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Entry version 147 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Zinc finger protein 675

Gene

ZNF675

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri144 – 166C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TD23

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 675
Alternative name(s):
TRAF6-binding zinc finger protein
TRAF6-inhibitory zinc finger protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF675
Synonyms:TIZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197372.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30768, ZNF675

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TD23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
171392

Open Targets

More...
OpenTargetsi
ENSG00000197372

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670476

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TD23, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF675

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453065

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003048751 – 568Zinc finger protein 675Add BLAST568

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TD23

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TD23

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TD23

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TD23

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TD23

PeptideAtlas

More...
PeptideAtlasi
Q8TD23

PRoteomics IDEntifications database

More...
PRIDEi
Q8TD23

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74222

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TD23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TD23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197372, Expressed in cortical plate and 148 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TD23, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TD23, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197372, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF6.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128116, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TD23, 3 interactors

Molecular INTeraction database

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MINTi
Q8TD23

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352836

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TD23, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TD23

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TD23

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
HMENKPF

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TD23

TreeFam database of animal gene trees

More...
TreeFami
TF342117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q8TD23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLTFRDVA IEFSLEEWQC LDTAQRNLYK NVILENYRNL VFLGIAVSKQ
60 70 80 90 100
DLITCLEQEK EPLTVKRHEM VNEPPVMCSH FAQEFWPEQN IKDSFEKVTL
110 120 130 140 150
RRYEKCGNDN FQLKGCKSVD ECKLHKGGYN GLNQCLPTMQ SKMFQCDKYV
160 170 180 190 200
KVFNKFSHSD RHKIKHMENK PFKCKECGRS FCMLSHLTRH ERNYTKVNFC
210 220 230 240 250
KCEECEKAVN QSSKLTKHKR IYTCEKLYKC QECDRTFNQF SNLTEYKKDY
260 270 280 290 300
AREKPYKCEE CGKAFNQSSH LTTHKIIHTG EKPYKCEECG KAFNQFSNLT
310 320 330 340 350
THKKIHTGEQ PYICEECGKA FTQSSTLTTH KRIHTGEKPY KCEECGKAFN
360 370 380 390 400
RSSKLTEHKN IHTGEQPYKC EECGKAFNRS SNLTEHRKIH TEEKPYKCKE
410 420 430 440 450
CGKAFKHSSA LTTHKRIHTG EKPYKCEECG KAFNRSSKLT EHKKLHTGKK
460 470 480 490 500
PYKCEECGKA FIQSSKLTEH KKIHSGEIPY KCEECGKAFK HSSSLTTHKR
510 520 530 540 550
IHTGEKPYKC EECGKAFSRS SKLTEHKIIH TGEKPYKCER CDKAFNQSAN
560
LTKHKKIHTG EKLQNWNV
Length:568
Mass (Da):66,299
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD11640BF26D10B04
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXM7M0QXM7_HUMAN
Zinc finger protein 675
ZNF675
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXU1M0QXU1_HUMAN
Zinc finger protein 675
ZNF675
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1X5M0R1X5_HUMAN
Zinc finger protein 675
ZNF675
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3E4M0R3E4_HUMAN
Zinc finger protein 675
ZNF675
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3G8M0R3G8_HUMAN
Zinc finger protein 675
ZNF675
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1W1M0R1W1_HUMAN
Zinc finger protein 675
ZNF675
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R373M0R373_HUMAN
Zinc finger protein 675
ZNF675
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29Y → C in AAK95822 (PubMed:11751921).Curated1
Sequence conflicti148K → E in AAK95822 (PubMed:11751921).Curated1
Sequence conflicti191 – 218Missing in BAC04216 (PubMed:14702039).CuratedAdd BLAST28
Sequence conflicti293F → S in AAK95822 (PubMed:11751921).Curated1
Sequence conflicti442H → Y in AAK95822 (PubMed:11751921).Curated1
Sequence conflicti514G → S in AAK95822 (PubMed:11751921).Curated1
Sequence conflicti537K → E in AAK95822 (PubMed:11751921).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060430124L → V2 PublicationsCorresponds to variant dbSNP:rs4380159Ensembl.1
Natural variantiVAR_057440197V → A. Corresponds to variant dbSNP:rs11671053Ensembl.1
Natural variantiVAR_060431410A → T. Corresponds to variant dbSNP:rs73029758Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY044432 mRNA Translation: AAK95822.1
AK093669 mRNA Translation: BAC04216.1
AC073544 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32981.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F42075

NCBI Reference Sequences

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RefSeqi
NP_612203.2, NM_138330.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359788; ENSP00000352836; ENSG00000197372

Database of genes from NCBI RefSeq genomes

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GeneIDi
171392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:171392

UCSC genome browser

More...
UCSCi
uc002nri.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044432 mRNA Translation: AAK95822.1
AK093669 mRNA Translation: BAC04216.1
AC073544 Genomic DNA No translation available.
CCDSiCCDS32981.1
PIRiF42075
RefSeqiNP_612203.2, NM_138330.2

3D structure databases

SMRiQ8TD23
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128116, 6 interactors
IntActiQ8TD23, 3 interactors
MINTiQ8TD23
STRINGi9606.ENSP00000352836

PTM databases

iPTMnetiQ8TD23
PhosphoSitePlusiQ8TD23

Polymorphism and mutation databases

BioMutaiZNF675
DMDMi296453065

Proteomic databases

EPDiQ8TD23
jPOSTiQ8TD23
MassIVEiQ8TD23
MaxQBiQ8TD23
PaxDbiQ8TD23
PeptideAtlasiQ8TD23
PRIDEiQ8TD23
ProteomicsDBi74222

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28764, 88 antibodies

The DNASU plasmid repository

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DNASUi
171392

Genome annotation databases

EnsembliENST00000359788; ENSP00000352836; ENSG00000197372
GeneIDi171392
KEGGihsa:171392
UCSCiuc002nri.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
171392
DisGeNETi171392
EuPathDBiHostDB:ENSG00000197372.9

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF675
HGNCiHGNC:30768, ZNF675
HPAiENSG00000197372, Low tissue specificity
neXtProtiNX_Q8TD23
OpenTargetsiENSG00000197372
PharmGKBiPA142670476

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT01000000214404
HOGENOMiCLU_002678_44_0_1
InParanoidiQ8TD23
KOiK09228
OMAiHMENKPF
OrthoDBi1318335at2759
PhylomeDBiQ8TD23
TreeFamiTF342117

Enzyme and pathway databases

PathwayCommonsiQ8TD23
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
171392, 11 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF675, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
171392
PharosiQ8TD23, Tbio

Protein Ontology

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PROi
PR:Q8TD23
RNActiQ8TD23, protein

Gene expression databases

BgeeiENSG00000197372, Expressed in cortical plate and 148 other tissues
ExpressionAtlasiQ8TD23, baseline and differential
GenevisibleiQ8TD23, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN675_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TD23
Secondary accession number(s): Q8N211
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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