Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropilin and tolloid-like protein 1

Gene

NETO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Protein family/group databases

TCDBi8.A.47.1.1 the neuropilin and tolloid-like (neto) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin and tolloid-like protein 1
Alternative name(s):
Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
Gene namesi
Name:NETO1
Synonyms:BTCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000166342.18
HGNCiHGNC:13823 NETO1
MIMi607973 gene
neXtProtiNX_Q8TDF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 344ExtracellularSequence analysisAdd BLAST322
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 533CytoplasmicSequence analysisAdd BLAST168

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi81832
OpenTargetsiENSG00000166342
PharmGKBiPA31558

Polymorphism and mutation databases

BioMutaiNETO1
DMDMi334302837

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002179923 – 533Neuropilin and tolloid-like protein 1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 68By similarity
Disulfide bondi96 ↔ 118By similarity
Disulfide bondi172 ↔ 202By similarity
Disulfide bondi229 ↔ 251By similarity
Disulfide bondi292 ↔ 304By similarity
Disulfide bondi299 ↔ 317By similarity
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi311 ↔ 326By similarity
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei417PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8TDF5
PeptideAtlasiQ8TDF5
PRIDEiQ8TDF5
ProteomicsDBi74273
74274 [Q8TDF5-1]
74275 [Q8TDF5-2]

PTM databases

iPTMnetiQ8TDF5
PhosphoSitePlusiQ8TDF5

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000166342 Expressed in 89 organ(s), highest expression level in caudate nucleus
CleanExiHS_NETO1
ExpressionAtlasiQ8TDF5 baseline and differential
GenevisibleiQ8TDF5 HS

Organism-specific databases

HPAiHPA064630

Interactioni

Subunit structurei

Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123590, 3 interactors
STRINGi9606.ENSP00000313088

Structurei

3D structure databases

ProteinModelPortaliQ8TDF5
SMRiQ8TDF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 155CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini172 – 287CUB 2PROSITE-ProRule annotationAdd BLAST116
Domaini291 – 327LDL-receptor class APROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi531 – 533PDZ-binding3

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJXA Eukaryota
ENOG410ZS19 LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000060303
HOVERGENiHBG052600
InParanoidiQ8TDF5
OMAiMKHNYSQ
OrthoDBiEOG091G060O
PhylomeDBiQ8TDF5

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00112 LDLa, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR028867 NETO1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR44143:SF1 PTHR44143:SF1, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00057 Ldl_recept_a, 1 hit
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00192 LDLa, 1 hit
SUPFAMiSSF49854 SSF49854, 2 hits
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 3 (identifier: Q8TDF5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIHGRSVLHI VASLIILHLS GATKKGTEKQ TTSETQKSVQ CGTWTKHAEG
60 70 80 90 100
GIFTSPNYPS KYPPDRECIY IIEAAPRQCI ELYFDEKYSI EPSWECKFDH
110 120 130 140 150
IEVRDGPFGF SPIIGRFCGQ QNPPVIKSSG RFLWIKFFAD GELESMGFSA
160 170 180 190 200
RYNFTPDPDF KDLGALKPLP ACEFEMGGSE GIVESIQIMK EGKATASEAV
210 220 230 240 250
DCKWYIRAPP RSKIYLRFLD YEMQNSNECK RNFVAVYDGS SSVEDLKAKF
260 270 280 290 300
CSTVANDVML RTGLGVIRMW ADEGSRNSRF QMLFTSFQEP PCEGNTFFCH
310 320 330 340 350
SNMCINNTLV CNGLQNCVYP WDENHCKEKR KTSLLDQLTN TSGTVIGVTS
360 370 380 390 400
CIVIILIIIS VIVQIKQPRK KYVQRKSDFD QTVFQEVFEP PHYELCTLRG
410 420 430 440 450
TGATADFADV ADDFENYHKL RRSSSKCIHD HHCGSQLSST KGSRSNLSTR
460 470 480 490 500
DASILTEMPT QPGKPLIPPM NRRNILVMKH SYSQDAADAC DIDEIEEVPT
510 520 530
TSHRLSRHDK AVQRFCLIGS LSKHESEYNT TRV
Length:533
Mass (Da):60,191
Last modified:May 31, 2011 - v2
Checksum:i763EBE7BAF06EAC8
GO
Isoform 1 (identifier: Q8TDF5-1) [UniParc]FASTAAdd to basket
Also known as: Soluble, sNETO1

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MIHGRSVLHI → MLAEPFPKV
     157-157: D → E
     158-533: Missing.

Show »
Length:156
Mass (Da):17,669
Checksum:i25FE8BEF4553C2AB
GO
Isoform 2 (identifier: Q8TDF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MIHGRSVLHI → MLAEPFPKV

Show »
Length:532
Mass (Da):60,060
Checksum:iA4B0F5672D286E97
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRF5J3QRF5_HUMAN
Neuropilin and tolloid-like protein...
NETO1
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140D → A in AAH50329 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051230481S → N3 PublicationsCorresponds to variant dbSNP:rs922999Ensembl.1
Natural variantiVAR_051231487A → G. Corresponds to variant dbSNP:rs17086286Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0128531 – 10MIHGRSVLHI → MLAEPFPKV in isoform 1 and isoform 2. 1 Publication10
Alternative sequenceiVSP_012854157D → E in isoform 1. 1 Publication1
Alternative sequenceiVSP_012855158 – 533Missing in isoform 1. 1 PublicationAdd BLAST376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448838 mRNA Translation: AAM18026.1
AF448839 mRNA Translation: AAM18027.1
AC023301 Genomic DNA No translation available.
AC091138 Genomic DNA No translation available.
BC050329 mRNA Translation: AAH50329.1
AL834354 mRNA Translation: CAD39019.1
CCDSiCCDS12000.1 [Q8TDF5-3]
CCDS42444.1 [Q8TDF5-1]
RefSeqiNP_001188394.1, NM_001201465.1
NP_620416.1, NM_138966.3
NP_620552.1, NM_138999.1 [Q8TDF5-1]
XP_005266831.1, XM_005266774.4
XP_016881506.1, XM_017026017.1 [Q8TDF5-3]
XP_016881507.1, XM_017026018.1 [Q8TDF5-3]
UniGeneiHs.465407

Genome annotation databases

EnsembliENST00000327305; ENSP00000313088; ENSG00000166342 [Q8TDF5-3]
ENST00000397929; ENSP00000381024; ENSG00000166342 [Q8TDF5-1]
ENST00000583169; ENSP00000464312; ENSG00000166342 [Q8TDF5-3]
GeneIDi81832
KEGGihsa:81832
UCSCiuc002lkw.3 human [Q8TDF5-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNETO1_HUMAN
AccessioniPrimary (citable) accession number: Q8TDF5
Secondary accession number(s): Q86W85, Q8ND78, Q8TDF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 31, 2011
Last modified: September 12, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again