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UniProtKB - Q8TD33 (SG1C1_HUMAN)

Entry version 143 (25 May 2022)
Sequence version 2 (18 May 2010)
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Protein

Secretoglobin family 1C member 1

Gene

SCGB1C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TD33

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8TD33

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secretoglobin family 1C member 1
Alternative name(s):
Secretoglobin RYD5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCGB1C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18394, SCGB1C1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610176, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TD33

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000188076

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		147199
653486

Open Targets

More...OpenTargetsi		ENSG00000188076

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TD33, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SCGB1C1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452904

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022333224 – 95Secretoglobin family 1C member 1Add BLAST72

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TD33

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TD33

PeptideAtlas

More...PeptideAtlasi		Q8TD33

PRoteomics IDEntifications database

More...PRIDEi		Q8TD33

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TD33

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TD33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188076, Expressed in monocyte and 61 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TD33, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188076, Tissue enhanced (brain, pancreas, retina, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127046, 26 interactors
575819, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q8TD33, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000344545

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TD33, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8TD33

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TD33

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SDMQ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155073

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_184622_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TD33

Identification of Orthologs from Complete Genome Data

More...OMAi		DNNEFFM

Database of Orthologous Groups

More...OrthoDBi		1523777at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TD33

TreeFam database of animal gene trees

More...TreeFami		TF337061

Family and domain databases

Conserved Domains Database

More...CDDi		cd00633, Secretoglobin, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016126, Secretoglobin
IPR043215, Secretoglobin_1C-like
IPR028659, Secretoglobin_1C1/2
IPR035960, Secretoglobin_sf

The PANTHER Classification System

More...PANTHERi		PTHR10136, PTHR10136, 1 hit
PTHR10136:SF8, PTHR10136:SF8, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01099, Uteroglobin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48201, SSF48201, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51311, SCGB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TD33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGSRALLLV ALTLFCICRM ATGEDNDEFF MDFLQTLLVG TPEELYEGTL 
        60         70         80         90 
GKYNVNEDAK AAMTELKSCI DGLQPMHKAE LVKLLVQVLG SQDGA
Length:95
Mass (Da):10,414
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6331EADC96D2392
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06310270I → R3 PublicationsCorresponds to variant dbSNP:rs2686894Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY026938 mRNA Translation: AAK08972.1
AC069287 Genomic DNA No translation available.
BC069287 mRNA Translation: AAH69287.1
BC111427 mRNA Translation: AAI11428.1
BC111433 mRNA Translation: AAI11434.1
BK000201 mRNA Translation: DAA00358.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41581.1

NCBI Reference Sequences

More...RefSeqi		NP_001091079.1, NM_001097610.2
NP_663626.2, NM_145651.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342878.3; ENSP00000344545.2; ENSG00000188076.3

Database of genes from NCBI RefSeq genomes

More...GeneIDi		147199
653486

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:147199
hsa:653486

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000342878.3; ENSP00000344545.2; NM_145651.3; NP_663626.2

UCSC genome browser

More...UCSCi		uc001loa.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026938 mRNA Translation: AAK08972.1
AC069287 Genomic DNA No translation available.
BC069287 mRNA Translation: AAH69287.1
BC111427 mRNA Translation: AAI11428.1
BC111433 mRNA Translation: AAI11434.1
BK000201 mRNA Translation: DAA00358.1
CCDSiCCDS41581.1
RefSeqiNP_001091079.1, NM_001097610.2
NP_663626.2, NM_145651.2

3D structure databases

AlphaFoldDBiQ8TD33
SMRiQ8TD33
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127046, 26 interactors
575819, 1 interactor
IntActiQ8TD33, 1 interactor
STRINGi9606.ENSP00000344545

PTM databases

iPTMnetiQ8TD33
PhosphoSitePlusiQ8TD33

Genetic variation databases

BioMutaiSCGB1C1
DMDMi296452904

Proteomic databases

MassIVEiQ8TD33
PaxDbiQ8TD33
PeptideAtlasiQ8TD33
PRIDEiQ8TD33

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		76942, 24 antibodies from 5 providers

The DNASU plasmid repository

More...DNASUi		147199

Genome annotation databases

EnsembliENST00000342878.3; ENSP00000344545.2; ENSG00000188076.3
GeneIDi147199
653486
KEGGihsa:147199
hsa:653486
MANE-SelectiENST00000342878.3; ENSP00000344545.2; NM_145651.3; NP_663626.2
UCSCiuc001loa.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		147199
653486
DisGeNETi147199
653486

GeneCards: human genes, protein and diseases

More...GeneCardsi		SCGB1C1
HGNCiHGNC:18394, SCGB1C1
HPAiENSG00000188076, Tissue enhanced (brain, pancreas, retina, salivary gland)
MIMi610176, gene
neXtProtiNX_Q8TD33
OpenTargetsiENSG00000188076
VEuPathDBiHostDB:ENSG00000188076

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SDMQ, Eukaryota
GeneTreeiENSGT00940000155073
HOGENOMiCLU_184622_0_0_1
InParanoidiQ8TD33
OMAiDNNEFFM
OrthoDBi1523777at2759
PhylomeDBiQ8TD33
TreeFamiTF337061

Enzyme and pathway databases

PathwayCommonsiQ8TD33
SignaLinkiQ8TD33

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		147199, 182 hits in 660 CRISPR screens
653486, 10 hits in 155 CRISPR screens
PharosiQ8TD33, Tdark

Protein Ontology

More...PROi		PR:Q8TD33
RNActiQ8TD33, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188076, Expressed in monocyte and 61 other tissues
GenevisibleiQ8TD33, HS

Family and domain databases

CDDicd00633, Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126, Secretoglobin
IPR043215, Secretoglobin_1C-like
IPR028659, Secretoglobin_1C1/2
IPR035960, Secretoglobin_sf
PANTHERiPTHR10136, PTHR10136, 1 hit
PTHR10136:SF8, PTHR10136:SF8, 1 hit
PfamiView protein in Pfam
PF01099, Uteroglobin, 1 hit
SUPFAMiSSF48201, SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311, SCGB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSG1C1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD33
Secondary accession number(s): A8MSI9, Q14DW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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