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UniProtKB - Q8TD26 (CHD6_HUMAN)

Protein

Chromodomain-helicase-DNA-binding protein 6

Gene

CHD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 Publications
(Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner.3 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi486 – 493ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • DNA-dependent ATPase activity Source: UniProtKB
  • helicase activity Source: UniProtKB-KW
  • transcription cofactor binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processHost-virus interaction, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 6 (EC:3.6.4.12)
Short name:
CHD-6
Alternative name(s):
ATP-dependent helicase CHD6
Radiation-induced gene B protein
Gene namesi
Name:CHD6
Synonyms:CHD5, KIAA1335, RIGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124177.14
HGNCiHGNC:19057 CHD6
MIMi616114 gene
neXtProtiNX_Q8TD26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration disrupting CHD6 has been found in a patient with mild to moderate mental retardation and minor facial anomalies. Translocation t(18;20)(q21.1;q11.2) with TCF4 producing a CHD6-TCF4 fusion transcript (PubMed:18627065).1 Publication

Organism-specific databases

DisGeNETi84181
OpenTargetsiENSG00000124177
PharmGKBiPA134974700

Polymorphism and mutation databases

BioMutaiCHD6
DMDMi296439466

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802311 – 2715Chromodomain-helicase-DNA-binding protein 6Add BLAST2715

Proteomic databases

EPDiQ8TD26
MaxQBiQ8TD26
PaxDbiQ8TD26
PeptideAtlasiQ8TD26
PRIDEiQ8TD26
ProteomicsDBi74223
74224 [Q8TD26-2]
74225 [Q8TD26-3]

PTM databases

CarbonylDBiQ8TD26
iPTMnetiQ8TD26
PhosphoSitePlusiQ8TD26

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000124177 Expressed in 197 organ(s), highest expression level in lung
CleanExiHS_CHD5
HS_CHD6
ExpressionAtlasiQ8TD26 baseline and differential
GenevisibleiQ8TD26 HS

Organism-specific databases

HPAiHPA015543

Interactioni

Subunit structurei

Interacts with NFE2L2; involved in activation of the transcription.1 Publication
(Microbial infection) Interacts with the influenza A polymerase complex composed fo PB1, PB2 and PA.1 Publication
(Microbial infection) Interacts (via N-terminus) with human papillomavirus protein E8^E2C (via C-terminus); this interaction induces transcriptional repression of the viral genome.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi123931, 16 interactors
IntActiQ8TD26, 13 interactors
MINTiQ8TD26
STRINGi9606.ENSP00000362330

Structurei

Secondary structure

12715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TD26
SMRiQ8TD26
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TD26

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 343Chromo 1PROSITE-ProRule annotationAdd BLAST52
Domaini375 – 439Chromo 2PROSITE-ProRule annotationAdd BLAST65
Domaini473 – 647Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini787 – 956Helicase C-terminalPROSITE-ProRule annotationAdd BLAST170
Domaini1449 – 1503Myb-likeAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 747Required for DNA-dependent ATPase activityAdd BLAST747

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi598 – 601DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi93 – 202Lys-richAdd BLAST110

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0383 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00760000119067
HOVERGENiHBG081150
InParanoidiQ8TD26
KOiK14436
OMAiTIYQRCN
OrthoDBiEOG091G0022
PhylomeDBiQ8TD26
TreeFamiTF313572

Family and domain databases

CDDicd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592 BRK, 1 hit
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF160481 SSF160481, 1 hit
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 1 hit
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TD26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMKIQKKEK QLSNLKVLNH SPMSDASVNF DYKSPSPFDC STDQEEKIED 
        60         70         80         90        100
VASHCLPQKD LYTAEEEAAT LFPRKMTSHN GMEDSGGGGT GVKKKRKKKE 
       110        120        130        140        150
PGDQEGAAKG SKDREPKPKR KREPKEPKEP RKAKEPKKAK EHKEPKQKDG 
       160        170        180        190        200
AKKARKPREA SGTKEAKEKR SCTDSAARTK SRKASKEQGP TPVEKKKKGK 
       210        220        230        240        250
RKSETTVESL ELDQGLTNPS LRSPEESTES TDSQKRRSGR QVKRRKYNED 
       260        270        280        290        300
LDFKVVDDDG ETIAVLGAGR TSALSASTLA WQAEEPPEDD ANIIEKILAS 
       310        320        330        340        350
KTVQEVHPGE PPFDLELFYV KYRNFSYLHC KWATMEELEK DPRIAQKIKR 
       360        370        380        390        400
FRNKQAQMKH IFTEPDEDLF NPDYVEVDRI LEVAHTKDAE TGEEVTHYLV 
       410        420        430        440        450
KWCSLPYEES TWELEEDVDP AKVKEFESLQ VLPEIKHVER PASDSWQKLE 
       460        470        480        490        500
KSREYKNSNQ LREYQLEGMN WLLFNWYNRK NCILADEMGL GKTIQSITFL 
       510        520        530        540        550
SEIFLRGIHG PFLIIAPLST ITNWEREFRT WTEMNAIVYH GSQISRQMIQ 
       560        570        580        590        600
QYEMVYRDAQ GNPLSGVFKF HVVITTFEMI LADCPELKKI HWSCVIIDEA 
       610        620        630        640        650
HRLKNRNCKL LEGLKLMALE HKVLLTGTPL QNSVEELFSL LNFLEPSQFP 
       660        670        680        690        700
SETAFLEEFG DLKTEEQVKK LQSILKPMML RRLKDDVEKN LAPKQETIIE 
       710        720        730        740        750
VELTNIQKKY YRAILEKNFS FLTKGANQHN MPNLINTMME LRKCCNHPYL 
       760        770        780        790        800
INGAEEKILE DFRKTHSPDA PDFQLQAMIQ AAGKLVLIDK LLPKLIAGGH 
       810        820        830        840        850
KVLIFSQMVR CLDILEDYLI QRRYTYERID GRVRGNLRQA AIDRFCKPDS 
       860        870        880        890        900
DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK 
       910        920        930        940        950
AVKVYRLITR NSYEREMFDK ASLKLGLDKA VLQDINRKGG TNGVQQLSKM 
       960        970        980        990       1000
EVEDLLRKGA YGALMDEEDE GSKFCEEDID QILQRRTHTI TIQSEGKGST 
      1010       1020       1030       1040       1050
FAKASFVASG NRTDISLDDP NFWQKWAKIA ELDTEAKNEK ESLVIDRPRV 
      1060       1070       1080       1090       1100
RKQTKHYNSF EEDELMEFSE LDSDSDERPT RSRRLNDKAR RYLRAECFRV 
      1110       1120       1130       1140       1150
EKNLLIFGWG RWKDILTHGR FKWHLNEKDM EMICRALLVY CVKHYKGDEK 
      1160       1170       1180       1190       1200
IKSFIWELIT PTKDGQAQTL QNHSGLSAPV PRGRKGKKTK NQLLIPELKD 
      1210       1220       1230       1240       1250
ADWLATCNPE VVLHDDGYKK HLKQHCNKVL LRVRMLYYLK AEILGEAAEK 
      1260       1270       1280       1290       1300
AFEGSPAREL DVPLPDIDYM EIPVDWWDAE ADKSLLIGVF KHGYERYNAM 
      1310       1320       1330       1340       1350
RADPALCFLE KVGMPDEKSL SAEQGVTDGT SDIPERGNTD KEDNAEDKVD 
      1360       1370       1380       1390       1400
GLQKQTESSS DGGDGVFSEK KDDSRAAQDG SDPDKSPWPV SSALTARLRR 
      1410       1420       1430       1440       1450
LVTVYQRCNR KELCRPEILG PGNQGYWVQE EMFRRTSEMD LINKEAQKRW 
      1460       1470       1480       1490       1500
TRREQADFYR TVSSFGVVYD QEKKTFDWTQ FRIISRLDKK SDESLEQYFY 
      1510       1520       1530       1540       1550
SFVAMCRNVC RLPTWKDGGP PDTTIYVEPI TEERAARTLY RIELLRKVRE 
      1560       1570       1580       1590       1600
QVLKCPQLHE RLQLCRPSLY LPVWWECGKH DRDLLIGTAK HGLNRTDCYI 
      1610       1620       1630       1640       1650
MNDPQLSFLD AYRNYAQHKR SGTQAPGNLC CLYQTNSKLY ESLTYSQMSR 
      1660       1670       1680       1690       1700
TSESLENEPE NLVRVESRDD HLSLPDVTCE NFISKVQDVI SINHDESLLP 
      1710       1720       1730       1740       1750
ESLESMMYGK KVLSQEPSSF QESPSTNTES RKDVITISIS KDGNCQSGGP 
      1760       1770       1780       1790       1800
EAEIASGPTF MGSLEAGGVA QANIKNGKHL LMSISKEGEL CCSEAGQRPE 
      1810       1820       1830       1840       1850
NIGQLEAKCL ASPSLNPGNE SGFVDMCSLS VCDSKRNLSS DQQLIDLLEN 
      1860       1870       1880       1890       1900
KSLESKLILS QNHSDEEEEE EENEEENLAM AVGMGERPEV LHLTEPTTNI 
      1910       1920       1930       1940       1950
SREKNQGFQD ETKKGSLEVA NQTPGLQRAF PAPAACQCHC KHMERWMHGL 
      1960       1970       1980       1990       2000
ENDEFEIEKP KAYIPDLFKS KTNTIAMEGE PTAIPSQPFK VKHELLKEPW 
      2010       2020       2030       2040       2050
KESAEGQNVF PTYPLEGSEL KSEDMDFENK DDYDRDGNCH SQDYPGKYSE 
      2060       2070       2080       2090       2100
EESKSSTSGI TGDIGDELQE ARAPTIAQLL QEKTLYSFSE WPKDRVIINR 
      2110       2120       2130       2140       2150
LDNICHVVLK GKWPSSQQYE PSGTLPTPVL TSSAGSRTSL SEPEAAEHSF 
      2160       2170       2180       2190       2200
SNGAALAAQI HKESFLAPVF TKDEQKHRRP YEFEVERDAK ARGLEQFSAT 
      2210       2220       2230       2240       2250
HGHTPIILNG WHGESAMDLS CSSEGSPGAT SPFPVSASTP KIGAISSLQG 
      2260       2270       2280       2290       2300
ALGMDLSGIL QAGLIHPVTG QIVNGSLRRD DAATRRRRGR RKHVEGGMDL 
      2310       2320       2330       2340       2350
IFLKEQTLQA GILEVHEDPG QATLSTTHPE GPGPATSAPE PATAASSQAE 
      2360       2370       2380       2390       2400
KSIPSKSLLD WLRQQADYSL EVPGFGANFS DKPKQRRPRC KEPGKLDVSS 
      2410       2420       2430       2440       2450
LSGEERVPAI PKEPGLRGFL PENKFNHTLA EPILRDTGPR RRGRRPRSEL 
      2460       2470       2480       2490       2500
LKAPSIVADS PSGMGPLFMN GLIAGMDLVG LQNMRNMPGI PLTGLVGFPA 
      2510       2520       2530       2540       2550
GFATMPTGEE VKSTLSMLPM MLPGMAAVPQ MFGVGGLLSP PMATTCTSTA 
      2560       2570       2580       2590       2600
PASLSSTTKS GTAVTEKTAE DKPSSHDVKT DTLAEDKPGP GPFSDQSEPA 
      2610       2620       2630       2640       2650
ITTSSPVAFN PFLIPGVSPG LIYPSMFLSP GMGMALPAMQ QARHSEIVGL 
      2660       2670       2680       2690       2700
ESQKRKKKKT KGDNPNSHPE PAPSCEREPS GDENCAEPSA PLPAEREHGA 
      2710 
QAGEGALKDS NNDTN
Length:2,715
Mass (Da):305,412
Last modified:May 18, 2010 - v4
Checksum:i5B3FEC537340A8B7
GO
Isoform 2 (identifier: Q8TD26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MKMKIQKKEK → MCQSHMIGFCTSSVNEETETQGDQISCPNPTTLVFRTQISSLPSL
     325-338: FSYLHCKWATMEEL → LYVYLKYSLYLGFI
     339-2715: Missing.

Note: Gene prediction based on EST data.
Show »
Length:373
Mass (Da):41,654
Checksum:i0264B708481CB446
GO
Isoform 3 (identifier: Q8TD26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-1108: Missing.
     1337-1339: GNT → QHR
     1340-2715: Missing.

Note: No experimental confirmation available.
Show »
Length:822
Mass (Da):94,609
Checksum:iBC0D0A3987286332
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFU2C9JFU2_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD6
488Annotation score:
H7C294H7C294_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD6
525Annotation score:
A0A075B6P4A0A075B6P4_HUMAN
Chromodomain-helicase-DNA-binding p...
CHD6
149Annotation score:

Sequence cautioni

The sequence AAK56405 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAN59903 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15325 differs from that shown. The sequence differs from position 1528 onward for unknown reasons.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134K → E in AAK56405 (PubMed:11889561).Curated1
Sequence conflicti575T → A in AAN59903 (Ref. 4) Curated1
Sequence conflicti1031E → K in AAK56405 (PubMed:11889561).Curated1
Sequence conflicti2442 – 2447RGRRPR → EIVGLE in AAH21907 (PubMed:15489334).Curated6
Sequence conflicti2663D → G in AAK56405 (PubMed:11889561).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059213780Q → H. Corresponds to variant dbSNP:rs4474937Ensembl.1
Natural variantiVAR_0233632161H → Q. Corresponds to variant dbSNP:rs3817893Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0152961 – 10MKMKIQKKEK → MCQSHMIGFCTSSVNEETET QGDQISCPNPTTLVFRTQIS SLPSL in isoform 2. 1 Publication10
Alternative sequenceiVSP_015297325 – 338FSYLH…TMEEL → LYVYLKYSLYLGFI in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_015298339 – 2715Missing in isoform 2. 1 PublicationAdd BLAST2377
Alternative sequenceiVSP_015299592 – 1108Missing in isoform 3. 1 PublicationAdd BLAST517
Alternative sequenceiVSP_0153001337 – 1339GNT → QHR in isoform 3. 1 Publication3
Alternative sequenceiVSP_0153011340 – 2715Missing in isoform 3. 1 PublicationAdd BLAST1376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034072 mRNA Translation: AAK56405.1 Different initiation.
AL031667 Genomic DNA No translation available.
AL031669 Genomic DNA No translation available.
AL121674 Genomic DNA No translation available.
BC021907 mRNA Translation: AAH21907.1
BC039860 mRNA No translation available.
BC040016 mRNA No translation available.
AF525085 mRNA Translation: AAN59903.1 Different initiation.
AB037756 mRNA Translation: BAA92573.2
AK026022 mRNA Translation: BAB15325.1 Sequence problems.
CCDSiCCDS13317.1 [Q8TD26-1]
RefSeqiNP_115597.3, NM_032221.4 [Q8TD26-1]
UniGeneiHs.740645

Genome annotation databases

EnsembliENST00000373222; ENSP00000362319; ENSG00000124177 [Q8TD26-2]
ENST00000373233; ENSP00000362330; ENSG00000124177 [Q8TD26-1]
GeneIDi84181
KEGGihsa:84181
UCSCiuc002xka.3 human [Q8TD26-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034072 mRNA Translation: AAK56405.1 Different initiation.
AL031667 Genomic DNA No translation available.
AL031669 Genomic DNA No translation available.
AL121674 Genomic DNA No translation available.
BC021907 mRNA Translation: AAH21907.1
BC039860 mRNA No translation available.
BC040016 mRNA No translation available.
AF525085 mRNA Translation: AAN59903.1 Different initiation.
AB037756 mRNA Translation: BAA92573.2
AK026022 mRNA Translation: BAB15325.1 Sequence problems.
CCDSiCCDS13317.1 [Q8TD26-1]
RefSeqiNP_115597.3, NM_032221.4 [Q8TD26-1]
UniGeneiHs.740645

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EPBNMR-A371-431[»]
ProteinModelPortaliQ8TD26
SMRiQ8TD26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123931, 16 interactors
IntActiQ8TD26, 13 interactors
MINTiQ8TD26
STRINGi9606.ENSP00000362330

PTM databases

CarbonylDBiQ8TD26
iPTMnetiQ8TD26
PhosphoSitePlusiQ8TD26

Polymorphism and mutation databases

BioMutaiCHD6
DMDMi296439466

Proteomic databases

EPDiQ8TD26
MaxQBiQ8TD26
PaxDbiQ8TD26
PeptideAtlasiQ8TD26
PRIDEiQ8TD26
ProteomicsDBi74223
74224 [Q8TD26-2]
74225 [Q8TD26-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373222; ENSP00000362319; ENSG00000124177 [Q8TD26-2]
ENST00000373233; ENSP00000362330; ENSG00000124177 [Q8TD26-1]
GeneIDi84181
KEGGihsa:84181
UCSCiuc002xka.3 human [Q8TD26-1]

Organism-specific databases

CTDi84181
DisGeNETi84181
EuPathDBiHostDB:ENSG00000124177.14
GeneCardsiCHD6
H-InvDBiHIX0015824
HIX0027712
HGNCiHGNC:19057 CHD6
HPAiHPA015543
MIMi616114 gene
neXtProtiNX_Q8TD26
OpenTargetsiENSG00000124177
PharmGKBiPA134974700
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0383 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00760000119067
HOVERGENiHBG081150
InParanoidiQ8TD26
KOiK14436
OMAiTIYQRCN
OrthoDBiEOG091G0022
PhylomeDBiQ8TD26
TreeFamiTF313572

Miscellaneous databases

ChiTaRSiCHD6 human
EvolutionaryTraceiQ8TD26
GenomeRNAii84181
PROiPR:Q8TD26
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124177 Expressed in 197 organ(s), highest expression level in lung
CleanExiHS_CHD5
HS_CHD6
ExpressionAtlasiQ8TD26 baseline and differential
GenevisibleiQ8TD26 HS

Family and domain databases

CDDicd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592 BRK, 1 hit
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF160481 SSF160481, 1 hit
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 1 hit
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHD6_HUMAN
AccessioniPrimary (citable) accession number: Q8TD26
Secondary accession number(s): Q5JYQ0
, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 168 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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