UniProtKB - Q8TD07 (RAE1E_HUMAN)
Retinoic acid early transcript 1E
RAET1E
Functioni
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
2 PublicationsMiscellaneous
Caution
GO - Molecular functioni
- natural killer cell lectin-like receptor binding Source: UniProtKB
GO - Biological processi
- natural killer cell mediated cytotoxicity Source: UniProtKB
- positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
Keywordsi
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q8TD07 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q8TD07 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoic acid early transcript 1E1 PublicationImportedAlternative name(s): Lymphocyte effector toxicity activation ligand1 Publication NKG2D ligand 4 Short name: N2DL-4 Short name: NKG2DL4 RAE-1-like transcript 41 Publication UL16-binding protein 4 |
Gene namesi | ORF Names:UNQ1867/PRO43031 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16793, RAET1E |
MIMi | 609243, gene |
neXtProti | NX_Q8TD07 |
VEuPathDBi | HostDB:ENSG00000164520 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Single-pass type I membrane protein
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 225 | ExtracellularSequence analysisAdd BLAST | 195 | |
Transmembranei | 226 – 248 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 249 – 263 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 135250 |
OpenTargetsi | ENSG00000164520 |
PharmGKBi | PA134913788 |
Miscellaneous databases
Pharosi | Q8TD07, Tbio |
Genetic variation databases
BioMutai | RAET1E |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000019021 | 31 – 263 | Retinoic acid early transcript 1EAdd BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 126 ↔ 189 | By similarity | ||
Glycosylationi | 154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 212 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q8TD07 |
jPOSTi | Q8TD07 |
MassIVEi | Q8TD07 |
PaxDbi | Q8TD07 |
PeptideAtlasi | Q8TD07 |
PRIDEi | Q8TD07 |
ProteomicsDBi | 1774 74206 [Q8TD07-1] 74207 [Q8TD07-2] 74208 [Q8TD07-3] |
PTM databases
GlyGeni | Q8TD07, 3 sites |
PhosphoSitePlusi | Q8TD07 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000164520, Expressed in ectocervix and 112 other tissues |
ExpressionAtlasi | Q8TD07, baseline and differential |
Genevisiblei | Q8TD07, HS |
Organism-specific databases
HPAi | ENSG00000164520, Tissue enhanced (esophagus, skin, vagina) |
Interactioni
Subunit structurei
Binds to KLRK1/NKG2D.
2 Publications(Microbial infection) Contrary to other family members, does not interact with CMV glycoprotein UL16.
1 PublicationBinary interactionsi
Q8TD07
With | #Exp. | IntAct |
---|---|---|
KLRK1 [P26718] | 4 | EBI-16365677,EBI-458344 |
Isoform 1 [Q8TD07-1]
With | #Exp. | IntAct |
---|---|---|
KLRK1 [P26718] | 2 | EBI-16747021,EBI-458344 |
Isoform 2 [Q8TD07-2]
With | #Exp. | IntAct |
---|---|---|
KLRK1 [P26718] | 2 | EBI-16417277,EBI-458344 |
Isoform 5 [Q8TD07-5]
With | #Exp. | IntAct |
---|---|---|
KLRK1 [P26718] | 2 | EBI-16747044,EBI-458344 |
Isoform 6 [Q8TD07-6]
With | #Exp. | IntAct |
---|---|---|
KLRK1 [P26718] | 2 | EBI-16747033,EBI-458344 |
GO - Molecular functioni
- natural killer cell lectin-like receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 126425, 25 interactors |
IntActi | Q8TD07, 19 interactors |
STRINGi | 9606.ENSP00000349709 |
Miscellaneous databases
RNActi | Q8TD07, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 116 | MHC class I alpha-1 like; down-regulates the cell surface expression of KLRK11 PublicationAdd BLAST | 86 | |
Regioni | 117 – 207 | MHC class I alpha-2 like; down-regulates the cell surface expression of KLRK11 PublicationAdd BLAST | 91 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TM6M, Eukaryota |
GeneTreei | ENSGT01040000240396 |
HOGENOMi | CLU_086235_0_0_1 |
InParanoidi | Q8TD07 |
OMAi | GHREAMP |
OrthoDBi | 1092787at2759 |
PhylomeDBi | Q8TD07 |
TreeFami | TF339658 |
Family and domain databases
Gene3Di | 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF00129, MHC_I, 1 hit |
SUPFAMi | SSF54452, SSF54452, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRISLTSSP VRLLLFLLLL LIALEIMVGG HSLCFNFTIK SLSRPGQPWC
60 70 80 90 100
EAQVFLNKNL FLQYNSDNNM VKPLGLLGKK VYATSTWGEL TQTLGEVGRD
110 120 130 140 150
LRMLLCDIKP QIKTSDPSTL QVEMFCQREA ERCTGASWQF ATNGEKSLLF
160 170 180 190 200
DAMNMTWTVI NHEASKIKET WKKDRGLEKY FRKLSKGDCD HWLREFLGHW
210 220 230 240 250
EAMPEPTVSP VNASDIHWSS SSLPDRWIIL GAFILLVLMG IVLICVWWQN
260
GEWQAGLWPL RTS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3T1D4 | Q3T1D4_HUMAN | RAET1E protein | RAET1E | 117 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 141 – 142 | AT → TI in AAL76417 (PubMed:11827464).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024534 | 12 | R → H. Corresponds to variant dbSNP:rs9383583Ensembl. | 1 | |
Natural variantiVAR_020271 | 82 | Y → N2 PublicationsCorresponds to variant dbSNP:rs2151910Ensembl. | 1 | |
Natural variantiVAR_024535 | 128 | R → H1 PublicationCorresponds to variant dbSNP:rs6925151Ensembl. | 1 | |
Natural variantiVAR_050408 | 141 | A → T. Corresponds to variant dbSNP:rs9383921Ensembl. | 1 | |
Natural variantiVAR_050409 | 142 | T → I. Corresponds to variant dbSNP:rs9371533Ensembl. | 1 | |
Natural variantiVAR_061483 | 194 | R → G. Corresponds to variant dbSNP:rs57292884Ensembl. | 1 | |
Natural variantiVAR_024536 | 237 | V → L. Corresponds to variant dbSNP:rs2342767Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010441 | 28 – 63 | Missing in isoform 2. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_059262 | 29 | G → GECPEHKNWLRTRRREKG in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_059263 | 165 – 208 | SKIKE…PEPTV → M in isoform 5. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_045012 | 208 – 263 | VSPVN…PLRTS → GN in isoform 4. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_010442 | 208 – 212 | VSPVN → GRRST in isoform 3. 1 Publication | 5 | |
Alternative sequenceiVSP_010443 | 213 – 263 | Missing in isoform 3. 1 PublicationAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY069961 mRNA Translation: AAL58090.1 AY252119 mRNA Translation: AAP15166.1 AY176317 mRNA Translation: AAO22240.1 EF489426 mRNA Translation: ABR29881.1 AY054974 mRNA Translation: AAL11005.1 AY359075 mRNA Translation: AAQ89434.1 AL355312 Genomic DNA No translation available. AF359243 mRNA Translation: AAL76417.1 |
CCDSi | CCDS5221.1 [Q8TD07-1] CCDS59042.1 [Q8TD07-4] CCDS59043.1 [Q8TD07-3] CCDS59044.1 [Q8TD07-2] |
RefSeqi | NP_001230254.1, NM_001243325.1 [Q8TD07-2] NP_001230256.1, NM_001243327.1 [Q8TD07-4] NP_001230257.1, NM_001243328.1 [Q8TD07-3] NP_631904.1, NM_139165.2 [Q8TD07-1] XP_011533781.1, XM_011535479.2 [Q8TD07-3] |
Genome annotation databases
Ensembli | ENST00000357183.9; ENSP00000349709.4; ENSG00000164520.12 ENST00000367363.3; ENSP00000356332.3; ENSG00000164520.12 [Q8TD07-2] ENST00000529948.1; ENSP00000432366.1; ENSG00000164520.12 [Q8TD07-4] ENST00000532335.5; ENSP00000437067.1; ENSG00000164520.12 [Q8TD07-3] |
GeneIDi | 135250 |
KEGGi | hsa:135250 |
MANE-Selecti | ENST00000357183.9; ENSP00000349709.4; NM_001394057.1; NP_001380986.1 |
UCSCi | uc003qnj.3, human [Q8TD07-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY069961 mRNA Translation: AAL58090.1 AY252119 mRNA Translation: AAP15166.1 AY176317 mRNA Translation: AAO22240.1 EF489426 mRNA Translation: ABR29881.1 AY054974 mRNA Translation: AAL11005.1 AY359075 mRNA Translation: AAQ89434.1 AL355312 Genomic DNA No translation available. AF359243 mRNA Translation: AAL76417.1 |
CCDSi | CCDS5221.1 [Q8TD07-1] CCDS59042.1 [Q8TD07-4] CCDS59043.1 [Q8TD07-3] CCDS59044.1 [Q8TD07-2] |
RefSeqi | NP_001230254.1, NM_001243325.1 [Q8TD07-2] NP_001230256.1, NM_001243327.1 [Q8TD07-4] NP_001230257.1, NM_001243328.1 [Q8TD07-3] NP_631904.1, NM_139165.2 [Q8TD07-1] XP_011533781.1, XM_011535479.2 [Q8TD07-3] |
3D structure databases
AlphaFoldDBi | Q8TD07 |
SMRi | Q8TD07 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126425, 25 interactors |
IntActi | Q8TD07, 19 interactors |
STRINGi | 9606.ENSP00000349709 |
PTM databases
GlyGeni | Q8TD07, 3 sites |
PhosphoSitePlusi | Q8TD07 |
Genetic variation databases
BioMutai | RAET1E |
Proteomic databases
EPDi | Q8TD07 |
jPOSTi | Q8TD07 |
MassIVEi | Q8TD07 |
PaxDbi | Q8TD07 |
PeptideAtlasi | Q8TD07 |
PRIDEi | Q8TD07 |
ProteomicsDBi | 1774 74206 [Q8TD07-1] 74207 [Q8TD07-2] 74208 [Q8TD07-3] |
Protocols and materials databases
Antibodypediai | 33297, 292 antibodies from 21 providers |
DNASUi | 135250 |
Genome annotation databases
Ensembli | ENST00000357183.9; ENSP00000349709.4; ENSG00000164520.12 ENST00000367363.3; ENSP00000356332.3; ENSG00000164520.12 [Q8TD07-2] ENST00000529948.1; ENSP00000432366.1; ENSG00000164520.12 [Q8TD07-4] ENST00000532335.5; ENSP00000437067.1; ENSG00000164520.12 [Q8TD07-3] |
GeneIDi | 135250 |
KEGGi | hsa:135250 |
MANE-Selecti | ENST00000357183.9; ENSP00000349709.4; NM_001394057.1; NP_001380986.1 |
UCSCi | uc003qnj.3, human [Q8TD07-1] |
Organism-specific databases
CTDi | 135250 |
DisGeNETi | 135250 |
GeneCardsi | RAET1E |
HGNCi | HGNC:16793, RAET1E |
HPAi | ENSG00000164520, Tissue enhanced (esophagus, skin, vagina) |
MIMi | 609243, gene |
neXtProti | NX_Q8TD07 |
OpenTargetsi | ENSG00000164520 |
PharmGKBi | PA134913788 |
VEuPathDBi | HostDB:ENSG00000164520 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TM6M, Eukaryota |
GeneTreei | ENSGT01040000240396 |
HOGENOMi | CLU_086235_0_0_1 |
InParanoidi | Q8TD07 |
OMAi | GHREAMP |
OrthoDBi | 1092787at2759 |
PhylomeDBi | Q8TD07 |
TreeFami | TF339658 |
Enzyme and pathway databases
PathwayCommonsi | Q8TD07 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q8TD07 |
Miscellaneous databases
BioGRID-ORCSi | 135250, 10 hits in 1063 CRISPR screens |
GeneWikii | RAET1E |
GenomeRNAii | 135250 |
Pharosi | Q8TD07, Tbio |
PROi | PR:Q8TD07 |
RNActi | Q8TD07, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164520, Expressed in ectocervix and 112 other tissues |
ExpressionAtlasi | Q8TD07, baseline and differential |
Genevisiblei | Q8TD07, HS |
Family and domain databases
Gene3Di | 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF00129, MHC_I, 1 hit |
SUPFAMi | SSF54452, SSF54452, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAE1E_HUMAN | |
Accessioni | Q8TD07Primary (citable) accession number: Q8TD07 Secondary accession number(s): A6YF59 Q96L41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families