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UniProtKB - Q8TD57 (DYH3_HUMAN)

Entry version 147 (23 Feb 2022)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
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Protein

Dynein axonemal heavy chain 3

Gene

DNAH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1429 – 1436ATPSequence analysis8
Nucleotide bindingi1710 – 1717ATPSequence analysis8
Nucleotide bindingi2074 – 2081ATPSequence analysis8
Nucleotide bindingi2434 – 2441ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TD57

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8TD57

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein axonemal heavy chain 3
Alternative name(s):
Axonemal beta dynein heavy chain 3
Short name:
HsADHC3
Ciliary dynein heavy chain 3
Dnahc3-b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH3
Synonyms:DNAHC3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2949, DNAH3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603334, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TD57

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000158486

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55567

Open Targets

More...OpenTargetsi		ENSG00000158486

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27402

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TD57, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNAH3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762616

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003225441 – 4116Dynein axonemal heavy chain 3Add BLAST4116

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TD57

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TD57

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TD57

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TD57

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TD57

PeptideAtlas

More...PeptideAtlasi		Q8TD57

PRoteomics IDEntifications database

More...PRIDEi		Q8TD57

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74244 [Q8TD57-1]
74245 [Q8TD57-2]
74246 [Q8TD57-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q8TD57

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TD57, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TD57

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TD57

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000158486, Expressed in epithelium of bronchus and 135 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TD57, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000158486, Tissue enhanced (brain, fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120722, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q8TD57, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261383

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TD57, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TD57

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1390StemBy similarityAdd BLAST1390
Regioni1 – 68DisorderedSequence analysisAdd BLAST68
Regioni137 – 172DisorderedSequence analysisAdd BLAST36
Regioni1391 – 1612AAA 1By similarityAdd BLAST222
Regioni1672 – 1903AAA 2By similarityAdd BLAST232
Regioni2036 – 2284AAA 3By similarityAdd BLAST249
Regioni2395 – 2646AAA 4By similarityAdd BLAST252
Regioni2661 – 2960StalkBy similarityAdd BLAST300
Regioni3045 – 3275AAA 5By similarityAdd BLAST231
Regioni3488 – 3712AAA 6By similarityAdd BLAST225

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili785 – 852Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 41Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi137 – 155Polar residuesSequence analysisAdd BLAST19
Compositional biasi156 – 172Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3595, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154959

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000038_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TD57

Identification of Orthologs from Complete Genome Data

More...OMAi		FFQSCAK

Database of Orthologous Groups

More...OrthoDBi		2079at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TD57

TreeFam database of animal gene trees

More...TreeFami		TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
3.40.50.300, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_linker
IPR042228, Dynein_linker_3
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR10676, PTHR10676, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TD57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGATGRLELT LAAPPHPGPA FQRSKARETQ GEEEGSEMQI AKSDSIHHMS 
        60         70         80         90        100
HSQGQPELPP LPASANEEPS GLYQTVMSHS FYPPLMQRTS WTLAAPFKEQ 
       110        120        130        140        150
HHHRGPSDSI ANNYSLMAQD LKLKDLLKVY QPATISVPRD RTGQGLPSSG 
       160        170        180        190        200
NRSSSEPMRK KTKFSSRNKE DSTRIKLAFK TSIFSPMKKE VKTSLTFPGS 
       210        220        230        240        250
RPMSPEQQLD VMLQQEMEME SKEKKPSESD LERYYYYLTN GIRKDMIAPE 
       260        270        280        290        300
EGEVMVRISK LISNTLLTSP FLEPLMVVLV QEKENDYYCS LMKSIVDYIL 
       310        320        330        340        350
MDPMERKRLF IESIPRLFPQ RVIRAPVPWH SVYRSAKKWN EEHLHTVNPM 
       360        370        380        390        400
MLRLKELWFA EFRDLRFVRT AEILAGKLPL QPQEFWDVIQ KHCLEAHQTL 
       410        420        430        440        450
LNKWIPTCAQ LFTSRKEHWI HFAPKSNYDS SRNIEEYFAS VASFMSLQLR 
       460        470        480        490        500
ELVIKSLEDL VSLFMIHKDG NDFKEPYQEM KFFIPQLIMI KLEVSEPIIV 
       510        520        530        540        550
FNPSFDGCWE LIRDSFLEII KNSNGIPKLK YIPLKFSFTA AAADRQCVKA 
       560        570        580        590        600
AEPGEPSMHA AATAMAELKG YNLLLGTVNA EEKLVSDFLI QTFKVFQKNQ 
       610        620        630        640        650
VGPCKYLNVY KKYVDLLDNT AEQNIAAFLK ENHDIDDFVT KINAIKKRRN 
       660        670        680        690        700
EIASMNITVP LAMFCLDATA LNHDLCERAQ NLKDHLIQFQ VDVNRDTNTS 
       710        720        730        740        750
ICNQYSHIAD KVSEVPANTK ELVSLIEFLK KSSAVTVFKL RRQLRDASER 
       760        770        780        790        800
LEFLMDYADL PYQIEDIFDN SRNLLLHKRD QAEMDLIKRC SEFELRLEGY 
       810        820        830        840        850
HRELESFRKR EVMTTEEMKH NVEKLNELSK NLNRAFAEFE LINKEEELLE 
       860        870        880        890        900
KEKSTYPLLQ AMLKNKVPYE QLWSTAYEFS IKSEEWMNGP LFLLNAEQIA 
       910        920        930        940        950
EEIGNMWRTT YKLIKTLSDV PAPRRLAENV KIKIDKFKQY IPILSISCNP 
       960        970        980        990       1000
GMKDRHWQQI SEIVGYEIKP TETTCLSNML EFGFGKFVEK LEPIGAAASK 
      1010       1020       1030       1040       1050
EYSLEKNLDR MKLDWVNVTF SFVKYRDTDT NILCAIDDIQ MLLDDHVIKT 
      1060       1070       1080       1090       1100
QTMCGSPFIK PIEAECRKWE EKLIRIQDNL DAWLKCQATW LYLEPIFSSE 
      1110       1120       1130       1140       1150
DIIAQMPEEG RKFGIVDSYW KSLMSQAVKD NRILVAADQP RMAEKLQEAN 
      1160       1170       1180       1190       1200
FLLEDIQKGL NDYLEKKRLF FPRFFFLSND ELLEILSETK DPLRVQPHLK 
      1210       1220       1230       1240       1250
KCFEGIAKLE FTDNLEIVGM ISSEKETVPF IQKIYPANAK GMVEKWLQQV 
      1260       1270       1280       1290       1300
EQMMLASMRE VIGLGIEAYV KVPRNHWVLQ WPGQVVICVS SIFWTQEVSQ 
      1310       1320       1330       1340       1350
ALAENTLLDF LKKSNDQIAQ IVQLVRGKLS SGARLTLGAL TVIDVHARDV 
      1360       1370       1380       1390       1400
VAKLSEDRVS DLNDFQWISQ LRYYWVAKDV QVQIITTEAL YGYEYLGNSP 
      1410       1420       1430       1440       1450
RLVITPLTDR CYRTLMGALK LNLGGAPEGP AGTGKTETTK DLAKALAKQC 
      1460       1470       1480       1490       1500
VVFNCSDGLD YKAMGKFFKG LAQAGAWACF DEFNRIEVEV LSVVAQQILS 
      1510       1520       1530       1540       1550
IQQAIIRKLK TFIFEGTELS LNPTCAVFIT MNPGYAGRAE LPDNLKALFR 
      1560       1570       1580       1590       1600
TVAMMVPDYA LIGEISLYSM GFLDSRSLAQ KIVATYRLCS EQLSSQHHYD 
      1610       1620       1630       1640       1650
YGMRAVKSVL TAAGNLKLKY PEENESVLLL RALLDVNLAK FLAQDVPLFQ 
      1660       1670       1680       1690       1700
GIISDLFPGV VLPKPDYEVF LKVLNDNIKK MKLQPVPWFI GKIIQIYEMM 
      1710       1720       1730       1740       1750
LVRHGYMIVG DPMGGKTSAY KVLAAALGDL HAANQMEEFA VEYKIINPKA 
      1760       1770       1780       1790       1800
ITMGQLYGCF DQVSHEWMDG VLANAFREQA SSLSDDRKWI IFDGPVDAIW 
      1810       1820       1830       1840       1850
IENMNTVLDD NKKLCLMSGE IIQMNSKMSL IFEPADLEQA SPATVSRCGM 
      1860       1870       1880       1890       1900
IYMEPHQLGW KPLKDSYMDT LPSSLTKEHK ELVNDMFMWL VQPCLEFGRL 
      1910       1920       1930       1940       1950
HCKFVVQTSP IHLAFSMMRL YSSLLDEIRA VEEEEMELGE GLSSQQIFLW 
      1960       1970       1980       1990       2000
LQGLFLFSLV WTVAGTINAD SRKKFDVFFR NLIMGMDDNH PRPKSVKLTK 
      2010       2020       2030       2040       2050
NNIFPERGSI YDFYFIKQAS GHWETWTQYI TKEEEKVPAG AKVSELIIPT 
      2060       2070       2080       2090       2100
METARQSFFL KTYLDHEIPM LFVGPTGTGK SAITNNFLLH LPKNTYLPNC 
      2110       2120       2130       2140       2150
INFSARTSAN QTQDIIMSKL DRRRKGLFGP PIGKKAVVFV DDLNMPAKEV 
      2160       2170       2180       2190       2200
YGAQPPIELL RQWIDHGYWF DKKDTTRLDI VDMLLVTAMG PPGGGRNDIT 
      2210       2220       2230       2240       2250
GRFTRHLNII SINAFEDDIL TKIFSSIVDW HFGKGFDVMF LRYGKMLVQA 
      2260       2270       2280       2290       2300
TKTIYRDAVE NFLPTPSKSH YVFNLRDFSR VIQGVLLCPH THLQDVEKCI 
      2310       2320       2330       2340       2350
RLWIHEVYRV FYDRLIDKED RQVFFNMVKE TTSNCFKQTI EKVLIHLSPT 
      2360       2370       2380       2390       2400
GKIVDDNIRS LFFGDYFKPE SDQKIYDEIT DLKQLTVVME HYLEEFNNIS 
      2410       2420       2430       2440       2450
KAPMSLVMFR FAIEHISRIC RVLKQDKGHL LLVGIGGSGR QSAAKLSTFM 
      2460       2470       2480       2490       2500
NAYELYQIEI TKNYAGNDWR EDLKKIILQV GVATKSTVFL FADNQIKDES 
      2510       2520       2530       2540       2550
FVEDINMLLN TGDVPNIFPA DEKADIVEKM QTAARTQGEK VEVTPLSMYN 
      2560       2570       2580       2590       2600
FFIERVINKI SFSLAMSPIG DAFRNRLRMF PSLINCCTID WFQSWPTDAL 
      2610       2620       2630       2640       2650
ELVANKFLED VELDDNIRVE VVSMCKYFQE SVKKLSLDYY NKLRRHNYVT 
      2660       2670       2680       2690       2700
PTSYLELILT FKTLLNSKRQ EVAMMRNRYL TGLQKLDFAA SQVAVMQREL 
      2710       2720       2730       2740       2750
TALQPQLILT SEETAKMMVK IEAETREADG KKLLVQADEK EANVAAAIAQ 
      2760       2770       2780       2790       2800
GIKNECEGDL AEAMPALEAA LAALDTLNPA DISLVKSMQN PPGPVKLVME 
      2810       2820       2830       2840       2850
SICIMKGMKP ERKPDPSGSG KMIEDYWGVS KKILGDLKFL ESLKTYDKDN 
      2860       2870       2880       2890       2900
IPPLTMKRIR ERFINHPEFQ PAVIKNVSSA CEGLCKWVRA MEVYDRVAKV 
      2910       2920       2930       2940       2950
VAPKRERLRE AEGKLAAQMQ KLNQKRAELK LVVDRLQALN DDFEEMNTKK 
      2960       2970       2980       2990       3000
KDLEENIEIC SQKLVRAEKL ISGLGGEKDR WTEAARQLGI RYTNLTGDVL 
      3010       3020       3030       3040       3050
LSSGTVAYLG AFTVDYRVQC QNQWLAECKD KVIPGFSDFS LSHTLGDPIK 
      3060       3070       3080       3090       3100
IRAWQIAGLP VDSFSIDNGI IVSNSRRWAL MIDPHGQANK WIKNMEKANK 
      3110       3120       3130       3140       3150
LAVIKFSDSN YMRMLENALQ LGTPVLIENI GEELDASIEP ILLKATFKQQ 
      3160       3170       3180       3190       3200
GVEYMRLGEN IIEYSRDFKL YITTRLRNPH YLPEVAVKVC LLNFMITPLG 
      3210       3220       3230       3240       3250
LQDQLLGIVA AKEKPELEEK KNQLIVESAK NKKHLKEIED KILEVLSMSK 
      3260       3270       3280       3290       3300
GNILEDETAI KVLSSSKVLS EEISEKQKVA SMTETQIDET RMGYKPVAVH 
      3310       3320       3330       3340       3350
SATIFFCISD LANIEPMYQY SLTWFINLYM HSLTHSTKSE ELNLRIKYII 
      3360       3370       3380       3390       3400
DHFTLSIYNN VCRSLFEKDK LLFSLLLTIG IMKQKKEITE EVWYFLLTGG 
      3410       3420       3430       3440       3450
IALDNPYPNP APQWLSEKAW AEIVRASALP KLHGLMEHLE QNLGEWKLIY 
      3460       3470       3480       3490       3500
DSAWPHEEQL PGSWKFSQGL EKMVILRCLR PDKMVPAVRE FIAEHMGKLY 
      3510       3520       3530       3540       3550
IEAPTFDLQG SYNDSSCCAP LIFVLSPSAD PMAGLLKFAD DLGMGGTRTQ 
      3560       3570       3580       3590       3600
TISLGQGQGP IAAKMINNAI KDGTWVVLQN CHLAASWMPT LEKICEEVIV 
      3610       3620       3630       3640       3650
PESTNARFRL WLTSYPSEKF PVSILQNGIK MTNEPPKGLR ANLLRSYLND 
      3660       3670       3680       3690       3700
PISDPVFFQS CAKAVMWQKM LFGLCFFHAV VQERRNFGPL GWNIPYEFNE 
      3710       3720       3730       3740       3750
SDLRISMWQI QMFLNDYKEV PFDALTYLTG ECNYGGRVTD DKDRRLLLSL 
      3760       3770       3780       3790       3800
LSMFYCKEIE EDYYSLAPGD TYYIPPHGSY QSYIDYLRNL PITAHPEVFG 
      3810       3820       3830       3840       3850
LHENADITKD NQETNQLFEG VLLTLPRQSG GSGKSPQEVV EELAQDILSK 
      3860       3870       3880       3890       3900
LPRDFDLEEV MKLYPVVYEE SMNTVLRQEL IRFNRLTKVV RRSLINLGRA 
      3910       3920       3930       3940       3950
IKGQVLMSSE LEEVFNSMLV GKVPAMWAAK SYPSLKPLGG YVADLLARLT 
      3960       3970       3980       3990       4000
FFQEWIDKGP PVVFWISGFY FTQSFLTGVS QNYARKYTIP IDHIGFEFEV 
      4010       4020       4030       4040       4050
TPQETVMENN PEDGAYIKGL FLEGARWDRK TMQIGESLPK ILYDPLPIIW 
      4060       4070       4080       4090       4100
LKPGESAMFL HQDIYVCPVY KTSARRGTLS TTGHSTNYVL SIELPTDMPQ 
      4110 
KHWINRGVAS LCQLDN
Length:4,116
Mass (Da):470,771
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF387246540D9DF2
GO
Isoform 2 (identifier: Q8TD57-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQ → MGDMDCSSQK
     528-566: KLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMA → KVESVLFP
     762-762: Y → YEDIKLNSTLFLWPD
     790-799: CSEFELRLEG → YRESLGLSWK
     800-4116: Missing.

Show »
Length:753
Mass (Da):87,501
Checksum:i0BDED2AED898AD0C
GO
Isoform 3 (identifier: Q8TD57-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1883-1887: VNDMF → MKSGQ
     1888-4116: Missing.

Show »
Length:1,887
Mass (Da):216,078
Checksum:iDC3B4B00F469AD22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1393Y → F in CAA10558 (Ref. 4) Curated1
Sequence conflicti1441D → V in CAB06059 (PubMed:9373155).Curated1
Sequence conflicti1601 – 1604YGMR → FGLH in CAB06059 (PubMed:9373155).Curated4
Sequence conflicti3828Q → M in CAB46377 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039412484I → L in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_039413545R → W. Corresponds to variant dbSNP:rs16970910Ensembl.1
Natural variantiVAR_0394141565I → M. Corresponds to variant dbSNP:rs330150EnsemblClinVar.1
Natural variantiVAR_0394151583V → I. Corresponds to variant dbSNP:rs16970832Ensembl.1
Natural variantiVAR_0394161608S → F in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0394171752T → M. Corresponds to variant dbSNP:rs13332291Ensembl.1
Natural variantiVAR_0394182399I → N. Corresponds to variant dbSNP:rs34179606EnsemblClinVar.1
Natural variantiVAR_0394192804I → V. Corresponds to variant dbSNP:rs12929546Ensembl.1
Natural variantiVAR_0394202949K → T. Corresponds to variant dbSNP:rs33928718Ensembl.1
Natural variantiVAR_0394213457E → K. Corresponds to variant dbSNP:rs3743695Ensembl.1
Natural variantiVAR_0394223639L → I. Corresponds to variant dbSNP:rs34771199Ensembl.1
Natural variantiVAR_0394233645R → C. Corresponds to variant dbSNP:rs12924551Ensembl.1
Natural variantiVAR_0394243744R → W. Corresponds to variant dbSNP:rs2301620Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0319191 – 39MGATG…GSEMQ → MGDMDCSSQK in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_031920528 – 566KLKYI…ATAMA → KVESVLFP in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_031921762Y → YEDIKLNSTLFLWPD in isoform 2. 1 Publication1
Alternative sequenceiVSP_031922790 – 799CSEFELRLEG → YRESLGLSWK in isoform 2. 1 Publication10
Alternative sequenceiVSP_031923800 – 4116Missing in isoform 2. 1 PublicationAdd BLAST3317
Alternative sequenceiVSP_0319241883 – 1887VNDMF → MKSGQ in isoform 3. 1 Publication5
Alternative sequenceiVSP_0319251888 – 4116Missing in isoform 3. 1 PublicationAdd BLAST2229

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF494040 mRNA Translation: AAM12861.1
AK056509 mRNA Translation: BAE46616.1
CH471228 Genomic DNA Translation: EAW66851.1
AJ132085 mRNA Translation: CAA10558.1
AJ132092 Genomic DNA Translation: CAA10565.1
Z83805 mRNA Translation: CAB06059.1
U83574 Genomic DNA Translation: AAB82763.1
BC019878 mRNA Translation: AAH19878.1
AL096732 mRNA Translation: CAB46377.1
AC002394 Genomic DNA Translation: AAC05809.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10594.1 [Q8TD57-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T12545

NCBI Reference Sequences

More...RefSeqi		NP_001334815.1, NM_001347886.1
NP_060009.1, NM_017539.2 [Q8TD57-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261383; ENSP00000261383; ENSG00000158486

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55567

UCSC genome browser

More...UCSCi		uc010vbe.3, human [Q8TD57-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494040 mRNA Translation: AAM12861.1
AK056509 mRNA Translation: BAE46616.1
CH471228 Genomic DNA Translation: EAW66851.1
AJ132085 mRNA Translation: CAA10558.1
AJ132092 Genomic DNA Translation: CAA10565.1
Z83805 mRNA Translation: CAB06059.1
U83574 Genomic DNA Translation: AAB82763.1
BC019878 mRNA Translation: AAH19878.1
AL096732 mRNA Translation: CAB46377.1
AC002394 Genomic DNA Translation: AAC05809.1
CCDSiCCDS10594.1 [Q8TD57-1]
PIRiT12545
RefSeqiNP_001334815.1, NM_001347886.1
NP_060009.1, NM_017539.2 [Q8TD57-1]

3D structure databases

SMRiQ8TD57
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120722, 7 interactors
IntActiQ8TD57, 6 interactors
STRINGi9606.ENSP00000261383

PTM databases

CarbonylDBiQ8TD57
GlyGeniQ8TD57, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ8TD57
PhosphoSitePlusiQ8TD57

Genetic variation databases

BioMutaiDNAH3
DMDMi74762616

Proteomic databases

EPDiQ8TD57
jPOSTiQ8TD57
MassIVEiQ8TD57
MaxQBiQ8TD57
PaxDbiQ8TD57
PeptideAtlasiQ8TD57
PRIDEiQ8TD57
ProteomicsDBi74244 [Q8TD57-1]
74245 [Q8TD57-2]
74246 [Q8TD57-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		67049, 29 antibodies from 6 providers

The DNASU plasmid repository

More...DNASUi		55567

Genome annotation databases

EnsembliENST00000261383; ENSP00000261383; ENSG00000158486
GeneIDi55567
KEGGihsa:55567
UCSCiuc010vbe.3, human [Q8TD57-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55567
DisGeNETi55567

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNAH3
HGNCiHGNC:2949, DNAH3
HPAiENSG00000158486, Tissue enhanced (brain, fallopian tube, testis)
MIMi603334, gene
neXtProtiNX_Q8TD57
OpenTargetsiENSG00000158486
PharmGKBiPA27402
VEuPathDBiHostDB:ENSG00000158486

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000154959
HOGENOMiCLU_000038_0_1_1
InParanoidiQ8TD57
OMAiFFQSCAK
OrthoDBi2079at2759
PhylomeDBiQ8TD57
TreeFamiTF316836

Enzyme and pathway databases

PathwayCommonsiQ8TD57
SignaLinkiQ8TD57

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55567, 3 hits in 1033 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNAH3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55567
PharosiQ8TD57, Tdark

Protein Ontology

More...PROi		PR:Q8TD57
RNActiQ8TD57, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000158486, Expressed in epithelium of bronchus and 135 other tissues
GenevisibleiQ8TD57, HS

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
3.40.50.300, 5 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_linker
IPR042228, Dynein_linker_3
IPR027417, P-loop_NTPase
PANTHERiPTHR10676, PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD57
Secondary accession number(s): O00437
, O15437, O43326, Q3C0H2, Q8WUP9, Q9UEM3, Q9UEM5, Q9UG35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2002
Last modified: February 23, 2022
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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