UniProtKB - Q8TD57 (DYH3_HUMAN)
Dynein axonemal heavy chain 3
DNAH3
Functioni
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1429 – 1436 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 1710 – 1717 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 2074 – 2081 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 2434 – 2441 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
- microtubule motor activity Source: UniProtKB
- minus-end-directed microtubule motor activity Source: GO_Central
GO - Biological processi
- cilium-dependent cell motility Source: UniProtKB
- microtubule-based movement Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8TD57 |
SignaLinki | Q8TD57 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynein axonemal heavy chain 3Alternative name(s): Axonemal beta dynein heavy chain 3 Short name: HsADHC3 Ciliary dynein heavy chain 3 Dnahc3-b |
Gene namesi | Name:DNAH3 Synonyms:DNAHC3B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2949, DNAH3 |
MIMi | 603334, gene |
neXtProti | NX_Q8TD57 |
VEuPathDBi | HostDB:ENSG00000158486 |
Subcellular locationi
Cytoskeleton
- cilium axoneme Curated
Cytoskeleton
- axonemal dynein complex Source: UniProtKB
- dynein complex Source: GO_Central
- microtubule Source: UniProtKB-KW
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 55567 |
OpenTargetsi | ENSG00000158486 |
PharmGKBi | PA27402 |
Miscellaneous databases
Pharosi | Q8TD57, Tdark |
Genetic variation databases
BioMutai | DNAH3 |
DMDMi | 74762616 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000322544 | 1 – 4116 | Dynein axonemal heavy chain 3Add BLAST | 4116 |
Proteomic databases
EPDi | Q8TD57 |
jPOSTi | Q8TD57 |
MassIVEi | Q8TD57 |
MaxQBi | Q8TD57 |
PaxDbi | Q8TD57 |
PeptideAtlasi | Q8TD57 |
PRIDEi | Q8TD57 |
ProteomicsDBi | 74244 [Q8TD57-1] 74245 [Q8TD57-2] 74246 [Q8TD57-3] |
PTM databases
CarbonylDBi | Q8TD57 |
GlyGeni | Q8TD57, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8TD57 |
PhosphoSitePlusi | Q8TD57 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000158486, Expressed in epithelium of bronchus and 135 other tissues |
Genevisiblei | Q8TD57, HS |
Organism-specific databases
HPAi | ENSG00000158486, Tissue enhanced (brain, fallopian tube, testis) |
Interactioni
Subunit structurei
Consists of at least two heavy chains and a number of intermediate and light chains.
GO - Molecular functioni
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 120722, 7 interactors |
IntActi | Q8TD57, 6 interactors |
STRINGi | 9606.ENSP00000261383 |
Miscellaneous databases
RNActi | Q8TD57, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 1390 | StemBy similarityAdd BLAST | 1390 | |
Regioni | 1 – 68 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 137 – 172 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 1391 – 1612 | AAA 1By similarityAdd BLAST | 222 | |
Regioni | 1672 – 1903 | AAA 2By similarityAdd BLAST | 232 | |
Regioni | 2036 – 2284 | AAA 3By similarityAdd BLAST | 249 | |
Regioni | 2395 – 2646 | AAA 4By similarityAdd BLAST | 252 | |
Regioni | 2661 – 2960 | StalkBy similarityAdd BLAST | 300 | |
Regioni | 3045 – 3275 | AAA 5By similarityAdd BLAST | 231 | |
Regioni | 3488 – 3712 | AAA 6By similarityAdd BLAST | 225 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 785 – 852 | Sequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 26 – 41 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 137 – 155 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 156 – 172 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3595, Eukaryota |
GeneTreei | ENSGT00940000154959 |
HOGENOMi | CLU_000038_0_1_1 |
InParanoidi | Q8TD57 |
OMAi | FFQSCAK |
OrthoDBi | 2079at2759 |
PhylomeDBi | Q8TD57 |
TreeFami | TF316836 |
Family and domain databases
Gene3Di | 1.10.8.710, 1 hit 1.10.8.720, 1 hit 1.20.140.100, 1 hit 3.10.490.20, 1 hit 3.20.180.20, 1 hit 3.40.50.300, 5 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR035699, AAA_6 IPR035706, AAA_9 IPR041658, AAA_lid_11 IPR042219, AAA_lid_11_sf IPR026983, DHC_fam IPR041589, DNAH3_AAA_lid_1 IPR042222, Dynein_2_N IPR043157, Dynein_AAA1S IPR041466, Dynein_AAA5_ext IPR041228, Dynein_C IPR043160, Dynein_C_barrel IPR024743, Dynein_HC_stalk IPR024317, Dynein_heavy_chain_D4_dom IPR004273, Dynein_heavy_D6_P-loop IPR013602, Dynein_heavy_linker IPR042228, Dynein_linker_3 IPR027417, P-loop_NTPase |
PANTHERi | PTHR10676, PTHR10676, 1 hit |
Pfami | View protein in Pfam PF12774, AAA_6, 1 hit PF12780, AAA_8, 1 hit PF12781, AAA_9, 1 hit PF17857, AAA_lid_1, 1 hit PF18198, AAA_lid_11, 1 hit PF08393, DHC_N2, 1 hit PF17852, Dynein_AAA_lid, 1 hit PF18199, Dynein_C, 1 hit PF03028, Dynein_heavy, 1 hit PF12777, MT, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 4 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGATGRLELT LAAPPHPGPA FQRSKARETQ GEEEGSEMQI AKSDSIHHMS
60 70 80 90 100
HSQGQPELPP LPASANEEPS GLYQTVMSHS FYPPLMQRTS WTLAAPFKEQ
110 120 130 140 150
HHHRGPSDSI ANNYSLMAQD LKLKDLLKVY QPATISVPRD RTGQGLPSSG
160 170 180 190 200
NRSSSEPMRK KTKFSSRNKE DSTRIKLAFK TSIFSPMKKE VKTSLTFPGS
210 220 230 240 250
RPMSPEQQLD VMLQQEMEME SKEKKPSESD LERYYYYLTN GIRKDMIAPE
260 270 280 290 300
EGEVMVRISK LISNTLLTSP FLEPLMVVLV QEKENDYYCS LMKSIVDYIL
310 320 330 340 350
MDPMERKRLF IESIPRLFPQ RVIRAPVPWH SVYRSAKKWN EEHLHTVNPM
360 370 380 390 400
MLRLKELWFA EFRDLRFVRT AEILAGKLPL QPQEFWDVIQ KHCLEAHQTL
410 420 430 440 450
LNKWIPTCAQ LFTSRKEHWI HFAPKSNYDS SRNIEEYFAS VASFMSLQLR
460 470 480 490 500
ELVIKSLEDL VSLFMIHKDG NDFKEPYQEM KFFIPQLIMI KLEVSEPIIV
510 520 530 540 550
FNPSFDGCWE LIRDSFLEII KNSNGIPKLK YIPLKFSFTA AAADRQCVKA
560 570 580 590 600
AEPGEPSMHA AATAMAELKG YNLLLGTVNA EEKLVSDFLI QTFKVFQKNQ
610 620 630 640 650
VGPCKYLNVY KKYVDLLDNT AEQNIAAFLK ENHDIDDFVT KINAIKKRRN
660 670 680 690 700
EIASMNITVP LAMFCLDATA LNHDLCERAQ NLKDHLIQFQ VDVNRDTNTS
710 720 730 740 750
ICNQYSHIAD KVSEVPANTK ELVSLIEFLK KSSAVTVFKL RRQLRDASER
760 770 780 790 800
LEFLMDYADL PYQIEDIFDN SRNLLLHKRD QAEMDLIKRC SEFELRLEGY
810 820 830 840 850
HRELESFRKR EVMTTEEMKH NVEKLNELSK NLNRAFAEFE LINKEEELLE
860 870 880 890 900
KEKSTYPLLQ AMLKNKVPYE QLWSTAYEFS IKSEEWMNGP LFLLNAEQIA
910 920 930 940 950
EEIGNMWRTT YKLIKTLSDV PAPRRLAENV KIKIDKFKQY IPILSISCNP
960 970 980 990 1000
GMKDRHWQQI SEIVGYEIKP TETTCLSNML EFGFGKFVEK LEPIGAAASK
1010 1020 1030 1040 1050
EYSLEKNLDR MKLDWVNVTF SFVKYRDTDT NILCAIDDIQ MLLDDHVIKT
1060 1070 1080 1090 1100
QTMCGSPFIK PIEAECRKWE EKLIRIQDNL DAWLKCQATW LYLEPIFSSE
1110 1120 1130 1140 1150
DIIAQMPEEG RKFGIVDSYW KSLMSQAVKD NRILVAADQP RMAEKLQEAN
1160 1170 1180 1190 1200
FLLEDIQKGL NDYLEKKRLF FPRFFFLSND ELLEILSETK DPLRVQPHLK
1210 1220 1230 1240 1250
KCFEGIAKLE FTDNLEIVGM ISSEKETVPF IQKIYPANAK GMVEKWLQQV
1260 1270 1280 1290 1300
EQMMLASMRE VIGLGIEAYV KVPRNHWVLQ WPGQVVICVS SIFWTQEVSQ
1310 1320 1330 1340 1350
ALAENTLLDF LKKSNDQIAQ IVQLVRGKLS SGARLTLGAL TVIDVHARDV
1360 1370 1380 1390 1400
VAKLSEDRVS DLNDFQWISQ LRYYWVAKDV QVQIITTEAL YGYEYLGNSP
1410 1420 1430 1440 1450
RLVITPLTDR CYRTLMGALK LNLGGAPEGP AGTGKTETTK DLAKALAKQC
1460 1470 1480 1490 1500
VVFNCSDGLD YKAMGKFFKG LAQAGAWACF DEFNRIEVEV LSVVAQQILS
1510 1520 1530 1540 1550
IQQAIIRKLK TFIFEGTELS LNPTCAVFIT MNPGYAGRAE LPDNLKALFR
1560 1570 1580 1590 1600
TVAMMVPDYA LIGEISLYSM GFLDSRSLAQ KIVATYRLCS EQLSSQHHYD
1610 1620 1630 1640 1650
YGMRAVKSVL TAAGNLKLKY PEENESVLLL RALLDVNLAK FLAQDVPLFQ
1660 1670 1680 1690 1700
GIISDLFPGV VLPKPDYEVF LKVLNDNIKK MKLQPVPWFI GKIIQIYEMM
1710 1720 1730 1740 1750
LVRHGYMIVG DPMGGKTSAY KVLAAALGDL HAANQMEEFA VEYKIINPKA
1760 1770 1780 1790 1800
ITMGQLYGCF DQVSHEWMDG VLANAFREQA SSLSDDRKWI IFDGPVDAIW
1810 1820 1830 1840 1850
IENMNTVLDD NKKLCLMSGE IIQMNSKMSL IFEPADLEQA SPATVSRCGM
1860 1870 1880 1890 1900
IYMEPHQLGW KPLKDSYMDT LPSSLTKEHK ELVNDMFMWL VQPCLEFGRL
1910 1920 1930 1940 1950
HCKFVVQTSP IHLAFSMMRL YSSLLDEIRA VEEEEMELGE GLSSQQIFLW
1960 1970 1980 1990 2000
LQGLFLFSLV WTVAGTINAD SRKKFDVFFR NLIMGMDDNH PRPKSVKLTK
2010 2020 2030 2040 2050
NNIFPERGSI YDFYFIKQAS GHWETWTQYI TKEEEKVPAG AKVSELIIPT
2060 2070 2080 2090 2100
METARQSFFL KTYLDHEIPM LFVGPTGTGK SAITNNFLLH LPKNTYLPNC
2110 2120 2130 2140 2150
INFSARTSAN QTQDIIMSKL DRRRKGLFGP PIGKKAVVFV DDLNMPAKEV
2160 2170 2180 2190 2200
YGAQPPIELL RQWIDHGYWF DKKDTTRLDI VDMLLVTAMG PPGGGRNDIT
2210 2220 2230 2240 2250
GRFTRHLNII SINAFEDDIL TKIFSSIVDW HFGKGFDVMF LRYGKMLVQA
2260 2270 2280 2290 2300
TKTIYRDAVE NFLPTPSKSH YVFNLRDFSR VIQGVLLCPH THLQDVEKCI
2310 2320 2330 2340 2350
RLWIHEVYRV FYDRLIDKED RQVFFNMVKE TTSNCFKQTI EKVLIHLSPT
2360 2370 2380 2390 2400
GKIVDDNIRS LFFGDYFKPE SDQKIYDEIT DLKQLTVVME HYLEEFNNIS
2410 2420 2430 2440 2450
KAPMSLVMFR FAIEHISRIC RVLKQDKGHL LLVGIGGSGR QSAAKLSTFM
2460 2470 2480 2490 2500
NAYELYQIEI TKNYAGNDWR EDLKKIILQV GVATKSTVFL FADNQIKDES
2510 2520 2530 2540 2550
FVEDINMLLN TGDVPNIFPA DEKADIVEKM QTAARTQGEK VEVTPLSMYN
2560 2570 2580 2590 2600
FFIERVINKI SFSLAMSPIG DAFRNRLRMF PSLINCCTID WFQSWPTDAL
2610 2620 2630 2640 2650
ELVANKFLED VELDDNIRVE VVSMCKYFQE SVKKLSLDYY NKLRRHNYVT
2660 2670 2680 2690 2700
PTSYLELILT FKTLLNSKRQ EVAMMRNRYL TGLQKLDFAA SQVAVMQREL
2710 2720 2730 2740 2750
TALQPQLILT SEETAKMMVK IEAETREADG KKLLVQADEK EANVAAAIAQ
2760 2770 2780 2790 2800
GIKNECEGDL AEAMPALEAA LAALDTLNPA DISLVKSMQN PPGPVKLVME
2810 2820 2830 2840 2850
SICIMKGMKP ERKPDPSGSG KMIEDYWGVS KKILGDLKFL ESLKTYDKDN
2860 2870 2880 2890 2900
IPPLTMKRIR ERFINHPEFQ PAVIKNVSSA CEGLCKWVRA MEVYDRVAKV
2910 2920 2930 2940 2950
VAPKRERLRE AEGKLAAQMQ KLNQKRAELK LVVDRLQALN DDFEEMNTKK
2960 2970 2980 2990 3000
KDLEENIEIC SQKLVRAEKL ISGLGGEKDR WTEAARQLGI RYTNLTGDVL
3010 3020 3030 3040 3050
LSSGTVAYLG AFTVDYRVQC QNQWLAECKD KVIPGFSDFS LSHTLGDPIK
3060 3070 3080 3090 3100
IRAWQIAGLP VDSFSIDNGI IVSNSRRWAL MIDPHGQANK WIKNMEKANK
3110 3120 3130 3140 3150
LAVIKFSDSN YMRMLENALQ LGTPVLIENI GEELDASIEP ILLKATFKQQ
3160 3170 3180 3190 3200
GVEYMRLGEN IIEYSRDFKL YITTRLRNPH YLPEVAVKVC LLNFMITPLG
3210 3220 3230 3240 3250
LQDQLLGIVA AKEKPELEEK KNQLIVESAK NKKHLKEIED KILEVLSMSK
3260 3270 3280 3290 3300
GNILEDETAI KVLSSSKVLS EEISEKQKVA SMTETQIDET RMGYKPVAVH
3310 3320 3330 3340 3350
SATIFFCISD LANIEPMYQY SLTWFINLYM HSLTHSTKSE ELNLRIKYII
3360 3370 3380 3390 3400
DHFTLSIYNN VCRSLFEKDK LLFSLLLTIG IMKQKKEITE EVWYFLLTGG
3410 3420 3430 3440 3450
IALDNPYPNP APQWLSEKAW AEIVRASALP KLHGLMEHLE QNLGEWKLIY
3460 3470 3480 3490 3500
DSAWPHEEQL PGSWKFSQGL EKMVILRCLR PDKMVPAVRE FIAEHMGKLY
3510 3520 3530 3540 3550
IEAPTFDLQG SYNDSSCCAP LIFVLSPSAD PMAGLLKFAD DLGMGGTRTQ
3560 3570 3580 3590 3600
TISLGQGQGP IAAKMINNAI KDGTWVVLQN CHLAASWMPT LEKICEEVIV
3610 3620 3630 3640 3650
PESTNARFRL WLTSYPSEKF PVSILQNGIK MTNEPPKGLR ANLLRSYLND
3660 3670 3680 3690 3700
PISDPVFFQS CAKAVMWQKM LFGLCFFHAV VQERRNFGPL GWNIPYEFNE
3710 3720 3730 3740 3750
SDLRISMWQI QMFLNDYKEV PFDALTYLTG ECNYGGRVTD DKDRRLLLSL
3760 3770 3780 3790 3800
LSMFYCKEIE EDYYSLAPGD TYYIPPHGSY QSYIDYLRNL PITAHPEVFG
3810 3820 3830 3840 3850
LHENADITKD NQETNQLFEG VLLTLPRQSG GSGKSPQEVV EELAQDILSK
3860 3870 3880 3890 3900
LPRDFDLEEV MKLYPVVYEE SMNTVLRQEL IRFNRLTKVV RRSLINLGRA
3910 3920 3930 3940 3950
IKGQVLMSSE LEEVFNSMLV GKVPAMWAAK SYPSLKPLGG YVADLLARLT
3960 3970 3980 3990 4000
FFQEWIDKGP PVVFWISGFY FTQSFLTGVS QNYARKYTIP IDHIGFEFEV
4010 4020 4030 4040 4050
TPQETVMENN PEDGAYIKGL FLEGARWDRK TMQIGESLPK ILYDPLPIIW
4060 4070 4080 4090 4100
LKPGESAMFL HQDIYVCPVY KTSARRGTLS TTGHSTNYVL SIELPTDMPQ
4110
KHWINRGVAS LCQLDN
The sequence of this isoform differs from the canonical sequence as follows:
1-39: MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQ → MGDMDCSSQK
528-566: KLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMA → KVESVLFP
762-762: Y → YEDIKLNSTLFLWPD
790-799: CSEFELRLEG → YRESLGLSWK
800-4116: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1393 | Y → F in CAA10558 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1441 | D → V in CAB06059 (PubMed:9373155).Curated | 1 | |
Sequence conflicti | 1601 – 1604 | YGMR → FGLH in CAB06059 (PubMed:9373155).Curated | 4 | |
Sequence conflicti | 3828 | Q → M in CAB46377 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039412 | 484 | I → L in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_039413 | 545 | R → W. Corresponds to variant dbSNP:rs16970910Ensembl. | 1 | |
Natural variantiVAR_039414 | 1565 | I → M. Corresponds to variant dbSNP:rs330150EnsemblClinVar. | 1 | |
Natural variantiVAR_039415 | 1583 | V → I. Corresponds to variant dbSNP:rs16970832Ensembl. | 1 | |
Natural variantiVAR_039416 | 1608 | S → F in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_039417 | 1752 | T → M. Corresponds to variant dbSNP:rs13332291Ensembl. | 1 | |
Natural variantiVAR_039418 | 2399 | I → N. Corresponds to variant dbSNP:rs34179606EnsemblClinVar. | 1 | |
Natural variantiVAR_039419 | 2804 | I → V. Corresponds to variant dbSNP:rs12929546Ensembl. | 1 | |
Natural variantiVAR_039420 | 2949 | K → T. Corresponds to variant dbSNP:rs33928718Ensembl. | 1 | |
Natural variantiVAR_039421 | 3457 | E → K. Corresponds to variant dbSNP:rs3743695Ensembl. | 1 | |
Natural variantiVAR_039422 | 3639 | L → I. Corresponds to variant dbSNP:rs34771199Ensembl. | 1 | |
Natural variantiVAR_039423 | 3645 | R → C. Corresponds to variant dbSNP:rs12924551Ensembl. | 1 | |
Natural variantiVAR_039424 | 3744 | R → W. Corresponds to variant dbSNP:rs2301620Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031919 | 1 – 39 | MGATG…GSEMQ → MGDMDCSSQK in isoform 2. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_031920 | 528 – 566 | KLKYI…ATAMA → KVESVLFP in isoform 2. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_031921 | 762 | Y → YEDIKLNSTLFLWPD in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_031922 | 790 – 799 | CSEFELRLEG → YRESLGLSWK in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_031923 | 800 – 4116 | Missing in isoform 2. 1 PublicationAdd BLAST | 3317 | |
Alternative sequenceiVSP_031924 | 1883 – 1887 | VNDMF → MKSGQ in isoform 3. 1 Publication | 5 | |
Alternative sequenceiVSP_031925 | 1888 – 4116 | Missing in isoform 3. 1 PublicationAdd BLAST | 2229 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF494040 mRNA Translation: AAM12861.1 AK056509 mRNA Translation: BAE46616.1 CH471228 Genomic DNA Translation: EAW66851.1 AJ132085 mRNA Translation: CAA10558.1 AJ132092 Genomic DNA Translation: CAA10565.1 Z83805 mRNA Translation: CAB06059.1 U83574 Genomic DNA Translation: AAB82763.1 BC019878 mRNA Translation: AAH19878.1 AL096732 mRNA Translation: CAB46377.1 AC002394 Genomic DNA Translation: AAC05809.1 |
CCDSi | CCDS10594.1 [Q8TD57-1] |
PIRi | T12545 |
RefSeqi | NP_001334815.1, NM_001347886.1 NP_060009.1, NM_017539.2 [Q8TD57-1] |
Genome annotation databases
Ensembli | ENST00000261383; ENSP00000261383; ENSG00000158486 |
GeneIDi | 55567 |
KEGGi | hsa:55567 |
UCSCi | uc010vbe.3, human [Q8TD57-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF494040 mRNA Translation: AAM12861.1 AK056509 mRNA Translation: BAE46616.1 CH471228 Genomic DNA Translation: EAW66851.1 AJ132085 mRNA Translation: CAA10558.1 AJ132092 Genomic DNA Translation: CAA10565.1 Z83805 mRNA Translation: CAB06059.1 U83574 Genomic DNA Translation: AAB82763.1 BC019878 mRNA Translation: AAH19878.1 AL096732 mRNA Translation: CAB46377.1 AC002394 Genomic DNA Translation: AAC05809.1 |
CCDSi | CCDS10594.1 [Q8TD57-1] |
PIRi | T12545 |
RefSeqi | NP_001334815.1, NM_001347886.1 NP_060009.1, NM_017539.2 [Q8TD57-1] |
3D structure databases
SMRi | Q8TD57 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120722, 7 interactors |
IntActi | Q8TD57, 6 interactors |
STRINGi | 9606.ENSP00000261383 |
PTM databases
CarbonylDBi | Q8TD57 |
GlyGeni | Q8TD57, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8TD57 |
PhosphoSitePlusi | Q8TD57 |
Genetic variation databases
BioMutai | DNAH3 |
DMDMi | 74762616 |
Proteomic databases
EPDi | Q8TD57 |
jPOSTi | Q8TD57 |
MassIVEi | Q8TD57 |
MaxQBi | Q8TD57 |
PaxDbi | Q8TD57 |
PeptideAtlasi | Q8TD57 |
PRIDEi | Q8TD57 |
ProteomicsDBi | 74244 [Q8TD57-1] 74245 [Q8TD57-2] 74246 [Q8TD57-3] |
Protocols and materials databases
Antibodypediai | 67049, 29 antibodies from 6 providers |
DNASUi | 55567 |
Genome annotation databases
Ensembli | ENST00000261383; ENSP00000261383; ENSG00000158486 |
GeneIDi | 55567 |
KEGGi | hsa:55567 |
UCSCi | uc010vbe.3, human [Q8TD57-1] |
Organism-specific databases
CTDi | 55567 |
DisGeNETi | 55567 |
GeneCardsi | DNAH3 |
HGNCi | HGNC:2949, DNAH3 |
HPAi | ENSG00000158486, Tissue enhanced (brain, fallopian tube, testis) |
MIMi | 603334, gene |
neXtProti | NX_Q8TD57 |
OpenTargetsi | ENSG00000158486 |
PharmGKBi | PA27402 |
VEuPathDBi | HostDB:ENSG00000158486 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3595, Eukaryota |
GeneTreei | ENSGT00940000154959 |
HOGENOMi | CLU_000038_0_1_1 |
InParanoidi | Q8TD57 |
OMAi | FFQSCAK |
OrthoDBi | 2079at2759 |
PhylomeDBi | Q8TD57 |
TreeFami | TF316836 |
Enzyme and pathway databases
PathwayCommonsi | Q8TD57 |
SignaLinki | Q8TD57 |
Miscellaneous databases
BioGRID-ORCSi | 55567, 3 hits in 1033 CRISPR screens |
ChiTaRSi | DNAH3, human |
GenomeRNAii | 55567 |
Pharosi | Q8TD57, Tdark |
PROi | PR:Q8TD57 |
RNActi | Q8TD57, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158486, Expressed in epithelium of bronchus and 135 other tissues |
Genevisiblei | Q8TD57, HS |
Family and domain databases
Gene3Di | 1.10.8.710, 1 hit 1.10.8.720, 1 hit 1.20.140.100, 1 hit 3.10.490.20, 1 hit 3.20.180.20, 1 hit 3.40.50.300, 5 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR035699, AAA_6 IPR035706, AAA_9 IPR041658, AAA_lid_11 IPR042219, AAA_lid_11_sf IPR026983, DHC_fam IPR041589, DNAH3_AAA_lid_1 IPR042222, Dynein_2_N IPR043157, Dynein_AAA1S IPR041466, Dynein_AAA5_ext IPR041228, Dynein_C IPR043160, Dynein_C_barrel IPR024743, Dynein_HC_stalk IPR024317, Dynein_heavy_chain_D4_dom IPR004273, Dynein_heavy_D6_P-loop IPR013602, Dynein_heavy_linker IPR042228, Dynein_linker_3 IPR027417, P-loop_NTPase |
PANTHERi | PTHR10676, PTHR10676, 1 hit |
Pfami | View protein in Pfam PF12774, AAA_6, 1 hit PF12780, AAA_8, 1 hit PF12781, AAA_9, 1 hit PF17857, AAA_lid_1, 1 hit PF18198, AAA_lid_11, 1 hit PF08393, DHC_N2, 1 hit PF17852, Dynein_AAA_lid, 1 hit PF18199, Dynein_C, 1 hit PF03028, Dynein_heavy, 1 hit PF12777, MT, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DYH3_HUMAN | |
Accessioni | Q8TD57Primary (citable) accession number: Q8TD57 Secondary accession number(s): O00437 Q9UG35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families