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UniProtKB - Q8TDF5 (NETO1_HUMAN)

Entry version 160 (02 Dec 2020)
Sequence version 2 (31 May 2011)
Previous versions | rss
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Protein

Neuropilin and tolloid-like protein 1

Gene

NETO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TDF5

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.47.1.1, the neuropilin and tolloid-like (neto) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuropilin and tolloid-like protein 1
Alternative name(s):
Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NETO1
Synonyms:BTCL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000166342.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:13823, NETO1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607973, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDF5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 344ExtracellularSequence analysisAdd BLAST322
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 533CytoplasmicSequence analysisAdd BLAST168

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Secreted, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		81832

Open Targets

More...OpenTargetsi		ENSG00000166342

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31558

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TDF5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NETO1

Domain mapping of disease mutations (DMDM)

More...DMDMi		334302837

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002179923 – 533Neuropilin and tolloid-like protein 1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 68By similarity
Disulfide bondi96 ↔ 118By similarity
Disulfide bondi172 ↔ 202By similarity
Disulfide bondi229 ↔ 251By similarity
Disulfide bondi292 ↔ 304By similarity
Disulfide bondi299 ↔ 317By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi311 ↔ 326By similarity
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei417PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TDF5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDF5

PeptideAtlas

More...PeptideAtlasi		Q8TDF5

PRoteomics IDEntifications database

More...PRIDEi		Q8TDF5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74273 [Q8TDF5-3]
74274 [Q8TDF5-1]
74275 [Q8TDF5-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TDF5, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDF5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDF5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166342, Expressed in caudate nucleus and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TDF5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDF5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166342, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain.

Interacts with GRIN2A and GRIN2B via its CUB domains (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123590, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000313088

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TDF5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDF5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 155CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini172 – 287CUB 2PROSITE-ProRule annotationAdd BLAST116
Domaini291 – 327LDL-receptor class APROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi531 – 533PDZ-binding3

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUD4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015228_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDF5

Identification of Orthologs from Complete Genome Data

More...OMAi		CEANTFF

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDF5

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 2 hits
cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR028867, NETO1
IPR035914, Sperma_CUB_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR45645:SF3, PTHR45645:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 2 hits
PF00057, Ldl_recept_a, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3 (identifier: Q8TDF5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIHGRSVLHI VASLIILHLS GATKKGTEKQ TTSETQKSVQ CGTWTKHAEG 
        60         70         80         90        100
GIFTSPNYPS KYPPDRECIY IIEAAPRQCI ELYFDEKYSI EPSWECKFDH 
       110        120        130        140        150
IEVRDGPFGF SPIIGRFCGQ QNPPVIKSSG RFLWIKFFAD GELESMGFSA 
       160        170        180        190        200
RYNFTPDPDF KDLGALKPLP ACEFEMGGSE GIVESIQIMK EGKATASEAV 
       210        220        230        240        250
DCKWYIRAPP RSKIYLRFLD YEMQNSNECK RNFVAVYDGS SSVEDLKAKF 
       260        270        280        290        300
CSTVANDVML RTGLGVIRMW ADEGSRNSRF QMLFTSFQEP PCEGNTFFCH 
       310        320        330        340        350
SNMCINNTLV CNGLQNCVYP WDENHCKEKR KTSLLDQLTN TSGTVIGVTS 
       360        370        380        390        400
CIVIILIIIS VIVQIKQPRK KYVQRKSDFD QTVFQEVFEP PHYELCTLRG 
       410        420        430        440        450
TGATADFADV ADDFENYHKL RRSSSKCIHD HHCGSQLSST KGSRSNLSTR 
       460        470        480        490        500
DASILTEMPT QPGKPLIPPM NRRNILVMKH SYSQDAADAC DIDEIEEVPT 
       510        520        530 
TSHRLSRHDK AVQRFCLIGS LSKHESEYNT TRV
Length:533
Mass (Da):60,191
Last modified:May 31, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i763EBE7BAF06EAC8
GO
Isoform 1 (identifier: Q8TDF5-1) [UniParc]FASTAAdd to basket
Also known as: Soluble, sNETO1

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MIHGRSVLHI → MLAEPFPKV
     157-157: D → E
     158-533: Missing.

Show »
Length:156
Mass (Da):17,669
Checksum:i25FE8BEF4553C2AB
GO
Isoform 2 (identifier: Q8TDF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MIHGRSVLHI → MLAEPFPKV

Show »
Length:532
Mass (Da):60,060
Checksum:iA4B0F5672D286E97
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRF5J3QRF5_HUMAN
Neuropilin and tolloid-like protein...
NETO1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140D → A in AAH50329 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051230481S → N3 PublicationsCorresponds to variant dbSNP:rs922999Ensembl.1
Natural variantiVAR_051231487A → G. Corresponds to variant dbSNP:rs17086286EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0128531 – 10MIHGRSVLHI → MLAEPFPKV in isoform 1 and isoform 2. 1 Publication10
Alternative sequenceiVSP_012854157D → E in isoform 1. 1 Publication1
Alternative sequenceiVSP_012855158 – 533Missing in isoform 1. 1 PublicationAdd BLAST376

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF448838 mRNA Translation: AAM18026.1
AF448839 mRNA Translation: AAM18027.1
AC023301 Genomic DNA No translation available.
AC091138 Genomic DNA No translation available.
BC050329 mRNA Translation: AAH50329.1
AL834354 mRNA Translation: CAD39019.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12000.1 [Q8TDF5-3]
CCDS42444.1 [Q8TDF5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001188394.1, NM_001201465.1 [Q8TDF5-3]
NP_620416.1, NM_138966.3 [Q8TDF5-3]
NP_620552.1, NM_138999.1 [Q8TDF5-1]
XP_005266831.1, XM_005266774.4
XP_016881506.1, XM_017026017.1 [Q8TDF5-3]
XP_016881507.1, XM_017026018.1 [Q8TDF5-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327305; ENSP00000313088; ENSG00000166342 [Q8TDF5-3]
ENST00000397929; ENSP00000381024; ENSG00000166342 [Q8TDF5-1]
ENST00000583169; ENSP00000464312; ENSG00000166342 [Q8TDF5-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81832

UCSC genome browser

More...UCSCi		uc002lkw.3, human [Q8TDF5-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448838 mRNA Translation: AAM18026.1
AF448839 mRNA Translation: AAM18027.1
AC023301 Genomic DNA No translation available.
AC091138 Genomic DNA No translation available.
BC050329 mRNA Translation: AAH50329.1
AL834354 mRNA Translation: CAD39019.1
CCDSiCCDS12000.1 [Q8TDF5-3]
CCDS42444.1 [Q8TDF5-1]
RefSeqiNP_001188394.1, NM_001201465.1 [Q8TDF5-3]
NP_620416.1, NM_138966.3 [Q8TDF5-3]
NP_620552.1, NM_138999.1 [Q8TDF5-1]
XP_005266831.1, XM_005266774.4
XP_016881506.1, XM_017026017.1 [Q8TDF5-3]
XP_016881507.1, XM_017026018.1 [Q8TDF5-3]

3D structure databases

SMRiQ8TDF5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123590, 3 interactors
STRINGi9606.ENSP00000313088

Protein family/group databases

TCDBi8.A.47.1.1, the neuropilin and tolloid-like (neto) family

PTM databases

GlyGeniQ8TDF5, 2 sites
iPTMnetiQ8TDF5
PhosphoSitePlusiQ8TDF5

Polymorphism and mutation databases

BioMutaiNETO1
DMDMi334302837

Proteomic databases

MassIVEiQ8TDF5
PaxDbiQ8TDF5
PeptideAtlasiQ8TDF5
PRIDEiQ8TDF5
ProteomicsDBi74273 [Q8TDF5-3]
74274 [Q8TDF5-1]
74275 [Q8TDF5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23286, 107 antibodies

Genome annotation databases

EnsembliENST00000327305; ENSP00000313088; ENSG00000166342 [Q8TDF5-3]
ENST00000397929; ENSP00000381024; ENSG00000166342 [Q8TDF5-1]
ENST00000583169; ENSP00000464312; ENSG00000166342 [Q8TDF5-3]
GeneIDi81832
KEGGihsa:81832
UCSCiuc002lkw.3, human [Q8TDF5-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81832
DisGeNETi81832
EuPathDBiHostDB:ENSG00000166342.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		NETO1
HGNCiHGNC:13823, NETO1
HPAiENSG00000166342, Tissue enriched (brain)
MIMi607973, gene
neXtProtiNX_Q8TDF5
OpenTargetsiENSG00000166342
PharmGKBiPA31558

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUD4, Eukaryota
GeneTreeiENSGT00940000156700
HOGENOMiCLU_015228_0_0_1
InParanoidiQ8TDF5
OMAiCEANTFF
PhylomeDBiQ8TDF5

Enzyme and pathway databases

PathwayCommonsiQ8TDF5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81832, 3 hits in 841 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NETO1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81832
PharosiQ8TDF5, Tbio

Protein Ontology

More...PROi		PR:Q8TDF5
RNActiQ8TDF5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166342, Expressed in caudate nucleus and 110 other tissues
ExpressionAtlasiQ8TDF5, baseline and differential
GenevisibleiQ8TDF5, HS

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00112, LDLa, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR028867, NETO1
IPR035914, Sperma_CUB_dom_sf
PANTHERiPTHR45645:SF3, PTHR45645:SF3, 1 hit
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF00057, Ldl_recept_a, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 1 hit
SUPFAMiSSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNETO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDF5
Secondary accession number(s): Q86W85, Q8ND78, Q8TDF4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 31, 2011
Last modified: December 2, 2020
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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