Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anterior gradient protein 3

Gene

AGR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.By similarity

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Anterior gradient protein 3
Short name:
AG-3
Short name:
AG3
Short name:
hAG-3
Alternative name(s):
Anterior gradient 3 homologImported
Breast cancer membrane protein 11Imported
Protein disulfide isomerase family A, member 18Imported
Gene namesi
Name:AGR3
Synonyms:BCMP11, PDIA18
ORF Names:UNQ642/PRO1272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000173467.8
HGNCiHGNC:24167 AGR3
MIMi609482 gene
neXtProtiNX_Q8TD06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi163 – 166Missing : Leads to Golgi localization;. 1 Publication4

Organism-specific databases

DisGeNETi155465
OpenTargetsiENSG00000173467
PharmGKBiPA162375917

Polymorphism and mutation databases

BioMutaiAGR3
DMDMi66774045

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000104022 – 166Anterior gradient protein 3Add BLAST145

Proteomic databases

MaxQBiQ8TD06
PaxDbiQ8TD06
PeptideAtlasiQ8TD06
PRIDEiQ8TD06
ProteomicsDBi74205

PTM databases

iPTMnetiQ8TD06
PhosphoSitePlusiQ8TD06

Expressioni

Tissue specificityi

Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690).2 Publications

Inductioni

Not induced as part of the cellular response to endoplasmic reticulum stress (PubMed:25751668). Up-regulated by androgens and by estrogens in prostate cancer cells (PubMed:23294566) Up-regulated by a hormone (estrogen-receptor alpha) independent mechanism in ovarian cancer (PubMed:22361111).3 Publications

Gene expression databases

BgeeiENSG00000173467
CleanExiHS_AGR3
ExpressionAtlasiQ8TD06 baseline and differential
GenevisibleiQ8TD06 HS

Organism-specific databases

HPAiHPA053942

Interactioni

Subunit structurei

Interacts with LYPD3 and DAG1 (alphaDAG1).1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127586, 17 interactors
IntActiQ8TD06, 29 interactors
MINTiQ8TD06
STRINGi9606.ENSP00000308606

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 35Combined sources3
Helixi48 – 58Combined sources11
Beta strandi62 – 66Combined sources5
Helixi72 – 83Combined sources12
Helixi85 – 93Combined sources9
Beta strandi96 – 102Combined sources7
Helixi107 – 109Combined sources3
Beta strandi116 – 122Combined sources7
Helixi145 – 147Combined sources3
Helixi148 – 159Combined sources12

3D structure databases

ProteinModelPortaliQ8TD06
SMRiQ8TD06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi163 – 166Prevents secretion from ER1 Publication4

Sequence similaritiesi

Belongs to the AGR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWAH Eukaryota
ENOG4111K70 LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG006516
InParanoidiQ8TD06
KOiK20357
OMAiAQNNFIM
OrthoDBiEOG091G0RHV
PhylomeDBiQ8TD06
TreeFamiTF321449

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TD06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLHSALGLC LLLVTVSSNL AIAIKKEKRP PQTLSRGWGD DITWVQTYEE
60 70 80 90 100
GLFYAQKSKK PLMVIHHLED CQYSQALKKV FAQNEEIQEM AQNKFIMLNL
110 120 130 140 150
MHETTDKNLS PDGQYVPRIM FVDPSLTVRA DIAGRYSNRL YTYEPRDLPL
160
LIENMKKALR LIQSEL
Length:166
Mass (Da):19,171
Last modified:June 1, 2002 - v1
Checksum:iB1A4804B47705D65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY069977 mRNA Translation: AAL55402.1
AY359065 mRNA Translation: AAQ89424.1
CH236948 Genomic DNA Translation: EAL24282.1
CH471073 Genomic DNA Translation: EAW93685.1
BC058284 mRNA Translation: AAH58284.1
CCDSiCCDS5365.1
RefSeqiNP_789783.1, NM_176813.4
XP_005249684.1, XM_005249627.2
UniGeneiHs.100686

Genome annotation databases

EnsembliENST00000310398; ENSP00000308606; ENSG00000173467
GeneIDi155465
KEGGihsa:155465
UCSCiuc003sts.4 human

Similar proteinsi

Entry informationi

Entry nameiAGR3_HUMAN
AccessioniPrimary (citable) accession number: Q8TD06
Secondary accession number(s): A4D120
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2002
Last modified: July 18, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health