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Entry version 132 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Pleckstrin homology domain-containing family O member 2

Gene

PLEKHO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TD55

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family O member 2
Short name:
PH domain-containing family O member 2
Alternative name(s):
Pleckstrin homology domain-containing family Q member 1
Short name:
PH domain-containing family Q member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHO2
Synonyms:PLEKHQ1
ORF Names:PP9099
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30026, PLEKHO2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TD55

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000241839.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000241839

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399756

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TD55, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLEKHO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74739384

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003094831 – 490Pleckstrin homology domain-containing family O member 2Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei164PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei232PhosphothreonineBy similarity1
Modified residuei235PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1
Modified residuei238PhosphoserineBy similarity1
Modified residuei273PhosphoserineCombined sources1
Modified residuei298PhosphothreonineBy similarity1
Modified residuei311PhosphothreonineCombined sources1
Modified residuei390PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TD55

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TD55

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TD55

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TD55

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TD55

PeptideAtlas

More...
PeptideAtlasi
Q8TD55

PRoteomics IDEntifications database

More...
PRIDEi
Q8TD55

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74242 [Q8TD55-1]
74243 [Q8TD55-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8TD55

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TD55

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TD55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000241839, Expressed in spleen and 204 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TD55, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000241839, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123215, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TD55, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326706

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TD55, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TD55

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 119PHPROSITE-ProRule annotationAdd BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni173 – 402DisorderedSequence analysisAdd BLAST230

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili439 – 481Sequence analysisAdd BLAST43

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVFF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026551_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TD55

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHWKDRY

Database of Orthologous Groups

More...
OrthoDBi
827145at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TD55

TreeFam database of animal gene trees

More...
TreeFami
TF333115

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR043448, PKHO1/2

The PANTHER Classification System

More...
PANTHERi
PTHR15871, PTHR15871, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TD55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEEGVKEAG EKPRGAQMVD KAGWIKKSSG GLLGFWKDRY LLLCQAQLLV
60 70 80 90 100
YENEDDQKCV ETVELGSYEK CQDLRALLKR KHRFILLRSP GNKVSDIKFQ
110 120 130 140 150
APTGEEKESW IKALNEGINR GKNKAFDEVK VDKSCALEHV TRDRVRGGQR
160 170 180 190 200
RRPPTRVHLK EVASAASDGL LRLDLDVPDS GPPVFAPSNH VSEAQPRETP
210 220 230 240 250
RPLMPPTKPF LAPETTSPGD RVETPVGERA PTPVSASSEV SPESQEDSET
260 270 280 290 300
PAEEDSGSEQ PPNSVLPDKL KVSWENPSPQ EAPAAESAEP SQAPCSETSE
310 320 330 340 350
AAPREGGKPP TPPPKILSEK LKASMGEMQA SGPPAPGTVQ VSVNGMDDSP
360 370 380 390 400
EPAKPSQAEG TPGTPPKDAT TSTALPPWDL PPQFHPRCSS LGDLLGEGPR
410 420 430 440 450
HPLQPRERLY RAQLEVKVAS EQTEKLLNKV LGSEPAPVSA ETLLSQAVEQ
460 470 480 490
LRQATQVLQE MRDLGELSQE APGLREKRKE LVTLYRRSAP
Length:490
Mass (Da):53,350
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02099F6ECAFA8BF3
GO
Isoform 2 (identifier: Q8TD55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-53: Missing.

Show »
Length:440
Mass (Da):47,785
Checksum:iB5E567A9A0F70E37
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL55880 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036964290P → S1 PublicationCorresponds to variant dbSNP:rs2010875Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0292124 – 53Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF494534 mRNA Translation: AAM18053.1
AC069368 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77697.1
CH471082 Genomic DNA Translation: EAW77699.1
BC008744 mRNA Translation: AAH08744.2
AF318373 mRNA Translation: AAL55880.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10196.1 [Q8TD55-1]
CCDS73739.1 [Q8TD55-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001181988.1, NM_001195059.1 [Q8TD55-2]
NP_079477.2, NM_025201.4 [Q8TD55-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323544; ENSP00000326706; ENSG00000241839 [Q8TD55-1]
ENST00000616065; ENSP00000483505; ENSG00000241839 [Q8TD55-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80301

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80301

UCSC genome browser

More...
UCSCi
uc002anv.4, human [Q8TD55-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494534 mRNA Translation: AAM18053.1
AC069368 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77697.1
CH471082 Genomic DNA Translation: EAW77699.1
BC008744 mRNA Translation: AAH08744.2
AF318373 mRNA Translation: AAL55880.1 Different initiation.
CCDSiCCDS10196.1 [Q8TD55-1]
CCDS73739.1 [Q8TD55-2]
RefSeqiNP_001181988.1, NM_001195059.1 [Q8TD55-2]
NP_079477.2, NM_025201.4 [Q8TD55-1]

3D structure databases

SMRiQ8TD55
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123215, 24 interactors
IntActiQ8TD55, 18 interactors
STRINGi9606.ENSP00000326706

PTM databases

CarbonylDBiQ8TD55
iPTMnetiQ8TD55
PhosphoSitePlusiQ8TD55

Genetic variation databases

BioMutaiPLEKHO2
DMDMi74739384

Proteomic databases

EPDiQ8TD55
jPOSTiQ8TD55
MassIVEiQ8TD55
MaxQBiQ8TD55
PaxDbiQ8TD55
PeptideAtlasiQ8TD55
PRIDEiQ8TD55
ProteomicsDBi74242 [Q8TD55-1]
74243 [Q8TD55-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34926, 105 antibodies

The DNASU plasmid repository

More...
DNASUi
80301

Genome annotation databases

EnsembliENST00000323544; ENSP00000326706; ENSG00000241839 [Q8TD55-1]
ENST00000616065; ENSP00000483505; ENSG00000241839 [Q8TD55-2]
GeneIDi80301
KEGGihsa:80301
UCSCiuc002anv.4, human [Q8TD55-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80301

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLEKHO2
HGNCiHGNC:30026, PLEKHO2
HPAiENSG00000241839, Tissue enhanced (lymphoid)
neXtProtiNX_Q8TD55
OpenTargetsiENSG00000241839
PharmGKBiPA162399756
VEuPathDBiHostDB:ENSG00000241839.9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QVFF, Eukaryota
GeneTreeiENSGT00530000063760
HOGENOMiCLU_026551_3_0_1
InParanoidiQ8TD55
OMAiGHWKDRY
OrthoDBi827145at2759
PhylomeDBiQ8TD55
TreeFamiTF333115

Enzyme and pathway databases

PathwayCommonsiQ8TD55
ReactomeiR-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80301, 6 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLEKHO2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80301
PharosiQ8TD55, Tdark

Protein Ontology

More...
PROi
PR:Q8TD55
RNActiQ8TD55, protein

Gene expression databases

BgeeiENSG00000241839, Expressed in spleen and 204 other tissues
GenevisibleiQ8TD55, HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR043448, PKHO1/2
PANTHERiPTHR15871, PTHR15871, 1 hit
PfamiView protein in Pfam
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHO2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD55
Secondary accession number(s): Q7L4H4, Q8WYS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: June 2, 2021
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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