ENOG410XQ12 LUCA
GeneTreeiENSGT00940000159883
HOGENOMiHOG000293171
InParanoidiQ8TDF6
KOiK12363
OMAiPETGCQL
OrthoDBi355412at2759
PhylomeDBiQ8TDF6

Enzyme and pathway databases

ReactomeiR-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5673001 RAF/MAP kinase cascade

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		115727

Pharos

More...Pharosi		Q8TDF6

Protein Ontology

More...PROi		PR:Q8TDF6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171777 Expressed in 91 organ(s), highest expression level in blood
ExpressionAtlasiQ8TDF6 baseline and differential
GenevisibleiQ8TDF6 HS

Family and domain databases

CDDicd00029 C1, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00147 RasGEF, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDF6
Secondary accession number(s): A6H8M4
, C0LTP2, C0LTP3, C0LTP4, C0LTP5, C0LTP7, C9J416, C9JHZ1, Q8N858, Q96QN5, Q96QN6, Q96QN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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