UniProtKB - Q8TDF5 (NETO1_HUMAN)
Protein
Neuropilin and tolloid-like protein 1
Gene
NETO1
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).By similarity
GO - Molecular functioni
- ionotropic glutamate receptor binding Source: Ensembl
GO - Biological processi
- memory Source: UniProtKB
- positive regulation of excitatory postsynaptic potential Source: Ensembl
- receptor localization to synapse Source: Ensembl
- regulation of kainate selective glutamate receptor activity Source: SynGO
- regulation of long-term neuronal synaptic plasticity Source: UniProtKB
- visual learning Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q8TDF5 |
Protein family/group databases
TCDBi | 8.A.47.1.1, the neuropilin and tolloid-like (neto) family |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropilin and tolloid-like protein 1Alternative name(s): Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1 |
Gene namesi | Name:NETO1 Synonyms:BTCL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166342.18 |
HGNCi | HGNC:13823, NETO1 |
MIMi | 607973, gene |
neXtProti | NX_Q8TDF5 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
- postsynaptic density membrane By similarity
Note: Component of the postsynaptic density (PSD) of excitatory synapses.By similarity
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of postsynaptic density membrane Source: Ensembl
- postsynaptic density membrane Source: SynGO
Other locations
- excitatory synapse Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- postsynaptic density Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 344 | ExtracellularSequence analysisAdd BLAST | 322 | |
Transmembranei | 345 – 365 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 366 – 533 | CytoplasmicSequence analysisAdd BLAST | 168 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Secreted, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 81832 |
OpenTargetsi | ENSG00000166342 |
PharmGKBi | PA31558 |
Miscellaneous databases
Pharosi | Q8TDF5, Tbio |
Polymorphism and mutation databases
BioMutai | NETO1 |
DMDMi | 334302837 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000021799 | 23 – 533 | Neuropilin and tolloid-like protein 1Add BLAST | 511 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 68 | By similarity | ||
Disulfide bondi | 96 ↔ 118 | By similarity | ||
Disulfide bondi | 172 ↔ 202 | By similarity | ||
Disulfide bondi | 229 ↔ 251 | By similarity | ||
Disulfide bondi | 292 ↔ 304 | By similarity | ||
Disulfide bondi | 299 ↔ 317 | By similarity | ||
Glycosylationi | 306 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 311 ↔ 326 | By similarity | ||
Glycosylationi | 340 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 417 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q8TDF5 |
PaxDbi | Q8TDF5 |
PeptideAtlasi | Q8TDF5 |
PRIDEi | Q8TDF5 |
ProteomicsDBi | 74273 [Q8TDF5-3] 74274 [Q8TDF5-1] 74275 [Q8TDF5-2] |
PTM databases
GlyGeni | Q8TDF5, 2 sites |
iPTMneti | Q8TDF5 |
PhosphoSitePlusi | Q8TDF5 |
Expressioni
Tissue specificityi
Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.1 Publication
Gene expression databases
Bgeei | ENSG00000166342, Expressed in caudate nucleus and 110 other tissues |
ExpressionAtlasi | Q8TDF5, baseline and differential |
Genevisiblei | Q8TDF5, HS |
Organism-specific databases
HPAi | ENSG00000166342, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain.
Interacts with GRIN2A and GRIN2B via its CUB domains (By similarity).
By similarityGO - Molecular functioni
- ionotropic glutamate receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 123590, 3 interactors |
STRINGi | 9606.ENSP00000313088 |
Miscellaneous databases
RNActi | Q8TDF5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 155 | CUB 1PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 172 – 287 | CUB 2PROSITE-ProRule annotationAdd BLAST | 116 | |
Domaini | 291 – 327 | LDL-receptor class APROSITE-ProRule annotationAdd BLAST | 37 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 531 – 533 | PDZ-binding | 3 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUD4, Eukaryota |
GeneTreei | ENSGT00940000156700 |
HOGENOMi | CLU_015228_0_0_1 |
InParanoidi | Q8TDF5 |
OMAi | CEANTFF |
PhylomeDBi | Q8TDF5 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 1 hit |
Gene3Di | 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR028867, NETO1 IPR035914, Sperma_CUB_dom_sf |
PANTHERi | PTHR45645:SF3, PTHR45645:SF3, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00057, Ldl_recept_a, 1 hit |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 1 hit |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 3 (identifier: Q8TDF5-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIHGRSVLHI VASLIILHLS GATKKGTEKQ TTSETQKSVQ CGTWTKHAEG
60 70 80 90 100
GIFTSPNYPS KYPPDRECIY IIEAAPRQCI ELYFDEKYSI EPSWECKFDH
110 120 130 140 150
IEVRDGPFGF SPIIGRFCGQ QNPPVIKSSG RFLWIKFFAD GELESMGFSA
160 170 180 190 200
RYNFTPDPDF KDLGALKPLP ACEFEMGGSE GIVESIQIMK EGKATASEAV
210 220 230 240 250
DCKWYIRAPP RSKIYLRFLD YEMQNSNECK RNFVAVYDGS SSVEDLKAKF
260 270 280 290 300
CSTVANDVML RTGLGVIRMW ADEGSRNSRF QMLFTSFQEP PCEGNTFFCH
310 320 330 340 350
SNMCINNTLV CNGLQNCVYP WDENHCKEKR KTSLLDQLTN TSGTVIGVTS
360 370 380 390 400
CIVIILIIIS VIVQIKQPRK KYVQRKSDFD QTVFQEVFEP PHYELCTLRG
410 420 430 440 450
TGATADFADV ADDFENYHKL RRSSSKCIHD HHCGSQLSST KGSRSNLSTR
460 470 480 490 500
DASILTEMPT QPGKPLIPPM NRRNILVMKH SYSQDAADAC DIDEIEEVPT
510 520 530
TSHRLSRHDK AVQRFCLIGS LSKHESEYNT TRV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3QRF5 | J3QRF5_HUMAN | Neuropilin and tolloid-like protein... | NETO1 | 101 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 140 | D → A in AAH50329 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051230 | 481 | S → N3 PublicationsCorresponds to variant dbSNP:rs922999Ensembl. | 1 | |
Natural variantiVAR_051231 | 487 | A → G. Corresponds to variant dbSNP:rs17086286EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012853 | 1 – 10 | MIHGRSVLHI → MLAEPFPKV in isoform 1 and isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_012854 | 157 | D → E in isoform 1. 1 Publication | 1 | |
Alternative sequenceiVSP_012855 | 158 – 533 | Missing in isoform 1. 1 PublicationAdd BLAST | 376 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF448838 mRNA Translation: AAM18026.1 AF448839 mRNA Translation: AAM18027.1 AC023301 Genomic DNA No translation available. AC091138 Genomic DNA No translation available. BC050329 mRNA Translation: AAH50329.1 AL834354 mRNA Translation: CAD39019.1 |
CCDSi | CCDS12000.1 [Q8TDF5-3] CCDS42444.1 [Q8TDF5-1] |
RefSeqi | NP_001188394.1, NM_001201465.1 [Q8TDF5-3] NP_620416.1, NM_138966.3 [Q8TDF5-3] NP_620552.1, NM_138999.1 [Q8TDF5-1] XP_005266831.1, XM_005266774.4 XP_016881506.1, XM_017026017.1 [Q8TDF5-3] XP_016881507.1, XM_017026018.1 [Q8TDF5-3] |
Genome annotation databases
Ensembli | ENST00000327305; ENSP00000313088; ENSG00000166342 [Q8TDF5-3] ENST00000397929; ENSP00000381024; ENSG00000166342 [Q8TDF5-1] ENST00000583169; ENSP00000464312; ENSG00000166342 [Q8TDF5-3] |
GeneIDi | 81832 |
KEGGi | hsa:81832 |
UCSCi | uc002lkw.3, human [Q8TDF5-3] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF448838 mRNA Translation: AAM18026.1 AF448839 mRNA Translation: AAM18027.1 AC023301 Genomic DNA No translation available. AC091138 Genomic DNA No translation available. BC050329 mRNA Translation: AAH50329.1 AL834354 mRNA Translation: CAD39019.1 |
CCDSi | CCDS12000.1 [Q8TDF5-3] CCDS42444.1 [Q8TDF5-1] |
RefSeqi | NP_001188394.1, NM_001201465.1 [Q8TDF5-3] NP_620416.1, NM_138966.3 [Q8TDF5-3] NP_620552.1, NM_138999.1 [Q8TDF5-1] XP_005266831.1, XM_005266774.4 XP_016881506.1, XM_017026017.1 [Q8TDF5-3] XP_016881507.1, XM_017026018.1 [Q8TDF5-3] |
3D structure databases
SMRi | Q8TDF5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123590, 3 interactors |
STRINGi | 9606.ENSP00000313088 |
Protein family/group databases
TCDBi | 8.A.47.1.1, the neuropilin and tolloid-like (neto) family |
PTM databases
GlyGeni | Q8TDF5, 2 sites |
iPTMneti | Q8TDF5 |
PhosphoSitePlusi | Q8TDF5 |
Polymorphism and mutation databases
BioMutai | NETO1 |
DMDMi | 334302837 |
Proteomic databases
MassIVEi | Q8TDF5 |
PaxDbi | Q8TDF5 |
PeptideAtlasi | Q8TDF5 |
PRIDEi | Q8TDF5 |
ProteomicsDBi | 74273 [Q8TDF5-3] 74274 [Q8TDF5-1] 74275 [Q8TDF5-2] |
Protocols and materials databases
Antibodypediai | 23286, 107 antibodies |
Genome annotation databases
Ensembli | ENST00000327305; ENSP00000313088; ENSG00000166342 [Q8TDF5-3] ENST00000397929; ENSP00000381024; ENSG00000166342 [Q8TDF5-1] ENST00000583169; ENSP00000464312; ENSG00000166342 [Q8TDF5-3] |
GeneIDi | 81832 |
KEGGi | hsa:81832 |
UCSCi | uc002lkw.3, human [Q8TDF5-3] |
Organism-specific databases
CTDi | 81832 |
DisGeNETi | 81832 |
EuPathDBi | HostDB:ENSG00000166342.18 |
GeneCardsi | NETO1 |
HGNCi | HGNC:13823, NETO1 |
HPAi | ENSG00000166342, Tissue enriched (brain) |
MIMi | 607973, gene |
neXtProti | NX_Q8TDF5 |
OpenTargetsi | ENSG00000166342 |
PharmGKBi | PA31558 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUD4, Eukaryota |
GeneTreei | ENSGT00940000156700 |
HOGENOMi | CLU_015228_0_0_1 |
InParanoidi | Q8TDF5 |
OMAi | CEANTFF |
PhylomeDBi | Q8TDF5 |
Enzyme and pathway databases
PathwayCommonsi | Q8TDF5 |
Miscellaneous databases
BioGRID-ORCSi | 81832, 3 hits in 841 CRISPR screens |
ChiTaRSi | NETO1, human |
GenomeRNAii | 81832 |
Pharosi | Q8TDF5, Tbio |
PROi | PR:Q8TDF5 |
RNActi | Q8TDF5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166342, Expressed in caudate nucleus and 110 other tissues |
ExpressionAtlasi | Q8TDF5, baseline and differential |
Genevisiblei | Q8TDF5, HS |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 1 hit |
Gene3Di | 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR028867, NETO1 IPR035914, Sperma_CUB_dom_sf |
PANTHERi | PTHR45645:SF3, PTHR45645:SF3, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00057, Ldl_recept_a, 1 hit |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 1 hit |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NETO1_HUMAN | |
Accessioni | Q8TDF5Primary (citable) accession number: Q8TDF5 Secondary accession number(s): Q86W85, Q8ND78, Q8TDF4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | May 31, 2011 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations