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Protein

Krueppel-like factor 14

Gene

KLF14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri225 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri255 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 14
Alternative name(s):
Basic transcription element-binding protein 5
Short name:
BTE-binding protein 5
Transcription factor BTEB5
Gene namesi
Name:KLF14
Synonyms:BTEB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000266265.2
HGNCiHGNC:23025 KLF14
MIMi609393 gene
neXtProtiNX_Q8TD94

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi136259
OpenTargetsiENSG00000266265
PharmGKBiPA134868089

Polymorphism and mutation databases

DMDMi32129442

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471861 – 323Krueppel-like factor 14Add BLAST323

Proteomic databases

PaxDbiQ8TD94
PeptideAtlasiQ8TD94
PRIDEiQ8TD94
ProteomicsDBi74254

PTM databases

iPTMnetiQ8TD94
PhosphoSitePlusiQ8TD94

Expressioni

Gene expression databases

BgeeiENSG00000266265 Expressed in 31 organ(s), highest expression level in blood
CleanExiHS_KLF14

Organism-specific databases

HPAiHPA044729

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310878

Structurei

3D structure databases

ProteinModelPortaliQ8TD94
SMRiQ8TD94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri225 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri255 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ8TD94
KOiK09208
OMAiWENSGEA
PhylomeDBiQ8TD94
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8TD94-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAVACLDY FAAECLVSMS AGAVVHRRPP DPEGAGGAAG SEVGAAPPES
60 70 80 90 100
ALPGPGPPGP ASVPQLPQVP APSPGAGGAA PHLLAASVWA DLRGSSGEGS
110 120 130 140 150
WENSGEAPRA SSGFSDPIPC SVQTPCSELA PASGAAAVCA PESSSDAPAV
160 170 180 190 200
PSAPAAPGAP AASGGFSGGA LGAGPAPAAD QAPRRRSVTP AAKRHQCPFP
210 220 230 240 250
GCTKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT
260 270 280 290 300
GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRIDPPL
310 320
TSEVESSASG SGPGPAPSFT TCL
Length:323
Mass (Da):33,094
Last modified:March 28, 2018 - v2
Checksum:iD77A87CA6C61C4B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47P → H in AAM08349 (Ref. 1) 1
Sequence conflicti47P → H in EAL24083 (Ref. 4) 1
Sequence conflicti47P → H in EAW83773 (Ref. 4) 1
Sequence conflicti47P → Q in ABF82392 (Ref. 2) Curated1
Sequence conflicti47P → Q in ABF82393 (Ref. 2) Curated1
Sequence conflicti58P → S in AAM08349 (Ref. 1) 1
Sequence conflicti58P → S in ABF82392 (Ref. 2) 1
Sequence conflicti58P → S in ABF82393 (Ref. 2) 1
Sequence conflicti58P → S in EAL24083 (Ref. 4) 1
Sequence conflicti58P → S in EAW83773 (Ref. 4) 1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052718173A → P. Corresponds to variant dbSNP:rs35770036Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490374 mRNA Translation: AAM08349.1
DQ534756 Genomic DNA Translation: ABF82392.1
DQ534757 mRNA Translation: ABF82393.1
AC234644 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24083.1
CH471070 Genomic DNA Translation: EAW83773.1
CCDSiCCDS5825.1
RefSeqiNP_619638.2, NM_138693.3
UniGeneiHs.125240

Genome annotation databases

EnsembliENST00000583337; ENSP00000463287; ENSG00000266265
GeneIDi136259
KEGGihsa:136259

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490374 mRNA Translation: AAM08349.1
DQ534756 Genomic DNA Translation: ABF82392.1
DQ534757 mRNA Translation: ABF82393.1
AC234644 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24083.1
CH471070 Genomic DNA Translation: EAW83773.1
CCDSiCCDS5825.1
RefSeqiNP_619638.2, NM_138693.3
UniGeneiHs.125240

3D structure databases

ProteinModelPortaliQ8TD94
SMRiQ8TD94
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310878

PTM databases

iPTMnetiQ8TD94
PhosphoSitePlusiQ8TD94

Polymorphism and mutation databases

DMDMi32129442

Proteomic databases

PaxDbiQ8TD94
PeptideAtlasiQ8TD94
PRIDEiQ8TD94
ProteomicsDBi74254

Protocols and materials databases

DNASUi136259
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000583337; ENSP00000463287; ENSG00000266265
GeneIDi136259
KEGGihsa:136259

Organism-specific databases

CTDi136259
DisGeNETi136259
EuPathDBiHostDB:ENSG00000266265.2
GeneCardsiKLF14
HGNCiHGNC:23025 KLF14
HPAiHPA044729
MIMi609393 gene
neXtProtiNX_Q8TD94
OpenTargetsiENSG00000266265
PharmGKBiPA134868089
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ8TD94
KOiK09208
OMAiWENSGEA
PhylomeDBiQ8TD94
TreeFamiTF351003

Miscellaneous databases

GenomeRNAii136259
PROiPR:Q8TD94
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000266265 Expressed in 31 organ(s), highest expression level in blood
CleanExiHS_KLF14

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF14_HUMAN
AccessioniPrimary (citable) accession number: Q8TD94
Secondary accession number(s): A0A075B756
, A4D1N0, Q19A42, Q19A43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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