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UniProtKB - Q8TD91 (MAGC3_HUMAN)

Entry version 130 (07 Apr 2021)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
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Protein

Melanoma-associated antigen C3

Gene

MAGEC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TD91

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen C3
Alternative name(s):
Cancer/testis antigen 7.2
Short name:
CT7.2
Hepatocellular carcinoma-associated antigen 2
MAGE-C3 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGEC3
Synonyms:HCA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23798, MAGEC3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300469, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TD91

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165509.13

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		139081

Open Targets

More...OpenTargetsi		ENSG00000165509

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134916199

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TD91, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAGEC3

Domain mapping of disease mutations (DMDM)

More...DMDMi		41017367

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567221 – 643Melanoma-associated antigen C3Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei478PhosphothreonineCombined sources1
Modified residuei484PhosphothreonineCombined sources1
Modified residuei485PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TD91

PeptideAtlas

More...PeptideAtlasi		Q8TD91

PRoteomics IDEntifications database

More...PRIDEi		Q8TD91

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74252 [Q8TD91-1]
74253 [Q8TD91-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TD91

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TD91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165509, Expressed in C1 segment of cervical spinal cord and 85 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TD91, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TD91, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165509, Tissue enhanced (brain, epididymis, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126542, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q8TD91, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000298296

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TD91, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TD91

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 384MAGE 1PROSITE-ProRule annotationAdd BLAST201
Domaini456 – 643MAGE 2PROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi380 – 415Pro-richAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4562, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164981

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_508623_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TD91

Identification of Orthologs from Complete Genome Data

More...OMAi		LLTIHWV

Database of Orthologous Groups

More...OrthoDBi		1195799at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TD91

TreeFam database of animal gene trees

More...TreeFami		TF328505

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1200, 2 hits
1.10.10.1210, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037445, MAGE
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR002190, MHD_dom

The PANTHER Classification System

More...PANTHERi		PTHR11736, PTHR11736, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01373, MAGE, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50838, MAGE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TD91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPCHWVLD ATFSDGSLGQ WVKNTCATYA LSPVVLPPQP QPRKKATDKD 
        60         70         80         90        100
YSAFHLGHLR EVRLFLRGGT SDQRMDSLVL CPTYFKLWRT LSGSPGLQLS 
       110        120        130        140        150
DLHFGSQPEG KFSLRRAVSV KQREEPQDWP LNEKRTLWKD SDLPTWRRGT 
       160        170        180        190        200
GYTLSLPAVS PGKRLWGEKA GSLPESEPLF TYTLDEKVDK LVQFLLLKYQ 
       210        220        230        240        250
AKEPLTRAEM QMNVINTYTG YFPMIFRKAR EFIEILFGIS LTEVDPDHFY 
       260        270        280        290        300
VFVNTLDLTC EGSLSDEQGM PQNRLLILIL SVIFIKGNCA SEEVIWEVLN 
       310        320        330        340        350
AIGPWSALAG FADVLSRLAL WESEGPEAFC EESGLRSAEG SVLDLANPQG 
       360        370        380        390        400
LAGHRQEDGR RGLTEASPQQ KKGGEDEDMP AAGMPPLPQS PPEIPPQGPP 
       410        420        430        440        450
KISPQGPPQS PPQSPLDSCS SPLLWTRLDE ESSSEEEDTA TWHALPESES 
       460        470        480        490        500
LPRYALDEKV AELVQFLLLK YQTKEPVTKA EMLTTVIKKY KDYFPMIFGK 
       510        520        530        540        550
AHEFIELIFG IALTDMDPDN HSYFFEDTLD LTYEGSLIDD QGMPKNCLLI 
       560        570        580        590        600
LILSMIFIKG SCVPEEVIWE VLSAIGPIQR PAREVLEFLS KLSSIIPSAF 
       610        620        630        640 
PSWYMDALKD MEDRAQAIID TTDDATAMAS ASPSVMSTNF CPE
Length:643
Mass (Da):71,909
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EB342288B3FB8A6
GO
Isoform 2 (identifier: Q8TD91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MLLPCHWVLD...RGGTSDQRMD → MPLFPNLPRL...LPSTLILGVP
     77-374: Missing.
     577-643: PIQRPAREVL...SVMSTNFCPE → VCAGREHFIY...VFIQAIQYHP

Show »
Length:346
Mass (Da):38,906
Checksum:iDBE6CAEAB5623097
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3SYA6Q3SYA6_HUMAN
MAGEC3 protein
MAGEC3
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti362 – 374GLTEA…QKKGG → SSPLPSTLILGVP (PubMed:15489334).CuratedAdd BLAST13

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060069155S → P. Corresponds to variant dbSNP:rs11095909Ensembl.1
Natural variantiVAR_053505165L → M. Corresponds to variant dbSNP:rs11095910Ensembl.1
Natural variantiVAR_053506307A → T. Corresponds to variant dbSNP:rs176024Ensembl.1
Natural variantiVAR_053507328A → T. Corresponds to variant dbSNP:rs176026Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0434891 – 76MLLPC…DQRMD → MPLFPNLPRLSFEEDFQNPS VTEDLVDAQDSIDEEEEDAS STSSSSFHFLFPSSSSLSSS SPLSSPLPSTLILGVP in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_04349077 – 374Missing in isoform 2. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_043491577 – 643PIQRP…NFCPE → VCAGREHFIYGDPRKLLTIH WVQRKYLEYREVPNSAPPRY EFLWGPRAHSEASKRSLRVF IQAIQYHP in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF490508 mRNA Translation: AAM08355.1
AL022152 Genomic DNA No translation available.
AL023279 Genomic DNA No translation available.
AL049177 Genomic DNA No translation available.
BC103893 mRNA Translation: AAI03894.1
AF333706 Genomic DNA Translation: AAK00358.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14676.1 [Q8TD91-1]
CCDS14677.1 [Q8TD91-2]

NCBI Reference Sequences

More...RefSeqi		NP_619647.1, NM_138702.1 [Q8TD91-1]
NP_803251.1, NM_177456.2 [Q8TD91-2]
XP_011529569.1, XM_011531267.2 [Q8TD91-2]
XP_016884754.1, XM_017029265.1 [Q8TD91-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000298296; ENSP00000298296; ENSG00000165509 [Q8TD91-1]
ENST00000409007; ENSP00000386566; ENSG00000165509 [Q8TD91-2]
ENST00000544766; ENSP00000440444; ENSG00000165509 [Q8TD91-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		139081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:139081

UCSC genome browser

More...UCSCi		uc004fbs.3, human [Q8TD91-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490508 mRNA Translation: AAM08355.1
AL022152 Genomic DNA No translation available.
AL023279 Genomic DNA No translation available.
AL049177 Genomic DNA No translation available.
BC103893 mRNA Translation: AAI03894.1
AF333706 Genomic DNA Translation: AAK00358.1
CCDSiCCDS14676.1 [Q8TD91-1]
CCDS14677.1 [Q8TD91-2]
RefSeqiNP_619647.1, NM_138702.1 [Q8TD91-1]
NP_803251.1, NM_177456.2 [Q8TD91-2]
XP_011529569.1, XM_011531267.2 [Q8TD91-2]
XP_016884754.1, XM_017029265.1 [Q8TD91-2]

3D structure databases

SMRiQ8TD91
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126542, 6 interactors
IntActiQ8TD91, 14 interactors
STRINGi9606.ENSP00000298296

PTM databases

iPTMnetiQ8TD91
PhosphoSitePlusiQ8TD91

Genetic variation databases

BioMutaiMAGEC3
DMDMi41017367

Proteomic databases

PaxDbiQ8TD91
PeptideAtlasiQ8TD91
PRIDEiQ8TD91
ProteomicsDBi74252 [Q8TD91-1]
74253 [Q8TD91-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45024, 67 antibodies

Genome annotation databases

EnsembliENST00000298296; ENSP00000298296; ENSG00000165509 [Q8TD91-1]
ENST00000409007; ENSP00000386566; ENSG00000165509 [Q8TD91-2]
ENST00000544766; ENSP00000440444; ENSG00000165509 [Q8TD91-2]
GeneIDi139081
KEGGihsa:139081
UCSCiuc004fbs.3, human [Q8TD91-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		139081
DisGeNETi139081

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAGEC3
HGNCiHGNC:23798, MAGEC3
HPAiENSG00000165509, Tissue enhanced (brain, epididymis, testis)
MIMi300469, gene
neXtProtiNX_Q8TD91
OpenTargetsiENSG00000165509
PharmGKBiPA134916199
VEuPathDBiHostDB:ENSG00000165509.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4562, Eukaryota
GeneTreeiENSGT00940000164981
HOGENOMiCLU_508623_0_0_1
InParanoidiQ8TD91
OMAiLLTIHWV
OrthoDBi1195799at2759
PhylomeDBiQ8TD91
TreeFamiTF328505

Enzyme and pathway databases

PathwayCommonsiQ8TD91

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		139081, 5 hits in 613 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAGEC3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		139081
PharosiQ8TD91, Tdark

Protein Ontology

More...PROi		PR:Q8TD91
RNActiQ8TD91, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165509, Expressed in C1 segment of cervical spinal cord and 85 other tissues
ExpressionAtlasiQ8TD91, baseline and differential
GenevisibleiQ8TD91, HS

Family and domain databases

Gene3Di1.10.10.1200, 2 hits
1.10.10.1210, 2 hits
InterProiView protein in InterPro
IPR037445, MAGE
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR002190, MHD_dom
PANTHERiPTHR11736, PTHR11736, 2 hits
SMARTiView protein in SMART
SM01373, MAGE, 2 hits
PROSITEiView protein in PROSITE
PS50838, MAGE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGC3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD91
Secondary accession number(s): Q3SYA7, Q5JZ43, Q9BZ80
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2002
Last modified: April 7, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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