UniProtKB - Q8TD26 (CHD6_HUMAN)
Chromodomain-helicase-DNA-binding protein 6
CHD6
Functioni
Catalytic activityi
- EC:3.6.4.121 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 486 – 493 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA-dependent ATPase activity Source: UniProtKB
- DNA helicase activity Source: UniProtKB-EC
- transcription cofactor binding Source: UniProtKB
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Helicase, Hydrolase |
Biological process | Host-virus interaction, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8TD26 |
Names & Taxonomyi
Protein namesi | Recommended name: Chromodomain-helicase-DNA-binding protein 6 (EC:3.6.4.12)Short name: CHD-6 Alternative name(s): ATP-dependent helicase CHD6 Radiation-induced gene B protein |
Gene namesi | Name:CHD6 Synonyms:CHD5, KIAA1335, RIGB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000124177.14 |
HGNCi | HGNC:19057, CHD6 |
MIMi | 616114, gene |
neXtProti | NX_Q8TD26 |
Subcellular locationi
Nucleus
- nucleoplasm 2 Publications
Note: Enriched at sites of mRNA synthesis (PubMed:17027977). During influenza A virus infection, localizes to inactive chromatin.2 Publications
Nucleus
- nucleoplasm Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Organism-specific databases
DisGeNETi | 84181 |
OpenTargetsi | ENSG00000124177 |
PharmGKBi | PA134974700 |
Miscellaneous databases
Pharosi | Q8TD26, Tbio |
Polymorphism and mutation databases
BioMutai | CHD6 |
DMDMi | 296439466 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080231 | 1 – 2715 | Chromodomain-helicase-DNA-binding protein 6Add BLAST | 2715 |
Proteomic databases
EPDi | Q8TD26 |
jPOSTi | Q8TD26 |
MassIVEi | Q8TD26 |
MaxQBi | Q8TD26 |
PaxDbi | Q8TD26 |
PeptideAtlasi | Q8TD26 |
PRIDEi | Q8TD26 |
ProteomicsDBi | 74223 [Q8TD26-1] 74224 [Q8TD26-2] 74225 [Q8TD26-3] |
PTM databases
CarbonylDBi | Q8TD26 |
iPTMneti | Q8TD26 |
PhosphoSitePlusi | Q8TD26 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000124177, Expressed in sural nerve and 213 other tissues |
ExpressionAtlasi | Q8TD26, baseline and differential |
Genevisiblei | Q8TD26, HS |
Organism-specific databases
HPAi | ENSG00000124177, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with NFE2L2; involved in activation of the transcription.
1 Publication(Microbial infection) Interacts with the influenza A polymerase complex composed fo PB1, PB2 and PA.
1 Publication(Microbial infection) Interacts (via N-terminus) with human papillomavirus protein E8^E2C (via C-terminus); this interaction induces transcriptional repression of the viral genome.
1 PublicationGO - Molecular functioni
- transcription cofactor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 123931, 24 interactors |
IntActi | Q8TD26, 15 interactors |
MINTi | Q8TD26 |
STRINGi | 9606.ENSP00000362330 |
Miscellaneous databases
RNActi | Q8TD26, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q8TD26 |
SMRi | Q8TD26 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TD26 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 292 – 343 | Chromo 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 375 – 439 | Chromo 2PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 473 – 647 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 175 | |
Domaini | 787 – 956 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 170 | |
Domaini | 1449 – 1503 | Myb-likeAdd BLAST | 55 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 747 | Required for DNA-dependent ATPase activityAdd BLAST | 747 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 598 – 601 | DEAH box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 93 – 202 | Lys-richAdd BLAST | 110 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0384, Eukaryota |
GeneTreei | ENSGT00940000158986 |
HOGENOMi | CLU_000315_5_1_1 |
InParanoidi | Q8TD26 |
OMAi | PSGDENC |
OrthoDBi | 7181at2759 |
PhylomeDBi | Q8TD26 |
TreeFami | TF313572 |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR006576, BRK_domain IPR037259, BRK_sf IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR023780, Chromo_domain IPR002464, DNA/RNA_helicase_DEAH_CS IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
Pfami | View protein in Pfam PF00385, Chromo, 2 hits PF00271, Helicase_C, 1 hit PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00592, BRK, 1 hit SM00298, CHROMO, 2 hits SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF160481, SSF160481, 1 hit SSF52540, SSF52540, 2 hits SSF54160, SSF54160, 2 hits |
PROSITEi | View protein in PROSITE PS50013, CHROMO_2, 1 hit PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKMKIQKKEK QLSNLKVLNH SPMSDASVNF DYKSPSPFDC STDQEEKIED
60 70 80 90 100
VASHCLPQKD LYTAEEEAAT LFPRKMTSHN GMEDSGGGGT GVKKKRKKKE
110 120 130 140 150
PGDQEGAAKG SKDREPKPKR KREPKEPKEP RKAKEPKKAK EHKEPKQKDG
160 170 180 190 200
AKKARKPREA SGTKEAKEKR SCTDSAARTK SRKASKEQGP TPVEKKKKGK
210 220 230 240 250
RKSETTVESL ELDQGLTNPS LRSPEESTES TDSQKRRSGR QVKRRKYNED
260 270 280 290 300
LDFKVVDDDG ETIAVLGAGR TSALSASTLA WQAEEPPEDD ANIIEKILAS
310 320 330 340 350
KTVQEVHPGE PPFDLELFYV KYRNFSYLHC KWATMEELEK DPRIAQKIKR
360 370 380 390 400
FRNKQAQMKH IFTEPDEDLF NPDYVEVDRI LEVAHTKDAE TGEEVTHYLV
410 420 430 440 450
KWCSLPYEES TWELEEDVDP AKVKEFESLQ VLPEIKHVER PASDSWQKLE
460 470 480 490 500
KSREYKNSNQ LREYQLEGMN WLLFNWYNRK NCILADEMGL GKTIQSITFL
510 520 530 540 550
SEIFLRGIHG PFLIIAPLST ITNWEREFRT WTEMNAIVYH GSQISRQMIQ
560 570 580 590 600
QYEMVYRDAQ GNPLSGVFKF HVVITTFEMI LADCPELKKI HWSCVIIDEA
610 620 630 640 650
HRLKNRNCKL LEGLKLMALE HKVLLTGTPL QNSVEELFSL LNFLEPSQFP
660 670 680 690 700
SETAFLEEFG DLKTEEQVKK LQSILKPMML RRLKDDVEKN LAPKQETIIE
710 720 730 740 750
VELTNIQKKY YRAILEKNFS FLTKGANQHN MPNLINTMME LRKCCNHPYL
760 770 780 790 800
INGAEEKILE DFRKTHSPDA PDFQLQAMIQ AAGKLVLIDK LLPKLIAGGH
810 820 830 840 850
KVLIFSQMVR CLDILEDYLI QRRYTYERID GRVRGNLRQA AIDRFCKPDS
860 870 880 890 900
DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK
910 920 930 940 950
AVKVYRLITR NSYEREMFDK ASLKLGLDKA VLQDINRKGG TNGVQQLSKM
960 970 980 990 1000
EVEDLLRKGA YGALMDEEDE GSKFCEEDID QILQRRTHTI TIQSEGKGST
1010 1020 1030 1040 1050
FAKASFVASG NRTDISLDDP NFWQKWAKIA ELDTEAKNEK ESLVIDRPRV
1060 1070 1080 1090 1100
RKQTKHYNSF EEDELMEFSE LDSDSDERPT RSRRLNDKAR RYLRAECFRV
1110 1120 1130 1140 1150
EKNLLIFGWG RWKDILTHGR FKWHLNEKDM EMICRALLVY CVKHYKGDEK
1160 1170 1180 1190 1200
IKSFIWELIT PTKDGQAQTL QNHSGLSAPV PRGRKGKKTK NQLLIPELKD
1210 1220 1230 1240 1250
ADWLATCNPE VVLHDDGYKK HLKQHCNKVL LRVRMLYYLK AEILGEAAEK
1260 1270 1280 1290 1300
AFEGSPAREL DVPLPDIDYM EIPVDWWDAE ADKSLLIGVF KHGYERYNAM
1310 1320 1330 1340 1350
RADPALCFLE KVGMPDEKSL SAEQGVTDGT SDIPERGNTD KEDNAEDKVD
1360 1370 1380 1390 1400
GLQKQTESSS DGGDGVFSEK KDDSRAAQDG SDPDKSPWPV SSALTARLRR
1410 1420 1430 1440 1450
LVTVYQRCNR KELCRPEILG PGNQGYWVQE EMFRRTSEMD LINKEAQKRW
1460 1470 1480 1490 1500
TRREQADFYR TVSSFGVVYD QEKKTFDWTQ FRIISRLDKK SDESLEQYFY
1510 1520 1530 1540 1550
SFVAMCRNVC RLPTWKDGGP PDTTIYVEPI TEERAARTLY RIELLRKVRE
1560 1570 1580 1590 1600
QVLKCPQLHE RLQLCRPSLY LPVWWECGKH DRDLLIGTAK HGLNRTDCYI
1610 1620 1630 1640 1650
MNDPQLSFLD AYRNYAQHKR SGTQAPGNLC CLYQTNSKLY ESLTYSQMSR
1660 1670 1680 1690 1700
TSESLENEPE NLVRVESRDD HLSLPDVTCE NFISKVQDVI SINHDESLLP
1710 1720 1730 1740 1750
ESLESMMYGK KVLSQEPSSF QESPSTNTES RKDVITISIS KDGNCQSGGP
1760 1770 1780 1790 1800
EAEIASGPTF MGSLEAGGVA QANIKNGKHL LMSISKEGEL CCSEAGQRPE
1810 1820 1830 1840 1850
NIGQLEAKCL ASPSLNPGNE SGFVDMCSLS VCDSKRNLSS DQQLIDLLEN
1860 1870 1880 1890 1900
KSLESKLILS QNHSDEEEEE EENEEENLAM AVGMGERPEV LHLTEPTTNI
1910 1920 1930 1940 1950
SREKNQGFQD ETKKGSLEVA NQTPGLQRAF PAPAACQCHC KHMERWMHGL
1960 1970 1980 1990 2000
ENDEFEIEKP KAYIPDLFKS KTNTIAMEGE PTAIPSQPFK VKHELLKEPW
2010 2020 2030 2040 2050
KESAEGQNVF PTYPLEGSEL KSEDMDFENK DDYDRDGNCH SQDYPGKYSE
2060 2070 2080 2090 2100
EESKSSTSGI TGDIGDELQE ARAPTIAQLL QEKTLYSFSE WPKDRVIINR
2110 2120 2130 2140 2150
LDNICHVVLK GKWPSSQQYE PSGTLPTPVL TSSAGSRTSL SEPEAAEHSF
2160 2170 2180 2190 2200
SNGAALAAQI HKESFLAPVF TKDEQKHRRP YEFEVERDAK ARGLEQFSAT
2210 2220 2230 2240 2250
HGHTPIILNG WHGESAMDLS CSSEGSPGAT SPFPVSASTP KIGAISSLQG
2260 2270 2280 2290 2300
ALGMDLSGIL QAGLIHPVTG QIVNGSLRRD DAATRRRRGR RKHVEGGMDL
2310 2320 2330 2340 2350
IFLKEQTLQA GILEVHEDPG QATLSTTHPE GPGPATSAPE PATAASSQAE
2360 2370 2380 2390 2400
KSIPSKSLLD WLRQQADYSL EVPGFGANFS DKPKQRRPRC KEPGKLDVSS
2410 2420 2430 2440 2450
LSGEERVPAI PKEPGLRGFL PENKFNHTLA EPILRDTGPR RRGRRPRSEL
2460 2470 2480 2490 2500
LKAPSIVADS PSGMGPLFMN GLIAGMDLVG LQNMRNMPGI PLTGLVGFPA
2510 2520 2530 2540 2550
GFATMPTGEE VKSTLSMLPM MLPGMAAVPQ MFGVGGLLSP PMATTCTSTA
2560 2570 2580 2590 2600
PASLSSTTKS GTAVTEKTAE DKPSSHDVKT DTLAEDKPGP GPFSDQSEPA
2610 2620 2630 2640 2650
ITTSSPVAFN PFLIPGVSPG LIYPSMFLSP GMGMALPAMQ QARHSEIVGL
2660 2670 2680 2690 2700
ESQKRKKKKT KGDNPNSHPE PAPSCEREPS GDENCAEPSA PLPAEREHGA
2710
QAGEGALKDS NNDTN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JFU2 | C9JFU2_HUMAN | DNA helicase | CHD6 | 488 | Annotation score: | ||
H7C294 | H7C294_HUMAN | DNA helicase | CHD6 | 525 | Annotation score: | ||
A0A075B6P4 | A0A075B6P4_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD6 | 149 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 134 | K → E in AAK56405 (PubMed:11889561).Curated | 1 | |
Sequence conflicti | 575 | T → A in AAN59903 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1031 | E → K in AAK56405 (PubMed:11889561).Curated | 1 | |
Sequence conflicti | 2442 – 2447 | RGRRPR → EIVGLE in AAH21907 (PubMed:15489334).Curated | 6 | |
Sequence conflicti | 2663 | D → G in AAK56405 (PubMed:11889561).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059213 | 780 | Q → H. Corresponds to variant dbSNP:rs4474937Ensembl. | 1 | |
Natural variantiVAR_023363 | 2161 | H → Q. Corresponds to variant dbSNP:rs3817893Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015296 | 1 – 10 | MKMKIQKKEK → MCQSHMIGFCTSSVNEETET QGDQISCPNPTTLVFRTQIS SLPSL in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_015297 | 325 – 338 | FSYLH…TMEEL → LYVYLKYSLYLGFI in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_015298 | 339 – 2715 | Missing in isoform 2. 1 PublicationAdd BLAST | 2377 | |
Alternative sequenceiVSP_015299 | 592 – 1108 | Missing in isoform 3. 1 PublicationAdd BLAST | 517 | |
Alternative sequenceiVSP_015300 | 1337 – 1339 | GNT → QHR in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_015301 | 1340 – 2715 | Missing in isoform 3. 1 PublicationAdd BLAST | 1376 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY034072 mRNA Translation: AAK56405.1 Different initiation. AL031667 Genomic DNA No translation available. AL031669 Genomic DNA No translation available. AL121674 Genomic DNA No translation available. BC021907 mRNA Translation: AAH21907.1 BC039860 mRNA No translation available. BC040016 mRNA No translation available. AF525085 mRNA Translation: AAN59903.1 Different initiation. AB037756 mRNA Translation: BAA92573.2 AK026022 mRNA Translation: BAB15325.1 Sequence problems. |
CCDSi | CCDS13317.1 [Q8TD26-1] |
RefSeqi | NP_115597.3, NM_032221.4 [Q8TD26-1] |
Genome annotation databases
Ensembli | ENST00000373222; ENSP00000362319; ENSG00000124177 [Q8TD26-2] ENST00000373233; ENSP00000362330; ENSG00000124177 [Q8TD26-1] |
GeneIDi | 84181 |
KEGGi | hsa:84181 |
UCSCi | uc002xka.3, human [Q8TD26-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY034072 mRNA Translation: AAK56405.1 Different initiation. AL031667 Genomic DNA No translation available. AL031669 Genomic DNA No translation available. AL121674 Genomic DNA No translation available. BC021907 mRNA Translation: AAH21907.1 BC039860 mRNA No translation available. BC040016 mRNA No translation available. AF525085 mRNA Translation: AAN59903.1 Different initiation. AB037756 mRNA Translation: BAA92573.2 AK026022 mRNA Translation: BAB15325.1 Sequence problems. |
CCDSi | CCDS13317.1 [Q8TD26-1] |
RefSeqi | NP_115597.3, NM_032221.4 [Q8TD26-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EPB | NMR | - | A | 371-431 | [»] | |
BMRBi | Q8TD26 | |||||
SMRi | Q8TD26 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123931, 24 interactors |
IntActi | Q8TD26, 15 interactors |
MINTi | Q8TD26 |
STRINGi | 9606.ENSP00000362330 |
PTM databases
CarbonylDBi | Q8TD26 |
iPTMneti | Q8TD26 |
PhosphoSitePlusi | Q8TD26 |
Polymorphism and mutation databases
BioMutai | CHD6 |
DMDMi | 296439466 |
Proteomic databases
EPDi | Q8TD26 |
jPOSTi | Q8TD26 |
MassIVEi | Q8TD26 |
MaxQBi | Q8TD26 |
PaxDbi | Q8TD26 |
PeptideAtlasi | Q8TD26 |
PRIDEi | Q8TD26 |
ProteomicsDBi | 74223 [Q8TD26-1] 74224 [Q8TD26-2] 74225 [Q8TD26-3] |
Protocols and materials databases
Antibodypediai | 27058, 46 antibodies |
Genome annotation databases
Ensembli | ENST00000373222; ENSP00000362319; ENSG00000124177 [Q8TD26-2] ENST00000373233; ENSP00000362330; ENSG00000124177 [Q8TD26-1] |
GeneIDi | 84181 |
KEGGi | hsa:84181 |
UCSCi | uc002xka.3, human [Q8TD26-1] |
Organism-specific databases
CTDi | 84181 |
DisGeNETi | 84181 |
EuPathDBi | HostDB:ENSG00000124177.14 |
GeneCardsi | CHD6 |
HGNCi | HGNC:19057, CHD6 |
HPAi | ENSG00000124177, Low tissue specificity |
MIMi | 616114, gene |
neXtProti | NX_Q8TD26 |
OpenTargetsi | ENSG00000124177 |
PharmGKBi | PA134974700 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0384, Eukaryota |
GeneTreei | ENSGT00940000158986 |
HOGENOMi | CLU_000315_5_1_1 |
InParanoidi | Q8TD26 |
OMAi | PSGDENC |
OrthoDBi | 7181at2759 |
PhylomeDBi | Q8TD26 |
TreeFami | TF313572 |
Enzyme and pathway databases
PathwayCommonsi | Q8TD26 |
Miscellaneous databases
BioGRID-ORCSi | 84181, 5 hits in 847 CRISPR screens |
ChiTaRSi | CHD6, human |
EvolutionaryTracei | Q8TD26 |
GenomeRNAii | 84181 |
Pharosi | Q8TD26, Tbio |
PROi | PR:Q8TD26 |
RNActi | Q8TD26, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124177, Expressed in sural nerve and 213 other tissues |
ExpressionAtlasi | Q8TD26, baseline and differential |
Genevisiblei | Q8TD26, HS |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR006576, BRK_domain IPR037259, BRK_sf IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR023780, Chromo_domain IPR002464, DNA/RNA_helicase_DEAH_CS IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
Pfami | View protein in Pfam PF00385, Chromo, 2 hits PF00271, Helicase_C, 1 hit PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00592, BRK, 1 hit SM00298, CHROMO, 2 hits SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF160481, SSF160481, 1 hit SSF52540, SSF52540, 2 hits SSF54160, SSF54160, 2 hits |
PROSITEi | View protein in PROSITE PS50013, CHROMO_2, 1 hit PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHD6_HUMAN | |
Accessioni | Q8TD26Primary (citable) accession number: Q8TD26 Secondary accession number(s): Q5JYQ0 Q9P2L1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations