UniProtKB - Q8TD91 (MAGC3_HUMAN)
Protein
Melanoma-associated antigen C3
Gene
MAGEC3
Organism
Homo sapiens (Human)
Status
Functioni
Keywordsi
Molecular function | Tumor antigen |
Enzyme and pathway databases
PathwayCommonsi | Q8TD91 |
Names & Taxonomyi
Protein namesi | Recommended name: Melanoma-associated antigen C3Alternative name(s): Cancer/testis antigen 7.2 Short name: CT7.2 Hepatocellular carcinoma-associated antigen 2 MAGE-C3 antigen |
Gene namesi | Name:MAGEC3 Synonyms:HCA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23798, MAGEC3 |
MIMi | 300469, gene |
neXtProti | NX_Q8TD91 |
VEuPathDBi | HostDB:ENSG00000165509.13 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 139081 |
OpenTargetsi | ENSG00000165509 |
PharmGKBi | PA134916199 |
Miscellaneous databases
Pharosi | Q8TD91, Tdark |
Genetic variation databases
BioMutai | MAGEC3 |
DMDMi | 41017367 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156722 | 1 – 643 | Melanoma-associated antigen C3Add BLAST | 643 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 478 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 484 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 485 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q8TD91 |
PeptideAtlasi | Q8TD91 |
PRIDEi | Q8TD91 |
ProteomicsDBi | 74252 [Q8TD91-1] 74253 [Q8TD91-2] |
PTM databases
iPTMneti | Q8TD91 |
PhosphoSitePlusi | Q8TD91 |
Expressioni
Tissue specificityi
Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.1 Publication
Gene expression databases
Bgeei | ENSG00000165509, Expressed in C1 segment of cervical spinal cord and 85 other tissues |
ExpressionAtlasi | Q8TD91, baseline and differential |
Genevisiblei | Q8TD91, HS |
Organism-specific databases
HPAi | ENSG00000165509, Tissue enhanced (brain, epididymis, testis) |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [Q8TD91-2]
Protein-protein interaction databases
BioGRIDi | 126542, 4 interactors |
IntActi | Q8TD91, 14 interactors |
STRINGi | 9606.ENSP00000298296 |
Miscellaneous databases
RNActi | Q8TD91, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 184 – 384 | MAGE 1PROSITE-ProRule annotationAdd BLAST | 201 | |
Domaini | 456 – 643 | MAGE 2PROSITE-ProRule annotationAdd BLAST | 188 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 380 – 415 | Pro-richAdd BLAST | 36 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000164981 |
HOGENOMi | CLU_508623_0_0_1 |
InParanoidi | Q8TD91 |
OMAi | LLTIHWV |
OrthoDBi | 1195799at2759 |
PhylomeDBi | Q8TD91 |
TreeFami | TF328505 |
Family and domain databases
Gene3Di | 1.10.10.1200, 2 hits 1.10.10.1210, 2 hits |
InterProi | View protein in InterPro IPR037445, MAGE IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 2 hits |
SMARTi | View protein in SMART SM01373, MAGE, 2 hits |
PROSITEi | View protein in PROSITE PS50838, MAGE, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TD91-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLPCHWVLD ATFSDGSLGQ WVKNTCATYA LSPVVLPPQP QPRKKATDKD
60 70 80 90 100
YSAFHLGHLR EVRLFLRGGT SDQRMDSLVL CPTYFKLWRT LSGSPGLQLS
110 120 130 140 150
DLHFGSQPEG KFSLRRAVSV KQREEPQDWP LNEKRTLWKD SDLPTWRRGT
160 170 180 190 200
GYTLSLPAVS PGKRLWGEKA GSLPESEPLF TYTLDEKVDK LVQFLLLKYQ
210 220 230 240 250
AKEPLTRAEM QMNVINTYTG YFPMIFRKAR EFIEILFGIS LTEVDPDHFY
260 270 280 290 300
VFVNTLDLTC EGSLSDEQGM PQNRLLILIL SVIFIKGNCA SEEVIWEVLN
310 320 330 340 350
AIGPWSALAG FADVLSRLAL WESEGPEAFC EESGLRSAEG SVLDLANPQG
360 370 380 390 400
LAGHRQEDGR RGLTEASPQQ KKGGEDEDMP AAGMPPLPQS PPEIPPQGPP
410 420 430 440 450
KISPQGPPQS PPQSPLDSCS SPLLWTRLDE ESSSEEEDTA TWHALPESES
460 470 480 490 500
LPRYALDEKV AELVQFLLLK YQTKEPVTKA EMLTTVIKKY KDYFPMIFGK
510 520 530 540 550
AHEFIELIFG IALTDMDPDN HSYFFEDTLD LTYEGSLIDD QGMPKNCLLI
560 570 580 590 600
LILSMIFIKG SCVPEEVIWE VLSAIGPIQR PAREVLEFLS KLSSIIPSAF
610 620 630 640
PSWYMDALKD MEDRAQAIID TTDDATAMAS ASPSVMSTNF CPE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3SYA6 | Q3SYA6_HUMAN | MAGEC3 protein | MAGEC3 | 266 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 362 – 374 | GLTEA…QKKGG → SSPLPSTLILGVP (PubMed:15489334).CuratedAdd BLAST | 13 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060069 | 155 | S → P. Corresponds to variant dbSNP:rs11095909Ensembl. | 1 | |
Natural variantiVAR_053505 | 165 | L → M. Corresponds to variant dbSNP:rs11095910Ensembl. | 1 | |
Natural variantiVAR_053506 | 307 | A → T. Corresponds to variant dbSNP:rs176024Ensembl. | 1 | |
Natural variantiVAR_053507 | 328 | A → T. Corresponds to variant dbSNP:rs176026Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043489 | 1 – 76 | MLLPC…DQRMD → MPLFPNLPRLSFEEDFQNPS VTEDLVDAQDSIDEEEEDAS STSSSSFHFLFPSSSSLSSS SPLSSPLPSTLILGVP in isoform 2. 1 PublicationAdd BLAST | 76 | |
Alternative sequenceiVSP_043490 | 77 – 374 | Missing in isoform 2. 1 PublicationAdd BLAST | 298 | |
Alternative sequenceiVSP_043491 | 577 – 643 | PIQRP…NFCPE → VCAGREHFIYGDPRKLLTIH WVQRKYLEYREVPNSAPPRY EFLWGPRAHSEASKRSLRVF IQAIQYHP in isoform 2. 1 PublicationAdd BLAST | 67 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF490508 mRNA Translation: AAM08355.1 AL022152 Genomic DNA No translation available. AL023279 Genomic DNA No translation available. AL049177 Genomic DNA No translation available. BC103893 mRNA Translation: AAI03894.1 AF333706 Genomic DNA Translation: AAK00358.1 |
CCDSi | CCDS14676.1 [Q8TD91-1] CCDS14677.1 [Q8TD91-2] |
RefSeqi | NP_619647.1, NM_138702.1 [Q8TD91-1] NP_803251.1, NM_177456.2 [Q8TD91-2] XP_011529569.1, XM_011531267.2 [Q8TD91-2] XP_016884754.1, XM_017029265.1 [Q8TD91-2] |
Genome annotation databases
Ensembli | ENST00000298296; ENSP00000298296; ENSG00000165509 [Q8TD91-1] ENST00000409007; ENSP00000386566; ENSG00000165509 [Q8TD91-2] ENST00000544766; ENSP00000440444; ENSG00000165509 [Q8TD91-2] |
GeneIDi | 139081 |
KEGGi | hsa:139081 |
UCSCi | uc004fbs.3, human [Q8TD91-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF490508 mRNA Translation: AAM08355.1 AL022152 Genomic DNA No translation available. AL023279 Genomic DNA No translation available. AL049177 Genomic DNA No translation available. BC103893 mRNA Translation: AAI03894.1 AF333706 Genomic DNA Translation: AAK00358.1 |
CCDSi | CCDS14676.1 [Q8TD91-1] CCDS14677.1 [Q8TD91-2] |
RefSeqi | NP_619647.1, NM_138702.1 [Q8TD91-1] NP_803251.1, NM_177456.2 [Q8TD91-2] XP_011529569.1, XM_011531267.2 [Q8TD91-2] XP_016884754.1, XM_017029265.1 [Q8TD91-2] |
3D structure databases
SMRi | Q8TD91 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126542, 4 interactors |
IntActi | Q8TD91, 14 interactors |
STRINGi | 9606.ENSP00000298296 |
PTM databases
iPTMneti | Q8TD91 |
PhosphoSitePlusi | Q8TD91 |
Genetic variation databases
BioMutai | MAGEC3 |
DMDMi | 41017367 |
Proteomic databases
PaxDbi | Q8TD91 |
PeptideAtlasi | Q8TD91 |
PRIDEi | Q8TD91 |
ProteomicsDBi | 74252 [Q8TD91-1] 74253 [Q8TD91-2] |
Protocols and materials databases
Antibodypediai | 45024, 62 antibodies |
Genome annotation databases
Ensembli | ENST00000298296; ENSP00000298296; ENSG00000165509 [Q8TD91-1] ENST00000409007; ENSP00000386566; ENSG00000165509 [Q8TD91-2] ENST00000544766; ENSP00000440444; ENSG00000165509 [Q8TD91-2] |
GeneIDi | 139081 |
KEGGi | hsa:139081 |
UCSCi | uc004fbs.3, human [Q8TD91-1] |
Organism-specific databases
CTDi | 139081 |
DisGeNETi | 139081 |
GeneCardsi | MAGEC3 |
HGNCi | HGNC:23798, MAGEC3 |
HPAi | ENSG00000165509, Tissue enhanced (brain, epididymis, testis) |
MIMi | 300469, gene |
neXtProti | NX_Q8TD91 |
OpenTargetsi | ENSG00000165509 |
PharmGKBi | PA134916199 |
VEuPathDBi | HostDB:ENSG00000165509.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4562, Eukaryota |
GeneTreei | ENSGT00940000164981 |
HOGENOMi | CLU_508623_0_0_1 |
InParanoidi | Q8TD91 |
OMAi | LLTIHWV |
OrthoDBi | 1195799at2759 |
PhylomeDBi | Q8TD91 |
TreeFami | TF328505 |
Enzyme and pathway databases
PathwayCommonsi | Q8TD91 |
Miscellaneous databases
BioGRID-ORCSi | 139081, 5 hits in 502 CRISPR screens |
ChiTaRSi | MAGEC3, human |
GenomeRNAii | 139081 |
Pharosi | Q8TD91, Tdark |
PROi | PR:Q8TD91 |
RNActi | Q8TD91, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165509, Expressed in C1 segment of cervical spinal cord and 85 other tissues |
ExpressionAtlasi | Q8TD91, baseline and differential |
Genevisiblei | Q8TD91, HS |
Family and domain databases
Gene3Di | 1.10.10.1200, 2 hits 1.10.10.1210, 2 hits |
InterProi | View protein in InterPro IPR037445, MAGE IPR041898, MAGE_WH1 IPR041899, MAGE_WH2 IPR002190, MHD_dom |
PANTHERi | PTHR11736, PTHR11736, 2 hits |
SMARTi | View protein in SMART SM01373, MAGE, 2 hits |
PROSITEi | View protein in PROSITE PS50838, MAGE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAGC3_HUMAN | |
Accessioni | Q8TD91Primary (citable) accession number: Q8TD91 Secondary accession number(s): Q3SYA7, Q5JZ43, Q9BZ80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot