The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q8TD33 (SG1C1_HUMAN)
Protein
Secretoglobin family 1C member 1
Gene
SCGB1C1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Secretoglobin family 1C member 1Alternative name(s): Secretoglobin RYD5 |
Gene namesi | Name:SCGB1C1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18394, SCGB1C1 |
MIMi | 610176, gene |
neXtProti | NX_Q8TD33 |
VEuPathDBi | HostDB:ENSG00000188076 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 147199 653486 |
OpenTargetsi | ENSG00000188076 |
Miscellaneous databases
Pharosi | Q8TD33, Tdark |
Genetic variation databases
BioMutai | SCGB1C1 |
DMDMi | 296452904 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000223332 | 24 – 95 | Secretoglobin family 1C member 1Add BLAST | 72 |
Proteomic databases
MassIVEi | Q8TD33 |
PaxDbi | Q8TD33 |
PeptideAtlasi | Q8TD33 |
PRIDEi | Q8TD33 |
PTM databases
iPTMneti | Q8TD33 |
PhosphoSitePlusi | Q8TD33 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188076, Expressed in monocyte and 61 other tissues |
Genevisiblei | Q8TD33, HS |
Organism-specific databases
HPAi | ENSG00000188076, Tissue enhanced (brain, pancreas, retina, salivary gland) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127046, 26 interactors 575819, 1 interactor |
IntActi | Q8TD33, 1 interactor |
STRINGi | 9606.ENSP00000344545 |
Miscellaneous databases
RNActi | Q8TD33, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the secretoglobin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SDMQ, Eukaryota |
GeneTreei | ENSGT00940000155073 |
HOGENOMi | CLU_184622_0_0_1 |
InParanoidi | Q8TD33 |
OMAi | DNNEFFM |
OrthoDBi | 1523777at2759 |
PhylomeDBi | Q8TD33 |
TreeFami | TF337061 |
Family and domain databases
CDDi | cd00633, Secretoglobin, 1 hit |
InterProi | View protein in InterPro IPR016126, Secretoglobin IPR043215, Secretoglobin_1C-like IPR028659, Secretoglobin_1C1/2 IPR035960, Secretoglobin_sf |
PANTHERi | PTHR10136, PTHR10136, 1 hit PTHR10136:SF8, PTHR10136:SF8, 1 hit |
Pfami | View protein in Pfam PF01099, Uteroglobin, 1 hit |
SUPFAMi | SSF48201, SSF48201, 1 hit |
PROSITEi | View protein in PROSITE PS51311, SCGB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8TD33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKGSRALLLV ALTLFCICRM ATGEDNDEFF MDFLQTLLVG TPEELYEGTL
60 70 80 90
GKYNVNEDAK AAMTELKSCI DGLQPMHKAE LVKLLVQVLG SQDGA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063102 | 70 | I → R3 PublicationsCorresponds to variant dbSNP:rs2686894Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY026938 mRNA Translation: AAK08972.1 AC069287 Genomic DNA No translation available. BC069287 mRNA Translation: AAH69287.1 BC111427 mRNA Translation: AAI11428.1 BC111433 mRNA Translation: AAI11434.1 BK000201 mRNA Translation: DAA00358.1 |
CCDSi | CCDS41581.1 |
RefSeqi | NP_001091079.1, NM_001097610.2 NP_663626.2, NM_145651.2 |
Genome annotation databases
Ensembli | ENST00000342878.3; ENSP00000344545.2; ENSG00000188076.3 |
GeneIDi | 147199 653486 |
KEGGi | hsa:147199 hsa:653486 |
MANE-Selecti | ENST00000342878.3; ENSP00000344545.2; NM_145651.3; NP_663626.2 |
UCSCi | uc001loa.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY026938 mRNA Translation: AAK08972.1 AC069287 Genomic DNA No translation available. BC069287 mRNA Translation: AAH69287.1 BC111427 mRNA Translation: AAI11428.1 BC111433 mRNA Translation: AAI11434.1 BK000201 mRNA Translation: DAA00358.1 |
CCDSi | CCDS41581.1 |
RefSeqi | NP_001091079.1, NM_001097610.2 NP_663626.2, NM_145651.2 |
3D structure databases
AlphaFoldDBi | Q8TD33 |
SMRi | Q8TD33 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127046, 26 interactors 575819, 1 interactor |
IntActi | Q8TD33, 1 interactor |
STRINGi | 9606.ENSP00000344545 |
PTM databases
iPTMneti | Q8TD33 |
PhosphoSitePlusi | Q8TD33 |
Genetic variation databases
BioMutai | SCGB1C1 |
DMDMi | 296452904 |
Proteomic databases
MassIVEi | Q8TD33 |
PaxDbi | Q8TD33 |
PeptideAtlasi | Q8TD33 |
PRIDEi | Q8TD33 |
Protocols and materials databases
Antibodypediai | 76942, 24 antibodies from 5 providers |
DNASUi | 147199 |
Genome annotation databases
Ensembli | ENST00000342878.3; ENSP00000344545.2; ENSG00000188076.3 |
GeneIDi | 147199 653486 |
KEGGi | hsa:147199 hsa:653486 |
MANE-Selecti | ENST00000342878.3; ENSP00000344545.2; NM_145651.3; NP_663626.2 |
UCSCi | uc001loa.1, human |
Organism-specific databases
CTDi | 147199 653486 |
DisGeNETi | 147199 653486 |
GeneCardsi | SCGB1C1 |
HGNCi | HGNC:18394, SCGB1C1 |
HPAi | ENSG00000188076, Tissue enhanced (brain, pancreas, retina, salivary gland) |
MIMi | 610176, gene |
neXtProti | NX_Q8TD33 |
OpenTargetsi | ENSG00000188076 |
VEuPathDBi | HostDB:ENSG00000188076 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SDMQ, Eukaryota |
GeneTreei | ENSGT00940000155073 |
HOGENOMi | CLU_184622_0_0_1 |
InParanoidi | Q8TD33 |
OMAi | DNNEFFM |
OrthoDBi | 1523777at2759 |
PhylomeDBi | Q8TD33 |
TreeFami | TF337061 |
Enzyme and pathway databases
PathwayCommonsi | Q8TD33 |
SignaLinki | Q8TD33 |
Miscellaneous databases
BioGRID-ORCSi | 147199, 182 hits in 660 CRISPR screens 653486, 10 hits in 155 CRISPR screens |
Pharosi | Q8TD33, Tdark |
PROi | PR:Q8TD33 |
RNActi | Q8TD33, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188076, Expressed in monocyte and 61 other tissues |
Genevisiblei | Q8TD33, HS |
Family and domain databases
CDDi | cd00633, Secretoglobin, 1 hit |
InterProi | View protein in InterPro IPR016126, Secretoglobin IPR043215, Secretoglobin_1C-like IPR028659, Secretoglobin_1C1/2 IPR035960, Secretoglobin_sf |
PANTHERi | PTHR10136, PTHR10136, 1 hit PTHR10136:SF8, PTHR10136:SF8, 1 hit |
Pfami | View protein in Pfam PF01099, Uteroglobin, 1 hit |
SUPFAMi | SSF48201, SSF48201, 1 hit |
PROSITEi | View protein in PROSITE PS51311, SCGB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SG1C1_HUMAN | |
Accessioni | Q8TD33Primary (citable) accession number: Q8TD33 Secondary accession number(s): A8MSI9, Q14DW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families