UniProtKB - Q8TD84 (DSCL1_HUMAN)
Protein
Down syndrome cell adhesion molecule-like protein 1
Gene
DSCAML1
Organism
Homo sapiens (Human)
Status
Functioni
Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).By similarity1 Publication
GO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- axon guidance Source: GO_Central
- axonogenesis Source: UniProtKB
- brain development Source: UniProtKB
- cell fate determination Source: UniProtKB
- central nervous system development Source: UniProtKB
- dendrite self-avoidance Source: GO_Central
- dorsal/ventral pattern formation Source: UniProtKB
- embryonic skeletal system morphogenesis Source: UniProtKB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Keywordsi
Biological process | Cell adhesion, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q8TD84 |
Reactomei | R-HSA-376172, DSCAM interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Down syndrome cell adhesion molecule-like protein 1Alternative name(s): Down syndrome cell adhesion molecule 2 |
Gene namesi | Name:DSCAML1 Synonyms:DSCAM2, KIAA11321 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177103.13 |
HGNCi | HGNC:14656, DSCAML1 |
MIMi | 611782, gene |
neXtProti | NX_Q8TD84 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Other locations
- synapse By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- axon Source: GO_Central
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- synapse Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 1591 | ExtracellularSequence analysisAdd BLAST | 1573 | |
Transmembranei | 1592 – 1612 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1613 – 2053 | CytoplasmicSequence analysisAdd BLAST | 441 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 57453 |
OpenTargetsi | ENSG00000177103 |
PharmGKBi | PA38384 |
Miscellaneous databases
Pharosi | Q8TD84, Tbio |
Polymorphism and mutation databases
BioMutai | DSCAML1 |
DMDMi | 73620825 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000014748 | 19 – 2053 | Down syndrome cell adhesion molecule-like protein 1Add BLAST | 2035 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 47 ↔ 103 | PROSITE-ProRule annotation | ||
Glycosylationi | 79 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 146 ↔ 198 | PROSITE-ProRule annotation | ||
Disulfide bondi | 247 ↔ 294 | PROSITE-ProRule annotation | ||
Disulfide bondi | 336 ↔ 386 | PROSITE-ProRule annotation | ||
Glycosylationi | 368 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 429 ↔ 485 | PROSITE-ProRule annotation | ||
Glycosylationi | 471 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 513 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 526 ↔ 575 | PROSITE-ProRule annotation | ||
Glycosylationi | 556 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 617 ↔ 669 | PROSITE-ProRule annotation | ||
Glycosylationi | 666 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 710 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 711 ↔ 767 | PROSITE-ProRule annotation | ||
Glycosylationi | 749 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 796 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 809 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 810 ↔ 867 | PROSITE-ProRule annotation | ||
Glycosylationi | 926 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1082 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1144 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1162 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1275 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1311 ↔ 1363 | PROSITE-ProRule annotation | ||
Glycosylationi | 1345 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1492 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1531 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1561 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8TD84 |
PeptideAtlasi | Q8TD84 |
PRIDEi | Q8TD84 |
ProteomicsDBi | 32317 74248 [Q8TD84-1] 74249 [Q8TD84-2] |
PTM databases
GlyGeni | Q8TD84, 20 sites |
iPTMneti | Q8TD84 |
PhosphoSitePlusi | Q8TD84 |
Expressioni
Tissue specificityi
Detected in heart, liver, pancreas, skeletal muscle, kidney and in brain, in particular in the amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, thalamus and subthalamus.2 Publications
Gene expression databases
Bgeei | ENSG00000177103, Expressed in cortical plate and 141 other tissues |
ExpressionAtlasi | Q8TD84, baseline and differential |
Genevisiblei | Q8TD84, HS |
Organism-specific databases
HPAi | ENSG00000177103, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Homodimer; mediates homophilic interactions to promote cell adhesion.
By similarityGO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121525, 4 interactors |
IntActi | Q8TD84, 3 interactors |
STRINGi | 9606.ENSP00000315465 |
Miscellaneous databases
RNActi | Q8TD84, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8TD84 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TD84 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 119 | Ig-like C2-type 1Add BLAST | 101 | |
Domaini | 115 – 217 | Ig-like C2-type 2Add BLAST | 103 | |
Domaini | 226 – 306 | Ig-like C2-type 3Add BLAST | 81 | |
Domaini | 314 – 402 | Ig-like C2-type 4Add BLAST | 89 | |
Domaini | 408 – 501 | Ig-like C2-type 5Add BLAST | 94 | |
Domaini | 506 – 586 | Ig-like C2-type 6Add BLAST | 81 | |
Domaini | 596 – 685 | Ig-like C2-type 7Add BLAST | 90 | |
Domaini | 690 – 784 | Ig-like C2-type 8Add BLAST | 95 | |
Domaini | 788 – 885 | Ig-like C2-type 9Add BLAST | 98 | |
Domaini | 887 – 984 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 989 – 1088 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 1093 – 1189 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 1193 – 1288 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 1278 – 1377 | Ig-like C2-type 10Add BLAST | 100 | |
Domaini | 1383 – 1477 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 1478 – 1578 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 101 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1956 – 2016 | Pro-richAdd BLAST | 61 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3510, Eukaryota |
GeneTreei | ENSGT00940000155354 |
HOGENOMi | CLU_001038_0_1_1 |
InParanoidi | Q8TD84 |
OrthoDBi | 14047at2759 |
PhylomeDBi | Q8TD84 |
TreeFami | TF316846 |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 16 hits |
InterProi | View protein in InterPro IPR033029, DSCAML1 IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR13817:SF54, PTHR13817:SF54, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 5 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 10 hits SM00408, IGc2, 9 hits SM00406, IGv, 2 hits |
SUPFAMi | SSF48726, SSF48726, 10 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 10 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TD84-1) [UniParc]FASTAAdd to basket
Also known as: 1a
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWLVTFLLLL DSLHKARPED VGTSLYFVND SLQQVTFSSS VGVVVPCPAA
60 70 80 90 100
GSPSAALRWY LATGDDIYDV PHIRHVHANG TLQLYPFSPS AFNSFIHDND
110 120 130 140 150
YFCTAENAAG KIRSPNIRVK AVFREPYTVR VEDQRSMRGN VAVFKCLIPS
160 170 180 190 200
SVQEYVSVVS WEKDTVSIIP EHRFFITYHG GLYISDVQKE DALSTYRCIT
210 220 230 240 250
KHKYSGETRQ SNGARLSVTD PAESIPTILD GFHSQEVWAG HTVELPCTAS
260 270 280 290 300
GYPIPAIRWL KDGRPLPADS RWTKRITGLT ISDLRTEDSG TYICEVTNTF
310 320 330 340 350
GSAEATGILM VIDPLHVTLT PKKLKTGIGS TVILSCALTG SPEFTIRWYR
360 370 380 390 400
NTELVLPDEA ISIRGLSNET LLITSAQKSH SGAYQCFATR KAQTAQDFAI
410 420 430 440 450
IALEDGTPRI VSSFSEKVVN PGEQFSLMCA AKGAPPPTVT WALDDEPIVR
460 470 480 490 500
DGSHRTNQYT MSDGTTISHM NVTGPQIRDG GVYRCTARNL VGSAEYQARI
510 520 530 540 550
NVRGPPSIRA MRNITAVAGR DTLINCRVIG YPYYSIKWYK DALLLPDNHR
560 570 580 590 600
QVVFENGTLK LTDVQKGMDE GEYLCSVLIQ PQLSISQSVH VAVKVPPLIQ
610 620 630 640 650
PFEFPPASIG QLLYIPCVVS SGDMPIRITW RKDGQVIISG SGVTIESKEF
660 670 680 690 700
MSSLQISSVS LKHNGNYTCI ASNAAATVSR ERQLIVRVPP RFVVQPNNQD
710 720 730 740 750
GIYGKAGVLN CSVDGYPPPK VMWKHAKGSG NPQQYHPVPL TGRIQILPNS
760 770 780 790 800
SLLIRHVLEE DIGYYLCQAS NGVGTDISKS MFLTVKIPAM ITSHPNTTIA
810 820 830 840 850
IKGHAKELNC TARGERPIII RWEKGDTVID PDRVMRYAIA TKDNGDEVVS
860 870 880 890 900
TLKLKPADRG DSVFFSCHAI NSYGEDRGLI QLTVQEPPDP PELEIREVKA
910 920 930 940 950
RSMNLRWTQR FDGNSIITGF DIEYKNKSDS WDFKQSTRNI SPTINQANIV
960 970 980 990 1000
DLHPASVYSI RMYSFNKIGR SEPSKELTIS TEEAAPDGPP MDVTLQPVTS
1010 1020 1030 1040 1050
QSIQVTWKAP KKELQNGVIR GYQIGYRENS PGSNGQYSIV EMKATGDSEV
1060 1070 1080 1090 1100
YTLDNLKKFA QYGVVVQAFN RAGTGPSSSE INATTLEDVP SQPPENVRAL
1110 1120 1130 1140 1150
SITSDVAVIS WSEPPRSTLN GVLKGYRVIF WSLYVDGEWG EMQNITTTRE
1160 1170 1180 1190 1200
RVELRGMEKF TNYSVQVLAY TQAGDGVRSS VLYIQTKEDV PGPPAGIKAV
1210 1220 1230 1240 1250
PSSASSVVVS WLPPTKPNGV IRKYTIFCSS PGSGQPAPSE YETSPEQLFY
1260 1270 1280 1290 1300
RIAHLNRGQQ YLLWVAAVTS AGRGNSSEKV TIEPAGKAPA KIISFGGTVT
1310 1320 1330 1340 1350
TPWMKDVRLP CNSVGDPAPA VKWTKDSEDS AIPVSMDGHR LIHTNGTLLL
1360 1370 1380 1390 1400
RAVKAEDSGY YTCTATNTGG FDTIIVNLLV QVPPDQPRLT VSKTSASSIT
1410 1420 1430 1440 1450
LTWIPGDNGG SSIRGFVLQY SVDNSEEWKD VFISSSERSF KLDSLKCGTW
1460 1470 1480 1490 1500
YKVKLAAKNS VGSGRISEII EAKTHGREPS FSKDQHLFTH INSTHARLNL
1510 1520 1530 1540 1550
QGWNNGGCPI TAIVLEYRPK GTWAWQGLRA NSSGEVFLTE LREATWYELR
1560 1570 1580 1590 1600
MRACNSAGCG NETAQFATLD YDGSTIPPIK SAQGEGDDVK KLFTIGCPVI
1610 1620 1630 1640 1650
LATLGVALLF IVRKKRKEKR LKRLRDAKSL AEMLISKNNR SFDTPVKGPP
1660 1670 1680 1690 1700
QGPRLHIDIP RVQLLIEDKE GIKQLGDDKA TIPVTDAEFS QAVNPQSFCT
1710 1720 1730 1740 1750
GVSLHHPTLI QSTGPLIDMS DIRPGTNPVS RKNVKSAHST RNRYSSQWTL
1760 1770 1780 1790 1800
TKCQASTPAR TLTSDWRTVG SQHGVTVTES DSYSASLSQD TDKGRNSMVS
1810 1820 1830 1840 1850
TESASSTYEE LARAYEHAKL EEQLQHAKFE ITECFISDSS SDQMTTGTNE
1860 1870 1880 1890 1900
NADSMTSMST PSEPGICRFT ASPPKPQDAD RGKNVAVPIP HRANKSDYCN
1910 1920 1930 1940 1950
LPLYAKSEAF FRKADGREPC PVVPPREASI RNLARTYHTQ ARHLTLDPAS
1960 1970 1980 1990 2000
KSLGLPHPGA PAAASTATLP QRTLAMPAPP AGTAPPAPGP TPAEPPTAPS
2010 2020 2030 2040 2050
AAPPAPSTEP PRAGGPHTKM GGSRDSLLEM STSGVGRSQK QGAGAYSKSY
TLV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A384DVL8 | A0A384DVL8_HUMAN | Down syndrome cell adhesion molecul... | DSCAML1 hCG_1810968 | 2,113 | Annotation score: | ||
E9PP71 | E9PP71_HUMAN | Down syndrome cell adhesion molecul... | DSCAML1 | 66 | Annotation score: |
Sequence cautioni
The sequence AAM09558 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA86446 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | V → L in AAN32613 (Ref. 3) Curated | 1 | |
Sequence conflicti | 4 | V → L in AAN32614 (Ref. 3) Curated | 1 | |
Sequence conflicti | 150 – 152 | SSV → FLG in AAN32613 (Ref. 3) Curated | 3 | |
Sequence conflicti | 172 | H → N in AAL57166 (PubMed:11453658).Curated | 1 | |
Sequence conflicti | 172 | H → N in BAA86446 (PubMed:10574461).Curated | 1 | |
Sequence conflicti | 250 | S → P in AAN32614 (Ref. 3) Curated | 1 | |
Sequence conflicti | 469 | H → Y in AAN32613 (Ref. 3) Curated | 1 | |
Sequence conflicti | 667 | Y → D in AAN32613 (Ref. 3) Curated | 1 | |
Sequence conflicti | 667 | Y → D in AAN32614 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035512 | 659 | V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs533175875Ensembl. | 1 | |
Natural variantiVAR_035513 | 1702 | V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs147907435Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014978 | 35 – 244 | Missing in isoform 2. 1 PublicationAdd BLAST | 210 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF334384 mRNA Translation: AAL57166.1 AF491813 mRNA Translation: AAM09558.1 Different initiation. AF304304 mRNA Translation: AAN32613.1 AF304305 mRNA Translation: AAN32614.1 Sequence problems. AB032958 mRNA Translation: BAA86446.2 Different initiation. AP000711 Genomic DNA No translation available. AP000757 Genomic DNA No translation available. AP001554 Genomic DNA No translation available. AP002342 Genomic DNA No translation available. KF511128 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67322.1 |
CCDSi | CCDS8384.1 [Q8TD84-1] |
RefSeqi | NP_065744.2, NM_020693.3 [Q8TD84-1] |
Genome annotation databases
Ensembli | ENST00000527706; ENSP00000434335; ENSG00000177103 [Q8TD84-2] ENST00000651296; ENSP00000498769; ENSG00000177103 [Q8TD84-1] |
GeneIDi | 57453 |
KEGGi | hsa:57453 |
UCSCi | uc001prh.1, human [Q8TD84-1] uc058hud.1, human |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF334384 mRNA Translation: AAL57166.1 AF491813 mRNA Translation: AAM09558.1 Different initiation. AF304304 mRNA Translation: AAN32613.1 AF304305 mRNA Translation: AAN32614.1 Sequence problems. AB032958 mRNA Translation: BAA86446.2 Different initiation. AP000711 Genomic DNA No translation available. AP000757 Genomic DNA No translation available. AP001554 Genomic DNA No translation available. AP002342 Genomic DNA No translation available. KF511128 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67322.1 |
CCDSi | CCDS8384.1 [Q8TD84-1] |
RefSeqi | NP_065744.2, NM_020693.3 [Q8TD84-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VA9 | NMR | - | A | 979-1087 | [»] | |
SMRi | Q8TD84 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121525, 4 interactors |
IntActi | Q8TD84, 3 interactors |
STRINGi | 9606.ENSP00000315465 |
PTM databases
GlyGeni | Q8TD84, 20 sites |
iPTMneti | Q8TD84 |
PhosphoSitePlusi | Q8TD84 |
Polymorphism and mutation databases
BioMutai | DSCAML1 |
DMDMi | 73620825 |
Proteomic databases
PaxDbi | Q8TD84 |
PeptideAtlasi | Q8TD84 |
PRIDEi | Q8TD84 |
ProteomicsDBi | 32317 74248 [Q8TD84-1] 74249 [Q8TD84-2] |
Protocols and materials databases
Antibodypediai | 62371, 22 antibodies |
Genome annotation databases
Ensembli | ENST00000527706; ENSP00000434335; ENSG00000177103 [Q8TD84-2] ENST00000651296; ENSP00000498769; ENSG00000177103 [Q8TD84-1] |
GeneIDi | 57453 |
KEGGi | hsa:57453 |
UCSCi | uc001prh.1, human [Q8TD84-1] uc058hud.1, human |
Organism-specific databases
CTDi | 57453 |
DisGeNETi | 57453 |
EuPathDBi | HostDB:ENSG00000177103.13 |
GeneCardsi | DSCAML1 |
HGNCi | HGNC:14656, DSCAML1 |
HPAi | ENSG00000177103, Tissue enhanced (brain) |
MIMi | 611782, gene |
neXtProti | NX_Q8TD84 |
OpenTargetsi | ENSG00000177103 |
PharmGKBi | PA38384 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3510, Eukaryota |
GeneTreei | ENSGT00940000155354 |
HOGENOMi | CLU_001038_0_1_1 |
InParanoidi | Q8TD84 |
OrthoDBi | 14047at2759 |
PhylomeDBi | Q8TD84 |
TreeFami | TF316846 |
Enzyme and pathway databases
PathwayCommonsi | Q8TD84 |
Reactomei | R-HSA-376172, DSCAM interactions |
Miscellaneous databases
BioGRID-ORCSi | 57453, 3 hits in 845 CRISPR screens |
ChiTaRSi | DSCAML1, human |
EvolutionaryTracei | Q8TD84 |
GenomeRNAii | 57453 |
Pharosi | Q8TD84, Tbio |
PROi | PR:Q8TD84 |
RNActi | Q8TD84, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177103, Expressed in cortical plate and 141 other tissues |
ExpressionAtlasi | Q8TD84, baseline and differential |
Genevisiblei | Q8TD84, HS |
Family and domain databases
CDDi | cd00063, FN3, 6 hits |
Gene3Di | 2.60.40.10, 16 hits |
InterProi | View protein in InterPro IPR033029, DSCAML1 IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR13817:SF54, PTHR13817:SF54, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 5 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 6 hits SM00409, IG, 10 hits SM00408, IGc2, 9 hits SM00406, IGv, 2 hits |
SUPFAMi | SSF48726, SSF48726, 10 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 6 hits PS50835, IG_LIKE, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DSCL1_HUMAN | |
Accessioni | Q8TD84Primary (citable) accession number: Q8TD84 Secondary accession number(s): G3V1B5 Q9ULT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | August 16, 2005 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations