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Entry version 131 (12 Aug 2020)
Sequence version 2 (18 May 2010)
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Protein

Myozenin-3

Gene

MYOZ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TDC0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myozenin-3
Alternative name(s):
Calsarcin-3
FATZ-related protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYOZ3Imported
Synonyms:FRP3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164591.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18565, MYOZ3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610735, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDC0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
91977

Open Targets

More...
OpenTargetsi
ENSG00000164591

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38577

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TDC0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYOZ3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439236

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001111021 – 251Myozenin-3Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TDC0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDC0

PeptideAtlas

More...
PeptideAtlasi
Q8TDC0

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDC0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74261 [Q8TDC0-1]
74262 [Q8TDC0-2]
74263 [Q8TDC0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDC0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in skeletal muscle. Not detected in heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164591, Expressed in muscle of leg and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TDC0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDC0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164591, Group enriched (skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TDC0
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-5662487,EBI-11096309
AKIRIN2 [Q53H80]3EBI-5662487,EBI-742928
ASPG [Q86U10]3EBI-5662487,EBI-19946665
ATXN1L [P0C7T5]3EBI-5662487,EBI-8624731
BAG4 [O95429]3EBI-5662487,EBI-2949658
BCAS2 [O75934]3EBI-5662487,EBI-1050106
C10orf55 [Q5SWW7]3EBI-5662487,EBI-12809220
C10orf82 - isoform 2 [Q8WW14-2]3EBI-5662487,EBI-12831628
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-5662487,EBI-10961624
CREM - isoform 22 [Q03060-25]3EBI-5662487,EBI-12884642
CRLF3 [Q8IUI8]3EBI-5662487,EBI-2872414
DAZAP2 [Q15038]3EBI-5662487,EBI-724310
DMRT3 [Q9NQL9]3EBI-5662487,EBI-9679045
EFS - isoform Efs2 [O43281-2]3EBI-5662487,EBI-11525448
ENKD1 [Q9H0I2]3EBI-5662487,EBI-744099
EXOC8 [Q8IYI6]3EBI-5662487,EBI-742102
FAM166B - isoform 2 [A8MTA8-2]3EBI-5662487,EBI-12160437
FAM168B - isoform 2 [A1KXE4-2]3EBI-5662487,EBI-12193763
FAM214B [Q7L5A3]3EBI-5662487,EBI-745689
FHL3 [Q13643]3EBI-5662487,EBI-741101
FHL5 [Q5TD97]3EBI-5662487,EBI-750641
GCM2 [O75603]3EBI-5662487,EBI-10188645
GOLGA6A [Q9NYA3]3EBI-5662487,EBI-11163335
GOLGA6L9 [A6NEM1]3EBI-5662487,EBI-5916454
hCG_1987119 [A0A024R8L2]3EBI-5662487,EBI-14103818
HSF2BP [O75031]3EBI-5662487,EBI-7116203
KANK2 [Q63ZY3]3EBI-5662487,EBI-2556193
KRT34 [O76011]3EBI-5662487,EBI-1047093
KRT36 - isoform 2 [O76013-2]3EBI-5662487,EBI-11958506
KRT75 [O95678]3EBI-5662487,EBI-2949715
KRTAP19-5 [Q3LI72]3EBI-5662487,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-5662487,EBI-12805508
KRTAP6-1 [Q3LI64]3EBI-5662487,EBI-12111050
KRTAP7-1 [Q8IUC3]3EBI-5662487,EBI-18394498
KRTAP8-1 [Q8IUC2]5EBI-5662487,EBI-10261141
KYNU - isoform 2 [Q16719-2]3EBI-5662487,EBI-12351611
LENG8 [Q96PV6]3EBI-5662487,EBI-739546
LMO2 - isoform 3 [P25791-3]3EBI-5662487,EBI-11959475
LMO3 - isoform 4 [Q8TAP4-4]3EBI-5662487,EBI-11742507
LMO4 [P61968]3EBI-5662487,EBI-2798728
LONRF1 [Q17RB8]3EBI-5662487,EBI-2341787
MORN3 [Q6PF18]3EBI-5662487,EBI-9675802
MRPL38 [Q96DV4]3EBI-5662487,EBI-720441
NEK6 - isoform 4 [Q9HC98-4]3EBI-5662487,EBI-11750983
NUTF2 [P61970]3EBI-5662487,EBI-591778
PITX1 [P78337]3EBI-5662487,EBI-748265
PM20D2 [Q8IYS1]3EBI-5662487,EBI-11339910
PRDM6 [Q9NQX0]3EBI-5662487,EBI-11320284
PSMB4 [P28070]3EBI-5662487,EBI-603350
PTK6 [Q13882]3EBI-5662487,EBI-1383632
RINT1 [Q6NUQ1]3EBI-5662487,EBI-726876
RUSC1 [Q9BVN2]3EBI-5662487,EBI-6257312
TBX15 [Q96SF7]3EBI-5662487,EBI-10191361
TEKT4 [Q8WW24]3EBI-5662487,EBI-750487
TRAPPC6A - isoform 2 [O75865-2]3EBI-5662487,EBI-8451480
TSC1 [Q86WV8]3EBI-5662487,EBI-12806590
TSSK3 [Q96PN8]3EBI-5662487,EBI-3918381
UFSP1 [Q6NVU6]3EBI-5662487,EBI-12068150
ZNF620 [Q6ZNG0]3EBI-5662487,EBI-4395669
ZNF688 [P0C7X2]3EBI-5662487,EBI-4395732

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124899, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TDC0, 62 interactors

Molecular INTeraction database

More...
MINTi
Q8TDC0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297130

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TDC0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni50 – 67Binding to ACTN2, PPP3CA and TCAP1 PublicationAdd BLAST18
Regioni67 – 110Binding to FLNC1 PublicationAdd BLAST44
Regioni186 – 207Binding to ACTN21 PublicationAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the myozenin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S22C, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183027

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_071316_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDC0

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWDFRSF

Database of Orthologous Groups

More...
OrthoDBi
979261at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDC0

TreeFam database of animal gene trees

More...
TreeFami
TF331748

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008438, MYOZ

The PANTHER Classification System

More...
PANTHERi
PTHR15941, PTHR15941, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05556, Calsarcin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8TDC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPKEQKGPV MAAMGDLTEP VPTLDLGKKL SVPQDLMMEE LSLRNNRGSL
60 70 80 90 100
LFQKRQRRVQ KFTFELAASQ RAMLAGSARR KVTGTAESGT VANANGPEGP
110 120 130 140 150
NYRSELHIFP ASPGASLGGP EGAHPAAAPA GCVPSPSALA PGYAEPLKGV
160 170 180 190 200
PPEKFNHTAI SKGYRCPWQE FVSYRDYQSD GRSHTPSPND YRNFNKTPVP
210 220 230 240 250
FGGPLVGGTF PRPGTPFIPE PLSGLELLRL RPSFNRVAQG WVRNLPESEE

L
Length:251
Mass (Da):27,157
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF1C09E49CD31D94
GO
Isoform 21 Publication (identifier: Q8TDC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-231: Missing.

Show »
Length:205
Mass (Da):22,155
Checksum:i90AAA3139F44B7A9
GO
Isoform 31 Publication (identifier: Q8TDC0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MIPKEQKGPVMAAMGDLTEP → MLREVGPGVYGGWGGESPLWPFLA
     73-83: MLAGSARRKVT → VSKPPLCSWGK
     84-251: Missing.

Show »
Length:87
Mass (Da):9,787
Checksum:i62F30F67235A78DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC50H0YC50_HUMAN
Myozenin-3
MYOZ3
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RII7E5RII7_HUMAN
Myozenin-3
MYOZ3
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067718161S → P5 PublicationsCorresponds to variant dbSNP:rs194134Ensembl.1
Natural variantiVAR_056203209T → N. Corresponds to variant dbSNP:rs7737542Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0518761 – 20MIPKE…DLTEP → MLREVGPGVYGGWGGESPLW PFLA in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_05187773 – 83MLAGSARRKVT → VSKPPLCSWGK in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_05187884 – 251Missing in isoform 3. 1 PublicationAdd BLAST168
Alternative sequenceiVSP_051879186 – 231Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF480443 mRNA Translation: AAL79336.1
AJ277961 mRNA Translation: CAC81912.1
AJ300586 mRNA Translation: CAC83076.1
AJ300587 mRNA Translation: CAC83077.1
AK313873 mRNA Translation: BAG36601.1
AC008453 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61713.1
CH471062 Genomic DNA Translation: EAW61714.1
BC069380 mRNA Translation: AAH69380.1
BC069553 mRNA Translation: AAH69553.1
BC074870 mRNA Translation: AAH74870.1
BC074871 mRNA Translation: AAH74871.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4309.1 [Q8TDC0-1]

NCBI Reference Sequences

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RefSeqi
NP_001116325.1, NM_001122853.2 [Q8TDC0-1]
NP_588612.2, NM_133371.4 [Q8TDC0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000297130; ENSP00000297130; ENSG00000164591 [Q8TDC0-1]
ENST00000517768; ENSP00000428815; ENSG00000164591 [Q8TDC0-1]
ENST00000615557; ENSP00000478375; ENSG00000164591 [Q8TDC0-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
91977

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:91977

UCSC genome browser

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UCSCi
uc003lsr.4, human [Q8TDC0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480443 mRNA Translation: AAL79336.1
AJ277961 mRNA Translation: CAC81912.1
AJ300586 mRNA Translation: CAC83076.1
AJ300587 mRNA Translation: CAC83077.1
AK313873 mRNA Translation: BAG36601.1
AC008453 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61713.1
CH471062 Genomic DNA Translation: EAW61714.1
BC069380 mRNA Translation: AAH69380.1
BC069553 mRNA Translation: AAH69553.1
BC074870 mRNA Translation: AAH74870.1
BC074871 mRNA Translation: AAH74871.1
CCDSiCCDS4309.1 [Q8TDC0-1]
RefSeqiNP_001116325.1, NM_001122853.2 [Q8TDC0-1]
NP_588612.2, NM_133371.4 [Q8TDC0-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124899, 3 interactors
IntActiQ8TDC0, 62 interactors
MINTiQ8TDC0
STRINGi9606.ENSP00000297130

PTM databases

iPTMnetiQ8TDC0
PhosphoSitePlusiQ8TDC0

Polymorphism and mutation databases

BioMutaiMYOZ3
DMDMi296439236

Proteomic databases

MassIVEiQ8TDC0
PaxDbiQ8TDC0
PeptideAtlasiQ8TDC0
PRIDEiQ8TDC0
ProteomicsDBi74261 [Q8TDC0-1]
74262 [Q8TDC0-2]
74263 [Q8TDC0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
50777, 25 antibodies

Genome annotation databases

EnsembliENST00000297130; ENSP00000297130; ENSG00000164591 [Q8TDC0-1]
ENST00000517768; ENSP00000428815; ENSG00000164591 [Q8TDC0-1]
ENST00000615557; ENSP00000478375; ENSG00000164591 [Q8TDC0-3]
GeneIDi91977
KEGGihsa:91977
UCSCiuc003lsr.4, human [Q8TDC0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91977
DisGeNETi91977
EuPathDBiHostDB:ENSG00000164591.13

GeneCards: human genes, protein and diseases

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GeneCardsi
MYOZ3
HGNCiHGNC:18565, MYOZ3
HPAiENSG00000164591, Group enriched (skeletal muscle, tongue)
MIMi610735, gene
neXtProtiNX_Q8TDC0
OpenTargetsiENSG00000164591
PharmGKBiPA38577

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502S22C, Eukaryota
GeneTreeiENSGT00950000183027
HOGENOMiCLU_071316_1_0_1
InParanoidiQ8TDC0
OMAiAWDFRSF
OrthoDBi979261at2759
PhylomeDBiQ8TDC0
TreeFamiTF331748

Enzyme and pathway databases

PathwayCommonsiQ8TDC0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
91977, 3 hits in 869 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91977
PharosiQ8TDC0, Tdark

Protein Ontology

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PROi
PR:Q8TDC0
RNActiQ8TDC0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164591, Expressed in muscle of leg and 168 other tissues
ExpressionAtlasiQ8TDC0, baseline and differential
GenevisibleiQ8TDC0, HS

Family and domain databases

InterProiView protein in InterPro
IPR008438, MYOZ
PANTHERiPTHR15941, PTHR15941, 1 hit
PfamiView protein in Pfam
PF05556, Calsarcin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYOZ3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDC0
Secondary accession number(s): B2R9Q4
, D3DQG9, Q8IVM1, Q8IVN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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