Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8TD46 (MO2R1_HUMAN)

Entry version 170 (07 Apr 2021)
Sequence version 2 (28 Nov 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Cell surface glycoprotein CD200 receptor 1

Gene

CD200R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TD46

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 1
Alternative name(s):
CD200 cell surface glycoprotein receptor
Cell surface glycoprotein OX2 receptor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD200R1
Synonyms:CD200R, CRTR2, MOX2R, OX2R
ORF Names:UNQ2522/PRO6015
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24235, CD200R1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607546, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TD46

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163606.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 243ExtracellularSequence analysisAdd BLAST215
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 325CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		131450

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134922446

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TD46, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD200R1

Domain mapping of disease mutations (DMDM)

More...DMDMi		26006823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001512829 – 325Cell surface glycoprotein CD200 receptor 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi60 ↔ 132PROSITE-ProRule annotation
Disulfide bondi84 ↔ 100PROSITE-ProRule annotation
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi167 ↔ 216PROSITE-ProRule annotation
Disulfide bondi186 ↔ 204PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TD46

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TD46

PeptideAtlas

More...PeptideAtlasi		Q8TD46

PRoteomics IDEntifications database

More...PRIDEi		Q8TD46

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74236 [Q8TD46-1]
74237 [Q8TD46-2]
74238 [Q8TD46-3]
74239 [Q8TD46-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TD46, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TD46

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TD46

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8TD46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163606, Expressed in leukocyte and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TD46, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TD46, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163606, Group enriched (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity).

Interacts with Human herpesvirus 8 vOX2 protein.

By similarity

(Microbial infection) Interacts with human herpesvirus 8/HHV-8 protein vOX2/K14.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126281, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q8TD46, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000311035

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TD46, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TD46

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 139Ig-like V-typeAdd BLAST87
Domaini140 – 228Ig-like C2-typeAdd BLAST89

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S9IV, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_069156_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TD46

Database of Orthologous Groups

More...OrthoDBi		993609at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TD46

TreeFam database of animal gene trees

More...TreeFami		TF335960

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040012, CD200R
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold

The PANTHER Classification System

More...PANTHERi		PTHR21462, PTHR21462, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08205, C2-set_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TD46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCPWRTANL GLLLILTIFL VAASSSLCMD EKQITQNYSK VLAEVNTSWP 
        60         70         80         90        100
VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYRK ETNETKETNC 
       110        120        130        140        150
TDERITWVSR PDQNSDLQIR PVAITHDGYY RCIMVTPDGN FHRGYHLQVL 
       160        170        180        190        200
VTPEVTLFQN RNRTAVCKAV AGKPAAQISW IPEGDCATKQ EYWSNGTVTV 
       210        220        230        240        250
KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLYIPYIIL 
       260        270        280        290        300
TIIILTIVGF IWLLKVNGCR KYKLNKTEST PVVEEDEMQP YASYTEKNNP 
       310        320 
LYDTTNKVKA SEALQSEVDT DLHTL
Length:325
Mass (Da):36,620
Last modified:November 28, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD3F4B1F62337BBD
GO
Isoform 2 (identifier: Q8TD46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

Show »
Length:188
Mass (Da):21,315
Checksum:i2C3ED65FE155D0E1
GO
Isoform 3 (identifier: Q8TD46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

Show »
Length:165
Mass (Da):18,879
Checksum:iA5D21A228D255202
GO
Isoform 4 (identifier: Q8TD46-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL

Show »
Length:348
Mass (Da):39,056
Checksum:i32C0016F7757A5C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV32H9KV32_HUMAN
Cell surface glycoprotein CD200 rec...
CD200R1
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155V → L in AAQ89269 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01435289R → K in allele 2. 4 PublicationsCorresponds to variant dbSNP:rs2171509Ensembl.1
Natural variantiVAR_014353121P → T in allele 2. 5 PublicationsCorresponds to variant dbSNP:rs4596117Ensembl.1
Natural variantiVAR_014354177Q → H in allele 2. 5 PublicationsCorresponds to variant dbSNP:rs9826308Ensembl.1
Natural variantiVAR_031022312E → Q2 PublicationsCorresponds to variant dbSNP:rs9865242Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00261422A → AEAEGAAQPNNSLMLQTSKE NHAL in isoform 2 and isoform 4. 5 Publications1
Alternative sequenceiVSP_002615151 – 165VTPEV…RNRTA → GKEHHILRYFTSPDL in isoform 2 and isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_002616166 – 325Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY284975 mRNA Translation: AAQ19772.1
AF283760 mRNA Translation: AAN61171.1
AF497548 mRNA Translation: AAM16157.2
AF497549 mRNA Translation: AAM16158.2
AF497550 mRNA Translation: AAM16159.2
AF495380 mRNA Translation: AAM14622.2
AY358910 mRNA Translation: AAQ89269.2
AK126349 mRNA Translation: BAG54311.1
AK293071 mRNA Translation: BAF85760.1
AC074044 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79657.1
CH471052 Genomic DNA Translation: EAW79658.1
BC069661 mRNA Translation: AAH69661.1
BC069721 mRNA Translation: AAH69721.1
BC069743 mRNA Translation: AAH69743.1
BC093890 mRNA Translation: AAH93890.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2969.1 [Q8TD46-4]
CCDS2970.1 [Q8TD46-1]
CCDS46889.1 [Q8TD46-2]
CCDS54623.1 [Q8TD46-3]

NCBI Reference Sequences

More...RefSeqi		NP_620161.1, NM_138806.3
NP_620385.1, NM_138939.2
NP_620386.1, NM_138940.2
NP_740750.1, NM_170780.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308611; ENSP00000311035; ENSG00000163606
ENST00000440122; ENSP00000405733; ENSG00000163606
ENST00000471858; ENSP00000418928; ENSG00000163606
ENST00000490004; ENSP00000418801; ENSG00000163606

Database of genes from NCBI RefSeq genomes

More...GeneIDi		131450

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:131450

UCSC genome browser

More...UCSCi		uc003dzj.2, human [Q8TD46-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284975 mRNA Translation: AAQ19772.1
AF283760 mRNA Translation: AAN61171.1
AF497548 mRNA Translation: AAM16157.2
AF497549 mRNA Translation: AAM16158.2
AF497550 mRNA Translation: AAM16159.2
AF495380 mRNA Translation: AAM14622.2
AY358910 mRNA Translation: AAQ89269.2
AK126349 mRNA Translation: BAG54311.1
AK293071 mRNA Translation: BAF85760.1
AC074044 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79657.1
CH471052 Genomic DNA Translation: EAW79658.1
BC069661 mRNA Translation: AAH69661.1
BC069721 mRNA Translation: AAH69721.1
BC069743 mRNA Translation: AAH69743.1
BC093890 mRNA Translation: AAH93890.1
CCDSiCCDS2969.1 [Q8TD46-4]
CCDS2970.1 [Q8TD46-1]
CCDS46889.1 [Q8TD46-2]
CCDS54623.1 [Q8TD46-3]
RefSeqiNP_620161.1, NM_138806.3
NP_620385.1, NM_138939.2
NP_620386.1, NM_138940.2
NP_740750.1, NM_170780.2

3D structure databases

SMRiQ8TD46
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126281, 16 interactors
IntActiQ8TD46, 9 interactors
STRINGi9606.ENSP00000311035

PTM databases

GlyGeniQ8TD46, 8 sites
iPTMnetiQ8TD46
PhosphoSitePlusiQ8TD46
SwissPalmiQ8TD46

Genetic variation databases

BioMutaiCD200R1
DMDMi26006823

Proteomic databases

jPOSTiQ8TD46
MassIVEiQ8TD46
PeptideAtlasiQ8TD46
PRIDEiQ8TD46
ProteomicsDBi74236 [Q8TD46-1]
74237 [Q8TD46-2]
74238 [Q8TD46-3]
74239 [Q8TD46-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q8TD46, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16344, 702 antibodies

The DNASU plasmid repository

More...DNASUi		131450

Genome annotation databases

EnsembliENST00000308611; ENSP00000311035; ENSG00000163606
ENST00000440122; ENSP00000405733; ENSG00000163606
ENST00000471858; ENSP00000418928; ENSG00000163606
ENST00000490004; ENSP00000418801; ENSG00000163606
GeneIDi131450
KEGGihsa:131450
UCSCiuc003dzj.2, human [Q8TD46-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		131450
DisGeNETi131450

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD200R1
HGNCiHGNC:24235, CD200R1
HPAiENSG00000163606, Group enriched (blood, lymphoid tissue)
MIMi607546, gene
neXtProtiNX_Q8TD46
PharmGKBiPA134922446
VEuPathDBiHostDB:ENSG00000163606.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S9IV, Eukaryota
HOGENOMiCLU_069156_0_0_1
InParanoidiQ8TD46
OrthoDBi993609at2759
PhylomeDBiQ8TD46
TreeFamiTF335960

Enzyme and pathway databases

PathwayCommonsiQ8TD46
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		131450, 5 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD200R1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD200R1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		131450
PharosiQ8TD46, Tbio

Protein Ontology

More...PROi		PR:Q8TD46
RNActiQ8TD46, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163606, Expressed in leukocyte and 122 other tissues
ExpressionAtlasiQ8TD46, baseline and differential
GenevisibleiQ8TD46, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR040012, CD200R
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
PANTHERiPTHR21462, PTHR21462, 1 hit
PfamiView protein in Pfam
PF08205, C2-set_2, 1 hit
SUPFAMiSSF48726, SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMO2R1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD46
Secondary accession number(s): B3KWZ9
, E9PCM9, Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45, Q8TD52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: April 7, 2021
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again