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UniProtKB - Q8TD84 (DSCL1_HUMAN)

Protein

Down syndrome cell adhesion molecule-like protein 1

Gene

DSCAML1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cell-cell adhesion mediator activity Source: GO_Central
  • protein homodimerization activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-376172 DSCAM interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Down syndrome cell adhesion molecule-like protein 1
Alternative name(s):
Down syndrome cell adhesion molecule 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSCAML1
Synonyms:DSCAM2, KIAA11321 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000177103.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:14656 DSCAML1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611782 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TD84

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 1591ExtracellularSequence analysisAdd BLAST1573
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1592 – 1612HelicalSequence analysisAdd BLAST21
Topological domaini1613 – 2053CytoplasmicSequence analysisAdd BLAST441

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57453

Open Targets

More...OpenTargetsi		ENSG00000177103

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38384

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DSCAML1

Domain mapping of disease mutations (DMDM)

More...DMDMi		73620825

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001474819 – 2053Down syndrome cell adhesion molecule-like protein 1Add BLAST2035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 103PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 198PROSITE-ProRule annotation
Disulfide bondi247 ↔ 294PROSITE-ProRule annotation
Disulfide bondi336 ↔ 386PROSITE-ProRule annotation
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi429 ↔ 485PROSITE-ProRule annotation
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi526 ↔ 575PROSITE-ProRule annotation
Glycosylationi556N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi617 ↔ 669PROSITE-ProRule annotation
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi710N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi711 ↔ 767PROSITE-ProRule annotation
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi809N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi810 ↔ 867PROSITE-ProRule annotation
Glycosylationi926N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1082N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1275N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1311 ↔ 1363PROSITE-ProRule annotation
Glycosylationi1345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1492N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1531N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1561N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TD84

PeptideAtlas

More...PeptideAtlasi		Q8TD84

PRoteomics IDEntifications database

More...PRIDEi		Q8TD84

ProteomicsDB human proteome resource

More...ProteomicsDBi		74248
74249 [Q8TD84-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TD84

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TD84

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, liver, pancreas, skeletal muscle, kidney and in brain, in particular in the amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, thalamus and subthalamus.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177103 Expressed in 120 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

More...CleanExi		HS_DSCAML1

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TD84 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TD84 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA035230

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		121525, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q8TD84, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315465

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12053
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8TD84

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TD84

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8TD84

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 119Ig-like C2-type 1Add BLAST101
Domaini115 – 217Ig-like C2-type 2Add BLAST103
Domaini226 – 306Ig-like C2-type 3Add BLAST81
Domaini314 – 402Ig-like C2-type 4Add BLAST89
Domaini408 – 501Ig-like C2-type 5Add BLAST94
Domaini506 – 586Ig-like C2-type 6Add BLAST81
Domaini596 – 685Ig-like C2-type 7Add BLAST90
Domaini690 – 784Ig-like C2-type 8Add BLAST95
Domaini788 – 885Ig-like C2-type 9Add BLAST98
Domaini887 – 984Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini989 – 1088Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini1093 – 1189Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini1193 – 1288Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1278 – 1377Ig-like C2-type 10Add BLAST100
Domaini1383 – 1477Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95
Domaini1478 – 1578Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1956 – 2016Pro-richAdd BLAST61

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IQJM Eukaryota
ENOG410XQX7 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000112277

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051409

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TD84

KEGG Orthology (KO)

More...KOi		K06768

Database of Orthologous Groups

More...OrthoDBi		EOG091G005W

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TD84

TreeFam database of animal gene trees

More...TreeFami		TF316846

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 16 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033029 DSCAML1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

The PANTHER Classification System

More...PANTHERi		PTHR44107:SF3 PTHR44107:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TD84-1) [UniParc]FASTAAdd to basket
Also known as: 1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MWLVTFLLLL DSLHKARPED VGTSLYFVND SLQQVTFSSS VGVVVPCPAA 
        60         70         80         90        100
GSPSAALRWY LATGDDIYDV PHIRHVHANG TLQLYPFSPS AFNSFIHDND 
       110        120        130        140        150
YFCTAENAAG KIRSPNIRVK AVFREPYTVR VEDQRSMRGN VAVFKCLIPS 
       160        170        180        190        200
SVQEYVSVVS WEKDTVSIIP EHRFFITYHG GLYISDVQKE DALSTYRCIT 
       210        220        230        240        250
KHKYSGETRQ SNGARLSVTD PAESIPTILD GFHSQEVWAG HTVELPCTAS 
       260        270        280        290        300
GYPIPAIRWL KDGRPLPADS RWTKRITGLT ISDLRTEDSG TYICEVTNTF 
       310        320        330        340        350
GSAEATGILM VIDPLHVTLT PKKLKTGIGS TVILSCALTG SPEFTIRWYR 
       360        370        380        390        400
NTELVLPDEA ISIRGLSNET LLITSAQKSH SGAYQCFATR KAQTAQDFAI 
       410        420        430        440        450
IALEDGTPRI VSSFSEKVVN PGEQFSLMCA AKGAPPPTVT WALDDEPIVR 
       460        470        480        490        500
DGSHRTNQYT MSDGTTISHM NVTGPQIRDG GVYRCTARNL VGSAEYQARI 
       510        520        530        540        550
NVRGPPSIRA MRNITAVAGR DTLINCRVIG YPYYSIKWYK DALLLPDNHR 
       560        570        580        590        600
QVVFENGTLK LTDVQKGMDE GEYLCSVLIQ PQLSISQSVH VAVKVPPLIQ 
       610        620        630        640        650
PFEFPPASIG QLLYIPCVVS SGDMPIRITW RKDGQVIISG SGVTIESKEF 
       660        670        680        690        700
MSSLQISSVS LKHNGNYTCI ASNAAATVSR ERQLIVRVPP RFVVQPNNQD 
       710        720        730        740        750
GIYGKAGVLN CSVDGYPPPK VMWKHAKGSG NPQQYHPVPL TGRIQILPNS 
       760        770        780        790        800
SLLIRHVLEE DIGYYLCQAS NGVGTDISKS MFLTVKIPAM ITSHPNTTIA 
       810        820        830        840        850
IKGHAKELNC TARGERPIII RWEKGDTVID PDRVMRYAIA TKDNGDEVVS 
       860        870        880        890        900
TLKLKPADRG DSVFFSCHAI NSYGEDRGLI QLTVQEPPDP PELEIREVKA 
       910        920        930        940        950
RSMNLRWTQR FDGNSIITGF DIEYKNKSDS WDFKQSTRNI SPTINQANIV 
       960        970        980        990       1000
DLHPASVYSI RMYSFNKIGR SEPSKELTIS TEEAAPDGPP MDVTLQPVTS 
      1010       1020       1030       1040       1050
QSIQVTWKAP KKELQNGVIR GYQIGYRENS PGSNGQYSIV EMKATGDSEV 
      1060       1070       1080       1090       1100
YTLDNLKKFA QYGVVVQAFN RAGTGPSSSE INATTLEDVP SQPPENVRAL 
      1110       1120       1130       1140       1150
SITSDVAVIS WSEPPRSTLN GVLKGYRVIF WSLYVDGEWG EMQNITTTRE 
      1160       1170       1180       1190       1200
RVELRGMEKF TNYSVQVLAY TQAGDGVRSS VLYIQTKEDV PGPPAGIKAV 
      1210       1220       1230       1240       1250
PSSASSVVVS WLPPTKPNGV IRKYTIFCSS PGSGQPAPSE YETSPEQLFY 
      1260       1270       1280       1290       1300
RIAHLNRGQQ YLLWVAAVTS AGRGNSSEKV TIEPAGKAPA KIISFGGTVT 
      1310       1320       1330       1340       1350
TPWMKDVRLP CNSVGDPAPA VKWTKDSEDS AIPVSMDGHR LIHTNGTLLL 
      1360       1370       1380       1390       1400
RAVKAEDSGY YTCTATNTGG FDTIIVNLLV QVPPDQPRLT VSKTSASSIT 
      1410       1420       1430       1440       1450
LTWIPGDNGG SSIRGFVLQY SVDNSEEWKD VFISSSERSF KLDSLKCGTW 
      1460       1470       1480       1490       1500
YKVKLAAKNS VGSGRISEII EAKTHGREPS FSKDQHLFTH INSTHARLNL 
      1510       1520       1530       1540       1550
QGWNNGGCPI TAIVLEYRPK GTWAWQGLRA NSSGEVFLTE LREATWYELR 
      1560       1570       1580       1590       1600
MRACNSAGCG NETAQFATLD YDGSTIPPIK SAQGEGDDVK KLFTIGCPVI 
      1610       1620       1630       1640       1650
LATLGVALLF IVRKKRKEKR LKRLRDAKSL AEMLISKNNR SFDTPVKGPP 
      1660       1670       1680       1690       1700
QGPRLHIDIP RVQLLIEDKE GIKQLGDDKA TIPVTDAEFS QAVNPQSFCT 
      1710       1720       1730       1740       1750
GVSLHHPTLI QSTGPLIDMS DIRPGTNPVS RKNVKSAHST RNRYSSQWTL 
      1760       1770       1780       1790       1800
TKCQASTPAR TLTSDWRTVG SQHGVTVTES DSYSASLSQD TDKGRNSMVS 
      1810       1820       1830       1840       1850
TESASSTYEE LARAYEHAKL EEQLQHAKFE ITECFISDSS SDQMTTGTNE 
      1860       1870       1880       1890       1900
NADSMTSMST PSEPGICRFT ASPPKPQDAD RGKNVAVPIP HRANKSDYCN 
      1910       1920       1930       1940       1950
LPLYAKSEAF FRKADGREPC PVVPPREASI RNLARTYHTQ ARHLTLDPAS 
      1960       1970       1980       1990       2000
KSLGLPHPGA PAAASTATLP QRTLAMPAPP AGTAPPAPGP TPAEPPTAPS 
      2010       2020       2030       2040       2050
AAPPAPSTEP PRAGGPHTKM GGSRDSLLEM STSGVGRSQK QGAGAYSKSY 

TLV
Length:2,053
Mass (Da):224,463
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CC9644214FF19C4
GO
Isoform 2 (identifier: Q8TD84-2) [UniParc]FASTAAdd to basket
Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
     35-244: Missing.

Show »
Length:1,843
Mass (Da):201,110
Checksum:i45A615F6062CC1F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A384DVL8A0A384DVL8_HUMAN
Down syndrome cell adhesion molecul...
DSCAML1 hCG_1810968
2,113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP71E9PP71_HUMAN
Down syndrome cell adhesion molecul...
DSCAML1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM09558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAN32614 differs from that shown. Aberrant splice donor site.Curated
The sequence BAA86446 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4V → L in AAN32613 (Ref. 3) Curated1
Sequence conflicti4V → L in AAN32614 (Ref. 3) Curated1
Sequence conflicti150 – 152SSV → FLG in AAN32613 (Ref. 3) Curated3
Sequence conflicti172H → N in AAL57166 (PubMed:11453658).Curated1
Sequence conflicti172H → N in BAA86446 (PubMed:10574461).Curated1
Sequence conflicti250S → P in AAN32614 (Ref. 3) Curated1
Sequence conflicti469H → Y in AAN32613 (Ref. 3) Curated1
Sequence conflicti667Y → D in AAN32613 (Ref. 3) Curated1
Sequence conflicti667Y → D in AAN32614 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035512659V → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0355131702V → I in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01497835 – 244Missing in isoform 2. 1 PublicationAdd BLAST210

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF334384 mRNA Translation: AAL57166.1
AF491813 mRNA Translation: AAM09558.1 Different initiation.
AF304304 mRNA Translation: AAN32613.1
AF304305 mRNA Translation: AAN32614.1 Sequence problems.
AB032958 mRNA Translation: BAA86446.2 Different initiation.
AP000711 Genomic DNA No translation available.
AP000757 Genomic DNA No translation available.
AP001554 Genomic DNA No translation available.
AP002342 Genomic DNA No translation available.
KF511128 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67322.1

NCBI Reference Sequences

More...RefSeqi		NP_065744.2, NM_020693.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.659513

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000527706; ENSP00000434335; ENSG00000177103 [Q8TD84-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57453

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57453

UCSC genome browser

More...UCSCi		uc001prh.1 human [Q8TD84-1]
uc058hud.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334384 mRNA Translation: AAL57166.1
AF491813 mRNA Translation: AAM09558.1 Different initiation.
AF304304 mRNA Translation: AAN32613.1
AF304305 mRNA Translation: AAN32614.1 Sequence problems.
AB032958 mRNA Translation: BAA86446.2 Different initiation.
AP000711 Genomic DNA No translation available.
AP000757 Genomic DNA No translation available.
AP001554 Genomic DNA No translation available.
AP002342 Genomic DNA No translation available.
KF511128 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67322.1
RefSeqiNP_065744.2, NM_020693.3
UniGeneiHs.659513

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VA9NMR-A979-1087[»]
ProteinModelPortaliQ8TD84
SMRiQ8TD84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121525, 3 interactors
IntActiQ8TD84, 3 interactors
STRINGi9606.ENSP00000315465

PTM databases

iPTMnetiQ8TD84
PhosphoSitePlusiQ8TD84

Polymorphism and mutation databases

BioMutaiDSCAML1
DMDMi73620825

Proteomic databases

PaxDbiQ8TD84
PeptideAtlasiQ8TD84
PRIDEiQ8TD84
ProteomicsDBi74248
74249 [Q8TD84-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527706; ENSP00000434335; ENSG00000177103 [Q8TD84-2]
GeneIDi57453
KEGGihsa:57453
UCSCiuc001prh.1 human [Q8TD84-1]
uc058hud.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57453
DisGeNETi57453
EuPathDBiHostDB:ENSG00000177103.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		DSCAML1
HGNCiHGNC:14656 DSCAML1
HPAiHPA035230
MIMi611782 gene
neXtProtiNX_Q8TD84
OpenTargetsiENSG00000177103
PharmGKBiPA38384

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IQJM Eukaryota
ENOG410XQX7 LUCA
GeneTreeiENSGT00940000155354
HOGENOMiHOG000112277
HOVERGENiHBG051409
InParanoidiQ8TD84
KOiK06768
OrthoDBiEOG091G005W
PhylomeDBiQ8TD84
TreeFamiTF316846

Enzyme and pathway databases

ReactomeiR-HSA-376172 DSCAM interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DSCAML1 human
EvolutionaryTraceiQ8TD84

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57453

Protein Ontology

More...PROi		PR:Q8TD84

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000177103 Expressed in 120 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_DSCAML1
ExpressionAtlasiQ8TD84 baseline and differential
GenevisibleiQ8TD84 HS

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 16 hits
InterProiView protein in InterPro
IPR033029 DSCAML1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PANTHERiPTHR44107:SF3 PTHR44107:SF3, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSCL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD84
Secondary accession number(s): G3V1B5
, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: December 5, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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