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UniProtKB - Q8TD26 (CHD6_HUMAN)

Entry version 186 (29 Sep 2021)
Sequence version 4 (18 May 2010)
Previous versions | rss
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Protein

Chromodomain-helicase-DNA-binding protein 6

Gene

CHD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432).

Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.

2 Publications

(Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner.

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi486 – 493ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processHost-virus interaction, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TD26

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 6 (EC:3.6.4.12)
Short name:
CHD-6
Alternative name(s):
ATP-dependent helicase CHD6
Radiation-induced gene B protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHD6
Synonyms:CHD5, KIAA1335, RIGB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19057, CHD6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616114, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TD26

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000124177

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration disrupting CHD6 has been found in a patient with mild to moderate mental retardation and minor facial anomalies. Translocation t(18;20)(q21.1;q11.2) with TCF4 producing a CHD6-TCF4 fusion transcript (PubMed:18627065).1 Publication

Organism-specific databases

DisGeNET

More...DisGeNETi		84181

Open Targets

More...OpenTargetsi		ENSG00000124177

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134974700

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TD26, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHD6

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439466

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000802311 – 2715Chromodomain-helicase-DNA-binding protein 6Add BLAST2715

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TD26

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TD26

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TD26

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TD26

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TD26

PeptideAtlas

More...PeptideAtlasi		Q8TD26

PRoteomics IDEntifications database

More...PRIDEi		Q8TD26

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74223 [Q8TD26-1]
74224 [Q8TD26-2]
74225 [Q8TD26-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q8TD26

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TD26, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TD26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TD26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124177, Expressed in sural nerve and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TD26, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TD26, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124177, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NFE2L2; involved in activation of the transcription.

1 Publication

(Microbial infection) Interacts with the influenza A polymerase complex composed fo PB1, PB2 and PA.

1 Publication

(Microbial infection) Interacts (via N-terminus) with human papillomavirus protein E8^E2C (via C-terminus); this interaction induces transcriptional repression of the viral genome.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123931, 30 interactors

Protein interaction database and analysis system

More...IntActi		Q8TD26, 18 interactors

Molecular INTeraction database

More...MINTi		Q8TD26

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362330

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TD26, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q8TD26

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TD26

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8TD26

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini292 – 343Chromo 1PROSITE-ProRule annotationAdd BLAST52
Domaini375 – 439Chromo 2PROSITE-ProRule annotationAdd BLAST65
Domaini473 – 647Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini787 – 956Helicase C-terminalPROSITE-ProRule annotationAdd BLAST170
Domaini1449 – 1503Myb-likeAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 747Required for DNA-dependent ATPase activityAdd BLAST747
Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni66 – 244DisorderedSequence analysisAdd BLAST179
Regioni1318 – 1390DisorderedSequence analysisAdd BLAST73
Regioni2027 – 2063DisorderedSequence analysisAdd BLAST37
Regioni2116 – 2148DisorderedSequence analysisAdd BLAST33
Regioni2321 – 2351DisorderedSequence analysisAdd BLAST31
Regioni2373 – 2422DisorderedSequence analysisAdd BLAST50
Regioni2547 – 2602DisorderedSequence analysisAdd BLAST56
Regioni2648 – 2715DisorderedSequence analysisAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi598 – 601DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 30Polar residuesSequence analysisAdd BLAST16
Compositional biasi96 – 208Basic and acidic residuesSequence analysisAdd BLAST113
Compositional biasi209 – 227Polar residuesSequence analysisAdd BLAST19
Compositional biasi228 – 244Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1334 – 1354Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1364 – 1380Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi2027 – 2050Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi2116 – 2146Polar residuesSequence analysisAdd BLAST31
Compositional biasi2547 – 2564Polar residuesSequence analysisAdd BLAST18
Compositional biasi2565 – 2584Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0384, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158986

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000315_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TD26

Identification of Orthologs from Complete Genome Data

More...OMAi		PSGDENC

Database of Orthologous Groups

More...OrthoDBi		7181at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TD26

TreeFam database of animal gene trees

More...TreeFami		TF313572

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10810, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006576, BRK_domain
IPR037259, BRK_sf
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00385, Chromo, 2 hits
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00592, BRK, 1 hit
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF160481, SSF160481, 1 hit
SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50013, CHROMO_2, 1 hit
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TD26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMKIQKKEK QLSNLKVLNH SPMSDASVNF DYKSPSPFDC STDQEEKIED 
        60         70         80         90        100
VASHCLPQKD LYTAEEEAAT LFPRKMTSHN GMEDSGGGGT GVKKKRKKKE 
       110        120        130        140        150
PGDQEGAAKG SKDREPKPKR KREPKEPKEP RKAKEPKKAK EHKEPKQKDG 
       160        170        180        190        200
AKKARKPREA SGTKEAKEKR SCTDSAARTK SRKASKEQGP TPVEKKKKGK 
       210        220        230        240        250
RKSETTVESL ELDQGLTNPS LRSPEESTES TDSQKRRSGR QVKRRKYNED 
       260        270        280        290        300
LDFKVVDDDG ETIAVLGAGR TSALSASTLA WQAEEPPEDD ANIIEKILAS 
       310        320        330        340        350
KTVQEVHPGE PPFDLELFYV KYRNFSYLHC KWATMEELEK DPRIAQKIKR 
       360        370        380        390        400
FRNKQAQMKH IFTEPDEDLF NPDYVEVDRI LEVAHTKDAE TGEEVTHYLV 
       410        420        430        440        450
KWCSLPYEES TWELEEDVDP AKVKEFESLQ VLPEIKHVER PASDSWQKLE 
       460        470        480        490        500
KSREYKNSNQ LREYQLEGMN WLLFNWYNRK NCILADEMGL GKTIQSITFL 
       510        520        530        540        550
SEIFLRGIHG PFLIIAPLST ITNWEREFRT WTEMNAIVYH GSQISRQMIQ 
       560        570        580        590        600
QYEMVYRDAQ GNPLSGVFKF HVVITTFEMI LADCPELKKI HWSCVIIDEA 
       610        620        630        640        650
HRLKNRNCKL LEGLKLMALE HKVLLTGTPL QNSVEELFSL LNFLEPSQFP 
       660        670        680        690        700
SETAFLEEFG DLKTEEQVKK LQSILKPMML RRLKDDVEKN LAPKQETIIE 
       710        720        730        740        750
VELTNIQKKY YRAILEKNFS FLTKGANQHN MPNLINTMME LRKCCNHPYL 
       760        770        780        790        800
INGAEEKILE DFRKTHSPDA PDFQLQAMIQ AAGKLVLIDK LLPKLIAGGH 
       810        820        830        840        850
KVLIFSQMVR CLDILEDYLI QRRYTYERID GRVRGNLRQA AIDRFCKPDS 
       860        870        880        890        900
DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK 
       910        920        930        940        950
AVKVYRLITR NSYEREMFDK ASLKLGLDKA VLQDINRKGG TNGVQQLSKM 
       960        970        980        990       1000
EVEDLLRKGA YGALMDEEDE GSKFCEEDID QILQRRTHTI TIQSEGKGST 
      1010       1020       1030       1040       1050
FAKASFVASG NRTDISLDDP NFWQKWAKIA ELDTEAKNEK ESLVIDRPRV 
      1060       1070       1080       1090       1100
RKQTKHYNSF EEDELMEFSE LDSDSDERPT RSRRLNDKAR RYLRAECFRV 
      1110       1120       1130       1140       1150
EKNLLIFGWG RWKDILTHGR FKWHLNEKDM EMICRALLVY CVKHYKGDEK 
      1160       1170       1180       1190       1200
IKSFIWELIT PTKDGQAQTL QNHSGLSAPV PRGRKGKKTK NQLLIPELKD 
      1210       1220       1230       1240       1250
ADWLATCNPE VVLHDDGYKK HLKQHCNKVL LRVRMLYYLK AEILGEAAEK 
      1260       1270       1280       1290       1300
AFEGSPAREL DVPLPDIDYM EIPVDWWDAE ADKSLLIGVF KHGYERYNAM 
      1310       1320       1330       1340       1350
RADPALCFLE KVGMPDEKSL SAEQGVTDGT SDIPERGNTD KEDNAEDKVD 
      1360       1370       1380       1390       1400
GLQKQTESSS DGGDGVFSEK KDDSRAAQDG SDPDKSPWPV SSALTARLRR 
      1410       1420       1430       1440       1450
LVTVYQRCNR KELCRPEILG PGNQGYWVQE EMFRRTSEMD LINKEAQKRW 
      1460       1470       1480       1490       1500
TRREQADFYR TVSSFGVVYD QEKKTFDWTQ FRIISRLDKK SDESLEQYFY 
      1510       1520       1530       1540       1550
SFVAMCRNVC RLPTWKDGGP PDTTIYVEPI TEERAARTLY RIELLRKVRE 
      1560       1570       1580       1590       1600
QVLKCPQLHE RLQLCRPSLY LPVWWECGKH DRDLLIGTAK HGLNRTDCYI 
      1610       1620       1630       1640       1650
MNDPQLSFLD AYRNYAQHKR SGTQAPGNLC CLYQTNSKLY ESLTYSQMSR 
      1660       1670       1680       1690       1700
TSESLENEPE NLVRVESRDD HLSLPDVTCE NFISKVQDVI SINHDESLLP 
      1710       1720       1730       1740       1750
ESLESMMYGK KVLSQEPSSF QESPSTNTES RKDVITISIS KDGNCQSGGP 
      1760       1770       1780       1790       1800
EAEIASGPTF MGSLEAGGVA QANIKNGKHL LMSISKEGEL CCSEAGQRPE 
      1810       1820       1830       1840       1850
NIGQLEAKCL ASPSLNPGNE SGFVDMCSLS VCDSKRNLSS DQQLIDLLEN 
      1860       1870       1880       1890       1900
KSLESKLILS QNHSDEEEEE EENEEENLAM AVGMGERPEV LHLTEPTTNI 
      1910       1920       1930       1940       1950
SREKNQGFQD ETKKGSLEVA NQTPGLQRAF PAPAACQCHC KHMERWMHGL 
      1960       1970       1980       1990       2000
ENDEFEIEKP KAYIPDLFKS KTNTIAMEGE PTAIPSQPFK VKHELLKEPW 
      2010       2020       2030       2040       2050
KESAEGQNVF PTYPLEGSEL KSEDMDFENK DDYDRDGNCH SQDYPGKYSE 
      2060       2070       2080       2090       2100
EESKSSTSGI TGDIGDELQE ARAPTIAQLL QEKTLYSFSE WPKDRVIINR 
      2110       2120       2130       2140       2150
LDNICHVVLK GKWPSSQQYE PSGTLPTPVL TSSAGSRTSL SEPEAAEHSF 
      2160       2170       2180       2190       2200
SNGAALAAQI HKESFLAPVF TKDEQKHRRP YEFEVERDAK ARGLEQFSAT 
      2210       2220       2230       2240       2250
HGHTPIILNG WHGESAMDLS CSSEGSPGAT SPFPVSASTP KIGAISSLQG 
      2260       2270       2280       2290       2300
ALGMDLSGIL QAGLIHPVTG QIVNGSLRRD DAATRRRRGR RKHVEGGMDL 
      2310       2320       2330       2340       2350
IFLKEQTLQA GILEVHEDPG QATLSTTHPE GPGPATSAPE PATAASSQAE 
      2360       2370       2380       2390       2400
KSIPSKSLLD WLRQQADYSL EVPGFGANFS DKPKQRRPRC KEPGKLDVSS 
      2410       2420       2430       2440       2450
LSGEERVPAI PKEPGLRGFL PENKFNHTLA EPILRDTGPR RRGRRPRSEL 
      2460       2470       2480       2490       2500
LKAPSIVADS PSGMGPLFMN GLIAGMDLVG LQNMRNMPGI PLTGLVGFPA 
      2510       2520       2530       2540       2550
GFATMPTGEE VKSTLSMLPM MLPGMAAVPQ MFGVGGLLSP PMATTCTSTA 
      2560       2570       2580       2590       2600
PASLSSTTKS GTAVTEKTAE DKPSSHDVKT DTLAEDKPGP GPFSDQSEPA 
      2610       2620       2630       2640       2650
ITTSSPVAFN PFLIPGVSPG LIYPSMFLSP GMGMALPAMQ QARHSEIVGL 
      2660       2670       2680       2690       2700
ESQKRKKKKT KGDNPNSHPE PAPSCEREPS GDENCAEPSA PLPAEREHGA 
      2710 
QAGEGALKDS NNDTN
Length:2,715
Mass (Da):305,412
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B3FEC537340A8B7
GO
Isoform 2 (identifier: Q8TD26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MKMKIQKKEK → MCQSHMIGFCTSSVNEETETQGDQISCPNPTTLVFRTQISSLPSL
     325-338: FSYLHCKWATMEEL → LYVYLKYSLYLGFI
     339-2715: Missing.

Show »
Length:373
Mass (Da):41,654
Checksum:i0264B708481CB446
GO
Isoform 3 (identifier: Q8TD26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-1108: Missing.
     1337-1339: GNT → QHR
     1340-2715: Missing.

Show »
Length:822
Mass (Da):94,609
Checksum:iBC0D0A3987286332
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C294H7C294_HUMAN
DNA helicase
CHD6
525Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B6P4A0A075B6P4_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD6
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK56405 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAN59903 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15325 differs from that shown. The sequence differs from position 1528 onward for unknown reasons.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti134K → E in AAK56405 (PubMed:11889561).Curated1
Sequence conflicti575T → A in AAN59903 (Ref. 4) Curated1
Sequence conflicti1031E → K in AAK56405 (PubMed:11889561).Curated1
Sequence conflicti2442 – 2447RGRRPR → EIVGLE in AAH21907 (PubMed:15489334).Curated6
Sequence conflicti2663D → G in AAK56405 (PubMed:11889561).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059213780Q → H. Corresponds to variant dbSNP:rs4474937Ensembl.1
Natural variantiVAR_0233632161H → Q. Corresponds to variant dbSNP:rs3817893Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0152961 – 10MKMKIQKKEK → MCQSHMIGFCTSSVNEETET QGDQISCPNPTTLVFRTQIS SLPSL in isoform 2. 1 Publication10
Alternative sequenceiVSP_015297325 – 338FSYLH…TMEEL → LYVYLKYSLYLGFI in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_015298339 – 2715Missing in isoform 2. 1 PublicationAdd BLAST2377
Alternative sequenceiVSP_015299592 – 1108Missing in isoform 3. 1 PublicationAdd BLAST517
Alternative sequenceiVSP_0153001337 – 1339GNT → QHR in isoform 3. 1 Publication3
Alternative sequenceiVSP_0153011340 – 2715Missing in isoform 3. 1 PublicationAdd BLAST1376

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY034072 mRNA Translation: AAK56405.1 Different initiation.
AL031667 Genomic DNA No translation available.
AL031669 Genomic DNA No translation available.
AL121674 Genomic DNA No translation available.
BC021907 mRNA Translation: AAH21907.1
BC039860 mRNA No translation available.
BC040016 mRNA No translation available.
AF525085 mRNA Translation: AAN59903.1 Different initiation.
AB037756 mRNA Translation: BAA92573.2
AK026022 mRNA Translation: BAB15325.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13317.1 [Q8TD26-1]

NCBI Reference Sequences

More...RefSeqi		NP_115597.3, NM_032221.4 [Q8TD26-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373222; ENSP00000362319; ENSG00000124177 [Q8TD26-2]
ENST00000373233; ENSP00000362330; ENSG00000124177 [Q8TD26-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84181

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84181

UCSC genome browser

More...UCSCi		uc002xka.3, human [Q8TD26-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034072 mRNA Translation: AAK56405.1 Different initiation.
AL031667 Genomic DNA No translation available.
AL031669 Genomic DNA No translation available.
AL121674 Genomic DNA No translation available.
BC021907 mRNA Translation: AAH21907.1
BC039860 mRNA No translation available.
BC040016 mRNA No translation available.
AF525085 mRNA Translation: AAN59903.1 Different initiation.
AB037756 mRNA Translation: BAA92573.2
AK026022 mRNA Translation: BAB15325.1 Sequence problems.
CCDSiCCDS13317.1 [Q8TD26-1]
RefSeqiNP_115597.3, NM_032221.4 [Q8TD26-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EPBNMR-A371-431[»]
BMRBiQ8TD26
SMRiQ8TD26
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123931, 30 interactors
IntActiQ8TD26, 18 interactors
MINTiQ8TD26
STRINGi9606.ENSP00000362330

PTM databases

CarbonylDBiQ8TD26
GlyGeniQ8TD26, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ8TD26
PhosphoSitePlusiQ8TD26

Genetic variation databases

BioMutaiCHD6
DMDMi296439466

Proteomic databases

EPDiQ8TD26
jPOSTiQ8TD26
MassIVEiQ8TD26
MaxQBiQ8TD26
PaxDbiQ8TD26
PeptideAtlasiQ8TD26
PRIDEiQ8TD26
ProteomicsDBi74223 [Q8TD26-1]
74224 [Q8TD26-2]
74225 [Q8TD26-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27058, 51 antibodies

The DNASU plasmid repository

More...DNASUi		84181

Genome annotation databases

EnsembliENST00000373222; ENSP00000362319; ENSG00000124177 [Q8TD26-2]
ENST00000373233; ENSP00000362330; ENSG00000124177 [Q8TD26-1]
GeneIDi84181
KEGGihsa:84181
UCSCiuc002xka.3, human [Q8TD26-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84181
DisGeNETi84181

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHD6
HGNCiHGNC:19057, CHD6
HPAiENSG00000124177, Low tissue specificity
MIMi616114, gene
neXtProtiNX_Q8TD26
OpenTargetsiENSG00000124177
PharmGKBiPA134974700
VEuPathDBiHostDB:ENSG00000124177

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0384, Eukaryota
GeneTreeiENSGT00940000158986
HOGENOMiCLU_000315_5_1_1
InParanoidiQ8TD26
OMAiPSGDENC
OrthoDBi7181at2759
PhylomeDBiQ8TD26
TreeFamiTF313572

Enzyme and pathway databases

PathwayCommonsiQ8TD26

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84181, 10 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHD6, human
EvolutionaryTraceiQ8TD26

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84181
PharosiQ8TD26, Tbio

Protein Ontology

More...PROi		PR:Q8TD26
RNActiQ8TD26, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124177, Expressed in sural nerve and 214 other tissues
ExpressionAtlasiQ8TD26, baseline and differential
GenevisibleiQ8TD26, HS

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR006576, BRK_domain
IPR037259, BRK_sf
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PfamiView protein in Pfam
PF00385, Chromo, 2 hits
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592, BRK, 1 hit
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF160481, SSF160481, 1 hit
SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013, CHROMO_2, 1 hit
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD26
Secondary accession number(s): Q5JYQ0
, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 186 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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