Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 158 (17 Jun 2020)
Sequence version 2 (16 Feb 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Coiled-coil alpha-helical rod protein 1

Gene

CCHCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a regulator of keratinocyte proliferation or differentiation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil alpha-helical rod protein 1
Alternative name(s):
Alpha-helical coiled-coil rod protein
Putative gene 8 protein
Short name:
Pg8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCHCR1
Synonyms:C6orf18, HCR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204536.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13930 CCHCR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605310 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TD31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54535

Open Targets

More...
OpenTargetsi
ENSG00000204536

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134942738

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TD31 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCHCR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
42558938

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894161 – 782Coiled-coil alpha-helical rod protein 1Add BLAST782

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TD31

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TD31

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TD31

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TD31

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TD31

PeptideAtlas

More...
PeptideAtlasi
Q8TD31

PRoteomics IDEntifications database

More...
PRIDEi
Q8TD31

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19833
74228 [Q8TD31-1]
74229 [Q8TD31-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TD31

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TD31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204536 Expressed in testis and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TD31 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TD31 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204536 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TD31
With#Exp.IntAct
ABI2 [Q9NYB9]3EBI-949834,EBI-743598
Isoform 1 [Q8TD31-1]
With#Exp.IntAct
KIFC3 - isoform 4 [Q9BVG8-5]4EBI-21238948,EBI-14069005
CCHCR1 - isoform 3 [Q8TD31-3]
With#Exp.IntAct
ABI1 - isoform 5 [Q8IZP0-5]5EBI-10175300,EBI-11743294
ABI2 [Q9NYB9]3EBI-10175300,EBI-743598
ABI2 - isoform 2 [Q9NYB9-2]3EBI-10175300,EBI-11096309
ALAS1 [P13196]3EBI-10175300,EBI-3905054
AMOTL2 [Q9Y2J4]3EBI-10175300,EBI-746752
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-10175300,EBI-10187270
ANKRD11 [X5D778]3EBI-10175300,EBI-17183751
ATG5 [A9UGY9]3EBI-10175300,EBI-10175276
ATG5 [Q9H1Y0]3EBI-10175300,EBI-1047414
BFSP1 - isoform 2 [Q12934-2]3EBI-10175300,EBI-12123320
BICD2 - isoform 2 [Q8TD16-2]3EBI-10175300,EBI-11975051
BLOC1S2 [Q6QNY1]3EBI-10175300,EBI-465872
BLOC1S6 [Q9UL45]3EBI-10175300,EBI-465781
BORCS6 [Q96GS4]3EBI-10175300,EBI-10193358
C1orf109 [Q9NX04]3EBI-10175300,EBI-8643161
C1orf94 [Q6P1W5]4EBI-10175300,EBI-946029
CARD9 [Q9H257]3EBI-10175300,EBI-751319
CBY2 - isoform 2 [Q8NA61-2]5EBI-10175300,EBI-11524851
CCDC102B [Q68D86]6EBI-10175300,EBI-10171570
CCDC13 [Q8IYE1]6EBI-10175300,EBI-10961312
CCDC136 - isoform 2 [Q96JN2-2]3EBI-10175300,EBI-10171416
CCDC197 [Q8NCU1]3EBI-10175300,EBI-750686
CCDC88B [A6NC98]3EBI-10175300,EBI-347573
itself4EBI-10175300,EBI-10175300
CCNC [P24863]3EBI-10175300,EBI-395261
CDC37 [Q16543]3EBI-10175300,EBI-295634
CDR2 [Q01850]6EBI-10175300,EBI-1181367
CDR2L [Q86X02]3EBI-10175300,EBI-11063830
CEP55 [Q53EZ4]6EBI-10175300,EBI-747776
CEP57 - isoform 3 [Q86XR8-3]3EBI-10175300,EBI-11752486
CEP63 - isoform 3 [Q96MT8-3]7EBI-10175300,EBI-11522539
CFAP53 [Q96M91]6EBI-10175300,EBI-742422
CNOT2 [Q9NZN8]3EBI-10175300,EBI-743033
COG6 [Q9Y2V7]5EBI-10175300,EBI-3866319
CRACR2A [Q9BSW2]3EBI-10175300,EBI-739773
CTAG1A [P78358]3EBI-10175300,EBI-1188472
DEUP1 [Q05D60]3EBI-10175300,EBI-748597
DISC1 - isoform 2 [Q9NRI5-2]3EBI-10175300,EBI-11988027
DMAP1 [Q9NPF5]3EBI-10175300,EBI-399105
DTNB - isoform 5 [O60941-5]6EBI-10175300,EBI-11984733
DTNBP1 [Q96EV8]3EBI-10175300,EBI-465804
DYDC1 [Q8WWB3]3EBI-10175300,EBI-740680
EFHC2 [Q5JST6]6EBI-10175300,EBI-2349927
EXOC1 [Q9NV70]3EBI-10175300,EBI-1045313
EXOC4 - isoform 2 [Q96A65-2]3EBI-10175300,EBI-17869840
EXOC7 - isoform 1 [Q9UPT5-1]3EBI-10175300,EBI-6251402
EXOC8 [Q8IYI6]3EBI-10175300,EBI-742102
FANCG [O15287]3EBI-10175300,EBI-81610
FCHSD2 - isoform 3 [O94868-3]5EBI-10175300,EBI-11958845
FSD2 [A1L4K1]6EBI-10175300,EBI-5661036
GAS8 [O95995]3EBI-10175300,EBI-1052570
GNG13 [Q9P2W3]3EBI-10175300,EBI-11427343
GOLGA2 [Q08379]8EBI-10175300,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-10175300,EBI-5916454
HAUS1 [Q96CS2]6EBI-10175300,EBI-2514791
HAUS8 [Q9BT25]5EBI-10175300,EBI-2558143
HDDC3 - isoform 2 [Q8N4P3-2]3EBI-10175300,EBI-12037393
HGFAC [Q04756]3EBI-10175300,EBI-1041722
HMGXB4 [Q9UGU5]3EBI-10175300,EBI-7261162
HSBP1 [O75506]6EBI-10175300,EBI-748664
HSF2BP [O75031]3EBI-10175300,EBI-7116203
IFT20 - isoform 3 [Q8IY31-3]3EBI-10175300,EBI-9091197
IKZF3 [Q9UKT9]3EBI-10175300,EBI-747204
ING5 [Q8WYH8]3EBI-10175300,EBI-488533
IQCC [Q4KMZ1]3EBI-10175300,EBI-12206419
KIAA0753 [Q2KHM9]3EBI-10175300,EBI-2805604
KIAA1328 [Q86T90]3EBI-10175300,EBI-3437878
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-10175300,EBI-14069005
KRT13 [A1A4E9]3EBI-10175300,EBI-10171552
KRT15 [P19012]6EBI-10175300,EBI-739566
KRT16 [P08779]3EBI-10175300,EBI-356410
KRT18 [P05783]3EBI-10175300,EBI-297888
KRT19 [P08727]3EBI-10175300,EBI-742756
KRT24 [Q2M2I5]3EBI-10175300,EBI-2952736
KRT27 [Q7Z3Y8]3EBI-10175300,EBI-3044087
KRT31 [Q15323]6EBI-10175300,EBI-948001
KRT34 [O76011]3EBI-10175300,EBI-1047093
KRT35 [Q92764]3EBI-10175300,EBI-1058674
KRT36 - isoform 2 [O76013-2]3EBI-10175300,EBI-11958506
KRT40 [Q6A162]6EBI-10175300,EBI-10171697
KRT75 [O95678]3EBI-10175300,EBI-2949715
LENG1 [Q96BZ8]3EBI-10175300,EBI-726510
LHX8 [Q68G74]3EBI-10175300,EBI-8474075
LZTS1 [Q9Y250]3EBI-10175300,EBI-1216080
MAD1L1 [Q9Y6D9]6EBI-10175300,EBI-742610
MBD3 - isoform 2 [O95983-2]3EBI-10175300,EBI-11978579
MCRS1 [Q96EZ8]3EBI-10175300,EBI-348259
MED4 [Q9NPJ6]6EBI-10175300,EBI-394607
MIA2 [Q96PC5]3EBI-10175300,EBI-1050253
MID2 - isoform 2 [Q9UJV3-2]6EBI-10175300,EBI-10172526
MTUS2 [Q5JR59]3EBI-10175300,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]3EBI-10175300,EBI-11522433
NAB2 [Q15742]3EBI-10175300,EBI-8641936
NDC80 [O14777]6EBI-10175300,EBI-715849
NDEL1 [Q9GZM8]3EBI-10175300,EBI-928842
NFKBID [Q8NI38]3EBI-10175300,EBI-10271199
NINL [Q9Y2I6]3EBI-10175300,EBI-719716
NME7 [Q9Y5B8]6EBI-10175300,EBI-744782
NUP54 [Q7Z3B4]3EBI-10175300,EBI-741048
NUP62 [P37198]6EBI-10175300,EBI-347978
NUTM1 [Q86Y26]3EBI-10175300,EBI-10178410
OIP5 [O43482]3EBI-10175300,EBI-536879
PCM1 - isoform 3 [Q15154-3]5EBI-10175300,EBI-11742977
PFDN6 [O15212]3EBI-10175300,EBI-356973
PIAS2 [O75928]3EBI-10175300,EBI-348555
PIBF1 [Q4G0R1]3EBI-10175300,EBI-14066006
PKP2 - isoform 1 [Q99959-2]3EBI-10175300,EBI-10987518
PLEKHA7 - isoform 2 [Q6IQ23-2]3EBI-10175300,EBI-12069346
POU6F2 [P78424]3EBI-10175300,EBI-12029004
PPP1R13B [Q96KQ4]3EBI-10175300,EBI-1105153
PRDM6 [Q9NQX0]3EBI-10175300,EBI-11320284
PROSER3 [Q2NL68]5EBI-10175300,EBI-11336487
RABGEF1 - isoform 3 [Q9UJ41-4]3EBI-10175300,EBI-14093916
RALBP1 [Q15311]3EBI-10175300,EBI-749285
RBM17 [Q96I25]6EBI-10175300,EBI-740272
RBM41 [Q96IZ5]3EBI-10175300,EBI-740773
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-10175300,EBI-1504830
RINT1 [Q6NUQ1]5EBI-10175300,EBI-726876
RUSC1 [Q9BVN2]3EBI-10175300,EBI-6257312
SAMD11 [Q96NU1]3EBI-10175300,EBI-14067109
SAT1 [P21673]6EBI-10175300,EBI-711613
SMARCE1 [Q969G3]3EBI-10175300,EBI-455078
SORBS3 [O60504]3EBI-10175300,EBI-741237
SPAG5 [Q96R06]6EBI-10175300,EBI-413317
SPG21 [Q9NZD8]3EBI-10175300,EBI-742688
SSX2IP [Q9Y2D8]3EBI-10175300,EBI-2212028
STARD4 [Q96DR4]3EBI-10175300,EBI-17217258
STMN2 [Q93045]3EBI-10175300,EBI-714194
STX11 [O75558]3EBI-10175300,EBI-714135
SYCE1 [Q8N0S2]3EBI-10175300,EBI-6872807
TACC3 [Q9Y6A5]3EBI-10175300,EBI-2554984
TADA2A [O75478]3EBI-10175300,EBI-742268
TEKT1 [Q969V4]6EBI-10175300,EBI-10180409
TEX33 - isoform 2 [O43247-2]3EBI-10175300,EBI-12093053
TEX9 [Q8N6V9]3EBI-10175300,EBI-746341
TFIP11 [Q9UBB9]8EBI-10175300,EBI-1105213
TPM1 - isoform 10 [P09493-10]3EBI-10175300,EBI-12123928
TPM3 [P06753]13EBI-10175300,EBI-355607
TPM3 [Q5VU62]3EBI-10175300,EBI-10184033
TRAF1 [Q13077]6EBI-10175300,EBI-359224
TRAF2 [Q12933]8EBI-10175300,EBI-355744
TRIM27 [P14373]3EBI-10175300,EBI-719493
TRIM54 [Q9BYV2]3EBI-10175300,EBI-2130429
TRIML2 [Q8N7C3]3EBI-10175300,EBI-11059915
TSG101 [Q99816]3EBI-10175300,EBI-346882
TSGA10 [Q9BZW7]6EBI-10175300,EBI-744794
TSHZ3 [Q63HK5]3EBI-10175300,EBI-9053916
TXLNA [P40222]6EBI-10175300,EBI-359793
TXLNB [Q8N3L3]6EBI-10175300,EBI-6116822
USHBP1 [Q8N6Y0]6EBI-10175300,EBI-739895
VPS52 [Q8N1B4]3EBI-10175300,EBI-2799833
VPS9D1 [Q9Y2B5]3EBI-10175300,EBI-9031083
WASHC3 [Q9Y3C0]6EBI-10175300,EBI-712969
WDYHV1 [Q96HA8]3EBI-10175300,EBI-741158
ZBTB16 [Q05516]3EBI-10175300,EBI-711925
ZFYVE19 - isoform 3 [Q96K21-3]3EBI-10175300,EBI-10187928
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-10175300,EBI-10183064
ZNF620 [Q6ZNG0]3EBI-10175300,EBI-4395669
ZNF629 [Q9UEG4]3EBI-10175300,EBI-9977294
ZNF655 [Q8N720]3EBI-10175300,EBI-625509
ZNF774 [Q6NX45]3EBI-10175300,EBI-10251462
ZWINT [O95229]3EBI-10175300,EBI-1001132
A0A1U9X8X83EBI-10175300,EBI-17234977

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120022, 121 interactors

Database of interacting proteins

More...
DIPi
DIP-40394N

Protein interaction database and analysis system

More...
IntActi
Q8TD31, 194 interactors

Molecular INTeraction database

More...
MINTi
Q8TD31

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379566

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TD31 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TD31

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili111 – 303Sequence analysisAdd BLAST193
Coiled coili344 – 437Sequence analysisAdd BLAST94
Coiled coili498 – 691Sequence analysisAdd BLAST194

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGTY Eukaryota
ENOG410YGAD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153251

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TD31

KEGG Orthology (KO)

More...
KOi
K16760

Identification of Orthologs from Complete Genome Data

More...
OMAi
QELEQSW

Database of Orthologous Groups

More...
OrthoDBi
1046571at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TD31

TreeFam database of animal gene trees

More...
TreeFami
TF336947

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009800 HCR

The PANTHER Classification System

More...
PANTHERi
PTHR46822 PTHR46822, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07111 HCR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 37 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TD31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPPSGSTGL IPPSHFQARP LSTLPRMAPT WLSDIPLVQP PGHQDVSERR
60 70 80 90 100
LDTQRPQVTM WERDVSSDRQ EPGRRGRSWG LEGSQALSQQ AEVIVRQLQE
110 120 130 140 150
LRRLEEEVRL LRETSLQQKM RLEAQAMELE ALARAEKAGR AEAEGLRAAL
160 170 180 190 200
AGAEVVRKNL EEGSQRELEE VQRLHQEQLS SLTQAHEEAL SSLTSKAEGL
210 220 230 240 250
EKSLSSLETR RAGEAKELAE AQREAELLRK QLSKTQEDLE AQVTLVENLR
260 270 280 290 300
KYVGEQVPSE VHSQTWELER QKLLETMQHL QEDRDSLHAT AELLQVRVQS
310 320 330 340 350
LTHILALQEE ELTRKVQPSD SLEPEFTRKC QSLLNRWREK VFALMVQLKA
360 370 380 390 400
QELEHSDSVK QLKGQVASLQ EKVTSQSQEQ AILQRSLQDK AAEVEVERMG
410 420 430 440 450
AKGLQLELSR AQEARRRWQQ QTASAEEQLR LVVNAVSSSQ IWLETTMAKV
460 470 480 490 500
EGAAAQLPSL NNRLSYAVRK VHTIRGLIAR KLALAQLRQE SCPLPPPVTD
510 520 530 540 550
VSLELQQLRE ERNRLDAELQ LSARLIQQEV GRAREQGEAE RQQLSKVAQQ
560 570 580 590 600
LEQELQQTQE SLASLGLQLE VARQGQQEST EEAASLRQEL TQQQELYGQA
610 620 630 640 650
LQEKVAEVET RLREQLSDTE RRLNEARREH AKAVVSLRQI QRRAAQEKER
660 670 680 690 700
SQELRRLQEE ARKEEGQRLA RRLQELERDK NLMLATLQQE GLLSRYKQQR
710 720 730 740 750
LLTVLPSLLD KKKSVVSSPR PPECSASAPV AAAVPTRESI KGSLSVLLDD
760 770 780
LQDLSEAISK EEAVCQGDNL DRCSSSNPQM SS
Length:782
Mass (Da):88,671
Last modified:February 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E7DE742DB57B29E
GO
Isoform 2 (identifier: Q8TD31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWPHSAGARP...NLEPSNNVEM

Show »
Length:871
Mass (Da):99,007
Checksum:iCFB1EF2739BCCE8D
GO
Isoform 3 (identifier: Q8TD31-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MFPPSGSTGL...LSDIPLVQPP → MWPHSAGARP...SNNVEMFPPS

Show »
Length:835
Mass (Da):95,145
Checksum:i9207F3B3D2D68D64
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 37 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ABH1A2ABH1_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
729Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPK4E7EPK4_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAE7D6RAE7_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDI7D6RDI7_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQC5E7EQC5_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQE8E7EQE8_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGB6E9PGB6_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHV1E9PHV1_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ABH3A2ABH3_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ABH4A2ABH4_HUMAN
Coiled-coil alpha-helical rod prote...
CCHCR1
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF74221 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI10536 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAA81890 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA82158 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91236 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB63313 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC54937 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20P → A in BAA81890 (PubMed:10545595).Curated1
Sequence conflicti43H → Y in BAA91007 (PubMed:14702039).Curated1
Sequence conflicti395E → G in BAA91236 (PubMed:14702039).Curated1
Sequence conflicti472H → L in BAA91007 (PubMed:14702039).Curated1
Sequence conflicti498V → A in BAA91007 (PubMed:14702039).Curated1
Sequence conflicti667Q → L in BAA91236 (PubMed:14702039).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

HCR*WWCC is associated with susceptibility to psoriasis. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is a multifactorial disease characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age. Association of HCR with psoriasis seem to be due to linkage disequilibrium with Cw*06:02 (PubMed:11348465). HCR is unlikely to be directly involved in psoriasis development.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017761102R → Q2 PublicationsCorresponds to variant dbSNP:rs130075Ensembl.1
Natural variantiVAR_017762103R → W in allele HCR*WWCC; associated with psoriasis. 4 PublicationsCorresponds to variant dbSNP:rs130065Ensembl.1
Natural variantiVAR_017763109R → W in allele HCR*WWCC; associated with psoriasis. 5 PublicationsCorresponds to variant dbSNP:rs130076Ensembl.1
Natural variantiVAR_017764164S → R8 PublicationsCorresponds to variant dbSNP:rs130066Ensembl.1
Natural variantiVAR_017782179L → Q1 PublicationCorresponds to variant dbSNP:rs11540822Ensembl.1
Natural variantiVAR_017765275E → D6 PublicationsCorresponds to variant dbSNP:rs130067Ensembl.1
Natural variantiVAR_017783367A → T1 PublicationCorresponds to variant dbSNP:rs2027937Ensembl.1
Natural variantiVAR_017767417R → Q2 PublicationsCorresponds to variant dbSNP:rs130069Ensembl.1
Natural variantiVAR_017766417R → W6 PublicationsCorresponds to variant dbSNP:rs130068Ensembl.1
Natural variantiVAR_017768546K → R. Corresponds to variant dbSNP:rs2073720Ensembl.1
Natural variantiVAR_017769575G → C in allele HCR*WWCC; associated with psoriasis. 6 PublicationsCorresponds to variant dbSNP:rs130079Ensembl.1
Natural variantiVAR_017770627R → Q2 PublicationsCorresponds to variant dbSNP:rs130072Ensembl.1
Natural variantiVAR_017771639Q → H1 PublicationCorresponds to variant dbSNP:rs130074Ensembl.1
Natural variantiVAR_017784733A → V1 PublicationCorresponds to variant dbSNP:rs140560656Ensembl.1
Natural variantiVAR_017772776S → C in allele HCR*WWCC; associated with psoriasis. 6 PublicationsCorresponds to variant dbSNP:rs1576Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470691 – 41MFPPS…LVQPP → MWPHSAGARPWASTLTGKDP RVMACWCLDGLPSGLAEPWR ELWRWRSRPLHCVPPFSPLA RSSRDHRNLRRRGNIDGWRQ NLEPSNNVEMFPPS in isoform 3. CuratedAdd BLAST41
Alternative sequenceiVSP_0380621M → MWPHSAGARPWASTLTGKDP RVMACWCLDGLPSGLAEPWR ELWRWRSRPLHCVPPFSPLA RSSRDHRNLRRRGNIDGWRQ NLEPSNNVEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY029160 mRNA Translation: AAK55759.1
BA000025 Genomic DNA Translation: BAB63313.1 Sequence problems.
AB088104 Genomic DNA Translation: BAC54937.1 Sequence problems.
AK000204 mRNA Translation: BAA91007.1
AK000217 mRNA Translation: BAA91016.1
AK000533 mRNA Translation: BAA91236.1 Different initiation.
AL662833 Genomic DNA No translation available.
AL662844 Genomic DNA No translation available.
AL773544 Genomic DNA No translation available.
CR753819 Genomic DNA No translation available.
BC110535 mRNA Translation: AAI10536.1 Sequence problems.
AB029331 mRNA Translation: BAA81890.1 Different initiation.
AB029343 Genomic DNA Translation: BAA82158.1 Sequence problems.
AF216493 mRNA Translation: AAF74221.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43445.1 [Q8TD31-2]
CCDS4695.1 [Q8TD31-1]
CCDS47397.1 [Q8TD31-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001099033.1, NM_001105563.1 [Q8TD31-3]
NP_001099034.1, NM_001105564.1 [Q8TD31-2]
NP_061925.2, NM_019052.3 [Q8TD31-1]
XP_011513005.1, XM_011514703.1 [Q8TD31-1]
XP_016866451.1, XM_017010962.1 [Q8TD31-1]
XP_016866452.1, XM_017010963.1 [Q8TD31-1]
XP_016866453.1, XM_017010964.1 [Q8TD31-1]
XP_016866454.1, XM_017010965.1 [Q8TD31-1]
XP_016866455.1, XM_017010966.1 [Q8TD31-1]
XP_016866456.1, XM_017010967.1 [Q8TD31-1]
XP_016866457.1, XM_017010968.1 [Q8TD31-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376266; ENSP00000365442; ENSG00000204536 [Q8TD31-1]
ENST00000383341; ENSP00000372832; ENSG00000206355
ENST00000383527; ENSP00000373019; ENSG00000206457 [Q8TD31-1]
ENST00000396268; ENSP00000379566; ENSG00000204536 [Q8TD31-2]
ENST00000400352; ENSP00000383205; ENSG00000206355
ENST00000400412; ENSP00000383263; ENSG00000206457 [Q8TD31-2]
ENST00000416163; ENSP00000408012; ENSG00000234114
ENST00000425620; ENSP00000393042; ENSG00000234114
ENST00000451521; ENSP00000401039; ENSG00000204536 [Q8TD31-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54535

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54535

UCSC genome browser

More...
UCSCi
uc003nsp.4 human [Q8TD31-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029160 mRNA Translation: AAK55759.1
BA000025 Genomic DNA Translation: BAB63313.1 Sequence problems.
AB088104 Genomic DNA Translation: BAC54937.1 Sequence problems.
AK000204 mRNA Translation: BAA91007.1
AK000217 mRNA Translation: BAA91016.1
AK000533 mRNA Translation: BAA91236.1 Different initiation.
AL662833 Genomic DNA No translation available.
AL662844 Genomic DNA No translation available.
AL773544 Genomic DNA No translation available.
CR753819 Genomic DNA No translation available.
BC110535 mRNA Translation: AAI10536.1 Sequence problems.
AB029331 mRNA Translation: BAA81890.1 Different initiation.
AB029343 Genomic DNA Translation: BAA82158.1 Sequence problems.
AF216493 mRNA Translation: AAF74221.1 Different initiation.
CCDSiCCDS43445.1 [Q8TD31-2]
CCDS4695.1 [Q8TD31-1]
CCDS47397.1 [Q8TD31-3]
RefSeqiNP_001099033.1, NM_001105563.1 [Q8TD31-3]
NP_001099034.1, NM_001105564.1 [Q8TD31-2]
NP_061925.2, NM_019052.3 [Q8TD31-1]
XP_011513005.1, XM_011514703.1 [Q8TD31-1]
XP_016866451.1, XM_017010962.1 [Q8TD31-1]
XP_016866452.1, XM_017010963.1 [Q8TD31-1]
XP_016866453.1, XM_017010964.1 [Q8TD31-1]
XP_016866454.1, XM_017010965.1 [Q8TD31-1]
XP_016866455.1, XM_017010966.1 [Q8TD31-1]
XP_016866456.1, XM_017010967.1 [Q8TD31-1]
XP_016866457.1, XM_017010968.1 [Q8TD31-1]

3D structure databases

SMRiQ8TD31
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120022, 121 interactors
DIPiDIP-40394N
IntActiQ8TD31, 194 interactors
MINTiQ8TD31
STRINGi9606.ENSP00000379566

PTM databases

iPTMnetiQ8TD31
PhosphoSitePlusiQ8TD31

Polymorphism and mutation databases

BioMutaiCCHCR1
DMDMi42558938

Proteomic databases

EPDiQ8TD31
jPOSTiQ8TD31
MassIVEiQ8TD31
MaxQBiQ8TD31
PaxDbiQ8TD31
PeptideAtlasiQ8TD31
PRIDEiQ8TD31
ProteomicsDBi19833
74228 [Q8TD31-1]
74229 [Q8TD31-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53233 85 antibodies

Genome annotation databases

EnsembliENST00000376266; ENSP00000365442; ENSG00000204536 [Q8TD31-1]
ENST00000383341; ENSP00000372832; ENSG00000206355
ENST00000383527; ENSP00000373019; ENSG00000206457 [Q8TD31-1]
ENST00000396268; ENSP00000379566; ENSG00000204536 [Q8TD31-2]
ENST00000400352; ENSP00000383205; ENSG00000206355
ENST00000400412; ENSP00000383263; ENSG00000206457 [Q8TD31-2]
ENST00000416163; ENSP00000408012; ENSG00000234114
ENST00000425620; ENSP00000393042; ENSG00000234114
ENST00000451521; ENSP00000401039; ENSG00000204536 [Q8TD31-3]
GeneIDi54535
KEGGihsa:54535
UCSCiuc003nsp.4 human [Q8TD31-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54535
DisGeNETi54535
EuPathDBiHostDB:ENSG00000204536.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCHCR1
HGNCiHGNC:13930 CCHCR1
HPAiENSG00000204536 Tissue enriched (testis)
MIMi605310 gene
neXtProtiNX_Q8TD31
OpenTargetsiENSG00000204536
PharmGKBiPA134942738

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGTY Eukaryota
ENOG410YGAD LUCA
GeneTreeiENSGT00940000153251
InParanoidiQ8TD31
KOiK16760
OMAiQELEQSW
OrthoDBi1046571at2759
PhylomeDBiQ8TD31
TreeFamiTF336947

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54535 1 hit in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCHCR1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CCHCR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54535
PharosiQ8TD31 Tbio

Protein Ontology

More...
PROi
PR:Q8TD31
RNActiQ8TD31 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204536 Expressed in testis and 206 other tissues
ExpressionAtlasiQ8TD31 baseline and differential
GenevisibleiQ8TD31 HS

Family and domain databases

InterProiView protein in InterPro
IPR009800 HCR
PANTHERiPTHR46822 PTHR46822, 1 hit
PfamiView protein in Pfam
PF07111 HCR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCHCR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD31
Secondary accession number(s): A2ABH6
, E9PE84, Q2TB67, Q5SQ82, Q5STE9, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: June 17, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again