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UniProtKB - Q8TDF6 (GRP4_HUMAN)

Protein

RAS guanyl-releasing protein 4

Gene

RASGRP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri540 – 590Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • diacylglycerol binding Source: UniProtKB
  • GTP-dependent protein binding Source: UniProtKB
  • Ras guanyl-nucleotide exchange factor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processDifferentiation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Recommended name:
RAS guanyl-releasing protein 4
Gene namesi
Name:RASGRP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171777.15
HGNCiHGNC:18958 RASGRP4
MIMi607320 gene
neXtProtiNX_Q8TDF6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi548F → S: Loss of cell membrane targeting. 1 Publication1

Organism-specific databases

DisGeNETi115727
OpenTargetsiENSG00000171777
PharmGKBiPA38770

Polymorphism and mutation databases

BioMutaiRASGRP4
DMDMi296434529

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152131 – 673RAS guanyl-releasing protein 4Add BLAST673

Proteomic databases

EPDiQ8TDF6
PaxDbiQ8TDF6
PeptideAtlasiQ8TDF6
PRIDEiQ8TDF6
ProteomicsDBi74276
74277 [Q8TDF6-2]
74278 [Q8TDF6-3]
74279 [Q8TDF6-5]
74280 [Q8TDF6-6]
74281 [Q8TDF6-7]

PTM databases

iPTMnetiQ8TDF6
PhosphoSitePlusiQ8TDF6

Expressioni

Tissue specificityi

Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.2 Publications

Developmental stagei

Expressed early during development. Detected in all fetal tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000171777 Expressed in 91 organ(s), highest expression level in blood
CleanExiHS_RASGRP4
ExpressionAtlasiQ8TDF6 baseline and differential
GenevisibleiQ8TDF6 HS

Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi125451, 5 interactors
IntActiQ8TDF6, 5 interactors
STRINGi9606.ENSP00000465742

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TDF6
SMRiQ8TDF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 175N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST127
Domaini201 – 432Ras-GEFPROSITE-ProRule annotationAdd BLAST232
Domaini466 – 501EF-handPROSITE-ProRule annotationAdd BLAST36

Domaini

The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.

Sequence similaritiesi

Belongs to the RASGRP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri540 – 590Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ6I Eukaryota
ENOG410XQ12 LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000293171
HOVERGENiHBG007513
InParanoidiQ8TDF6
KOiK12363
OMAiNEGGCSE
OrthoDBiEOG091G03RN
PhylomeDBiQ8TDF6

Family and domain databases

CDDicd00029 C1, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00147 RasGEF, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL 
        60         70         80         90        100
LSEGGCSEDE LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA 
       110        120        130        140        150
RLLTSYQKAT GDTQELRRLQ ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW 
       160        170        180        190        200
ATVAREGNSA QRRLGDSSDL LSPGGPGPPL PMSSPGLGKK RKVSLLFDHL 
       210        220        230        240        250
ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL EGSVGLSNSV 
       260        270        280        290        300
SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS 
       310        320        330        340        350
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV 
       360        370        380        390        400
LGVHLKDLVS LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS 
       410        420        430        440        450
ANEDLLHLLT LSLDLFYTED EIYELSYARE PRCPKSLPPS PFNAPLVVEW 
       460        470        480        490        500
APGVTPKPDR VTLGRHVEQL VESVFKNYDP EGRGTISQED FERLSGNFPF 
       510        520        530        540        550
ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL HTFHEVTFRK 
       560        570        580        590        600
PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA 
       610        620        630        640        650
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS 
       660        670 
WETDTVPCPV MDPPSTASSK LDS
Length:673
Mass (Da):74,882
Last modified:May 18, 2010 - v2
Checksum:i3C007F595E3C7A02
GO
Isoform 2 (identifier: Q8TDF6-2) [UniParc]FASTAAdd to basket
Also known as: variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     171-184: Missing.

Note: Probably inactive.
Show »
Length:659
Mass (Da):73,607
Checksum:iAF5CEEBD186384DF
GO
Isoform 3 (identifier: Q8TDF6-3) [UniParc]FASTAAdd to basket
Also known as: variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     171-673: Missing.

Note: Probably inactive.
Show »
Length:170
Mass (Da):19,325
Checksum:i81FA75D21C6780F0
GO
Isoform 4 (identifier: Q8TDF6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-410: Missing.

Show »
Length:581
Mass (Da):64,491
Checksum:iCD8BBDAC9FA2F7A5
GO
Isoform 5 (identifier: Q8TDF6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-409: Missing.

Show »
Length:484
Mass (Da):53,910
Checksum:iFCE47E98E739BF31
GO
Isoform 6 (identifier: Q8TDF6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-318: Missing.

Note: No experimental confirmation available.
Show »
Length:576
Mass (Da):64,301
Checksum:iCF155F3D646655EE
GO
Isoform 7 (identifier: Q8TDF6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-255: Missing.

Show »
Length:639
Mass (Da):71,254
Checksum:i2E9D215E40CA9F2C
GO
Isoform 8 (identifier: Q8TDF6-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-387: Missing.

Show »
Length:604
Mass (Da):66,972
Checksum:iA31300C9C32D900E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C0LTP6C0LTP6_HUMAN
RAS guanyl releasing protein 4 vari...
RASGRP4
617Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27V → A in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti73G → D in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti554C → R in AAK85703 (PubMed:11956218).Curated1
Sequence conflicti671L → P in AAK85701 (PubMed:11956218).Curated1
Sequence conflicti671L → P in AAK85703 (PubMed:11956218).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03814418I → T3 PublicationsCorresponds to variant dbSNP:rs892055Ensembl.1
Natural variantiVAR_038145120Q → L1 Publication1
Natural variantiVAR_038146145V → A1 Publication1
Natural variantiVAR_038147261R → C1 Publication1
Natural variantiVAR_038148335R → G1 PublicationCorresponds to variant dbSNP:rs202008979Ensembl.1
Natural variantiVAR_057172620E → K. Corresponds to variant dbSNP:rs34377632Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030479171 – 673Missing in isoform 3. 1 PublicationAdd BLAST503
Alternative sequenceiVSP_030480171 – 184Missing in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_043176221 – 409Missing in isoform 5. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_043392222 – 318Missing in isoform 6. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_046907222 – 255Missing in isoform 7. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_043138319 – 410Missing in isoform 4. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_046908319 – 387Missing in isoform 8. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048119 mRNA Translation: AAK85701.1
AY048120 mRNA Translation: AAK85702.1
AY048121 mRNA Translation: AAK85703.1
AF448437 mRNA Translation: AAL87858.1
FJ768677 mRNA Translation: ACN82414.1
FJ768678 mRNA Translation: ACN82415.1
FJ768679 mRNA Translation: ACN82416.1
FJ768680 mRNA Translation: ACN82417.1
FJ768682 mRNA Translation: ACN82419.1
AC005789 Genomic DNA No translation available.
AC011469 Genomic DNA No translation available.
AC093076 Genomic DNA No translation available.
BC146669 mRNA Translation: AAI46670.1
BC150202 mRNA Translation: AAI50203.1
CCDSiCCDS46068.1 [Q8TDF6-1]
CCDS54262.1 [Q8TDF6-6]
CCDS54263.1 [Q8TDF6-7]
CCDS54264.1 [Q8TDF6-5]
CCDS59382.1 [Q8TDF6-2]
CCDS59383.1 [Q8TDF6-8]
CCDS59384.1 [Q8TDF6-9]
RefSeqiNP_001139674.1, NM_001146202.1 [Q8TDF6-2]
NP_001139675.1, NM_001146203.1 [Q8TDF6-5]
NP_001139676.1, NM_001146204.1 [Q8TDF6-9]
NP_001139677.1, NM_001146205.1 [Q8TDF6-8]
NP_001139678.1, NM_001146206.1 [Q8TDF6-6]
NP_001139679.1, NM_001146207.1 [Q8TDF6-7]
NP_733749.1, NM_170604.2 [Q8TDF6-1]
UniGeneiHs.130434

Genome annotation databases

EnsembliENST00000293062; ENSP00000293062; ENSG00000171777 [Q8TDF6-7]
ENST00000426920; ENSP00000445966; ENSG00000171777 [Q8TDF6-6]
ENST00000433821; ENSP00000411878; ENSG00000171777 [Q8TDF6-5]
ENST00000454404; ENSP00000416463; ENSG00000171777 [Q8TDF6-8]
ENST00000586305; ENSP00000467604; ENSG00000171777 [Q8TDF6-2]
ENST00000587738; ENSP00000465772; ENSG00000171777 [Q8TDF6-1]
ENST00000587753; ENSP00000468483; ENSG00000171777 [Q8TDF6-9]
ENST00000589358; ENSP00000465742; ENSG00000171777 [Q8TDF6-1]
ENST00000589474; ENSP00000466928; ENSG00000171777 [Q8TDF6-2]
ENST00000614135; ENSP00000479078; ENSG00000171777 [Q8TDF6-5]
ENST00000615439; ENSP00000479844; ENSG00000171777 [Q8TDF6-1]
ENST00000617966; ENSP00000479888; ENSG00000171777 [Q8TDF6-7]
ENST00000622174; ENSP00000484345; ENSG00000171777 [Q8TDF6-6]
GeneIDi115727
KEGGihsa:115727
UCSCiuc010efz.4 human [Q8TDF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048119 mRNA Translation: AAK85701.1
AY048120 mRNA Translation: AAK85702.1
AY048121 mRNA Translation: AAK85703.1
AF448437 mRNA Translation: AAL87858.1
FJ768677 mRNA Translation: ACN82414.1
FJ768678 mRNA Translation: ACN82415.1
FJ768679 mRNA Translation: ACN82416.1
FJ768680 mRNA Translation: ACN82417.1
FJ768682 mRNA Translation: ACN82419.1
AC005789 Genomic DNA No translation available.
AC011469 Genomic DNA No translation available.
AC093076 Genomic DNA No translation available.
BC146669 mRNA Translation: AAI46670.1
BC150202 mRNA Translation: AAI50203.1
CCDSiCCDS46068.1 [Q8TDF6-1]
CCDS54262.1 [Q8TDF6-6]
CCDS54263.1 [Q8TDF6-7]
CCDS54264.1 [Q8TDF6-5]
CCDS59382.1 [Q8TDF6-2]
CCDS59383.1 [Q8TDF6-8]
CCDS59384.1 [Q8TDF6-9]
RefSeqiNP_001139674.1, NM_001146202.1 [Q8TDF6-2]
NP_001139675.1, NM_001146203.1 [Q8TDF6-5]
NP_001139676.1, NM_001146204.1 [Q8TDF6-9]
NP_001139677.1, NM_001146205.1 [Q8TDF6-8]
NP_001139678.1, NM_001146206.1 [Q8TDF6-6]
NP_001139679.1, NM_001146207.1 [Q8TDF6-7]
NP_733749.1, NM_170604.2 [Q8TDF6-1]
UniGeneiHs.130434

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6AXGX-ray3.30A/C/E/G/I/K46-460[»]
ProteinModelPortaliQ8TDF6
SMRiQ8TDF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125451, 5 interactors
IntActiQ8TDF6, 5 interactors
STRINGi9606.ENSP00000465742

PTM databases

iPTMnetiQ8TDF6
PhosphoSitePlusiQ8TDF6

Polymorphism and mutation databases

BioMutaiRASGRP4
DMDMi296434529

Proteomic databases

EPDiQ8TDF6
PaxDbiQ8TDF6
PeptideAtlasiQ8TDF6
PRIDEiQ8TDF6
ProteomicsDBi74276
74277 [Q8TDF6-2]
74278 [Q8TDF6-3]
74279 [Q8TDF6-5]
74280 [Q8TDF6-6]
74281 [Q8TDF6-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293062; ENSP00000293062; ENSG00000171777 [Q8TDF6-7]
ENST00000426920; ENSP00000445966; ENSG00000171777 [Q8TDF6-6]
ENST00000433821; ENSP00000411878; ENSG00000171777 [Q8TDF6-5]
ENST00000454404; ENSP00000416463; ENSG00000171777 [Q8TDF6-8]
ENST00000586305; ENSP00000467604; ENSG00000171777 [Q8TDF6-2]
ENST00000587738; ENSP00000465772; ENSG00000171777 [Q8TDF6-1]
ENST00000587753; ENSP00000468483; ENSG00000171777 [Q8TDF6-9]
ENST00000589358; ENSP00000465742; ENSG00000171777 [Q8TDF6-1]
ENST00000589474; ENSP00000466928; ENSG00000171777 [Q8TDF6-2]
ENST00000614135; ENSP00000479078; ENSG00000171777 [Q8TDF6-5]
ENST00000615439; ENSP00000479844; ENSG00000171777 [Q8TDF6-1]
ENST00000617966; ENSP00000479888; ENSG00000171777 [Q8TDF6-7]
ENST00000622174; ENSP00000484345; ENSG00000171777 [Q8TDF6-6]
GeneIDi115727
KEGGihsa:115727
UCSCiuc010efz.4 human [Q8TDF6-1]

Organism-specific databases

CTDi115727
DisGeNETi115727
EuPathDBiHostDB:ENSG00000171777.15
GeneCardsiRASGRP4
H-InvDBiHIX0015095
HGNCiHGNC:18958 RASGRP4
MIMi607320 gene
neXtProtiNX_Q8TDF6
OpenTargetsiENSG00000171777
PharmGKBiPA38770
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ6I Eukaryota
ENOG410XQ12 LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000293171
HOVERGENiHBG007513
InParanoidiQ8TDF6
KOiK12363
OMAiNEGGCSE
OrthoDBiEOG091G03RN
PhylomeDBiQ8TDF6

Enzyme and pathway databases

ReactomeiR-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5673001 RAF/MAP kinase cascade

Miscellaneous databases

GenomeRNAii115727
PROiPR:Q8TDF6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171777 Expressed in 91 organ(s), highest expression level in blood
CleanExiHS_RASGRP4
ExpressionAtlasiQ8TDF6 baseline and differential
GenevisibleiQ8TDF6 HS

Family and domain databases

CDDicd00029 C1, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00147 RasGEF, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRP4_HUMAN
AccessioniPrimary (citable) accession number: Q8TDF6
Secondary accession number(s): A6H8M4
, C0LTP2, C0LTP3, C0LTP4, C0LTP5, C0LTP7, C9J416, C9JHZ1, Q8N858, Q96QN5, Q96QN6, Q96QN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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