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Protein

Cell surface glycoprotein CD200 receptor 1

Gene

CD200R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.1 Publication

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 1
Alternative name(s):
CD200 cell surface glycoprotein receptor
Cell surface glycoprotein OX2 receptor 1
Gene namesi
Name:CD200R1
Synonyms:CD200R, CRTR2, MOX2R, OX2R
ORF Names:UNQ2522/PRO6015
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163606.10
HGNCiHGNC:24235 CD200R1
MIMi607546 gene
neXtProtiNX_Q8TD46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 243ExtracellularSequence analysisAdd BLAST215
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 325CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi131450
PharmGKBiPA134922446

Polymorphism and mutation databases

BioMutaiCD200R1
DMDMi26006823

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001512829 – 325Cell surface glycoprotein CD200 receptor 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi60 ↔ 132PROSITE-ProRule annotation
Disulfide bondi84 ↔ 100PROSITE-ProRule annotation
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi167 ↔ 216PROSITE-ProRule annotation
Disulfide bondi186 ↔ 204PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ8TD46
PRIDEiQ8TD46
ProteomicsDBi74236
74237 [Q8TD46-2]
74238 [Q8TD46-3]
74239 [Q8TD46-4]

PTM databases

iPTMnetiQ8TD46
PhosphoSitePlusiQ8TD46
SwissPalmiQ8TD46

Expressioni

Tissue specificityi

Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.1 Publication

Gene expression databases

BgeeiENSG00000163606
CleanExiHS_CD200R1
ExpressionAtlasiQ8TD46 baseline and differential
GenevisibleiQ8TD46 HS

Organism-specific databases

HPAiHPA068512

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.By similarity
(Microbial infection) Interacts with human herpesvirus 8/HHV-8 protein vOX2/K14.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CD200P412172EBI-4314412,EBI-3910563

Protein-protein interaction databases

BioGridi126281, 8 interactors
IntActiQ8TD46, 7 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8TD46
SMRiQ8TD46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 139Ig-like V-typeAdd BLAST87
Domaini140 – 228Ig-like C2-typeAdd BLAST89

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108141
InParanoidiQ8TD46
KOiK21668
OrthoDBiEOG091G0IYA
PhylomeDBiQ8TD46
TreeFamiTF335960

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TD46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCPWRTANL GLLLILTIFL VAASSSLCMD EKQITQNYSK VLAEVNTSWP
60 70 80 90 100
VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYRK ETNETKETNC
110 120 130 140 150
TDERITWVSR PDQNSDLQIR PVAITHDGYY RCIMVTPDGN FHRGYHLQVL
160 170 180 190 200
VTPEVTLFQN RNRTAVCKAV AGKPAAQISW IPEGDCATKQ EYWSNGTVTV
210 220 230 240 250
KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLYIPYIIL
260 270 280 290 300
TIIILTIVGF IWLLKVNGCR KYKLNKTEST PVVEEDEMQP YASYTEKNNP
310 320
LYDTTNKVKA SEALQSEVDT DLHTL
Length:325
Mass (Da):36,620
Last modified:November 28, 2002 - v2
Checksum:iDD3F4B1F62337BBD
GO
Isoform 2 (identifier: Q8TD46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

Show »
Length:188
Mass (Da):21,315
Checksum:i2C3ED65FE155D0E1
GO
Isoform 3 (identifier: Q8TD46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-165: VTPEVTLFQNRNRTA → GKEHHILRYFTSPDL
     166-325: Missing.

Show »
Length:165
Mass (Da):18,879
Checksum:iA5D21A228D255202
GO
Isoform 4 (identifier: Q8TD46-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-22: A → AEAEGAAQPNNSLMLQTSKENHAL

Show »
Length:348
Mass (Da):39,056
Checksum:i32C0016F7757A5C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155V → L in AAQ89269 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01435289R → K in allele 2. 4 PublicationsCorresponds to variant dbSNP:rs2171509Ensembl.1
Natural variantiVAR_014353121P → T in allele 2. 5 PublicationsCorresponds to variant dbSNP:rs4596117Ensembl.1
Natural variantiVAR_014354177Q → H in allele 2. 5 PublicationsCorresponds to variant dbSNP:rs9826308Ensembl.1
Natural variantiVAR_031022312E → Q2 PublicationsCorresponds to variant dbSNP:rs9865242Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00261422A → AEAEGAAQPNNSLMLQTSKE NHAL in isoform 2 and isoform 4. 5 Publications1
Alternative sequenceiVSP_002615151 – 165VTPEV…RNRTA → GKEHHILRYFTSPDL in isoform 2 and isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_002616166 – 325Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284975 mRNA Translation: AAQ19772.1
AF283760 mRNA Translation: AAN61171.1
AF497548 mRNA Translation: AAM16157.2
AF497549 mRNA Translation: AAM16158.2
AF497550 mRNA Translation: AAM16159.2
AF495380 mRNA Translation: AAM14622.2
AY358910 mRNA Translation: AAQ89269.2
AK126349 mRNA Translation: BAG54311.1
AK293071 mRNA Translation: BAF85760.1
AC074044 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79657.1
CH471052 Genomic DNA Translation: EAW79658.1
BC069661 mRNA Translation: AAH69661.1
BC069721 mRNA Translation: AAH69721.1
BC069743 mRNA Translation: AAH69743.1
BC093890 mRNA Translation: AAH93890.1
CCDSiCCDS2969.1 [Q8TD46-4]
CCDS2970.1 [Q8TD46-1]
CCDS46889.1 [Q8TD46-2]
CCDS54623.1 [Q8TD46-3]
RefSeqiNP_620161.1, NM_138806.3
NP_620385.1, NM_138939.2
NP_620386.1, NM_138940.2
NP_740750.1, NM_170780.2
UniGeneiHs.309158

Genome annotation databases

EnsembliENST00000308611; ENSP00000311035; ENSG00000163606
ENST00000440122; ENSP00000405733; ENSG00000163606
ENST00000471858; ENSP00000418928; ENSG00000163606
ENST00000490004; ENSP00000418801; ENSG00000163606
GeneIDi131450
KEGGihsa:131450
UCSCiuc003dzj.2 human [Q8TD46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMO2R1_HUMAN
AccessioniPrimary (citable) accession number: Q8TD46
Secondary accession number(s): B3KWZ9
, E9PCM9, Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45, Q8TD52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: July 18, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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