Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8TD43 (TRPM4_HUMAN)

Protein

Transient receptor potential cation channel subfamily M member 4

Gene

TRPM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723). While it is activated by increase in intracellular Ca2+, it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.17 Publications

Activity regulationi

Gating is voltage-dependent and repressed by decavanadate (PubMed:15331675, PubMed:29211723). Calmodulin-binding confers the Ca2+ sensitivity (PubMed:15590641). ATP is able to restore Ca2+ sensitivity after desensitization (PubMed:15590641). ATP inhibits channel activity (PubMed:15331675, PubMed:14758478, PubMed:29211723). Phosphatidylinositol 4,5-bisphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca2+ sensitivity and shifting its voltage dependence of activation towards negative potentials (PubMed:16186107, PubMed:16424899). Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2) (PubMed:16407466).7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171ATP; shared with neighboring subunitBy similarity1
Binding sitei421ATPBy similarity1
Binding sitei448ATP; via carbonyl oxygenBy similarity1
Metal bindingi828CalciumCombined sources1 Publication1
Metal bindingi831CalciumCombined sources1 Publication1
Metal bindingi865CalciumCombined sources1 Publication1
Metal bindingi868CalciumCombined sources1 Publication1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processAdaptive immunity, Immunity, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
SIGNORiQ8TD43

Protein family/group databases

TCDBi1.A.4.5.4 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 4
Short name:
hTRPM4
Alternative name(s):
Calcium-activated non-selective cation channel 1
Long transient receptor potential channel 4
Short name:
LTrpC-4
Short name:
LTrpC4
Melastatin-4
Gene namesi
Name:TRPM4
Synonyms:LTRPC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130529.15
HGNCiHGNC:17993 TRPM4
MIMi606936 gene
neXtProtiNX_Q8TD43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 782Cytoplasmic2 PublicationsAdd BLAST782
Transmembranei783 – 803Helical2 PublicationsAdd BLAST21
Topological domaini804 – 814Extracellular2 PublicationsAdd BLAST11
Transmembranei815 – 835Helical2 PublicationsAdd BLAST21
Topological domaini836 – 863Cytoplasmic2 PublicationsAdd BLAST28
Transmembranei864 – 884Helical2 PublicationsAdd BLAST21
Topological domaini885 – 886Extracellular2 Publications2
Transmembranei887 – 910Helical2 PublicationsAdd BLAST24
Topological domaini911 – 930Cytoplasmic2 PublicationsAdd BLAST20
Transmembranei931 – 951Helical2 PublicationsAdd BLAST21
Topological domaini952 – 963Extracellular2 PublicationsAdd BLAST12
Intramembranei964 – 984Pore-forming2 PublicationsAdd BLAST21
Topological domaini985 – 1019Extracellular2 PublicationsAdd BLAST35
Transmembranei1020 – 1040Helical2 PublicationsAdd BLAST21
Topological domaini1041 – 1214Cytoplasmic2 PublicationsAdd BLAST174

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Progressive familial heart block 1B (PFHB1B)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
See also OMIM:604559
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0640427E → K in PFHB1B; attenuated desumoylation of TRPM4 resulting in constitutive sumoylation of the channel leading to impaired endocytosis and elevated channel density at the cell surface. 1 PublicationCorresponds to variant dbSNP:rs267607142EnsemblClinVar.1
Natural variantiVAR_066763131Q → H in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172146854Ensembl.1
Natural variantiVAR_066764164R → W in PFHB1B. 1 PublicationCorresponds to variant dbSNP:rs387907216EnsemblClinVar.1
Natural variantiVAR_066766293Q → R in PFHB1B; right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172147855Ensembl.1
Natural variantiVAR_066767432A → T in PFHB1B; atrioventricular block. 2 PublicationsCorresponds to variant dbSNP:rs201907325EnsemblClinVar.1
Natural variantiVAR_066770582G → S in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172149856EnsemblClinVar.1
Natural variantiVAR_066771790Y → H in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172150857Ensembl.1
Natural variantiVAR_066772844G → D in PFHB1B; right bundle-branch block. 2 PublicationsCorresponds to variant dbSNP:rs200038418EnsemblClinVar.1
Natural variantiVAR_066774914K → R in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172151858EnsemblClinVar.1
Natural variantiVAR_066775970P → S in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172152859EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi275L → A or C: Abolishes ability to restore sensitivity to Ca(2+) after desensitization. 1 Publication1
Mutagenesisi278I → N: No effect. 1 Publication1
Mutagenesisi279D → N: No effect. 1 Publication1
Mutagenesisi324G → A: No effect. 1 Publication1
Mutagenesisi325G → A: Abolishes ability to restore sensitivity to Ca(2+) after desensitization. 1 Publication1
Mutagenesisi327R → A: No effect. 1 Publication1
Mutagenesisi977Q → E: Alters the monovalent cation permeability sequence and results in a pore with moderate Ca(2+) permeability. 1 Publication1
Mutagenesisi981 – 986EDMDVA → TIIDGP: Induces a functional channel that combines the gating hallmarks of TRPM4 (activation by Ca(2+)) with TRPV6-like sensitivity to block by extracellular Ca(2+) and Mg(2+) as well as Ca(2+) permeation. 1 Publication6
Mutagenesisi981E → A: Results in a channel with normal permeability properties but with a reduced sensitivity to block by intracellular spermine. 1 Publication1
Mutagenesisi982D → A: Results in a functional channel that exhibits extremely fast desensitization, possibly indicating destabilization of the pore. 1 Publication1
Mutagenesisi984D → A: Results in a non-functional channel with a dominant negative phenotype. 1 Publication1
Mutagenesisi1059K → Q: Does not affect PIP2-binding. 1 Publication1
Mutagenesisi1072R → Q: Does not affect PIP2-binding. 1 Publication1
Mutagenesisi1136 – 1141Missing : Results in a channel with very rapid desensitization and highly reduced sensitivity to PIP2. 1 Publication6
Mutagenesisi1145S → A: Decreases the sensitivity to Ca(2+). 1 Publication1
Mutagenesisi1152S → A: Decreases the sensitivity to Ca(2+). 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi54795
MalaCardsiTRPM4
MIMi604559 phenotype
OpenTargetsiENSG00000130529
Orphaneti130 Brugada syndrome
871 Familial progressive cardiac conduction defect
PharmGKBiPA38272

Chemistry databases

ChEMBLiCHEMBL1628469
GuidetoPHARMACOLOGYi496

Polymorphism and mutation databases

BioMutaiTRPM4
DMDMi74715868

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595291 – 1214Transient receptor potential cation channel subfamily M member 4Add BLAST1214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi992N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi993 ↔ 1011Combined sources1 Publication
Modified residuei1145Phosphoserine; by PKC1 Publication1
Modified residuei1152Phosphoserine; by PKC1 Publication1

Post-translational modificationi

Phosphorylation by PKC leads to increase the sensitivity to Ca2+.1 Publication
Sumoylated. Desumoylated by SENP1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8TD43
MaxQBiQ8TD43
PaxDbiQ8TD43
PeptideAtlasiQ8TD43
PRIDEiQ8TD43
ProteomicsDBi74233
74234 [Q8TD43-2]
74235 [Q8TD43-3]

PTM databases

iPTMnetiQ8TD43
PhosphoSitePlusiQ8TD43

Expressioni

Tissue specificityi

Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells.7 Publications

Gene expression databases

BgeeiENSG00000130529 Expressed in 154 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TRPM4
ExpressionAtlasiQ8TD43 baseline and differential
GenevisibleiQ8TD43 HS

Organism-specific databases

HPAiHPA041169

Interactioni

Subunit structurei

Homotetramer.1 Publication2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi120154, 12 interactors
IntActiQ8TD43, 1 interactor
MINTiQ8TD43
STRINGi9606.ENSP00000252826

Structurei

Secondary structure

11214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TD43
SMRiQ8TD43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1076 – 1176Calmodulin-bindingAdd BLAST101
Regioni1136 – 1141Mediates modulation by decavanadate and PIP2-binding1 Publication6

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1134 – 1187Sequence analysisAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi975 – 977Selectivity filter1 Publication3

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00760000119127
HOGENOMiHOG000236350
HOVERGENiHBG108337
InParanoidiQ8TD43
KOiK04979
OMAiQMALYFW
OrthoDBiEOG091G017C
PhylomeDBiQ8TD43
TreeFamiTF314204

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029581 TRPM4
PANTHERiPTHR13800:SF6 PTHR13800:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TD43-1) [UniParc]FASTAAdd to basket
Also known as: TRPM4b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVPEKEQSW IPKIFKKKTC TTFIVDSTDP GGTLCQCGRP RTAHPAVAME 
        60         70         80         90        100
DAFGAAVVTV WDSDAHTTEK PTDAYGELDF TGAGRKHSNF LRLSDRTDPA 
       110        120        130        140        150
AVYSLVTRTW GFRAPNLVVS VLGGSGGPVL QTWLQDLLRR GLVRAAQSTG 
       160        170        180        190        200
AWIVTGGLHT GIGRHVGVAV RDHQMASTGG TKVVAMGVAP WGVVRNRDTL 
       210        220        230        240        250
INPKGSFPAR YRWRGDPEDG VQFPLDYNYS AFFLVDDGTH GCLGGENRFR 
       260        270        280        290        300
LRLESYISQQ KTGVGGTGID IPVLLLLIDG DEKMLTRIEN ATQAQLPCLL 
       310        320        330        340        350
VAGSGGAADC LAETLEDTLA PGSGGARQGE ARDRIRRFFP KGDLEVLQAQ 
       360        370        380        390        400
VERIMTRKEL LTVYSSEDGS EEFETIVLKA LVKACGSSEA SAYLDELRLA 
       410        420        430        440        450
VAWNRVDIAQ SELFRGDIQW RSFHLEASLM DALLNDRPEF VRLLISHGLS 
       460        470        480        490        500
LGHFLTPMRL AQLYSAAPSN SLIRNLLDQA SHSAGTKAPA LKGGAAELRP 
       510        520        530        540        550
PDVGHVLRML LGKMCAPRYP SGGAWDPHPG QGFGESMYLL SDKATSPLSL 
       560        570        580        590        600
DAGLGQAPWS DLLLWALLLN RAQMAMYFWE MGSNAVSSAL GACLLLRVMA 
       610        620        630        640        650
RLEPDAEEAA RRKDLAFKFE GMGVDLFGEC YRSSEVRAAR LLLRRCPLWG 
       660        670        680        690        700
DATCLQLAMQ ADARAFFAQD GVQSLLTQKW WGDMASTTPI WALVLAFFCP 
       710        720        730        740        750
PLIYTRLITF RKSEEEPTRE ELEFDMDSVI NGEGPVGTAD PAEKTPLGVP 
       760        770        780        790        800
RQSGRPGCCG GRCGGRRCLR RWFHFWGAPV TIFMGNVVSY LLFLLLFSRV 
       810        820        830        840        850
LLVDFQPAPP GSLELLLYFW AFTLLCEELR QGLSGGGGSL ASGGPGPGHA 
       860        870        880        890        900
SLSQRLRLYL ADSWNQCDLV ALTCFLLGVG CRLTPGLYHL GRTVLCIDFM 
       910        920        930        940        950
VFTVRLLHIF TVNKQLGPKI VIVSKMMKDV FFFLFFLGVW LVAYGVATEG 
       960        970        980        990       1000
LLRPRDSDFP SILRRVFYRP YLQIFGQIPQ EDMDVALMEH SNCSSEPGFW 
      1010       1020       1030       1040       1050
AHPPGAQAGT CVSQYANWLV VLLLVIFLLV ANILLVNLLI AMFSYTFGKV 
      1060       1070       1080       1090       1100
QGNSDLYWKA QRYRLIREFH SRPALAPPFI VISHLRLLLR QLCRRPRSPQ 
      1110       1120       1130       1140       1150
PSSPALEHFR VYLSKEAERK LLTWESVHKE NFLLARARDK RESDSERLKR 
      1160       1170       1180       1190       1200
TSQKVDLALK QLGHIREYEQ RLKVLEREVQ QCSRVLGWVA EALSRSALLP 
      1210 
PGGPPPPDLP GSKD
Length:1,214
Mass (Da):134,301
Last modified:June 1, 2002 - v1
Checksum:i76ADA452690ED8F5
GO
Isoform 2 (identifier: Q8TD43-2) [UniParc]FASTAAdd to basket
Also known as: TRPM4a

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.

Show »
Length:1,040
Mass (Da):115,566
Checksum:i684A8C554B2B0F2E
GO
Isoform 3 (identifier: Q8TD43-3) [UniParc]FASTAAdd to basket
Also known as: TRPM4c

The sequence of this isoform differs from the canonical sequence as follows:
     738-882: Missing.

Show »
Length:1,069
Mass (Da):118,630
Checksum:i80DEBD935A55F200
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R0H1M0R0H1_HUMAN
Transient receptor potential cation...
TRPM4
51Annotation score:
M0R3H6M0R3H6_HUMAN
Transient receptor potential cation...
TRPM4
156Annotation score:
M0QZ19M0QZ19_HUMAN
Transient receptor potential cation...
TRPM4
216Annotation score:
M0QYK7M0QYK7_HUMAN
Transient receptor potential cation...
TRPM4
77Annotation score:
M0QX92M0QX92_HUMAN
Transient receptor potential cation...
TRPM4
103Annotation score:
A0A087X0Z3A0A087X0Z3_HUMAN
Transient receptor potential cation...
TRPM4
31Annotation score:

Sequence cautioni

The sequence BAA90907 differs from that shown. Reason: Erroneous termination at position 1191. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1149K → E in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1207P → L in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1210P → H in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1214D → E in BAA90907 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0640427E → K in PFHB1B; attenuated desumoylation of TRPM4 resulting in constitutive sumoylation of the channel leading to impaired endocytosis and elevated channel density at the cell surface. 1 PublicationCorresponds to variant dbSNP:rs267607142EnsemblClinVar.1
Natural variantiVAR_066761101A → T1 PublicationCorresponds to variant dbSNP:rs113984787EnsemblClinVar.1
Natural variantiVAR_066762103Y → C1 PublicationCorresponds to variant dbSNP:rs144781529EnsemblClinVar.1
Natural variantiVAR_066763131Q → H in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172146854Ensembl.1
Natural variantiVAR_066764164R → W in PFHB1B. 1 PublicationCorresponds to variant dbSNP:rs387907216EnsemblClinVar.1
Natural variantiVAR_066765252R → H1 PublicationCorresponds to variant dbSNP:rs146564314EnsemblClinVar.1
Natural variantiVAR_066766293Q → R in PFHB1B; right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172147855Ensembl.1
Natural variantiVAR_066767432A → T in PFHB1B; atrioventricular block. 2 PublicationsCorresponds to variant dbSNP:rs201907325EnsemblClinVar.1
Natural variantiVAR_066768487 – 498Missing . Add BLAST12
Natural variantiVAR_066769561D → A1 PublicationCorresponds to variant dbSNP:rs56355369EnsemblClinVar.1
Natural variantiVAR_066770582G → S in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172149856EnsemblClinVar.1
Natural variantiVAR_066771790Y → H in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172150857Ensembl.1
Natural variantiVAR_066772844G → D in PFHB1B; right bundle-branch block. 2 PublicationsCorresponds to variant dbSNP:rs200038418EnsemblClinVar.1
Natural variantiVAR_066773854Q → R1 PublicationCorresponds to variant dbSNP:rs172155862EnsemblClinVar.1
Natural variantiVAR_066774914K → R in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172151858EnsemblClinVar.1
Natural variantiVAR_066775970P → S in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172152859EnsemblClinVar.1
Natural variantiVAR_0667761204P → L1 PublicationCorresponds to variant dbSNP:rs150391806EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0214421 – 174Missing in isoform 2. 2 PublicationsAdd BLAST174
Alternative sequenceiVSP_021443738 – 882Missing in isoform 3. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046396 mRNA Translation: AAL02142.1
AF497623 mRNA Translation: AAM18083.1
AY297044 mRNA Translation: AAP44473.1
AY297045 mRNA Translation: AAP44474.1
AY297046 mRNA Translation: AAP44475.1
AJ575813 mRNA Translation: CAE05941.1
AK000048 mRNA Translation: BAA90907.1 Sequence problems.
AK292862 mRNA Translation: BAF85551.1
BC132727 mRNA Translation: AAI32728.1
CCDSiCCDS33073.1 [Q8TD43-1]
CCDS56098.1 [Q8TD43-3]
RefSeqiNP_001182156.1, NM_001195227.1 [Q8TD43-3]
NP_001308212.1, NM_001321283.1 [Q8TD43-2]
NP_060106.2, NM_017636.3 [Q8TD43-1]
UniGeneiHs.467101

Genome annotation databases

EnsembliENST00000252826; ENSP00000252826; ENSG00000130529 [Q8TD43-1]
ENST00000427978; ENSP00000407492; ENSG00000130529 [Q8TD43-3]
GeneIDi54795
KEGGihsa:54795
UCSCiuc002pmw.4 human [Q8TD43-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046396 mRNA Translation: AAL02142.1
AF497623 mRNA Translation: AAM18083.1
AY297044 mRNA Translation: AAP44473.1
AY297045 mRNA Translation: AAP44474.1
AY297046 mRNA Translation: AAP44475.1
AJ575813 mRNA Translation: CAE05941.1
AK000048 mRNA Translation: BAA90907.1 Sequence problems.
AK292862 mRNA Translation: BAF85551.1
BC132727 mRNA Translation: AAI32728.1
CCDSiCCDS33073.1 [Q8TD43-1]
CCDS56098.1 [Q8TD43-3]
RefSeqiNP_001182156.1, NM_001195227.1 [Q8TD43-3]
NP_001308212.1, NM_001321283.1 [Q8TD43-2]
NP_060106.2, NM_017636.3 [Q8TD43-1]
UniGeneiHs.467101

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WP6electron microscopy3.80A/B/C/D1-1214[»]
6BQRelectron microscopy3.20A/B/C/D75-1168[»]
6BQVelectron microscopy3.10A/B/C/D2-1214[»]
ProteinModelPortaliQ8TD43
SMRiQ8TD43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120154, 12 interactors
IntActiQ8TD43, 1 interactor
MINTiQ8TD43
STRINGi9606.ENSP00000252826

Chemistry databases

ChEMBLiCHEMBL1628469
GuidetoPHARMACOLOGYi496

Protein family/group databases

TCDBi1.A.4.5.4 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ8TD43
PhosphoSitePlusiQ8TD43

Polymorphism and mutation databases

BioMutaiTRPM4
DMDMi74715868

Proteomic databases

EPDiQ8TD43
MaxQBiQ8TD43
PaxDbiQ8TD43
PeptideAtlasiQ8TD43
PRIDEiQ8TD43
ProteomicsDBi74233
74234 [Q8TD43-2]
74235 [Q8TD43-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252826; ENSP00000252826; ENSG00000130529 [Q8TD43-1]
ENST00000427978; ENSP00000407492; ENSG00000130529 [Q8TD43-3]
GeneIDi54795
KEGGihsa:54795
UCSCiuc002pmw.4 human [Q8TD43-1]

Organism-specific databases

CTDi54795
DisGeNETi54795
EuPathDBiHostDB:ENSG00000130529.15
GeneCardsiTRPM4
HGNCiHGNC:17993 TRPM4
HPAiHPA041169
MalaCardsiTRPM4
MIMi604559 phenotype
606936 gene
neXtProtiNX_Q8TD43
OpenTargetsiENSG00000130529
Orphaneti130 Brugada syndrome
871 Familial progressive cardiac conduction defect
PharmGKBiPA38272
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00760000119127
HOGENOMiHOG000236350
HOVERGENiHBG108337
InParanoidiQ8TD43
KOiK04979
OMAiQMALYFW
OrthoDBiEOG091G017C
PhylomeDBiQ8TD43
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
SIGNORiQ8TD43

Miscellaneous databases

GeneWikiiTRPM4
GenomeRNAii54795
PROiPR:Q8TD43
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130529 Expressed in 154 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TRPM4
ExpressionAtlasiQ8TD43 baseline and differential
GenevisibleiQ8TD43 HS

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029581 TRPM4
PANTHERiPTHR13800:SF6 PTHR13800:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPM4_HUMAN
AccessioniPrimary (citable) accession number: Q8TD43
Secondary accession number(s): A2RU25
, Q7Z5D9, Q96L84, Q9NXV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again