CD200R1

Functionⁱ

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.1 Publication

GO - Biological processⁱ

regulation of immune response Source: Reactome
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell surface glycoprotein CD200 receptor 1 Alternative name(s): CD200 cell surface glycoprotein receptor Cell surface glycoprotein OX2 receptor 1
Gene namesⁱ	Name:CD200R1 Synonyms:CD200R, CRTR2, MOX2R, OX2R ORF Names:UNQ2522/PRO6015
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163606.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24235 CD200R1
MIMⁱ	607546 gene
neXtProtⁱ	NX_Q8TD46

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	29 – 243	ExtracellularSequence analysisAdd BLAST	215
Transmembraneⁱ	244 – 264	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	265 – 325	CytoplasmicSequence analysisAdd BLAST	61

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	131450
PharmGKBⁱ	PA134922446

Polymorphism and mutation databases

BioMutaⁱ	CD200R1
DMDMⁱ	26006823

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_0000015128	29 – 325	Cell surface glycoprotein CD200 receptor 1Add BLAST		297

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	37	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	46	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	60 ↔ 132	PROSITE-ProRule annotation
Disulfide bondⁱ	84 ↔ 100	PROSITE-ProRule annotation
Glycosylationⁱ	93	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	99	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	162	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	167 ↔ 216	PROSITE-ProRule annotation
Disulfide bondⁱ	186 ↔ 204	PROSITE-ProRule annotation
Glycosylationⁱ	195	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	210	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	224	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q8TD46
PRIDEⁱ	Q8TD46
ProteomicsDBⁱ	74236 74237 [Q8TD46-2] 74238 [Q8TD46-3] 74239 [Q8TD46-4]

PTM databases

iPTMnetⁱ	Q8TD46
PhosphoSitePlusⁱ	Q8TD46
SwissPalmⁱ	Q8TD46

Expressionⁱ

Tissue specificityⁱ

Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163606
CleanExⁱ	HS_CD200R1
ExpressionAtlasⁱ	Q8TD46 baseline and differential
Genevisibleⁱ	Q8TD46 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA068512

HPAⁱ

HPA068512

Interactionⁱ

Subunit structureⁱ

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.By similarity

(Microbial infection) Interacts with human herpesvirus 8/HHV-8 protein vOX2/K14.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CD200	P41217	2	EBI-4314412,EBI-3910563

With

Entry

#Exp.

IntAct

Notes

CD200

P41217

2

EBI-4314412,EBI-3910563

Protein-protein interaction databases

BioGridⁱ	126281, 8 interactors
IntActⁱ	Q8TD46, 7 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TD46
SMRⁱ	Q8TD46
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	53 – 139	Ig-like V-typeAdd BLAST		87
Domainⁱ	140 – 228	Ig-like C2-typeAdd BLAST		89

Sequence similaritiesⁱ

Belongs to the CD200R family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENⁱ	HBG108141
InParanoidⁱ	Q8TD46
KEGG Orthology (KO) More...KOⁱ	K21668
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IYA
PhylomeDBⁱ	Q8TD46
TreeFamⁱ	TF335960

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR013162 CD80_C2-set IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08205 C2-set_2, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8TD46-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCPWRTANL GLLLILTIFL VAASSSLCMD EKQITQNYSK VLAEVNTSWP 
        60         70         80         90        100
VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYRK ETNETKETNC 
       110        120        130        140        150
TDERITWVSR PDQNSDLQIR PVAITHDGYY RCIMVTPDGN FHRGYHLQVL 
       160        170        180        190        200
VTPEVTLFQN RNRTAVCKAV AGKPAAQISW IPEGDCATKQ EYWSNGTVTV 
       210        220        230        240        250
KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLYIPYIIL 
       260        270        280        290        300
TIIILTIVGF IWLLKVNGCR KYKLNKTEST PVVEEDEMQP YASYTEKNNP 
       310        320 
LYDTTNKVKA SEALQSEVDT DLHTL

Length:325

Mass (Da):36,620

Last modified:November 28, 2002 - v2

Checksum:ⁱDD3F4B1F62337BBD

GO

Isoform 2 (identifier: Q8TD46-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

« Hide

        10         20         30         40         50
MLCPWRTANL GLLLILTIFL VAEAEGAAQP NNSLMLQTSK ENHALASSSL 
        60         70         80         90        100
CMDEKQITQN YSKVLAEVNT SWPVKMATNA VLCCPPIALR NLIIITWEII 
       110        120        130        140        150
LRGQPSCTKA YRKETNETKE TNCTDERITW VSRPDQNSDL QIRPVAITHD 
       160        170        180 
GYYRCIMVTP DGNFHRGYHL QVLGKEHHIL RYFTSPDL

Show »

Length:188

Mass (Da):21,315

Checksum:ⁱ2C3ED65FE155D0E1

GO

Isoform 3 (identifier: Q8TD46-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
166-325: Missing.

« Hide

        10         20         30         40         50
MLCPWRTANL GLLLILTIFL VAASSSLCMD EKQITQNYSK VLAEVNTSWP 
        60         70         80         90        100
VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYRK ETNETKETNC 
       110        120        130        140        150
TDERITWVSR PDQNSDLQIR PVAITHDGYY RCIMVTPDGN FHRGYHLQVL 
       160 
GKEHHILRYF TSPDL

Show »

Length:165

Mass (Da):18,879

Checksum:ⁱA5D21A228D255202

GO

Isoform 4 (identifier: Q8TD46-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
22-22: A → AEAEGAAQPNNSLMLQTSKENHAL

« Hide

        10         20         30         40         50
MLCPWRTANL GLLLILTIFL VAEAEGAAQP NNSLMLQTSK ENHALASSSL 
        60         70         80         90        100
CMDEKQITQN YSKVLAEVNT SWPVKMATNA VLCCPPIALR NLIIITWEII 
       110        120        130        140        150
LRGQPSCTKA YRKETNETKE TNCTDERITW VSRPDQNSDL QIRPVAITHD 
       160        170        180        190        200
GYYRCIMVTP DGNFHRGYHL QVLVTPEVTL FQNRNRTAVC KAVAGKPAAQ 
       210        220        230        240        250
ISWIPEGDCA TKQEYWSNGT VTVKSTCHWE VHNVSTVTCH VSHLTGNKSL 
       260        270        280        290        300
YIELLPVPGA KKSAKLYIPY IILTIIILTI VGFIWLLKVN GCRKYKLNKT 
       310        320        330        340 
ESTPVVEEDE MQPYASYTEK NNPLYDTTNK VKASEALQSE VDTDLHTL

Show »

Length:348

Mass (Da):39,056

Checksum:ⁱ32C0016F7757A5C1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	155	V → L in AAQ89269 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014352	89	R → K in allele 2. 4 PublicationsCorresponds to variant dbSNP:rs2171509Ensembl.	1
Natural variantⁱVAR_014353	121	P → T in allele 2. 5 PublicationsCorresponds to variant dbSNP:rs4596117Ensembl.	1
Natural variantⁱVAR_014354	177	Q → H in allele 2. 5 PublicationsCorresponds to variant dbSNP:rs9826308Ensembl.	1
Natural variantⁱVAR_031022	312	E → Q2 PublicationsCorresponds to variant dbSNP:rs9865242Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002614	22	A → AEAEGAAQPNNSLMLQTSKE NHAL in isoform 2 and isoform 4. 5 Publications	1
Alternative sequenceⁱVSP_002615	151 – 165	VTPEV…RNRTA → GKEHHILRYFTSPDL in isoform 2 and isoform 3. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_002616	166 – 325	Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST	160

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY284975 mRNA Translation: AAQ19772.1 AF283760 mRNA Translation: AAN61171.1 AF497548 mRNA Translation: AAM16157.2 AF497549 mRNA Translation: AAM16158.2 AF497550 mRNA Translation: AAM16159.2 AF495380 mRNA Translation: AAM14622.2 AY358910 mRNA Translation: AAQ89269.2 AK126349 mRNA Translation: BAG54311.1 AK293071 mRNA Translation: BAF85760.1 AC074044 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79657.1 CH471052 Genomic DNA Translation: EAW79658.1 BC069661 mRNA Translation: AAH69661.1 BC069721 mRNA Translation: AAH69721.1 BC069743 mRNA Translation: AAH69743.1 BC093890 mRNA Translation: AAH93890.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2969.1 [Q8TD46-4] CCDS2970.1 [Q8TD46-1] CCDS46889.1 [Q8TD46-2] CCDS54623.1 [Q8TD46-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_620161.1, NM_138806.3 NP_620385.1, NM_138939.2 NP_620386.1, NM_138940.2 NP_740750.1, NM_170780.2
UniGeneⁱ	Hs.309158

Genome annotation databases

Ensemblⁱ	ENST00000308611; ENSP00000311035; ENSG00000163606 ENST00000440122; ENSP00000405733; ENSG00000163606 ENST00000471858; ENSP00000418928; ENSG00000163606 ENST00000490004; ENSP00000418801; ENSG00000163606
GeneIDⁱ	131450
KEGGⁱ	hsa:131450
UCSC genome browser More...UCSCⁱ	uc003dzj.2 human [Q8TD46-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8TD46	CD200 receptor 1		PANTR		325
CD200 receptor 1		COLAP		325
CD200R1 isoform 3		PONAB		325
CD200 receptor 1		RHIRO		325
CD200 receptor 1		PANPA		325
+5
Q8TD46-2	CD200R1 isoform 4		PANTR		188
UPI0000161224		HUMAN		188
CD200R1 isoform 4		PONAB		187
Q8TD46-3	CD200R1 isoform 5		PANTR		165
UPI0000161225		HUMAN		165
CD200R1 isoform 5		PONAB		164
CD200 receptor 1		NOMLE		160
Q8TD46-4	CD200 receptor 1		MACMU		349
CD200 receptor 1		MACFA		349
CD200 receptor 1		CERAT		349
CD200 receptor 1		PAPAN		349
CD200 receptor 1		CHLSB		349
+27

Protein	Similar proteins		Species	Score	Length
Q8TD46	CD200 receptor 1		RHIBE		325
CD200 receptor 1		GORGO		325
UPI000C29DFF5		Ugandan red Colobus		325
CD200 receptor 1		PANTR		325
CD200 receptor 1		NOMLE		325
+69
Q8TD46-2	UPI0000161224		HUMAN		188
CD200R1 isoform 4		PANTR		188
CD200R1 isoform 4		PONAB		187
CD200 receptor 1 like		RHIBE		205
UPI0004F1E4DA		PAPAN		230
+1
Q8TD46-3	CD200R1 isoform 5		PANTR		165
UPI0000161225		HUMAN		165
CD200R1 isoform 5		PONAB		164
CD200 receptor 1		NOMLE		160

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY284975 mRNA Translation: AAQ19772.1 AF283760 mRNA Translation: AAN61171.1 AF497548 mRNA Translation: AAM16157.2 AF497549 mRNA Translation: AAM16158.2 AF497550 mRNA Translation: AAM16159.2 AF495380 mRNA Translation: AAM14622.2 AY358910 mRNA Translation: AAQ89269.2 AK126349 mRNA Translation: BAG54311.1 AK293071 mRNA Translation: BAF85760.1 AC074044 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79657.1 CH471052 Genomic DNA Translation: EAW79658.1 BC069661 mRNA Translation: AAH69661.1 BC069721 mRNA Translation: AAH69721.1 BC069743 mRNA Translation: AAH69743.1 BC093890 mRNA Translation: AAH93890.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2969.1 [Q8TD46-4] CCDS2970.1 [Q8TD46-1] CCDS46889.1 [Q8TD46-2] CCDS54623.1 [Q8TD46-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_620161.1, NM_138806.3 NP_620385.1, NM_138939.2 NP_620386.1, NM_138940.2 NP_740750.1, NM_170780.2
UniGeneⁱ	Hs.309158

3D structure databases

ProteinModelPortalⁱ	Q8TD46
SMRⁱ	Q8TD46
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126281, 8 interactors
IntActⁱ	Q8TD46, 7 interactors

PTM databases

iPTMnetⁱ	Q8TD46
PhosphoSitePlusⁱ	Q8TD46
SwissPalmⁱ	Q8TD46

Polymorphism and mutation databases

BioMutaⁱ	CD200R1
DMDMⁱ	26006823

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q8TD46
PRIDEⁱ	Q8TD46
ProteomicsDBⁱ	74236 74237 [Q8TD46-2] 74238 [Q8TD46-3] 74239 [Q8TD46-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	131450
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308611; ENSP00000311035; ENSG00000163606 ENST00000440122; ENSP00000405733; ENSG00000163606 ENST00000471858; ENSP00000418928; ENSG00000163606 ENST00000490004; ENSP00000418801; ENSG00000163606
GeneIDⁱ	131450
KEGGⁱ	hsa:131450
UCSC genome browser More...UCSCⁱ	uc003dzj.2 human [Q8TD46-1]

Organism-specific databases

CTDⁱ	131450
DisGeNET More...DisGeNETⁱ	131450
EuPathDBⁱ	HostDB:ENSG00000163606.10
GeneCardsⁱ	CD200R1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24235 CD200R1
Human Protein Atlas More...HPAⁱ	HPA068512
MIMⁱ	607546 gene
neXtProtⁱ	NX_Q8TD46
PharmGKBⁱ	PA134922446
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

HOVERGENⁱ	HBG108141
InParanoidⁱ	Q8TD46
KEGG Orthology (KO) More...KOⁱ	K21668
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IYA
PhylomeDBⁱ	Q8TD46
TreeFamⁱ	TF335960

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

GeneWikiⁱ	CD200R1
GenomeRNAiⁱ	131450
Protein Ontology More...PROⁱ	PR:Q8TD46
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163606
CleanExⁱ	HS_CD200R1
ExpressionAtlasⁱ	Q8TD46 baseline and differential
Genevisibleⁱ	Q8TD46 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR013162 CD80_C2-set IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08205 C2-set_2, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MO2R1_HUMAN
Accessionⁱ	Q8TD46Primary (citable) accession number: Q8TD46 Secondary accession number(s): B3KWZ9 Q8TD52
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
	Last sequence update:	November 28, 2002
	Last modified:	July 18, 2018
	This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8TD46 (MO2R1_HUMAN)

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Cell surface glycoprotein CD200 receptor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ