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Protein

Solute carrier family 2, facilitated glucose transporter member 12

Gene

SLC2A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBi2.A.1.1.87 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 12
Alternative name(s):
Glucose transporter type 12
Short name:
GLUT-12
Gene namesi
Name:SLC2A12
Synonyms:GLUT12, GLUT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146411.5
HGNCiHGNC:18067 SLC2A12
MIMi610372 gene
neXtProtiNX_Q8TD20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 80ExtracellularSequence analysisAdd BLAST15
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137ExtracellularSequence analysis1
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 172CytoplasmicSequence analysisAdd BLAST14
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 197ExtracellularSequence analysis4
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 278CytoplasmicSequence analysisAdd BLAST60
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 317ExtracellularSequence analysisAdd BLAST18
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 345CytoplasmicSequence analysis7
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 466ExtracellularSequence analysisAdd BLAST100
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 498CytoplasmicSequence analysisAdd BLAST11
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Topological domaini520 – 528ExtracellularSequence analysis9
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 617CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi154091
OpenTargetsiENSG00000146411
PharmGKBiPA38288

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMutaiSLC2A12
DMDMi74762615

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920141 – 617Solute carrier family 2, facilitated glucose transporter member 12Add BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TD20
PaxDbiQ8TD20
PeptideAtlasiQ8TD20
PRIDEiQ8TD20
ProteomicsDBi74220

PTM databases

iPTMnetiQ8TD20
PhosphoSitePlusiQ8TD20

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.1 Publication

Gene expression databases

BgeeiENSG00000146411 Expressed in 162 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC2A12
GenevisibleiQ8TD20 HS

Organism-specific databases

HPAiHPA031593
HPA031594

Interactioni

Protein-protein interaction databases

BioGridi127535, 65 interactors
STRINGi9606.ENSP00000275230

Structurei

3D structure databases

ProteinModelPortaliQ8TD20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00920000149002
HOGENOMiHOG000202868
HOVERGENiHBG051858
InParanoidiQ8TD20
KOiK08149
OMAiTSSMNWG
OrthoDBiEOG091G085H
PhylomeDBiQ8TD20
TreeFamiTF332408

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TD20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPVENTEGP SLLNQKGTAV ETEGSGSRHP PWARGCGMFT FLSSVTAAVS
60 70 80 90 100
GLLVGYELGI ISGALLQIKT LLALSCHEQE MVVSSLVIGA LLASLTGGVL
110 120 130 140 150
IDRYGRRTAI ILSSCLLGLG SLVLILSLSY TVLIVGRIAI GVSISLSSIA
160 170 180 190 200
TCVYIAEIAP QHRRGLLVSL NELMIVIGIL SAYISNYAFA NVFHGWKYMF
210 220 230 240 250
GLVIPLGVLQ AIAMYFLPPS PRFLVMKGQE GAASKVLGRL RALSDTTEEL
260 270 280 290 300
TVIKSSLKDE YQYSFWDLFR SKDNMRTRIM IGLTLVFFVQ ITGQPNILFY
310 320 330 340 350
ASTVLKSVGF QSNEAASLAS TGVGVVKVIS TIPATLLVDH VGSKTFLCIG
360 370 380 390 400
SSVMAASLVT MGIVNLNIHM NFTHICRSHN SINQSLDESV IYGPGNLSTN
410 420 430 440 450
NNTLRDHFKG ISSHSRSSLM PLRNDVDKRG ETTSASLLNA GLSHTEYQIV
460 470 480 490 500
TDPGDVPAFL KWLSLASLLV YVAAFSIGLG PMPWLVLSEI FPGGIRGRAM
510 520 530 540 550
ALTSSMNWGI NLLISLTFLT VTDLIGLPWV CFIYTIMSLA SLLFVVMFIP
560 570 580 590 600
ETKGCSLEQI SMELAKVNYV KNNICFMSHH QEELVPKQPQ KRKPQEQLLE
610
CNKLCGRGQS RQLSPET
Length:617
Mass (Da):66,966
Last modified:June 1, 2002 - v1
Checksum:iF176325CDED15249
GO

Sequence cautioni

The sequence BAB71214 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046419 mRNA Translation: AAL02327.1
AK056554 mRNA Translation: BAB71214.1 Different initiation.
AK122628 mRNA Translation: BAG53629.1
AL035699 Genomic DNA No translation available.
AL449363 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47994.1
BC070149 mRNA Translation: AAH70149.1
CCDSiCCDS5169.1
RefSeqiNP_660159.1, NM_145176.2
UniGeneiHs.486508

Genome annotation databases

EnsembliENST00000275230; ENSP00000275230; ENSG00000146411
GeneIDi154091
KEGGihsa:154091
UCSCiuc003qem.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046419 mRNA Translation: AAL02327.1
AK056554 mRNA Translation: BAB71214.1 Different initiation.
AK122628 mRNA Translation: BAG53629.1
AL035699 Genomic DNA No translation available.
AL449363 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47994.1
BC070149 mRNA Translation: AAH70149.1
CCDSiCCDS5169.1
RefSeqiNP_660159.1, NM_145176.2
UniGeneiHs.486508

3D structure databases

ProteinModelPortaliQ8TD20
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127535, 65 interactors
STRINGi9606.ENSP00000275230

Chemistry databases

DrugBankiDB09502 Fludeoxyglucose F-18

Protein family/group databases

TCDBi2.A.1.1.87 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8TD20
PhosphoSitePlusiQ8TD20

Polymorphism and mutation databases

BioMutaiSLC2A12
DMDMi74762615

Proteomic databases

EPDiQ8TD20
PaxDbiQ8TD20
PeptideAtlasiQ8TD20
PRIDEiQ8TD20
ProteomicsDBi74220

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275230; ENSP00000275230; ENSG00000146411
GeneIDi154091
KEGGihsa:154091
UCSCiuc003qem.2 human

Organism-specific databases

CTDi154091
DisGeNETi154091
EuPathDBiHostDB:ENSG00000146411.5
GeneCardsiSLC2A12
H-InvDBiHIX0006232
HGNCiHGNC:18067 SLC2A12
HPAiHPA031593
HPA031594
MIMi610372 gene
neXtProtiNX_Q8TD20
OpenTargetsiENSG00000146411
PharmGKBiPA38288
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00920000149002
HOGENOMiHOG000202868
HOVERGENiHBG051858
InParanoidiQ8TD20
KOiK08149
OMAiTSSMNWG
OrthoDBiEOG091G085H
PhylomeDBiQ8TD20
TreeFamiTF332408

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Miscellaneous databases

ChiTaRSiSLC2A12 human
GeneWikiiSLC2A12
GenomeRNAii154091
PROiPR:Q8TD20
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146411 Expressed in 162 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC2A12
GenevisibleiQ8TD20 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR12_HUMAN
AccessioniPrimary (citable) accession number: Q8TD20
Secondary accession number(s): B3KV17, Q7Z6U3, Q96MR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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