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UniProtKB - Q8TD43 (TRPM4_HUMAN)

Entry version 151 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Transient receptor potential cation channel subfamily M member 4

Gene

TRPM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822).

While it is activated by increase in intracellular Ca2+, it is impermeable to it (PubMed:12015988).

Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822).

18 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Gating is voltage-dependent and repressed by decavanadate (PubMed:15331675, PubMed:29211723). Calmodulin-binding confers the Ca2+ sensitivity (PubMed:15590641). ATP is able to restore Ca2+ sensitivity after desensitization (PubMed:15590641). ATP inhibits channel activity (PubMed:15331675, PubMed:14758478, PubMed:29211723). Phosphatidylinositol 4,5-bisphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca2+ sensitivity and shifting its voltage dependence of activation towards negative potentials (PubMed:16186107, PubMed:16424899). Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2) (PubMed:16407466).7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei171ATP; shared with neighboring subunitBy similarity1
Binding sitei421ATPBy similarity1
Binding sitei448ATP; via carbonyl oxygenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi828CalciumCombined sources1 Publication1
Metal bindingi831CalciumCombined sources1 Publication1
Metal bindingi865CalciumCombined sources1 Publication1
Metal bindingi868CalciumCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processAdaptive immunity, Immunity, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TD43

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3295583, TRP channels

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8TD43

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.4.5.4, the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 4
Short name:
hTRPM4
Alternative name(s):
Calcium-activated non-selective cation channel 1
Long transient receptor potential channel 4
Short name:
LTrpC-4
Short name:
LTrpC4
Melastatin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPM4Imported
Synonyms:LTRPC4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17993, TRPM4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606936, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TD43

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130529.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 782Cytoplasmic2 PublicationsAdd BLAST782
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei783 – 803Helical2 PublicationsAdd BLAST21
Topological domaini804 – 814Extracellular2 PublicationsAdd BLAST11
Transmembranei815 – 835Helical2 PublicationsAdd BLAST21
Topological domaini836 – 863Cytoplasmic2 PublicationsAdd BLAST28
Transmembranei864 – 884Helical2 PublicationsAdd BLAST21
Topological domaini885 – 886Extracellular2 Publications2
Transmembranei887 – 910Helical2 PublicationsAdd BLAST24
Topological domaini911 – 930Cytoplasmic2 PublicationsAdd BLAST20
Transmembranei931 – 951Helical2 PublicationsAdd BLAST21
Topological domaini952 – 963Extracellular2 PublicationsAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei964 – 984Pore-forming2 PublicationsAdd BLAST21
Topological domaini985 – 1019Extracellular2 PublicationsAdd BLAST35
Transmembranei1020 – 1040Helical2 PublicationsAdd BLAST21
Topological domaini1041 – 1214Cytoplasmic2 PublicationsAdd BLAST174

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Progressive familial heart block 1B (PFHB1B)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0640427E → K in PFHB1B; attenuated desumoylation of TRPM4 resulting in constitutive sumoylation of the channel leading to impaired endocytosis and elevated channel density at the cell surface. 1 PublicationCorresponds to variant dbSNP:rs267607142EnsemblClinVar.1
Natural variantiVAR_066763131Q → H in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172146854Ensembl.1
Natural variantiVAR_066764164R → W in PFHB1B. 1 PublicationCorresponds to variant dbSNP:rs387907216EnsemblClinVar.1
Natural variantiVAR_066766293Q → R in PFHB1B; right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172147855EnsemblClinVar.1
Natural variantiVAR_066767432A → T in PFHB1B; atrioventricular block. 2 PublicationsCorresponds to variant dbSNP:rs201907325EnsemblClinVar.1
Natural variantiVAR_066770582G → S in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172149856EnsemblClinVar.1
Natural variantiVAR_066771790Y → H in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172150857Ensembl.1
Natural variantiVAR_066772844G → D in PFHB1B; right bundle-branch block. 2 PublicationsCorresponds to variant dbSNP:rs200038418EnsemblClinVar.1
Natural variantiVAR_066774914K → R in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172151858EnsemblClinVar.1
Natural variantiVAR_066775970P → S in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172152859EnsemblClinVar.1
Erythrokeratodermia variabilis et progressiva 6 (EKVP6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases. EKVP6 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0831661033I → M in EKVP6; increased calcium activated cation channel activity; increased keratinocytes proliferation and differentiation; no effect on localization at cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1278993777EnsemblClinVar.1
Natural variantiVAR_0831671040I → T in EKVP6; increased calcium activated cation channel activity; increased keratinocytes proliferation and differentiation; no effect on localization at cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1369949906EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi275L → A or C: Abolishes ability to restore sensitivity to Ca(2+) after desensitization. 1 Publication1
Mutagenesisi278I → N: No effect. 1 Publication1
Mutagenesisi279D → N: No effect. 1 Publication1
Mutagenesisi324G → A: No effect. 1 Publication1
Mutagenesisi325G → A: Abolishes ability to restore sensitivity to Ca(2+) after desensitization. 1 Publication1
Mutagenesisi327R → A: No effect. 1 Publication1
Mutagenesisi977Q → E: Alters the monovalent cation permeability sequence and results in a pore with moderate Ca(2+) permeability. 1 Publication1
Mutagenesisi981 – 986EDMDVA → TIIDGP: Induces a functional channel that combines the gating hallmarks of TRPM4 (activation by Ca(2+)) with TRPV6-like sensitivity to block by extracellular Ca(2+) and Mg(2+) as well as Ca(2+) permeation. 1 Publication6
Mutagenesisi981E → A: Results in a channel with normal permeability properties but with a reduced sensitivity to block by intracellular spermine. 1 Publication1
Mutagenesisi982D → A: Results in a functional channel that exhibits extremely fast desensitization, possibly indicating destabilization of the pore. 1 Publication1
Mutagenesisi984D → A: Results in a non-functional channel with a dominant negative phenotype. 1 Publication1
Mutagenesisi1059K → Q: Does not affect PIP2-binding. 1 Publication1
Mutagenesisi1072R → Q: Does not affect PIP2-binding. 1 Publication1
Mutagenesisi1136 – 1141Missing : Results in a channel with very rapid desensitization and highly reduced sensitivity to PIP2. 1 Publication6
Mutagenesisi1145S → A: Decreases the sensitivity to Ca(2+). 1 Publication1
Mutagenesisi1152S → A: Decreases the sensitivity to Ca(2+). 1 Publication1

Keywords - Diseasei

Disease variant, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...DisGeNETi		54795

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TRPM4

MalaCards human disease database

More...MalaCardsi		TRPM4
MIMi604559, phenotype
618531, phenotype

Open Targets

More...OpenTargetsi		ENSG00000130529

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		130, Brugada syndrome
871, Familial progressive cardiac conduction defect
316, Progressive symmetric erythrokeratodermia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38272

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TD43, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1628469

Drug and drug target database

More...DrugBanki		DB01016, Glyburide

DrugCentral

More...DrugCentrali		Q8TD43

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		496

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRPM4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74715868

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595291 – 1214Transient receptor potential cation channel subfamily M member 4Add BLAST1214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi992N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi993 ↔ 1011Combined sources1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1145Phosphoserine; by PKC1 Publication1
Modified residuei1152Phosphoserine; by PKC1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by PKC leads to increase the sensitivity to Ca2+.1 Publication
Sumoylated. Desumoylated by SENP1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TD43

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TD43

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TD43

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TD43

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TD43

PeptideAtlas

More...PeptideAtlasi		Q8TD43

PRoteomics IDEntifications database

More...PRIDEi		Q8TD43

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74233 [Q8TD43-1]
74234 [Q8TD43-2]
74235 [Q8TD43-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TD43, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TD43

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TD43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. Expressed in keratocytes (PubMed:30528822).8 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130529, Expressed in adult mammalian kidney and 171 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TD43, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TD43, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130529, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

1 Publication2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120154, 29 interactors

Protein interaction database and analysis system

More...IntActi		Q8TD43, 24 interactors

Molecular INTeraction database

More...MINTi		Q8TD43

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000252826

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8TD43

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TD43, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TD43

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1076 – 1176Calmodulin-bindingAdd BLAST101
Regioni1136 – 1141Mediates modulation by decavanadate and PIP2-binding1 Publication6

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1134 – 1187Sequence analysisAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi975 – 977Selectivity filter1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3614, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158693

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001390_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TD43

Identification of Orthologs from Complete Genome Data

More...OMAi		FPATYYM

Database of Orthologous Groups

More...OrthoDBi		738147at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TD43

TreeFam database of animal gene trees

More...TreeFami		TF314204

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005821, Ion_trans_dom
IPR029581, TRPM4
IPR041491, TRPM_SLOG

The PANTHER Classification System

More...PANTHERi		PTHR13800:SF6, PTHR13800:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TD43-1) [UniParc]FASTAAdd to basket
Also known as: TRPM4b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVPEKEQSW IPKIFKKKTC TTFIVDSTDP GGTLCQCGRP RTAHPAVAME 
        60         70         80         90        100
DAFGAAVVTV WDSDAHTTEK PTDAYGELDF TGAGRKHSNF LRLSDRTDPA 
       110        120        130        140        150
AVYSLVTRTW GFRAPNLVVS VLGGSGGPVL QTWLQDLLRR GLVRAAQSTG 
       160        170        180        190        200
AWIVTGGLHT GIGRHVGVAV RDHQMASTGG TKVVAMGVAP WGVVRNRDTL 
       210        220        230        240        250
INPKGSFPAR YRWRGDPEDG VQFPLDYNYS AFFLVDDGTH GCLGGENRFR 
       260        270        280        290        300
LRLESYISQQ KTGVGGTGID IPVLLLLIDG DEKMLTRIEN ATQAQLPCLL 
       310        320        330        340        350
VAGSGGAADC LAETLEDTLA PGSGGARQGE ARDRIRRFFP KGDLEVLQAQ 
       360        370        380        390        400
VERIMTRKEL LTVYSSEDGS EEFETIVLKA LVKACGSSEA SAYLDELRLA 
       410        420        430        440        450
VAWNRVDIAQ SELFRGDIQW RSFHLEASLM DALLNDRPEF VRLLISHGLS 
       460        470        480        490        500
LGHFLTPMRL AQLYSAAPSN SLIRNLLDQA SHSAGTKAPA LKGGAAELRP 
       510        520        530        540        550
PDVGHVLRML LGKMCAPRYP SGGAWDPHPG QGFGESMYLL SDKATSPLSL 
       560        570        580        590        600
DAGLGQAPWS DLLLWALLLN RAQMAMYFWE MGSNAVSSAL GACLLLRVMA 
       610        620        630        640        650
RLEPDAEEAA RRKDLAFKFE GMGVDLFGEC YRSSEVRAAR LLLRRCPLWG 
       660        670        680        690        700
DATCLQLAMQ ADARAFFAQD GVQSLLTQKW WGDMASTTPI WALVLAFFCP 
       710        720        730        740        750
PLIYTRLITF RKSEEEPTRE ELEFDMDSVI NGEGPVGTAD PAEKTPLGVP 
       760        770        780        790        800
RQSGRPGCCG GRCGGRRCLR RWFHFWGAPV TIFMGNVVSY LLFLLLFSRV 
       810        820        830        840        850
LLVDFQPAPP GSLELLLYFW AFTLLCEELR QGLSGGGGSL ASGGPGPGHA 
       860        870        880        890        900
SLSQRLRLYL ADSWNQCDLV ALTCFLLGVG CRLTPGLYHL GRTVLCIDFM 
       910        920        930        940        950
VFTVRLLHIF TVNKQLGPKI VIVSKMMKDV FFFLFFLGVW LVAYGVATEG 
       960        970        980        990       1000
LLRPRDSDFP SILRRVFYRP YLQIFGQIPQ EDMDVALMEH SNCSSEPGFW 
      1010       1020       1030       1040       1050
AHPPGAQAGT CVSQYANWLV VLLLVIFLLV ANILLVNLLI AMFSYTFGKV 
      1060       1070       1080       1090       1100
QGNSDLYWKA QRYRLIREFH SRPALAPPFI VISHLRLLLR QLCRRPRSPQ 
      1110       1120       1130       1140       1150
PSSPALEHFR VYLSKEAERK LLTWESVHKE NFLLARARDK RESDSERLKR 
      1160       1170       1180       1190       1200
TSQKVDLALK QLGHIREYEQ RLKVLEREVQ QCSRVLGWVA EALSRSALLP 
      1210 
PGGPPPPDLP GSKD
Length:1,214
Mass (Da):134,301
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76ADA452690ED8F5
GO
Isoform 2 (identifier: Q8TD43-2) [UniParc]FASTAAdd to basket
Also known as: TRPM4a

The sequence of this isoform differs from the canonical sequence as follows:
     1-174: Missing.

Show »
Length:1,040
Mass (Da):115,566
Checksum:i684A8C554B2B0F2E
GO
Isoform 3 (identifier: Q8TD43-3) [UniParc]FASTAAdd to basket
Also known as: TRPM4c

The sequence of this isoform differs from the canonical sequence as follows:
     738-882: Missing.

Show »
Length:1,069
Mass (Da):118,630
Checksum:i80DEBD935A55F200
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZ19M0QZ19_HUMAN
Transient receptor potential cation...
TRPM4
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3H6M0R3H6_HUMAN
Transient receptor potential cation...
TRPM4
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX92M0QX92_HUMAN
Transient receptor potential cation...
TRPM4
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0H1M0R0H1_HUMAN
Transient receptor potential cation...
TRPM4
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0Z3A0A087X0Z3_HUMAN
Transient receptor potential cation...
TRPM4
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYK7M0QYK7_HUMAN
Transient receptor potential cation...
TRPM4
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90907 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1149K → E in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1207P → L in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1210P → H in BAA90907 (PubMed:14702039).Curated1
Sequence conflicti1214D → E in BAA90907 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0640427E → K in PFHB1B; attenuated desumoylation of TRPM4 resulting in constitutive sumoylation of the channel leading to impaired endocytosis and elevated channel density at the cell surface. 1 PublicationCorresponds to variant dbSNP:rs267607142EnsemblClinVar.1
Natural variantiVAR_066761101A → T1 PublicationCorresponds to variant dbSNP:rs113984787EnsemblClinVar.1
Natural variantiVAR_066762103Y → C1 PublicationCorresponds to variant dbSNP:rs144781529EnsemblClinVar.1
Natural variantiVAR_066763131Q → H in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172146854Ensembl.1
Natural variantiVAR_066764164R → W in PFHB1B. 1 PublicationCorresponds to variant dbSNP:rs387907216EnsemblClinVar.1
Natural variantiVAR_066765252R → H1 PublicationCorresponds to variant dbSNP:rs146564314EnsemblClinVar.1
Natural variantiVAR_066766293Q → R in PFHB1B; right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172147855EnsemblClinVar.1
Natural variantiVAR_066767432A → T in PFHB1B; atrioventricular block. 2 PublicationsCorresponds to variant dbSNP:rs201907325EnsemblClinVar.1
Natural variantiVAR_066768487 – 498Missing . Add BLAST12
Natural variantiVAR_066769561D → A1 PublicationCorresponds to variant dbSNP:rs56355369EnsemblClinVar.1
Natural variantiVAR_066770582G → S in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172149856EnsemblClinVar.1
Natural variantiVAR_066771790Y → H in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172150857Ensembl.1
Natural variantiVAR_066772844G → D in PFHB1B; right bundle-branch block. 2 PublicationsCorresponds to variant dbSNP:rs200038418EnsemblClinVar.1
Natural variantiVAR_066773854Q → R1 PublicationCorresponds to variant dbSNP:rs172155862EnsemblClinVar.1
Natural variantiVAR_066774914K → R in PFHB1B; atrioventricular block. 1 PublicationCorresponds to variant dbSNP:rs172151858EnsemblClinVar.1
Natural variantiVAR_066775970P → S in PFHB1B; incomplete right bundle-branch block. 1 PublicationCorresponds to variant dbSNP:rs172152859EnsemblClinVar.1
Natural variantiVAR_0831661033I → M in EKVP6; increased calcium activated cation channel activity; increased keratinocytes proliferation and differentiation; no effect on localization at cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1278993777EnsemblClinVar.1
Natural variantiVAR_0831671040I → T in EKVP6; increased calcium activated cation channel activity; increased keratinocytes proliferation and differentiation; no effect on localization at cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1369949906EnsemblClinVar.1
Natural variantiVAR_0667761204P → L1 PublicationCorresponds to variant dbSNP:rs150391806EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0214421 – 174Missing in isoform 2. 2 PublicationsAdd BLAST174
Alternative sequenceiVSP_021443738 – 882Missing in isoform 3. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY046396 mRNA Translation: AAL02142.1
AF497623 mRNA Translation: AAM18083.1
AY297044 mRNA Translation: AAP44473.1
AY297045 mRNA Translation: AAP44474.1
AY297046 mRNA Translation: AAP44475.1
AJ575813 mRNA Translation: CAE05941.1
AK000048 mRNA Translation: BAA90907.1 Sequence problems.
AK292862 mRNA Translation: BAF85551.1
BC132727 mRNA Translation: AAI32728.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33073.1 [Q8TD43-1]
CCDS56098.1 [Q8TD43-3]

NCBI Reference Sequences

More...RefSeqi		NP_001182156.1, NM_001195227.1 [Q8TD43-3]
NP_001308212.1, NM_001321283.1 [Q8TD43-2]
NP_060106.2, NM_017636.3 [Q8TD43-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000252826; ENSP00000252826; ENSG00000130529 [Q8TD43-1]
ENST00000427978; ENSP00000407492; ENSG00000130529 [Q8TD43-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54795

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54795

UCSC genome browser

More...UCSCi		uc002pmw.4, human [Q8TD43-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046396 mRNA Translation: AAL02142.1
AF497623 mRNA Translation: AAM18083.1
AY297044 mRNA Translation: AAP44473.1
AY297045 mRNA Translation: AAP44474.1
AY297046 mRNA Translation: AAP44475.1
AJ575813 mRNA Translation: CAE05941.1
AK000048 mRNA Translation: BAA90907.1 Sequence problems.
AK292862 mRNA Translation: BAF85551.1
BC132727 mRNA Translation: AAI32728.1
CCDSiCCDS33073.1 [Q8TD43-1]
CCDS56098.1 [Q8TD43-3]
RefSeqiNP_001182156.1, NM_001195227.1 [Q8TD43-3]
NP_001308212.1, NM_001321283.1 [Q8TD43-2]
NP_060106.2, NM_017636.3 [Q8TD43-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WP6electron microscopy3.80A/B/C/D1-1214[»]
6BQRelectron microscopy3.20A/B/C/D75-1168[»]
6BQVelectron microscopy3.10A/B/C/D2-1214[»]
6BWIelectron microscopy3.70A/B/C/D395-1176[»]
SMRiQ8TD43
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120154, 29 interactors
IntActiQ8TD43, 24 interactors
MINTiQ8TD43
STRINGi9606.ENSP00000252826

Chemistry databases

BindingDBiQ8TD43
ChEMBLiCHEMBL1628469
DrugBankiDB01016, Glyburide
DrugCentraliQ8TD43
GuidetoPHARMACOLOGYi496

Protein family/group databases

TCDBi1.A.4.5.4, the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

GlyGeniQ8TD43, 1 site
iPTMnetiQ8TD43
PhosphoSitePlusiQ8TD43

Genetic variation databases

BioMutaiTRPM4
DMDMi74715868

Proteomic databases

EPDiQ8TD43
jPOSTiQ8TD43
MassIVEiQ8TD43
MaxQBiQ8TD43
PaxDbiQ8TD43
PeptideAtlasiQ8TD43
PRIDEiQ8TD43
ProteomicsDBi74233 [Q8TD43-1]
74234 [Q8TD43-2]
74235 [Q8TD43-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q8TD43, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31943, 291 antibodies

The DNASU plasmid repository

More...DNASUi		54795

Genome annotation databases

EnsembliENST00000252826; ENSP00000252826; ENSG00000130529 [Q8TD43-1]
ENST00000427978; ENSP00000407492; ENSG00000130529 [Q8TD43-3]
GeneIDi54795
KEGGihsa:54795
UCSCiuc002pmw.4, human [Q8TD43-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54795
DisGeNETi54795

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRPM4
GeneReviewsiTRPM4
HGNCiHGNC:17993, TRPM4
HPAiENSG00000130529, Low tissue specificity
MalaCardsiTRPM4
MIMi604559, phenotype
606936, gene
618531, phenotype
neXtProtiNX_Q8TD43
OpenTargetsiENSG00000130529
Orphaneti130, Brugada syndrome
871, Familial progressive cardiac conduction defect
316, Progressive symmetric erythrokeratodermia
PharmGKBiPA38272
VEuPathDBiHostDB:ENSG00000130529.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3614, Eukaryota
GeneTreeiENSGT00940000158693
HOGENOMiCLU_001390_0_1_1
InParanoidiQ8TD43
OMAiFPATYYM
OrthoDBi738147at2759
PhylomeDBiQ8TD43
TreeFamiTF314204

Enzyme and pathway databases

PathwayCommonsiQ8TD43
ReactomeiR-HSA-3295583, TRP channels
SIGNORiQ8TD43

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54795, 8 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRPM4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRPM4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54795
PharosiQ8TD43, Tchem

Protein Ontology

More...PROi		PR:Q8TD43
RNActiQ8TD43, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130529, Expressed in adult mammalian kidney and 171 other tissues
ExpressionAtlasiQ8TD43, baseline and differential
GenevisibleiQ8TD43, HS

Family and domain databases

InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR029581, TRPM4
IPR041491, TRPM_SLOG
PANTHERiPTHR13800:SF6, PTHR13800:SF6, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD43
Secondary accession number(s): A2RU25
, Q7Z5D9, Q96L84, Q9NXV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2002
Last modified: June 2, 2021
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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