UniProtKB - Q8TD46 (MO2R1_HUMAN)
Cell surface glycoprotein CD200 receptor 1
CD200R1
Functioni
GO - Molecular functioni
- glycosylated region protein binding Source: ARUK-UCL
- immunoglobulin receptor activity Source: ARUK-UCL
- signaling receptor activity Source: GO_Central
GO - Biological processi
- heterotypic cell-cell adhesion Source: ARUK-UCL
- intracellular signal transduction Source: ARUK-UCL
- negative regulation of interleukin-6 production Source: ARUK-UCL
- negative regulation of macrophage migration Source: ARUK-UCL
- negative regulation of neuroinflammatory response Source: ARUK-UCL
- negative regulation of neuron death Source: ARUK-UCL
- negative regulation of T cell migration Source: ARUK-UCL
- regulation of immune response Source: Reactome
- regulation of neuroinflammatory response Source: ARUK-UCL
- signal transduction Source: ARUK-UCL
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Receptor |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q8TD46 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: Cell surface glycoprotein CD200 receptor 1Alternative name(s): CD200 cell surface glycoprotein receptor Cell surface glycoprotein OX2 receptor 1 |
Gene namesi | Name:CD200R1 Synonyms:CD200R, CRTR2, MOX2R, OX2R ORF Names:UNQ2522/PRO6015 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24235, CD200R1 |
MIMi | 607546, gene |
neXtProti | NX_Q8TD46 |
VEuPathDBi | HostDB:ENSG00000163606.10 |
Subcellular locationi
Plasma membrane
Plasma membrane
Extracellular region or secreted
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: HPA
Other locations
- cell surface Source: ARUK-UCL
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 243 | ExtracellularSequence analysisAdd BLAST | 215 | |
Transmembranei | 244 – 264 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 265 – 325 | CytoplasmicSequence analysisAdd BLAST | 61 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 131450 |
PharmGKBi | PA134922446 |
Miscellaneous databases
Pharosi | Q8TD46, Tbio |
Genetic variation databases
BioMutai | CD200R1 |
DMDMi | 26006823 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000015128 | 29 – 325 | Cell surface glycoprotein CD200 receptor 1Add BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 60 ↔ 132 | PROSITE-ProRule annotation | ||
Disulfide bondi | 84 ↔ 100 | PROSITE-ProRule annotation | ||
Glycosylationi | 93 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 162 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 167 ↔ 216 | PROSITE-ProRule annotation | ||
Disulfide bondi | 186 ↔ 204 | PROSITE-ProRule annotation | ||
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 210 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 224 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q8TD46 |
MassIVEi | Q8TD46 |
PeptideAtlasi | Q8TD46 |
PRIDEi | Q8TD46 |
ProteomicsDBi | 74236 [Q8TD46-1] 74237 [Q8TD46-2] 74238 [Q8TD46-3] 74239 [Q8TD46-4] |
PTM databases
GlyGeni | Q8TD46, 8 sites |
iPTMneti | Q8TD46 |
PhosphoSitePlusi | Q8TD46 |
SwissPalmi | Q8TD46 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000163606, Expressed in leukocyte and 122 other tissues |
ExpressionAtlasi | Q8TD46, baseline and differential |
Genevisiblei | Q8TD46, HS |
Organism-specific databases
HPAi | ENSG00000163606, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity).
Interacts with Human herpesvirus 8 vOX2 protein.
By similarity(Microbial infection) Interacts with human herpesvirus 8/HHV-8 protein vOX2/K14.
1 PublicationBinary interactionsi
Hide detailsQ8TD46
With | #Exp. | IntAct |
---|---|---|
CD200 [P41217] | 2 | EBI-4314412,EBI-3910563 |
Isoform 4 [Q8TD46-4]
GO - Molecular functioni
- glycosylated region protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 126281, 16 interactors |
IntActi | Q8TD46, 9 interactors |
STRINGi | 9606.ENSP00000311035 |
Miscellaneous databases
RNActi | Q8TD46, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 139 | Ig-like V-typeAdd BLAST | 87 | |
Domaini | 140 – 228 | Ig-like C2-typeAdd BLAST | 89 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S9IV, Eukaryota |
HOGENOMi | CLU_069156_0_0_1 |
InParanoidi | Q8TD46 |
OrthoDBi | 993609at2759 |
PhylomeDBi | Q8TD46 |
TreeFami | TF335960 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR040012, CD200R IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
PANTHERi | PTHR21462, PTHR21462, 1 hit |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLCPWRTANL GLLLILTIFL VAASSSLCMD EKQITQNYSK VLAEVNTSWP
60 70 80 90 100
VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYRK ETNETKETNC
110 120 130 140 150
TDERITWVSR PDQNSDLQIR PVAITHDGYY RCIMVTPDGN FHRGYHLQVL
160 170 180 190 200
VTPEVTLFQN RNRTAVCKAV AGKPAAQISW IPEGDCATKQ EYWSNGTVTV
210 220 230 240 250
KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLYIPYIIL
260 270 280 290 300
TIIILTIVGF IWLLKVNGCR KYKLNKTEST PVVEEDEMQP YASYTEKNNP
310 320
LYDTTNKVKA SEALQSEVDT DLHTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH9KV32 | H9KV32_HUMAN | Cell surface glycoprotein CD200 rec... | CD200R1 | 212 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 155 | V → L in AAQ89269 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014352 | 89 | R → K in allele 2. 4 PublicationsCorresponds to variant dbSNP:rs2171509Ensembl. | 1 | |
Natural variantiVAR_014353 | 121 | P → T in allele 2. 5 PublicationsCorresponds to variant dbSNP:rs4596117Ensembl. | 1 | |
Natural variantiVAR_014354 | 177 | Q → H in allele 2. 5 PublicationsCorresponds to variant dbSNP:rs9826308Ensembl. | 1 | |
Natural variantiVAR_031022 | 312 | E → Q2 PublicationsCorresponds to variant dbSNP:rs9865242Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002614 | 22 | A → AEAEGAAQPNNSLMLQTSKE NHAL in isoform 2 and isoform 4. 5 Publications | 1 | |
Alternative sequenceiVSP_002615 | 151 – 165 | VTPEV…RNRTA → GKEHHILRYFTSPDL in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_002616 | 166 – 325 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 160 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY284975 mRNA Translation: AAQ19772.1 AF283760 mRNA Translation: AAN61171.1 AF497548 mRNA Translation: AAM16157.2 AF497549 mRNA Translation: AAM16158.2 AF497550 mRNA Translation: AAM16159.2 AF495380 mRNA Translation: AAM14622.2 AY358910 mRNA Translation: AAQ89269.2 AK126349 mRNA Translation: BAG54311.1 AK293071 mRNA Translation: BAF85760.1 AC074044 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79657.1 CH471052 Genomic DNA Translation: EAW79658.1 BC069661 mRNA Translation: AAH69661.1 BC069721 mRNA Translation: AAH69721.1 BC069743 mRNA Translation: AAH69743.1 BC093890 mRNA Translation: AAH93890.1 |
CCDSi | CCDS2969.1 [Q8TD46-4] CCDS2970.1 [Q8TD46-1] CCDS46889.1 [Q8TD46-2] CCDS54623.1 [Q8TD46-3] |
RefSeqi | NP_620161.1, NM_138806.3 NP_620385.1, NM_138939.2 NP_620386.1, NM_138940.2 NP_740750.1, NM_170780.2 |
Genome annotation databases
Ensembli | ENST00000308611; ENSP00000311035; ENSG00000163606 ENST00000440122; ENSP00000405733; ENSG00000163606 ENST00000471858; ENSP00000418928; ENSG00000163606 ENST00000490004; ENSP00000418801; ENSG00000163606 |
GeneIDi | 131450 |
KEGGi | hsa:131450 |
UCSCi | uc003dzj.2, human [Q8TD46-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY284975 mRNA Translation: AAQ19772.1 AF283760 mRNA Translation: AAN61171.1 AF497548 mRNA Translation: AAM16157.2 AF497549 mRNA Translation: AAM16158.2 AF497550 mRNA Translation: AAM16159.2 AF495380 mRNA Translation: AAM14622.2 AY358910 mRNA Translation: AAQ89269.2 AK126349 mRNA Translation: BAG54311.1 AK293071 mRNA Translation: BAF85760.1 AC074044 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79657.1 CH471052 Genomic DNA Translation: EAW79658.1 BC069661 mRNA Translation: AAH69661.1 BC069721 mRNA Translation: AAH69721.1 BC069743 mRNA Translation: AAH69743.1 BC093890 mRNA Translation: AAH93890.1 |
CCDSi | CCDS2969.1 [Q8TD46-4] CCDS2970.1 [Q8TD46-1] CCDS46889.1 [Q8TD46-2] CCDS54623.1 [Q8TD46-3] |
RefSeqi | NP_620161.1, NM_138806.3 NP_620385.1, NM_138939.2 NP_620386.1, NM_138940.2 NP_740750.1, NM_170780.2 |
3D structure databases
SMRi | Q8TD46 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126281, 16 interactors |
IntActi | Q8TD46, 9 interactors |
STRINGi | 9606.ENSP00000311035 |
PTM databases
GlyGeni | Q8TD46, 8 sites |
iPTMneti | Q8TD46 |
PhosphoSitePlusi | Q8TD46 |
SwissPalmi | Q8TD46 |
Genetic variation databases
BioMutai | CD200R1 |
DMDMi | 26006823 |
Proteomic databases
jPOSTi | Q8TD46 |
MassIVEi | Q8TD46 |
PeptideAtlasi | Q8TD46 |
PRIDEi | Q8TD46 |
ProteomicsDBi | 74236 [Q8TD46-1] 74237 [Q8TD46-2] 74238 [Q8TD46-3] 74239 [Q8TD46-4] |
Protocols and materials databases
ABCDi | Q8TD46, 1 sequenced antibody |
Antibodypediai | 16344, 702 antibodies |
DNASUi | 131450 |
Genome annotation databases
Ensembli | ENST00000308611; ENSP00000311035; ENSG00000163606 ENST00000440122; ENSP00000405733; ENSG00000163606 ENST00000471858; ENSP00000418928; ENSG00000163606 ENST00000490004; ENSP00000418801; ENSG00000163606 |
GeneIDi | 131450 |
KEGGi | hsa:131450 |
UCSCi | uc003dzj.2, human [Q8TD46-1] |
Organism-specific databases
CTDi | 131450 |
DisGeNETi | 131450 |
GeneCardsi | CD200R1 |
HGNCi | HGNC:24235, CD200R1 |
HPAi | ENSG00000163606, Group enriched (blood, lymphoid tissue) |
MIMi | 607546, gene |
neXtProti | NX_Q8TD46 |
PharmGKBi | PA134922446 |
VEuPathDBi | HostDB:ENSG00000163606.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9IV, Eukaryota |
HOGENOMi | CLU_069156_0_0_1 |
InParanoidi | Q8TD46 |
OrthoDBi | 993609at2759 |
PhylomeDBi | Q8TD46 |
TreeFami | TF335960 |
Enzyme and pathway databases
PathwayCommonsi | Q8TD46 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 131450, 5 hits in 985 CRISPR screens |
ChiTaRSi | CD200R1, human |
GeneWikii | CD200R1 |
GenomeRNAii | 131450 |
Pharosi | Q8TD46, Tbio |
PROi | PR:Q8TD46 |
RNActi | Q8TD46, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163606, Expressed in leukocyte and 122 other tissues |
ExpressionAtlasi | Q8TD46, baseline and differential |
Genevisiblei | Q8TD46, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR040012, CD200R IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
PANTHERi | PTHR21462, PTHR21462, 1 hit |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MO2R1_HUMAN | |
Accessioni | Q8TD46Primary (citable) accession number: Q8TD46 Secondary accession number(s): B3KWZ9 Q8TD52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | November 28, 2002 | |
Last modified: | April 7, 2021 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families