Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8TDD1 (DDX54_HUMAN)

Entry version 179 (02 Jun 2021)
Sequence version 2 (26 Apr 2004)
Previous versions | rss
Add a publicationFeedback
Protein

ATP-dependent RNA helicase DDX54

Gene

DDX54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi140 – 147ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TDD1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX54 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent RNA helicase DP97
DEAD box RNA helicase 97 kDa
DEAD box protein 54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20084, DDX54

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611665, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TDD1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000123064.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79039

Open Targets

More...OpenTargetsi		ENSG00000123064

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134992026

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TDD1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DDX54

Domain mapping of disease mutations (DMDM)

More...DMDMi		46576615

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000550561 – 881ATP-dependent RNA helicase DDX54Add BLAST881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei696PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Modified residuei788PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TDD1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TDD1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TDD1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TDD1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TDD1

PeptideAtlas

More...PeptideAtlasi		Q8TDD1

PRoteomics IDEntifications database

More...PRIDEi		Q8TDD1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74267 [Q8TDD1-1]
74268 [Q8TDD1-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		Q8TDD1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TDD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TDD1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8TDD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the fallopian tube, cervix and uterus. Also expressed in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000123064, Expressed in layer of synovial tissue and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TDD1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TDD1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000123064, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts in a hormone-dependent manner with nuclear receptors.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122503, 182 interactors

Protein interaction database and analysis system

More...IntActi		Q8TDD1, 75 interactors

Molecular INTeraction database

More...MINTi		Q8TDD1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000323858

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TDD1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TDD1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini127 – 299Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST173
Domaini326 – 473Helicase C-terminalPROSITE-ProRule annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 78DisorderedSequence analysisAdd BLAST78
Regioni596 – 698DisorderedSequence analysisAdd BLAST103
Regioni605 – 647Interaction with nuclear receptorsAdd BLAST43
Regioni725 – 881DisorderedSequence analysisAdd BLAST157

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 124Q motifAdd BLAST29
Motifi247 – 250DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 31Basic residuesSequence analysisAdd BLAST15
Compositional biasi33 – 59Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi665 – 694Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi735 – 755Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi767 – 806Basic and acidic residuesSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0337, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075100

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003041_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TDD1

Identification of Orthologs from Complete Genome Data

More...OMAi		CVEMDLK

Database of Orthologous Groups

More...OrthoDBi		268859at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TDD1

TreeFam database of animal gene trees

More...TreeFami		TF105707

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012541, DBP10_C
IPR033517, DDX54/DBP10
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000629, RNA-helicase_DEAD-box_CS
IPR014014, RNA_helicase_DEAD_Q_motif

The PANTHER Classification System

More...PANTHERi		PTHR24031:SF292, PTHR24031:SF292, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08147, DBP10CT, 1 hit
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01123, DBP10CT, 1 hit
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00039, DEAD_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51195, Q_MOTIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAADKGPAAG PRSRAAMAQW RKKKGLRKRR GAASQARGSD SEDGEFEIQA 
        60         70         80         90        100
EDDARARKLG PGRPLPTFPT SECTSDVEPD TREMVRAQNK KKKKSGGFQS 
       110        120        130        140        150
MGLSYPVFKG IMKKGYKVPT PIQRKTIPVI LDGKDVVAMA RTGSGKTACF 
       160        170        180        190        200
LLPMFERLKT HSAQTGARAL ILSPTRELAL QTLKFTKELG KFTGLKTALI 
       210        220        230        240        250
LGGDRMEDQF AALHENPDII IATPGRLVHV AVEMSLKLQS VEYVVFDEAD 
       260        270        280        290        300
RLFEMGFAEQ LQEIIARLPG GHQTVLFSAT LPKLLVEFAR AGLTEPVLIR 
       310        320        330        340        350
LDVDTKLNEQ LKTSFFLVRE DTKAAVLLHL LHNVVRPQDQ TVVFVATKHH 
       360        370        380        390        400
AEYLTELLTT QRVSCAHIYS ALDPTARKIN LAKFTLGKCS TLIVTDLAAR 
       410        420        430        440        450
GLDIPLLDNV INYSFPAKGK LFLHRVGRVA RAGRSGTAYS LVAPDEIPYL 
       460        470        480        490        500
LDLHLFLGRS LTLARPLKEP SGVAGVDGML GRVPQSVVDE EDSGLQSTLE 
       510        520        530        540        550
ASLELRGLAR VADNAQQQYV RSRPAPSPES IKRAKEMDLV GLGLHPLFSS 
       560        570        580        590        600
RFEEEELQRL RLVDSIKNYR SRATIFEINA SSRDLCSQVM RAKRQKDRKA 
       610        620        630        640        650
IARFQQGQQG RQEQQEGPVG PAPSRPALQE KQPEKEEEEE AGESVEDIFS 
       660        670        680        690        700
EVVGRKRQRS GPNRGAKRRR EEARQRDQEF YIPYRPKDFD SERGLSISGE 
       710        720        730        740        750
GGAFEQQAAG AVLDLMGDEA QNLTRGRQQL KWDRKKKRFV GQSGQEDKKK 
       760        770        780        790        800
IKTESGRYIS SSYKRDLYQK WKQKQKIDDR DSDEEGASDR RGPERRGGKR 
       810        820        830        840        850
DRGQGASRPH APGTPAGRVR PELKTKQQIL KQRRRAQKLH FLQRGGLKQL 
       860        870        880 
SARNRRRVQE LQQGAFGRGA RSKKGKMRKR M
Length:881
Mass (Da):98,595
Last modified:April 26, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9823C75156D998C4
GO
Isoform 2 (identifier: Q8TDD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     804-804: Q → QA

Show »
Length:882
Mass (Da):98,666
Checksum:i947F50470F865F96
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VRX4F8VRX4_HUMAN
ATP-dependent RNA helicase DDX54
DDX54
208Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHH7H0YHH7_HUMAN
RNA helicase
DDX54
160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHZ9H0YHZ9_HUMAN
ATP-dependent RNA helicase DDX54
DDX54
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN59978 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08361520W → R Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs774035439EnsemblClinVar.1
Natural variantiVAR_083616216N → S Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs764707570EnsemblClinVar.1
Natural variantiVAR_083617286V → M Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148961522EnsemblClinVar.1
Natural variantiVAR_083618298L → F Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_052171570R → H. Corresponds to variant dbSNP:rs35519289Ensembl.1
Natural variantiVAR_083619611R → Q Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs777276705EnsemblClinVar.1
Natural variantiVAR_052172693R → Q. Corresponds to variant dbSNP:rs11564Ensembl.1
Natural variantiVAR_052173712V → A. Corresponds to variant dbSNP:rs10354Ensembl.1
Natural variantiVAR_033860821P → L. Corresponds to variant dbSNP:rs1048889Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040135804Q → QA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF478457 mRNA Translation: AAL85336.1
AC089999 Genomic DNA No translation available.
AY148094 mRNA Translation: AAN59978.1 Sequence problems.
BC005848 mRNA Translation: AAH05848.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31907.1 [Q8TDD1-1]
CCDS44984.1 [Q8TDD1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001104792.1, NM_001111322.1 [Q8TDD1-2]
NP_076977.3, NM_024072.3 [Q8TDD1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306014; ENSP00000304072; ENSG00000123064 [Q8TDD1-1]
ENST00000314045; ENSP00000323858; ENSG00000123064 [Q8TDD1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79039

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79039

UCSC genome browser

More...UCSCi		uc001tup.4, human [Q8TDD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478457 mRNA Translation: AAL85336.1
AC089999 Genomic DNA No translation available.
AY148094 mRNA Translation: AAN59978.1 Sequence problems.
BC005848 mRNA Translation: AAH05848.2
CCDSiCCDS31907.1 [Q8TDD1-1]
CCDS44984.1 [Q8TDD1-2]
RefSeqiNP_001104792.1, NM_001111322.1 [Q8TDD1-2]
NP_076977.3, NM_024072.3 [Q8TDD1-1]

3D structure databases

SMRiQ8TDD1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122503, 182 interactors
IntActiQ8TDD1, 75 interactors
MINTiQ8TDD1
STRINGi9606.ENSP00000323858

PTM databases

iPTMnetiQ8TDD1
PhosphoSitePlusiQ8TDD1
SwissPalmiQ8TDD1

Genetic variation databases

BioMutaiDDX54
DMDMi46576615

2D gel databases

SWISS-2DPAGEiQ8TDD1

Proteomic databases

EPDiQ8TDD1
jPOSTiQ8TDD1
MassIVEiQ8TDD1
MaxQBiQ8TDD1
PaxDbiQ8TDD1
PeptideAtlasiQ8TDD1
PRIDEiQ8TDD1
ProteomicsDBi74267 [Q8TDD1-1]
74268 [Q8TDD1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18719, 157 antibodies

The DNASU plasmid repository

More...DNASUi		79039

Genome annotation databases

EnsembliENST00000306014; ENSP00000304072; ENSG00000123064 [Q8TDD1-1]
ENST00000314045; ENSP00000323858; ENSG00000123064 [Q8TDD1-2]
GeneIDi79039
KEGGihsa:79039
UCSCiuc001tup.4, human [Q8TDD1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79039
DisGeNETi79039

GeneCards: human genes, protein and diseases

More...GeneCardsi		DDX54
HGNCiHGNC:20084, DDX54
HPAiENSG00000123064, Low tissue specificity
MIMi611665, gene
neXtProtiNX_Q8TDD1
OpenTargetsiENSG00000123064
PharmGKBiPA134992026
VEuPathDBiHostDB:ENSG00000123064.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0337, Eukaryota
GeneTreeiENSGT00550000075100
HOGENOMiCLU_003041_5_2_1
InParanoidiQ8TDD1
OMAiCVEMDLK
OrthoDBi268859at2759
PhylomeDBiQ8TDD1
TreeFamiTF105707

Enzyme and pathway databases

PathwayCommonsiQ8TDD1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79039, 750 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DDX54, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79039
PharosiQ8TDD1, Tbio

Protein Ontology

More...PROi		PR:Q8TDD1
RNActiQ8TDD1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000123064, Expressed in layer of synovial tissue and 216 other tissues
ExpressionAtlasiQ8TDD1, baseline and differential
GenevisibleiQ8TDD1, HS

Family and domain databases

InterProiView protein in InterPro
IPR012541, DBP10_C
IPR033517, DDX54/DBP10
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000629, RNA-helicase_DEAD-box_CS
IPR014014, RNA_helicase_DEAD_Q_motif
PANTHERiPTHR24031:SF292, PTHR24031:SF292, 1 hit
PfamiView protein in Pfam
PF08147, DBP10CT, 1 hit
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
SMARTiView protein in SMART
SM01123, DBP10CT, 1 hit
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039, DEAD_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51195, Q_MOTIF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX54_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDD1
Secondary accession number(s): Q86YT8, Q9BRZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: June 2, 2021
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again