MCOLN3

Functionⁱ

Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca²⁺-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca²⁺ from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca²⁺ for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151).By similarityCurated8 Publications

Activity regulationⁱ

Inhibited by lumenal H⁺ and Na⁺ (PubMed:18369318, PubMed:29106414). The channel pore shows dynamic behavior and undergoes spontaneous, Ca²⁺-dependent modulation when conducting Ca²⁺ (PubMed:20378547).3 Publications

GO - Molecular functionⁱ

calcium channel activity Source: Reactome
lipid binding Source: UniProtKB-KW
NAADP-sensitive calcium-release channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion transmembrane transport Source: Reactome
inner ear auditory receptor cell differentiation Source: Ensembl
locomotory behavior Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel
Biological process	Ion transport, Transport
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3295583 TRP channels

Reactomeⁱ

R-HSA-3295583 TRP channels

Protein family/group databases

TCDBⁱ	1.A.5.3.4 the polycystin cation channel (pcc) family

TCDBⁱ

1.A.5.3.4 the polycystin cation channel (pcc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mucolipin-31 Publication Alternative name(s): Transient receptor potential channel mucolipin 3 Short name: TRPML31 Publication
Gene namesⁱ	Name:MCOLN3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000055732.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13358 MCOLN3
MIMⁱ	607400 gene
neXtProtⁱ	NX_Q8TDD5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 62	Cytoplasmic1 PublicationAdd BLAST	62
Transmembraneⁱ	63 – 83	Helical1 PublicationAdd BLAST	21
Topological domainⁱ	84 – 283	Extracellular1 PublicationAdd BLAST	200
Transmembraneⁱ	284 – 304	Helical1 PublicationAdd BLAST	21
Topological domainⁱ	305 – 341	Cytoplasmic1 PublicationAdd BLAST	37
Transmembraneⁱ	342 – 362	Helical1 PublicationAdd BLAST	21
Topological domainⁱ	363 – 371	Extracellular1 Publication	9
Transmembraneⁱ	372 – 392	Helical1 PublicationAdd BLAST	21
Topological domainⁱ	393 – 414	Cytoplasmic1 PublicationAdd BLAST	22
Transmembraneⁱ	415 – 435	Helical1 PublicationAdd BLAST	21
Topological domainⁱ	436 – 443	Extracellular1 Publication	8
Intramembraneⁱ	444 – 464	Pore-forming1 PublicationAdd BLAST	21
Topological domainⁱ	465 – 475	Extracellular1 PublicationAdd BLAST	11
Transmembraneⁱ	476 – 497	Helical1 PublicationAdd BLAST	22
Topological domainⁱ	498 – 553	Cytoplasmic1 PublicationAdd BLAST	56

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasmic vesicle, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	108	D → N: Abolishes basal channel activity without affecting channel activation by a synthetic agonist; when associated with N-111 and N-112. 1 Publication	1
Mutagenesisⁱ	111	D → N: Abolishes basal channel activity without affecting channel activation by a synthetic agonist; when associated with N-108 and N-112. 1 Publication	1
Mutagenesisⁱ	112	D → N: Abolishes basal channel activity without affecting channel activation by a synthetic agonist; when associated with N-108 and N-111. 1 Publication	1
Mutagenesisⁱ	252	H → A: Increases inhibition by lumenal H(+). Decreases inhibition by lumenal H(+); when associated with A-283. 1 Publication	1
Mutagenesisⁱ	273	H → A: Increases inhibition by lumenal H(+). Decreases inhibition by lumenal H(+); when associated with A-283. 1 Publication	1
Mutagenesisⁱ	283	H → A: Constitutive active channel; abolishes inhibition by lumenal H(+); retains the Ca(2+)-dependent inactivation of the Ca(2+) current. Decreases inhibition by lumenal H(+); when associated with A-252. Decreases inhibition by lumenal H(+); when associated with A-273. 1 Publication	1
Mutagenesisⁱ	283	H → R: Increases inhibition by lumenal H(+). 1 Publication	1
Mutagenesisⁱ	419	A → P: Constitutive active channel; abolishes inhibition by lumenal H(+); increases the pore diameter. 2 Publications	1
Mutagenesisⁱ	423	Y → A: Nearly abolishes channel activation by a synthetic agonist. 1 Publication	1
Mutagenesisⁱ	449	E → A: Constitutive active channel; greatly impairs inhibition by lumenal Na(+). 1 Publication	1
Mutagenesisⁱ	449	E → K: Abolishes channel activity. 1 Publication	1
Mutagenesisⁱ	458 – 459	DD → KK: Enhances endocytosis. 1 Publication	2
Mutagenesisⁱ	458	D → K: Nearly abolishes channel activity; inhibits starvation-induced autophagy. 1 Publication	1
Mutagenesisⁱ	459	D → A: Decreases in Ca(2+) permeability and selectivity; decreases channel pore dynamic behavior. 1 Publication	1
Mutagenesisⁱ	497	F → A: Nearly abolishes channel activation by a synthetic agonist. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55283
Open Targets More...OpenTargetsⁱ	ENSG00000055732
PharmGKBⁱ	PA134947324

Chemistry databases

ChEMBLⁱ	CHEMBL1293243
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	503

Polymorphism and mutation databases

BioMutaⁱ	MCOLN3
DMDMⁱ	50401084

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215367	1 – 553	Mucolipin-3Add BLAST		553

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	138	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	159 ↔ 185	By similarity
Glycosylationⁱ	172	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	205	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	238 ↔ 269	By similarity

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TDD5
PaxDbⁱ	Q8TDD5
PeptideAtlas More...PeptideAtlasⁱ	Q8TDD5
PRIDEⁱ	Q8TDD5
ProteomicsDBⁱ	74270 74271 [Q8TDD5-2]

PTM databases

GlyConnectⁱ	1522
iPTMnetⁱ	Q8TDD5
PhosphoSitePlusⁱ	Q8TDD5
SwissPalmⁱ	Q8TDD5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000055732 Expressed in 160 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_MCOLN3
ExpressionAtlasⁱ	Q8TDD5 baseline and differential
Genevisibleⁱ	Q8TDD5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018106 HPA062137

HPAⁱ

HPA018106
HPA062137

Interactionⁱ

Subunit structureⁱ

Homotetramer (PubMed:29106414). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific (PubMed:19885840). May heterooligomerize with TRPV5 to form a functional distinct ion channel (PubMed:23469151). Interacts with GABARAPL2 (By similarity).By similarity1 Publication2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	305	Interaction with phosphoinositidesBy similarity		1

Protein-protein interaction databases

BioGridⁱ	120571, 60 interactors
IntActⁱ	Q8TDD5, 1 interactor
STRINGⁱ	9606.ENSP00000304843

Chemistry databases

BindingDBⁱ

Q8TDD5

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TDD5
SMRⁱ	Q8TDD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	52 – 62	Interaction with phosphoinositidesBy similarityAdd BLAST		11
Regionⁱ	104 – 118	Extracellular/lumenal pore loopBy similarityAdd BLAST		15

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	456 – 459	Selectivity filter1 Publication		4

Domainⁱ

The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca²⁺ and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.By similarity

Sequence similaritiesⁱ

Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3733 Eukaryota ENOG410Z1HH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017126
HOGENOMⁱ	HOG000232158
HOVERGENⁱ	HBG052430
InParanoidⁱ	Q8TDD5
KEGG Orthology (KO) More...KOⁱ	K04994
OMAⁱ	QHTSPSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G026A
PhylomeDBⁱ	Q8TDD5
TreeFamⁱ	TF317783

Family and domain databases

InterProⁱ	View protein in InterPro IPR039031 Mucolipin IPR013122 PKD1_2_channel
PANTHERⁱ	PTHR12127 PTHR12127, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08016 PKD_channel, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TDD5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADPEVVVSS CSSHEEENRC NFNQQTSPSE ELLLEDQMRR KLKFFFMNPC 
        60         70         80         90        100
EKFWARGRKP WKLAIQILKI AMVTIQLVLF GLSNQMVVAF KEENTIAFKH 
       110        120        130        140        150
LFLKGYMDRM DDTYAVYTQS DVYDQLIFAV NQYLQLYNVS VGNHAYENKG 
       160        170        180        190        200
TKQSAMAICQ HFYKRGNIYP GNDTFDIDPE IETECFFVEP DEPFHIGTPA 
       210        220        230        240        250
ENKLNLTLDF HRLLTVELQF KLKAINLQTV RHQELPDCYD FTLTITFDNK 
       260        270        280        290        300
AHSGRIKISL DNDISIRECK DWHVSGSIQK NTHYMMIFDA FVILTCLVSL 
       310        320        330        340        350
ILCIRSVIRG LQLQQEFVNF FLLHYKKEVS VSDQMEFVNG WYIMIIISDI 
       360        370        380        390        400
LTIIGSILKM EIQAKSLTSY DVCSILLGTS TMLVWLGVIR YLGFFAKYNL 
       410        420        430        440        450
LILTLQAALP NVIRFCCCAA MIYLGYCFCG WIVLGPYHDK FRSLNMVSEC 
       460        470        480        490        500
LFSLINGDDM FATFAKMQQK SYLVWLFSRI YLYSFISLFI YMILSLFIAL 
       510        520        530        540        550
ITDTYETIKQ YQQDGFPETE LRTFISECKD LPNSGKYRLE DDPPVSLFCC 

CKK

Length:553

Mass (Da):64,248

Last modified:June 1, 2002 - v1

Checksum:ⁱ2E63DA196379F9E3

GO

Isoform 2 (identifier: Q8TDD5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
77-132: Missing.

« Hide

        10         20         30         40         50
MADPEVVVSS CSSHEEENRC NFNQQTSPSE ELLLEDQMRR KLKFFFMNPC 
        60         70         80         90        100
EKFWARGRKP WKLAIQILKI AMVTIQYLQL YNVSVGNHAY ENKGTKQSAM 
       110        120        130        140        150
AICQHFYKRG NIYPGNDTFD IDPEIETECF FVEPDEPFHI GTPAENKLNL 
       160        170        180        190        200
TLDFHRLLTV ELQFKLKAIN LQTVRHQELP DCYDFTLTIT FDNKAHSGRI 
       210        220        230        240        250
KISLDNDISI RECKDWHVSG SIQKNTHYMM IFDAFVILTC LVSLILCIRS 
       260        270        280        290        300
VIRGLQLQQE FVNFFLLHYK KEVSVSDQME FVNGWYIMII ISDILTIIGS 
       310        320        330        340        350
ILKMEIQAKS LTSYDVCSIL LGTSTMLVWL GVIRYLGFFA KYNLLILTLQ 
       360        370        380        390        400
AALPNVIRFC CCAAMIYLGY CFCGWIVLGP YHDKFRSLNM VSECLFSLIN 
       410        420        430        440        450
GDDMFATFAK MQQKSYLVWL FSRIYLYSFI SLFIYMILSL FIALITDTYE 
       460        470        480        490 
TIKQYQQDGF PETELRTFIS ECKDLPNSGK YRLEDDPPVS LFCCCKK

Show »

Length:497

Mass (Da):57,723

Checksum:ⁱB014DF953C034761

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1ANB7	B1ANB7_HUMAN	Mucolipin 3, isoform CRA_d Mucolipin 3, isoform CRA_d (Mucolipin-3)	MCOLN3 hCG_1775160	321	Annotation score:
S4R386	S4R386_HUMAN	Mucolipin-3 Mucolipin-3	MCOLN3	141	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	9	S → C in BAA91951 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010823	77 – 132	Missing in isoform 2. 1 PublicationAdd BLAST		56

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF475085 mRNA Translation: AAL84622.1 AK001868 mRNA Translation: BAA91951.1 AL358789 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58009.1 [Q8TDD5-2] CCDS701.1 [Q8TDD5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001240622.1, NM_001253693.1 [Q8TDD5-2] NP_060768.8, NM_018298.10 [Q8TDD5-1] XP_005271060.1, XM_005271003.1 [Q8TDD5-1] XP_006710813.1, XM_006710750.1 [Q8TDD5-1]
UniGeneⁱ	Hs.535239

Genome annotation databases

Ensemblⁱ	ENST00000341115; ENSP00000342698; ENSG00000055732 [Q8TDD5-2] ENST00000370589; ENSP00000359621; ENSG00000055732 [Q8TDD5-1]
GeneIDⁱ	55283
KEGGⁱ	hsa:55283
UCSC genome browser More...UCSCⁱ	uc001dkp.4 human [Q8TDD5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TDD5	Uncharacterized protein		CERAT		577	UniRef90_Q8TDD5
Uncharacterized protein		PANPA		554
Uncharacterized protein		CHLSB		553
Uncharacterized protein		RHIRO		553
Uncharacterized protein		RHIBE		553
+75
Q8TDD5-2	MCOLN3 isoform 3		PANTR		497	UniRef90_Q8TDD5-2
Uncharacterized protein		PROCO		497
Mucolipin 3		SAIBB		497
Uncharacterized protein		MACMU		497
Mucolipin-3		CALJA		497
+30

Protein	Similar proteins		Species	Score	Length	Source
Q8TDD5	Mucolipin-3	)	CALJA		553	UniRef50_Q8TDD5
Uncharacterized protein		CERAT		577
Uncharacterized protein		PANPA		554
Mucolipin 3		GORGO		553
cDNA FLJ77997, highly similar to Homo sapiens mucolipin 3 (MCOLN3), mRNA		HUMAN		553
+428
Q8TDD5-2	Mucolipin 3		SAIBB		497	UniRef50_Q8TDD5-2
Uncharacterized protein		PROCO		497
Uncharacterized protein		COLAP		497
Uncharacterized protein		AOTNA		497
Uncharacterized protein		Cebus capucinus imitator		497
+136

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF475085 mRNA Translation: AAL84622.1 AK001868 mRNA Translation: BAA91951.1 AL358789 Genomic DNA No translation available.
CCDSⁱ	CCDS58009.1 [Q8TDD5-2] CCDS701.1 [Q8TDD5-1]
RefSeqⁱ	NP_001240622.1, NM_001253693.1 [Q8TDD5-2] NP_060768.8, NM_018298.10 [Q8TDD5-1] XP_005271060.1, XM_005271003.1 [Q8TDD5-1] XP_006710813.1, XM_006710750.1 [Q8TDD5-1]
UniGeneⁱ	Hs.535239

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6AYE	electron microscopy	4.06	A/B/C/D	1-553	[»]
	6AYF	electron microscopy	3.62	A/B/C/D	1-553	[»]
	6AYG	electron microscopy	4.65	A/B/C/D	1-553	[»]
ProteinModelPortalⁱ	Q8TDD5
SMRⁱ	Q8TDD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120571, 60 interactors
IntActⁱ	Q8TDD5, 1 interactor
STRINGⁱ	9606.ENSP00000304843

Chemistry databases

BindingDBⁱ	Q8TDD5
ChEMBLⁱ	CHEMBL1293243
GuidetoPHARMACOLOGYⁱ	503

Protein family/group databases

TCDBⁱ	1.A.5.3.4 the polycystin cation channel (pcc) family

TCDBⁱ

1.A.5.3.4 the polycystin cation channel (pcc) family

PTM databases

GlyConnectⁱ	1522
iPTMnetⁱ	Q8TDD5
PhosphoSitePlusⁱ	Q8TDD5
SwissPalmⁱ	Q8TDD5

Polymorphism and mutation databases

BioMutaⁱ	MCOLN3
DMDMⁱ	50401084

Proteomic databases

MaxQBⁱ	Q8TDD5
PaxDbⁱ	Q8TDD5
PeptideAtlasⁱ	Q8TDD5
PRIDEⁱ	Q8TDD5
ProteomicsDBⁱ	74270 74271 [Q8TDD5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000341115; ENSP00000342698; ENSG00000055732 [Q8TDD5-2] ENST00000370589; ENSP00000359621; ENSG00000055732 [Q8TDD5-1]
GeneIDⁱ	55283
KEGGⁱ	hsa:55283
UCSCⁱ	uc001dkp.4 human [Q8TDD5-1]

Organism-specific databases

CTDⁱ	55283
DisGeNETⁱ	55283
EuPathDBⁱ	HostDB:ENSG00000055732.12
GeneCardsⁱ	MCOLN3
HGNCⁱ	HGNC:13358 MCOLN3
HPAⁱ	HPA018106 HPA062137
MIMⁱ	607400 gene
neXtProtⁱ	NX_Q8TDD5
OpenTargetsⁱ	ENSG00000055732
PharmGKBⁱ	PA134947324
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3733 Eukaryota ENOG410Z1HH LUCA
GeneTreeⁱ	ENSGT00390000017126
HOGENOMⁱ	HOG000232158
HOVERGENⁱ	HBG052430
InParanoidⁱ	Q8TDD5
KOⁱ	K04994
OMAⁱ	QHTSPSE
OrthoDBⁱ	EOG091G026A
PhylomeDBⁱ	Q8TDD5
TreeFamⁱ	TF317783

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3295583 TRP channels

Reactomeⁱ

R-HSA-3295583 TRP channels

Miscellaneous databases

GeneWikiⁱ	MCOLN3
GenomeRNAiⁱ	55283
Protein Ontology More...PROⁱ	PR:Q8TDD5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000055732 Expressed in 160 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_MCOLN3
ExpressionAtlasⁱ	Q8TDD5 baseline and differential
Genevisibleⁱ	Q8TDD5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039031 Mucolipin IPR013122 PKD1_2_channel
PANTHERⁱ	PTHR12127 PTHR12127, 1 hit
Pfamⁱ	View protein in Pfam PF08016 PKD_channel, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MCLN3_HUMAN
Accessionⁱ	Q8TDD5Primary (citable) accession number: Q8TDD5 Secondary accession number(s): Q5T4H5, Q5T4H6, Q9NV09
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q8TDD5 (MCLN3_HUMAN)

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Mucolipin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Endosome

Plasma membrane

Other locations

Endosome

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ